Uploaded April 2026 | Updated September 2026, 2 weeks ago
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I asked a biochemist what life isβ¦ and the answer was basically: βIf you think you know, you donβt.β
In this video, I talk with Nick Lane about a radical idea: life isnβt really about genesβitβs about energy flow. We go from the dreaded Krebs cycle to the possibility that metabolism came before DNA, and why defining life might be the wrong question altogether.
So hereβs what Iβm left wondering: if life is just chemistry with a current running through itβ¦ where do we draw the line?
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Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U
My tell-all cosmic memoir Losing the Nobel Prize: amzn.to/2sa5UpA
The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un
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#universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #intotheimpossible #briankeating
Please join my mailing list here π briankeating.com/yt to win a meteorite π₯
I asked a biochemist what life isβ¦ and the answer was basically: βIf you think you know, you donβt.β
In this video, I talk with Nick Lane about a radical idea: life isnβt really about genesβitβs about energy flow. We go from the dreaded Krebs cycle to the possibility that metabolism came before DNA, and why defining life might be the wrong question altogether.
So hereβs what Iβm left wondering: if life is just chemistry with a current running through itβ¦ where do we draw the line?
-----------------------------------------------------------------------------------------
Join this channel to get access to perks like monthly Office Hours:
youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join
π Get my books:
Think Like a Nobel Prize Winner, with productivity tips from 9 Nobel Prize winners: https://a.co/d/03ezQFu
Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U
My tell-all cosmic memoir Losing the Nobel Prize: amzn.to/2sa5UpA
The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un
Follow me to ask questions of my guests:
πββοΈ Twitter: twitter.com/DrBrianKeating
π Subscribe youtube.com/DrBrianKeating?sub_confirmation=1
π Join my mailing list; just click here briankeating.com/list
βοΈ Detailed Blog posts here: briankeating.com/blog
ποΈ Listen on audio-only platforms: briankeating.com/podcast
#universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #intotheimpossible #briankeating

![Sam Harris: The Self Disappears When You Look For It.
Sam Harris on why meditation tells you nothing about the Big Bang β but everything about why youre suffering.
In this segment, the neuroscientist and creator of the Waking Up app draws the cleanest line Ive heard between the contemplative traditions first-person discoveries and the metaphysical inflation that usually rides on top of them. He breaks publicly with Deepak Chopra on exactly where that line sits.
What we cover:
- Why levels of consciousness is the wrong frame, and what changes when you switch to contents
- The optic-blind-spot analogy for finding the self β a falsifiable experiment you can run on yourself
- The difference between changing what you think about and changing the witness that thinks
- Why nearly every state of psychological suffering is anchored to a sense of self that disappears under inspection
- Where Harris parts company with Chopra on what meditative experience can and cannot tell you about the cosmos
- The claim that wisdom is nothing more profound than the ability to take your own advice
The argument matters because its empirically tractable. Either the felt sense of I survives close phenomenological inspection or it doesnt. Run the experiment.
Sam Harris is a neuroscientist, philosopher, five-time New York Times bestselling author, and creator of the Waking Up app: https://www.wakingup.com, Its my operating system for the mind that I use every day [unsponsored!]
He hosts the Making Sense podcast: https://www.samharris.org
Brians Substack β full transcript, bonus material, and the Monday M.A.G.I.C. Message: https://briankeating.substack.com/
Brians books and reading list: https://briankeating.com
Timestamps:
00:00 Why You Canβt Find Your Brain
01:03 The Mystery of Consciousness
03:08 Wisdom Is Taking Your Own Advice
05:18 Meditation Isnβt Self-Improvement
07:06 Where Sam Harris Breaks From Deepak Chopra
09:10 You Are the Universe Seeing Itself
12:31 The Meditation Experiment That Changes Everything
15:00 What Happens When the Self Disappears
βββ
π¬ Get the transcript, fascinating bonus content, and my Monday M.A.G.I.C. Message: https://briankeating.com/yt
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β Join this channel for perks, monthly Office Hours, and your name in the Member Roster at the end of every episode:
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π My books:
Losing the Nobel Prize (memoir): http://amzn.to/2sa5UpA
Think Like a Nobel Prize Winner: https://a.co/d/03ezQFu
Focus Like a Nobel Prize Winner: https://a.co/d/hi50U9U
Galileos Dialogue (first-ever audiobook): https://a.co/d/iZPi9Un
π More:
πββοΈ Twitter: https://twitter.com/DrBrianKeating
π Substack https://briankeating.substack.com/ss
βοΈ Blog: https://briankeating.com/blog
ποΈ Audio-only: https://briankeating.com/podcast
#intotheimpossible #briankeating #science #physics #astronomy #cosmology #podcast #universe Sam Harris: The Self Disappears When You Look For It.](https://i.ytimg.com/vi/oDa1Dakkza8/mqdefault.jpg)








