Uploaded May 2024 | Updated September 2026, 2 hours ago
Seminar Title - From GWAS to molecular insights into islet cell dysfunction
Dr. Anna L. Gloyn is a Professor of Pediatrics & by Courtesy Genetics, Associate Chair for Basic Research (Pediatrics), Stanford School of Medicine, Stanford University, USA. The over-arching aim of Dr. Gloyn’s research is to use human genetics as a tool to understand cellular and molecular mechanisms for pancreatic beta cell failure in diabetes and related conditions. To achieve this, Dr. Gloyn has deployed several different approaches, including genomics, genome-editing of in vitro human cell models and integrative physiology which she uses to study both monogenic forms of diabetes due to rare mutations which are causal for disease through to common variants present in most of the population which increase an individual’s risk for developing diabetes. Dr. Gloyn’s goal is to capitalize on an improved mechanistic understanding of pancreatic beta cell dysfunction to improve treatment options for patients via the identification of safe and effective therapeutic targets and patient stratification. In addition, Dr. Gloyn is involved in several efforts to integrate genetic data on diabetes heterogeneity into human islet research within the Human Islet Research Network (HIRN).
About the National Human Genome Research Institute (NHGRI) Division of Intramural Research (DIR) Seminar Series: The NHGRI DIR Seminar Series sponsors a monthly series of talks by intramural and special guest speakers celebrating genetics and genomics research. Speakers are selected by NHGRI intramural faculty and trainees and cover research topics of interest to a wide audience.
Relevant Links:
DIR Seminar Series: genome.gov/dir/seminars
Anna Gloyn (Stanford University): https://med.stanford.edu/profiles/anna-gloyn
Seminar Title - From GWAS to molecular insights into islet cell dysfunction
Dr. Anna L. Gloyn is a Professor of Pediatrics & by Courtesy Genetics, Associate Chair for Basic Research (Pediatrics), Stanford School of Medicine, Stanford University, USA. The over-arching aim of Dr. Gloyn’s research is to use human genetics as a tool to understand cellular and molecular mechanisms for pancreatic beta cell failure in diabetes and related conditions. To achieve this, Dr. Gloyn has deployed several different approaches, including genomics, genome-editing of in vitro human cell models and integrative physiology which she uses to study both monogenic forms of diabetes due to rare mutations which are causal for disease through to common variants present in most of the population which increase an individual’s risk for developing diabetes. Dr. Gloyn’s goal is to capitalize on an improved mechanistic understanding of pancreatic beta cell dysfunction to improve treatment options for patients via the identification of safe and effective therapeutic targets and patient stratification. In addition, Dr. Gloyn is involved in several efforts to integrate genetic data on diabetes heterogeneity into human islet research within the Human Islet Research Network (HIRN).
About the National Human Genome Research Institute (NHGRI) Division of Intramural Research (DIR) Seminar Series: The NHGRI DIR Seminar Series sponsors a monthly series of talks by intramural and special guest speakers celebrating genetics and genomics research. Speakers are selected by NHGRI intramural faculty and trainees and cover research topics of interest to a wide audience.
Relevant Links:
DIR Seminar Series: genome.gov/dir/seminars
Anna Gloyn (Stanford University): https://med.stanford.edu/profiles/anna-gloyn
