Uploaded July 2025 | Updated September 2026, 26 minutes ago
In this presentation, Dr. Matthew Budoff reveals preliminary results from Heartflow’s AI-guided quantitative analysis of the Keto-CTA study. The data focus on coronary plaque progression in participants adhering to a ketogenic diet who experienced a significant rise in LDL cholesterol. Budoff compares the Heartflow data to previously released analyses, discussing patterns of regression, progression, and distribution across key subgroups. This early analysis supports the plausibility and biological consistency expected in longitudinal CCTA imaging, particularly among those with low baseline plaque burden.
Note: Heartflow was unable to process 5 of the 200 scans due to technical limitations. These participants are excluded from all quantitative analyses in this presentation to ensure consistent comparison across datasets.
0:00 – Introduction
1:12 – Overview of the Keto-CTA study design
3:08 – Introduction to Heartflow's AI-based analysis
5:22 – Heartflow vs Cleerly comparison: patterns of regression
7:40 – Stratification by baseline CAC = 0 vs CAC more than 0
9:18 – Interpretation of regression and progression patterns
11:02 – Distribution curve comparison: Heartflow vs Cleerly
13:25 – Summary of early findings and next steps
15:10 – Q&A and final thoughts
In this presentation, Dr. Matthew Budoff reveals preliminary results from Heartflow’s AI-guided quantitative analysis of the Keto-CTA study. The data focus on coronary plaque progression in participants adhering to a ketogenic diet who experienced a significant rise in LDL cholesterol. Budoff compares the Heartflow data to previously released analyses, discussing patterns of regression, progression, and distribution across key subgroups. This early analysis supports the plausibility and biological consistency expected in longitudinal CCTA imaging, particularly among those with low baseline plaque burden.
Note: Heartflow was unable to process 5 of the 200 scans due to technical limitations. These participants are excluded from all quantitative analyses in this presentation to ensure consistent comparison across datasets.
0:00 – Introduction
1:12 – Overview of the Keto-CTA study design
3:08 – Introduction to Heartflow's AI-based analysis
5:22 – Heartflow vs Cleerly comparison: patterns of regression
7:40 – Stratification by baseline CAC = 0 vs CAC more than 0
9:18 – Interpretation of regression and progression patterns
11:02 – Distribution curve comparison: Heartflow vs Cleerly
13:25 – Summary of early findings and next steps
15:10 – Q&A and final thoughts
