Uploaded October 2023 | Updated September 2026, 1 week ago
Pluripotent mouse embryonic #stemcells can maintain their identity throughout virtually infinite cell divisions. This phenomenon, known as self-renewal, is dependent on a network of sequence-specific transcription factors (TFs) that ensure daughter cells accurately reproduce the gene expression pattern of the mother. However, dramatic chromosomal changes take place in mitosis, leading to the eviction of TFs from chromatin.
A recent study has shown that Mitotic ESRRB binding is highly dynamic and driven by specific recognition of its DNA-binding motif. It is associated with early transcriptional activation of target genes after completion of mitosis. These results indicate that ESRRB may act as a mitotic bookmarking factor, opening another perspective to molecularly understand the role of sequence-specific TFs in the epigenetic control of self-renewal, pluripotency, and genome reprogramming.
It is crucial to have a scientific animation explaining the research to a broader audience because it can help to convey complex scientific concepts in an engaging and accessible way. Animations can help to illustrate the mechanisms behind the research, making it easier for non-scientists to understand the significance of the findings. They can also help to generate interest in the research, which can lead to increased funding and support for future studies.
In addition, scientific animations can be used to educate students and the public about scientific concepts, which can help to promote scientific literacy and encourage more people to pursue careers in science. By making scientific research more accessible and engaging, we can help to promote a better understanding of the world around us and inspire future generations of scientists.
Watch full animation: youtu.be/4qnuPxTkEqg
#ScienceCommunication #Epigentics #MitoticBookmarking
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Pluripotent mouse embryonic #stemcells can maintain their identity throughout virtually infinite cell divisions. This phenomenon, known as self-renewal, is dependent on a network of sequence-specific transcription factors (TFs) that ensure daughter cells accurately reproduce the gene expression pattern of the mother. However, dramatic chromosomal changes take place in mitosis, leading to the eviction of TFs from chromatin.
A recent study has shown that Mitotic ESRRB binding is highly dynamic and driven by specific recognition of its DNA-binding motif. It is associated with early transcriptional activation of target genes after completion of mitosis. These results indicate that ESRRB may act as a mitotic bookmarking factor, opening another perspective to molecularly understand the role of sequence-specific TFs in the epigenetic control of self-renewal, pluripotency, and genome reprogramming.
It is crucial to have a scientific animation explaining the research to a broader audience because it can help to convey complex scientific concepts in an engaging and accessible way. Animations can help to illustrate the mechanisms behind the research, making it easier for non-scientists to understand the significance of the findings. They can also help to generate interest in the research, which can lead to increased funding and support for future studies.
In addition, scientific animations can be used to educate students and the public about scientific concepts, which can help to promote scientific literacy and encourage more people to pursue careers in science. By making scientific research more accessible and engaging, we can help to promote a better understanding of the world around us and inspire future generations of scientists.
Watch full animation: youtu.be/4qnuPxTkEqg
#ScienceCommunication #Epigentics #MitoticBookmarking
FOLLOW US
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Twitter: twitter.com/nymus3d
Facebook: facebook.com/nymus3d
LinkedIn: linkedin.com/company/nymus-3d
Xing: xing.com/pages/nymus3d
Instagram: instagram.com/nymus3d
Behance: behance.net/nymus3d
Artstation: artstation.com/nymus3d
► More videos from Nymus 3D: nymus3d.com
