Uploaded September 2023 | Updated September 2026, 4 days ago
Chris Masterjohn, PhD is the Founder and Scientific Director of the mitochondrial test mito.me. Get the written and referenced version here:
chrismasterjohnphd.substack.com/p/the-guide-to-methylene-blue
Get whole genome sequenced so you know why you would even need to consider MB:
chrismasterjohnphd.com/genome
00:00:00 The Origin of Methylene Blue
00:08:54 The Entry of Methylene Blue Into Medicine
00:13:59 From Malaria to Many Uses in Medicine
00:26:20 How Methylene Blue Works
A Redox-Reactive Dye
The Blue Bottle Experiment
Methylene Blue Radicals, Photoexcited States, and Demethylated Metabolites
Methylene Blue Can Oxidize and Reduce Many Targets
Methylene Blue Can Rewire the Mitochondrial Respiratory Chain
Rewiring the Respiratory Chain Does Not Make It Better
Methylene Blue Increases Hydrogen Peroxide
Hydrogen Peroxide Kills Microbes, Has Hormetic Benefits, But Is Still Ultimately Toxic
Methylene Blue Causes Redox Cycling of Hemoglobin
Methylene Blue Is a Strong Monoamine Oxidase A Inhibitor
Methylene Blue Inhibits Nitric Oxide Synthase
Mechanistic Conclusions
02:09:14 Is Methylene Blue Fundamentally Hormetic?
02:15:06 Methylene Blue Fails in Alzheimer’s, and Causes a Worrisome Side Effect
02:23:57 Whether Methylene Blue Helps Or Hurts Depends on Whether You Need It
02:30:16 Natural Alternatives for Hormesis and Rewiring the Respiratory Chain
02:33:27 Who Should Use Methylene Blue?
Once more you can get it here:
chrismasterjohnphd.substack.com/p/the-guide-to-methylene-blue
Do You Have Hidden Mitochondrial Dysfunction?
Mitochondrial dysfunction is one of the earliest signs of aging and chronic disease—and most people don’t know they have it. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease.
Find my comprehensive mitochondrial analysis at mito.me
For more information and to read more of my work, visit chrismasterjohn-phd.com
Chris Masterjohn, PhD is the Founder and Scientific Director of the mitochondrial test mito.me. Get the written and referenced version here:
chrismasterjohnphd.substack.com/p/the-guide-to-methylene-blue
Get whole genome sequenced so you know why you would even need to consider MB:
chrismasterjohnphd.com/genome
00:00:00 The Origin of Methylene Blue
00:08:54 The Entry of Methylene Blue Into Medicine
00:13:59 From Malaria to Many Uses in Medicine
00:26:20 How Methylene Blue Works
A Redox-Reactive Dye
The Blue Bottle Experiment
Methylene Blue Radicals, Photoexcited States, and Demethylated Metabolites
Methylene Blue Can Oxidize and Reduce Many Targets
Methylene Blue Can Rewire the Mitochondrial Respiratory Chain
Rewiring the Respiratory Chain Does Not Make It Better
Methylene Blue Increases Hydrogen Peroxide
Hydrogen Peroxide Kills Microbes, Has Hormetic Benefits, But Is Still Ultimately Toxic
Methylene Blue Causes Redox Cycling of Hemoglobin
Methylene Blue Is a Strong Monoamine Oxidase A Inhibitor
Methylene Blue Inhibits Nitric Oxide Synthase
Mechanistic Conclusions
02:09:14 Is Methylene Blue Fundamentally Hormetic?
02:15:06 Methylene Blue Fails in Alzheimer’s, and Causes a Worrisome Side Effect
02:23:57 Whether Methylene Blue Helps Or Hurts Depends on Whether You Need It
02:30:16 Natural Alternatives for Hormesis and Rewiring the Respiratory Chain
02:33:27 Who Should Use Methylene Blue?
Once more you can get it here:
chrismasterjohnphd.substack.com/p/the-guide-to-methylene-blue
Do You Have Hidden Mitochondrial Dysfunction?
Mitochondrial dysfunction is one of the earliest signs of aging and chronic disease—and most people don’t know they have it. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease.
Find my comprehensive mitochondrial analysis at mito.me
For more information and to read more of my work, visit chrismasterjohn-phd.com
