Lab Variability Drives Overtreatment @drstephenpetteruti
Lab Variability Drives Overtreatment  @drstephenpetteruti
Uploaded February 2026 | Updated September 2026, 2 weeks ago
Not every change in a lab value signals disease progression or demands aggressive intervention.

PSA levels can fluctuate due to analytic variability, sometimes by as much as 15% from the same blood sample. Small PSA changes often reflect testing noise rather than clinical reality. Overreacting can lead to unnecessary testosterone suppression, loss of vitality, and false reassurance.

A number alone should never dictate life-altering treatment decisions.

Tune in to the episode of Intellectual Medicine.

#BiochemicalRecurrence #PSAClarity #VitalityFirst
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Intellectual Medicine |

Lab Variability Drives Overtreatment

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