Uploaded September 2022 | Updated September 2026, 3 hours ago

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The inflammasome pathway is a key driver of pathological inflammation, contributing to several common human diseases (e.g. metabolic disease, neurodegenerative diseases, cancers). Inflammasomes are signalling hubs that induce cell lysis, culminating in immune system activation. Here, we reveal new mechanisms by which inflammasomes signal, and how a small molecule inflammasome inhibitor can silence pathological inflammasome signalling for therapeutic management of several human diseases.