Uploaded May 2026 | Updated September 2026, 2 weeks ago

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For clinicians considering an injection for cholesterol, PCSK9 inhibitors are cholesterol-lowering medications used in patients who are not reaching LDL targets on statin therapy. In this Medmastery lesson, learn how PCSK9 inhibitors work, when to use them, and the key clinical and practical considerations for prescribing evolocumab, alirocumab, and inclisiran in practice. #PCSK9inhibitors #hyperlipidemia #Medmastery

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⏰ In this video:
0:00 PCSK9 inhibitors: clinical use
0:28 PCSK9 enzyme and reduced LDL receptor expression
1:54 How PCSK9 inhibitors work
3:09 PCSK9 inhibitors: drugs and injection dosing
3:53 Indications and patient selection
4:17 Side effects of PCSK9 inhibitors
4:39 PCSK9 inhibitors in practice: cost, access, and monitoring
6:18 Patient challenges with PCSK9 inhibitors