Uploaded June 2023 | Updated September 2026, 3 weeks ago
TIC-CON 2023: Impact of Environmental Stress on Adults with Tourette Syndrome
Presenter: David Issacs, MD, MPH - Vanderbilt University (Center of Excellence)
Environmental stressors have been postulated to impact the course of Tourette syndrome (TS), given their known influence on brain developmentand adult mental and physical health. In children with TS, environmental stressors predict tic and psychiatric symptom severity at two-year follow-up. In adults with TS, childhood adversity is associated with worst-ever tic severity. However, the broader, longitudinal impact of environmental stressors on adults with TS remains uncertain. This lecture will review 1) the background evidence supporting the hypothesis that environmental stressors influence the course of TS into adulthood and 2) preliminary baseline results from a longitudinal study testing this hypothesis.
TIC-CON 2023: Impact of Environmental Stress on Adults with Tourette Syndrome
Presenter: David Issacs, MD, MPH - Vanderbilt University (Center of Excellence)
Environmental stressors have been postulated to impact the course of Tourette syndrome (TS), given their known influence on brain developmentand adult mental and physical health. In children with TS, environmental stressors predict tic and psychiatric symptom severity at two-year follow-up. In adults with TS, childhood adversity is associated with worst-ever tic severity. However, the broader, longitudinal impact of environmental stressors on adults with TS remains uncertain. This lecture will review 1) the background evidence supporting the hypothesis that environmental stressors influence the course of TS into adulthood and 2) preliminary baseline results from a longitudinal study testing this hypothesis.










