Uploaded January 2025 | Updated September 2026, 2 weeks ago

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Who's That Isaac is a brand new minigame about guessing items and trinkets from the The Binding of Isaac, inspired by the famous Who's That Pokémon question-and-answers segments from the Pokémon anime.

Choose from a variety of characters from The Binding of Isaac which are adapted to have their unique buffs and nerfs. Challenge your friend by using the same seed, or try out the unique Daily Runs! Bored of the base game? Try modded items - choose from a variety of popular and new mods that are supported on the IsaacGuru website.

Check out the game here: isaacguru.com/whos-that-isaac

Soundtrack used in the video: youtube.com/watch?v=-9ThSEA9SRo

Visit the IsaacGuru website: IsaacGuru.com
Join my Discord: discord.gg/FypTtsshgB
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#thebindingofisaac #tboi #repentance