Uploaded April 2026 | Updated September 2026, 2 weeks ago
Full Show Notes: bengreenfieldlife.com/nadplus
In this fascinating episode, Dr. Nichola Conlon, molecular biologist and founder of Nuchido, breaks down what NAD actually is, what it does inside your cells, and why most popular strategies for boosting it, including NAD IVs, patches, and high-dose NR or NMN, may be fundamentally flawed based on molecular biology.
You’ll discover why NAD declines by half every 20 years, why the NAMPT enzyme and not a shortage of raw material is the real bottleneck, and why flooding the body with precursors without fixing the salvage pathway can actually strain your methylation pathways rather than raise NAD.
You’ll also explore how inflammation through the cluster of differentiation 38 (CD38) enzyme silently drains NAD faster than almost anything else, what a gold standard double-blind placebo-controlled crossover clinical trial on Nuchido TIME+ actually showed, and why NAD sits at the intersection of energy production, cellular repair, sleep, skin health, and biological aging.
Dr. Nichola Conlon (BSc, MRes, PhD) specializes in cellular aging. After a career in drug development, Dr. Nichola founded Nuchido, driven by her belief that cutting-edge science should not lie hidden. At Nuchido, Dr. Nichola’s work focuses on delivering disruptive innovation in the field of anti-aging, rejuvenation, and healthspan. It has led to the development of Nuchido TIME+, a dietary supplement clinically proven to boost NAD+ and reverse biological age. Unlike standard precursors such as NMN or NR, Nuchido TIME+ uses a systems-based approach to target the root causes of NAD+ decline.
Timestamps
0:00 What is NAD?
0:38 Guest intro: Dr. Nicola Conlon
1:05 Why NAD supplements don't say "NAD" on the label
2:12 How NAD works in the body
6:30 The NAD salvage pathway
10:29 Why NAD declines with age
13:40 Why NR & NMN aren't enough
16:06 NAD & sleep / circadian rhythm
19:25 CD38: the biggest NAD drain
20:57 Are NAD IVs worth it?
23:15 NAD IVs may cause inflammation
26:32 The methylation problem with high-dose NR/NMN
32:13 Introducing Nuchido TIME+
35:10 Why nicotinamide beats NR & NMN
36:39 Rutin & ALA — reactivating NAMPT
37:35 Apigenin — inhibiting CD38
40:20 EGCG — fixing the methylation problem
42:46 Human clinical trial results
45:32 Biological age reversal: 1.26 years in 28 days
48:55 Daily dosing vs. pulsing
54:08 Where to learn more
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Full Show Notes: bengreenfieldlife.com/nadplus
In this fascinating episode, Dr. Nichola Conlon, molecular biologist and founder of Nuchido, breaks down what NAD actually is, what it does inside your cells, and why most popular strategies for boosting it, including NAD IVs, patches, and high-dose NR or NMN, may be fundamentally flawed based on molecular biology.
You’ll discover why NAD declines by half every 20 years, why the NAMPT enzyme and not a shortage of raw material is the real bottleneck, and why flooding the body with precursors without fixing the salvage pathway can actually strain your methylation pathways rather than raise NAD.
You’ll also explore how inflammation through the cluster of differentiation 38 (CD38) enzyme silently drains NAD faster than almost anything else, what a gold standard double-blind placebo-controlled crossover clinical trial on Nuchido TIME+ actually showed, and why NAD sits at the intersection of energy production, cellular repair, sleep, skin health, and biological aging.
Dr. Nichola Conlon (BSc, MRes, PhD) specializes in cellular aging. After a career in drug development, Dr. Nichola founded Nuchido, driven by her belief that cutting-edge science should not lie hidden. At Nuchido, Dr. Nichola’s work focuses on delivering disruptive innovation in the field of anti-aging, rejuvenation, and healthspan. It has led to the development of Nuchido TIME+, a dietary supplement clinically proven to boost NAD+ and reverse biological age. Unlike standard precursors such as NMN or NR, Nuchido TIME+ uses a systems-based approach to target the root causes of NAD+ decline.
Timestamps
0:00 What is NAD?
0:38 Guest intro: Dr. Nicola Conlon
1:05 Why NAD supplements don't say "NAD" on the label
2:12 How NAD works in the body
6:30 The NAD salvage pathway
10:29 Why NAD declines with age
13:40 Why NR & NMN aren't enough
16:06 NAD & sleep / circadian rhythm
19:25 CD38: the biggest NAD drain
20:57 Are NAD IVs worth it?
23:15 NAD IVs may cause inflammation
26:32 The methylation problem with high-dose NR/NMN
32:13 Introducing Nuchido TIME+
35:10 Why nicotinamide beats NR & NMN
36:39 Rutin & ALA — reactivating NAMPT
37:35 Apigenin — inhibiting CD38
40:20 EGCG — fixing the methylation problem
42:46 Human clinical trial results
45:32 Biological age reversal: 1.26 years in 28 days
48:55 Daily dosing vs. pulsing
54:08 Where to learn more
📲 Check out my FREE Top Health Community! - joinlifenetwork.com
💊Shop My Curated Marketplace of Vetted Products! - shoplifemarket.com
🏋️Sign up for a FREE Coaching Call! - jointriumphcoaching.com
📩 Check out my FREE newsletter! - bengreenfieldlife.com/newsletter
🔗My Website: bengreenfieldlife.com
🔗My Podcast: bengreenfieldlife.com/podcast
🔗My Books: shopbengreenfieldlife.com/collections/books
Connect with me: ⬇️
Instagram instagram.com/bengreenfieldfitness
Facebook facebook.com/BGFitness
X twitter.com/bengreenfield
TikTok tiktok.com/@bengreenfield
