Uploaded June 2026 | Updated September 2026, 3 weeks ago
Microplastics are building up inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows actually moves microplastics, heavy metals, BPA, and benzene out of your body..
-For next week, 25% off all Mara Labs products when you go to mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off.
Host Dave Asprey sits down with Dr. John Gildea, a Johns Hopkins-trained PhD with 60 scientific publications and over 20 NIH-funded studies, and David Roberts, co-founder of Mara Labs and co-creator of BrocElite, the only naturally derived stable form of sulforaphane available in a capsule. Together they bring decades of research-backed biohacking and functional medicine insight into one of the most pressing longevity conversations of our time.
They break down the lysosome, your cell's built-in incinerator, and explain exactly why it gets clogged with microplastics, advanced glycation end products, and other toxins that won't break down. New research shows that sulforaphane triggers a process called lysosomal surface translocation, which releases those trapped particles so your body can finally excrete them. An in-house Mara Labs study confirmed the excretion pathway: microplastics come out in feces. In the original study, the individual measured the highest microplastic levels ever recorded, and a repeat study a year later showed dramatically lower baseline microplastic levels, suggesting consistent use compounds the benefit over time.
You'll Learn:
-Why microplastics accumulate inside lysosomes and what sulforaphane does to release them
-How the three detox pathways, glutathione, glucuronidation, and sulfation, work together to remove every major class of toxin
-What an in-house study revealed about how and where microplastics actually leave the body
-How toxic estrogen metabolites form and why sulforaphane is the most effective natural tool to reroute them
-Why berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch
-How sulforaphane boosts BDNF and neuroplasticity at the cellular level
-What microplastic sources in your home, including your dryer, rugs, and receipts, are doing to your toxin load daily
-Why losing weight releases stored toxins and what to take to protect your brain and metabolism during fat loss
-How sulforaphane activates the same AMPK longevity pathways triggered by fasting without restricting food
Resources:
• For next week, 25% off all Mara Labs products when you go to mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off.
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at daveasprey.com/2026-clean-nicotine-roadmap
• Dave Asprey's Latest News | Go to daveasprey.com to join Inside Track today.
Thank you to our sponsors!
- iRestore | Reverse hair loss at irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
- HeartMath | Go to heartmath.com/dave to save 15% off.
- Timeline | Go to timeline.com/dave and you’ll get an additional 20% off your first month
- Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide
Timestamps:
00:00 – Trailer
01:55 – Intro & Context
04:48 – Microplastics & Sulforaphane
12:39 – Broccoli Sprouts Formulation
15:20 – Lab Origin Story
26:01 – Reducing Toxin Exposure
37:06 – Estrogen, Hormones & Berberine
52:46 – Autism, ADHD & Brain Health
59:01 – Wrap-Up
Connect with Dave Asprey!
Website: daveasprey.com
TikTok: tiktok.com/@daveaspreyofficial
Instagram: instagram.com/dave.asprey
Facebook: facebook.com/Daveaspreyofficial
X: https://x.com/daveasprey
YouTube: youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: instagram.com/TheHumanUpgradePodcast https://m.facebook.com/Thehumanupgrade
Danger Coffee: dangercoffee.com/discount/dave15?
Dave Asprey’s BEYOND Conference: beyondconference.com
Dave Asprey’s New Book - Heavily Meditated: daveasprey.com/heavily-meditated
Dave's favorite supplements: shopsuppgradelabs.com/discount/DAVE15
Join my Substack: substack.daveasprey.com
Upgrade Labs: upgradelabs.com
40 Years of Zen: 40yearsofzen.com
Microplastics are building up inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows actually moves microplastics, heavy metals, BPA, and benzene out of your body..
-For next week, 25% off all Mara Labs products when you go to mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off.
Host Dave Asprey sits down with Dr. John Gildea, a Johns Hopkins-trained PhD with 60 scientific publications and over 20 NIH-funded studies, and David Roberts, co-founder of Mara Labs and co-creator of BrocElite, the only naturally derived stable form of sulforaphane available in a capsule. Together they bring decades of research-backed biohacking and functional medicine insight into one of the most pressing longevity conversations of our time.
They break down the lysosome, your cell's built-in incinerator, and explain exactly why it gets clogged with microplastics, advanced glycation end products, and other toxins that won't break down. New research shows that sulforaphane triggers a process called lysosomal surface translocation, which releases those trapped particles so your body can finally excrete them. An in-house Mara Labs study confirmed the excretion pathway: microplastics come out in feces. In the original study, the individual measured the highest microplastic levels ever recorded, and a repeat study a year later showed dramatically lower baseline microplastic levels, suggesting consistent use compounds the benefit over time.
You'll Learn:
-Why microplastics accumulate inside lysosomes and what sulforaphane does to release them
-How the three detox pathways, glutathione, glucuronidation, and sulfation, work together to remove every major class of toxin
-What an in-house study revealed about how and where microplastics actually leave the body
-How toxic estrogen metabolites form and why sulforaphane is the most effective natural tool to reroute them
-Why berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch
-How sulforaphane boosts BDNF and neuroplasticity at the cellular level
-What microplastic sources in your home, including your dryer, rugs, and receipts, are doing to your toxin load daily
-Why losing weight releases stored toxins and what to take to protect your brain and metabolism during fat loss
-How sulforaphane activates the same AMPK longevity pathways triggered by fasting without restricting food
Resources:
• For next week, 25% off all Mara Labs products when you go to mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off.
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at daveasprey.com/2026-clean-nicotine-roadmap
• Dave Asprey's Latest News | Go to daveasprey.com to join Inside Track today.
Thank you to our sponsors!
- iRestore | Reverse hair loss at irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
- HeartMath | Go to heartmath.com/dave to save 15% off.
- Timeline | Go to timeline.com/dave and you’ll get an additional 20% off your first month
- Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide
Timestamps:
00:00 – Trailer
01:55 – Intro & Context
04:48 – Microplastics & Sulforaphane
12:39 – Broccoli Sprouts Formulation
15:20 – Lab Origin Story
26:01 – Reducing Toxin Exposure
37:06 – Estrogen, Hormones & Berberine
52:46 – Autism, ADHD & Brain Health
59:01 – Wrap-Up
Connect with Dave Asprey!
Website: daveasprey.com
TikTok: tiktok.com/@daveaspreyofficial
Instagram: instagram.com/dave.asprey
Facebook: facebook.com/Daveaspreyofficial
X: https://x.com/daveasprey
YouTube: youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: instagram.com/TheHumanUpgradePodcast https://m.facebook.com/Thehumanupgrade
Danger Coffee: dangercoffee.com/discount/dave15?
Dave Asprey’s BEYOND Conference: beyondconference.com
Dave Asprey’s New Book - Heavily Meditated: daveasprey.com/heavily-meditated
Dave's favorite supplements: shopsuppgradelabs.com/discount/DAVE15
Join my Substack: substack.daveasprey.com
Upgrade Labs: upgradelabs.com
40 Years of Zen: 40yearsofzen.com
