How the 3D organization of DNA controls cell identity @YourekaScience

Uploaded May 2021 | Updated September 2026, 2 weeks ago

How is our DNA organized? In researching a human disease, researchers at UPenn have discovered that the 3D organization of the genome may control cell identity.
Discover the experiments that led to this intriguing hypothesis.

This video is based on a recent publication by Shah et al. in Cell Stem Cell, May 2021 titled Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes.
cell.com/cell-stem-cell/fulltext/S1934-5909(20)30600-7

yourekascience.org/portfolio/how-the-3d-organization-of-dna-controls-cell-identity

How the 3D organization of DNA controls cell identity

Stem Cells 101: Building the Worlds Most Complex Construction Project

THE CLOCK THAT TELLS YOU ITS LUNCH TIME: How fat-specific circadian rhythms control obesity

GOING AGAINST THE GRAIN: A new explanation for pancreatic beta cell failure

Data Overload! Making Sense of Genome Sequencing with Bioinformatics

SIGNED, SEALED, RESECTED: Discovering the genetic clues within colorectal cancers.

Arabic: BECAUSE YOU CARE ABOUT ME لأنك تهتم بي: Antibiotic resistance in GCC countries

Bubble Boy Disease - Progress and Promise of Stem Cell Research

Designing a potential treatment for PMM2-CDG

Right on Target: Precision Medicine to Treat Rare Tumors

Small but mighty: harnessing the tiny exosome for better drug delivery and disease diagnosis