How are discoveries made? @MoleCluesTV

Uploaded May 2019 | Updated September 2026, 1 hour ago

Three outstanding scientists - Paul Alivisatos, Steven Chu and Daniel Nocera - give their views on how science works in this series of short videos, recorded during the Molecular Frontiers Symposium "Sustainable Energy" at Chalmers University of Technology, December 2017.

Cynthia Koenig: Wello: A Novel Approach to the Global Water Crisis

Shimon Weiss: Multiscale, Superresolved, Ultrasensitive Optical Molecular Imaging

Opening addresses, Planet Earth: A Scientific Journey

Richard Zare: Water microdroplet chemistry

Valter Longo: Nutrition, Fasting mimicking diets, Regeneration and Longevity

Gerald Joyce: Self-replicating synthetic systems

Atsushi Miyawaki: Cruising Inside Cells - New Fluorescent Probes and New Perspectives in Bioscience

$Stefan Hell: Molecular Resolution and Dynamics in Fluorescence Microscopy Lecture by 2014 Nobel laureate in Chemistry Stefan Hell, Max Planck Institute, at the Molecular Frontiers Symposium Frontiers of New Knowledge in Science in Hong Kong, Nov 15-17, 2024. ABSTRACT I will show how a deep understanding of the principles of diffraction-unlimited fluorescence microscopy has given rise to MINFLUX, a newer super-resolution method that reaches the Angstrom range, i.e. more than 200 times below the diffraction resolution limit. MINFLUX is currently being used for a variety of applications in the biomedical sciences. A unique advantage of MINFLUX is the direct measurement of dynamic processes and conformational changes of individual proteins in cells, such as the stepping of the motor proteins kinesin-1 and dynein on microtubules. In contrast to all super-resolution methods known to date, MINFLUX does not fundamentally require an ON/OFF process, meaning that it can also separate constantly emitting fluorophores in the nanometer range. The ability to separate constantly emitting fluorophores at nanometer distances has the potential to directly measure the inner workings of individual proteins.$

Panel discussion with Jessica V. Fayne, Cynthia Koenig and Omar Yaghi

Bengt Nordén: Discovery of a stretched conformation of DNA – could it have a biological role?

Q&A Session with Stefan Hell, Eric Betzig & Atushi Miyawaki