Uploaded May 2026 | Updated September 2026, 2 weeks ago
How does an antibody help make stem cell transplants safer?
For patients with Fanconi anemia, stem cell transplants can be lifesaving—but the chemotherapy or radiation used beforehand can cause significant harm.
This animation shows how briquilimab, an antibody developed from decades of discovery at Stanford Medicine, targets the CD117 receptor to temporarily block survival signals in blood-forming stem cells. By clearing space in the bone marrow, it allows healthy donor cells to engraft and rebuild the blood and immune system—without the need for traditional toxic conditioning.
Learn more about this research:
https://stan.md/4mYUIEa
https://stan.md/4ebOA9d
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Stanford Medicine advances human health through world-class biomedical research, education and patient care. Bringing together the resources of Stanford University School of Medicine, Stanford Health Care and Lucile Packard Children's Hospital, Stanford Medicine is committed to training future leaders in biomedicine and translating the latest discoveries into new ways to prevent, diagnose and treat disease.
The Stanford Medicine YouTube channel is a curated collection of contributions from our School of Medicine departments, divisions, students, and the community. Our diverse content includes coverage of events, presentations, lectures, and associated stories about the people of Stanford Medicine.
How does an antibody help make stem cell transplants safer?
For patients with Fanconi anemia, stem cell transplants can be lifesaving—but the chemotherapy or radiation used beforehand can cause significant harm.
This animation shows how briquilimab, an antibody developed from decades of discovery at Stanford Medicine, targets the CD117 receptor to temporarily block survival signals in blood-forming stem cells. By clearing space in the bone marrow, it allows healthy donor cells to engraft and rebuild the blood and immune system—without the need for traditional toxic conditioning.
Learn more about this research:
https://stan.md/4mYUIEa
https://stan.md/4ebOA9d
.
.
.
Stanford Medicine advances human health through world-class biomedical research, education and patient care. Bringing together the resources of Stanford University School of Medicine, Stanford Health Care and Lucile Packard Children's Hospital, Stanford Medicine is committed to training future leaders in biomedicine and translating the latest discoveries into new ways to prevent, diagnose and treat disease.
The Stanford Medicine YouTube channel is a curated collection of contributions from our School of Medicine departments, divisions, students, and the community. Our diverse content includes coverage of events, presentations, lectures, and associated stories about the people of Stanford Medicine.
