Uploaded March 2026 | Updated September 2026, 3 weeks ago
Most people think feeling tired, foggy, and “off” is just what happens with age.
But what if the real issue is that your cells are running on less fuel than they used to?
In this episode of the Kwik Brain podcast, I sit down with Dr. Andrew Salzman, Harvard-trained physician, inventor, and biomedical entrepreneur, to unpack what’s happening at the cellular level when energy drops and your brain stops feeling sharp.
We break down NAD, a molecule involved in hundreds of critical reactions in the body, why it declines as you age, and how inflammation can accelerate that decline. We also talk about NMN, and why your brain is often the first place you feel the effects when cellular energy dips.
In this episode, you’ll learn:
☑️ What NAD does for energy, cognition, and resilience
☑️ Why NAD drops so significantly by midlife
☑️ How NMN works as a precursor to support NAD production
☑️ The “bathtub” model: why boosting NAD is not just about adding more, but also slowing the drain
☑️ How inflammation can drive NAD depletion through CD38
☑️ Why better cellular energy can translate into clearer thinking, better memory, and sharper focus
If you’ve been feeling like your brain isn’t firing the way it used to, your energy is unpredictable, or your focus is slipping, this episode will help you understand what’s happening underneath the surface and what you can do to support your brain at the level where performance actually starts: your cells.
👉 Comment below: What is one habit you use to protect your brain energy as you age?
🔔 Don’t forget to like, subscribe, and save this video if you found it helpful.
Take a screenshot, tag us (@jimkwik & @getwonderfeel) and share your biggest takeaway.
Timestamps:
03:08 What's Happening at a Cellular Level as We Age?
04:54 Aging: What We Can and Cannot Control
06:00 The Role of NAD in Cellular Health
06:54 NAD Levels Drop by Half by Age 50
07:21 How NMN Supports NAD
08:35 NAD Production vs. Depletion
10:25 The Number One Way to Avoid NAD Depletion
11:06 How the CD38 Enzyme Depletes NAD
11:37 The Myth of Passive Aging
17:53 CD38's Role in NAD Depletion and Menopause
20:29 Why the Brain Needs High Levels of NAD
22:12 Cognitive Benefits of Restoring NAD Levels
29:33 Dr. Salzman's Simple Truth for Long-Term Health
Watch more videos like this:
4 Brain Exercises to Strengthen Your Memory (and Keep Your Brain Young): youtu.be/p8QVxJXhkDgplaylist?list=PLwf_ceM-L-lNrAizBOyG_rQMkkJAEkF63
24 Books That Will Rewire Your Brain and Transform Your Life: youtu.be/DhXZg5BLKEQplaylist?list=PLwf_ceM-L-lOhmoyl0Qe2O1zLL9qOkBR0
30 Years of Brain Training Secrets in Just 19 Minutes: youtu.be/6F_FEEmzmiEplaylist?list=PLwf_ceM-L-lMzXqYH2pHu6OVg1CKE_gxS
🚨 In-Person Event 🚨
Limitless Live | Unleash The Power of Your Mind to Thrive In This New Era: limitlesslive.com/2026
What’s your Brain Type? 🧠🤔
Take the Brain Quiz: bit.ly/3Ho9HXq
⚡️ Sharpen your mind and shape your future with our Kwik Brain newsletter: bit.ly/4gOPIP8 '
SUBSCRIBE for more brain performance tips: youtube.com/kwiklearning
💊 Products Mentioned:
Wonderfeel Youngr™ NMN: tidd.ly/3Y990Xi
Connect with Dr. Andrew Salzman
instagram.com/getwonderfeel
facebook.com/get.wonderfeel
tidd.ly/3Y990Xi
FOLLOW JIM:
Instagram: instagram.com/jimkwik
Twitter: twitter.com/jimkwik
Facebook: facebook.com/jimkwikofficial
Website: KwikBrain.com
Most people think feeling tired, foggy, and “off” is just what happens with age.
But what if the real issue is that your cells are running on less fuel than they used to?
In this episode of the Kwik Brain podcast, I sit down with Dr. Andrew Salzman, Harvard-trained physician, inventor, and biomedical entrepreneur, to unpack what’s happening at the cellular level when energy drops and your brain stops feeling sharp.
We break down NAD, a molecule involved in hundreds of critical reactions in the body, why it declines as you age, and how inflammation can accelerate that decline. We also talk about NMN, and why your brain is often the first place you feel the effects when cellular energy dips.
In this episode, you’ll learn:
☑️ What NAD does for energy, cognition, and resilience
☑️ Why NAD drops so significantly by midlife
☑️ How NMN works as a precursor to support NAD production
☑️ The “bathtub” model: why boosting NAD is not just about adding more, but also slowing the drain
☑️ How inflammation can drive NAD depletion through CD38
☑️ Why better cellular energy can translate into clearer thinking, better memory, and sharper focus
If you’ve been feeling like your brain isn’t firing the way it used to, your energy is unpredictable, or your focus is slipping, this episode will help you understand what’s happening underneath the surface and what you can do to support your brain at the level where performance actually starts: your cells.
👉 Comment below: What is one habit you use to protect your brain energy as you age?
🔔 Don’t forget to like, subscribe, and save this video if you found it helpful.
Take a screenshot, tag us (@jimkwik & @getwonderfeel) and share your biggest takeaway.
Timestamps:
03:08 What's Happening at a Cellular Level as We Age?
04:54 Aging: What We Can and Cannot Control
06:00 The Role of NAD in Cellular Health
06:54 NAD Levels Drop by Half by Age 50
07:21 How NMN Supports NAD
08:35 NAD Production vs. Depletion
10:25 The Number One Way to Avoid NAD Depletion
11:06 How the CD38 Enzyme Depletes NAD
11:37 The Myth of Passive Aging
17:53 CD38's Role in NAD Depletion and Menopause
20:29 Why the Brain Needs High Levels of NAD
22:12 Cognitive Benefits of Restoring NAD Levels
29:33 Dr. Salzman's Simple Truth for Long-Term Health
Watch more videos like this:
4 Brain Exercises to Strengthen Your Memory (and Keep Your Brain Young): youtu.be/p8QVxJXhkDgplaylist?list=PLwf_ceM-L-lNrAizBOyG_rQMkkJAEkF63
24 Books That Will Rewire Your Brain and Transform Your Life: youtu.be/DhXZg5BLKEQplaylist?list=PLwf_ceM-L-lOhmoyl0Qe2O1zLL9qOkBR0
30 Years of Brain Training Secrets in Just 19 Minutes: youtu.be/6F_FEEmzmiEplaylist?list=PLwf_ceM-L-lMzXqYH2pHu6OVg1CKE_gxS
🚨 In-Person Event 🚨
Limitless Live | Unleash The Power of Your Mind to Thrive In This New Era: limitlesslive.com/2026
What’s your Brain Type? 🧠🤔
Take the Brain Quiz: bit.ly/3Ho9HXq
⚡️ Sharpen your mind and shape your future with our Kwik Brain newsletter: bit.ly/4gOPIP8 '
SUBSCRIBE for more brain performance tips: youtube.com/kwiklearning
💊 Products Mentioned:
Wonderfeel Youngr™ NMN: tidd.ly/3Y990Xi
Connect with Dr. Andrew Salzman
instagram.com/getwonderfeel
facebook.com/get.wonderfeel
tidd.ly/3Y990Xi
FOLLOW JIM:
Instagram: instagram.com/jimkwik
Twitter: twitter.com/jimkwik
Facebook: facebook.com/jimkwikofficial
Website: KwikBrain.com
