Uploaded June 2023 | Updated September 2026, 1 week ago
Understanding how the complex interplay between genes and environment may lead to autoimmune disorders has contributed to the development of novel therapeutics for these illnesses. Much of this research has used genetic and genomic strategies to study patients with relatively rare inherited disorders of inflammation, such as those seen at the NIH’s Clinical Center. In our yearly Rudi Schmid Lecture, NIH Distinguished Investigator Dan Kastner, MD, PhD, will describe his work on the genetic investigations of autoimmune disease.
The Schmid Lecture is held in honor of Rudi Schmid, MD, PhD. Born in Switzerland, Rudi received his MD degree from the University of Zurich in 1947. After an internship at UCSF and residency at the University of Minnesota, he became a faculty member at the NIH, Harvard, and the University of Chicago before joining our UCSF faculty in 1966 as professor and chief of gastroenterology. Under his leadership, our GI division became one of the country’s leading research, educational and clinical gastroenterology and hepatology units. As dean of the UCSF School of Medicine from 1983-89, he fostered the continued growth of both basic and clinical sciences. He served as president of several professional organizations, including the American Association for the Study of Liver Diseases, and received many national and international awards in recognition of outstanding achievements throughout his career.
Speaker:
Dan Kastner, MD, PhD obtained his AB from Princeton University and a PhD and MD from Baylor College of Medicine. After internal medicine residency and chief residency at Baylor, Dan moved to the National Institutes of Health (NIH) in 1985, where he is an NIH distinguished investigator, chief of the Inflammatory Disease Section, and scientific director emeritus of the Division of Intramural Research of the National Human Genome Research Institute (NHGRI). Dan has won numerous national and international awards including election to the National Academy of Sciences and to the National Academy of Medicine, and the Thomas Waldmann Award for Excellence in Human Immunology.
Note: Closed captions will be available within 48-72 hours after posting.
Program
Bob Wachter: Introduction
00:05:20-00:59:05 – Dan Kastner, MD, PhD, NIH distinguished investigator, chief of the Inflammatory Disease Section, and scientific director emeritus of the Division of Intramural Research of the National Human Genome Research Institute (NHGRI).
00:59:12-01:03:04 – Q&A
See previous Medical Grand Rounds:
• May 25: Automation, Emotion, and Behavioral Economics in Health and Healthcare
youtu.be/-Bm8QDWunqo
• May 18: Medical Documentation in the EHR Age
youtu.be/xUaxi40Bdsk
• May 11: The 30th Annual Alice Hamilton Lecture: Climate Medicine and Occupational and Environmental Health
youtu.be/D8_MLXOdNdI
• May 4: Clinical Problem Solving with Nirav Bhakta
youtu.be/wca8mGGhjTM
See all UCSF Covid-19 grand rounds, which have been viewed over 3M times, at youtube.com/playlist?list=PLp2l8GCZXFqSgUfwaResQ7rGwKbGIUi_m.
Understanding how the complex interplay between genes and environment may lead to autoimmune disorders has contributed to the development of novel therapeutics for these illnesses. Much of this research has used genetic and genomic strategies to study patients with relatively rare inherited disorders of inflammation, such as those seen at the NIH’s Clinical Center. In our yearly Rudi Schmid Lecture, NIH Distinguished Investigator Dan Kastner, MD, PhD, will describe his work on the genetic investigations of autoimmune disease.
The Schmid Lecture is held in honor of Rudi Schmid, MD, PhD. Born in Switzerland, Rudi received his MD degree from the University of Zurich in 1947. After an internship at UCSF and residency at the University of Minnesota, he became a faculty member at the NIH, Harvard, and the University of Chicago before joining our UCSF faculty in 1966 as professor and chief of gastroenterology. Under his leadership, our GI division became one of the country’s leading research, educational and clinical gastroenterology and hepatology units. As dean of the UCSF School of Medicine from 1983-89, he fostered the continued growth of both basic and clinical sciences. He served as president of several professional organizations, including the American Association for the Study of Liver Diseases, and received many national and international awards in recognition of outstanding achievements throughout his career.
Speaker:
Dan Kastner, MD, PhD obtained his AB from Princeton University and a PhD and MD from Baylor College of Medicine. After internal medicine residency and chief residency at Baylor, Dan moved to the National Institutes of Health (NIH) in 1985, where he is an NIH distinguished investigator, chief of the Inflammatory Disease Section, and scientific director emeritus of the Division of Intramural Research of the National Human Genome Research Institute (NHGRI). Dan has won numerous national and international awards including election to the National Academy of Sciences and to the National Academy of Medicine, and the Thomas Waldmann Award for Excellence in Human Immunology.
Note: Closed captions will be available within 48-72 hours after posting.
Program
Bob Wachter: Introduction
00:05:20-00:59:05 – Dan Kastner, MD, PhD, NIH distinguished investigator, chief of the Inflammatory Disease Section, and scientific director emeritus of the Division of Intramural Research of the National Human Genome Research Institute (NHGRI).
00:59:12-01:03:04 – Q&A
See previous Medical Grand Rounds:
• May 25: Automation, Emotion, and Behavioral Economics in Health and Healthcare
youtu.be/-Bm8QDWunqo
• May 18: Medical Documentation in the EHR Age
youtu.be/xUaxi40Bdsk
• May 11: The 30th Annual Alice Hamilton Lecture: Climate Medicine and Occupational and Environmental Health
youtu.be/D8_MLXOdNdI
• May 4: Clinical Problem Solving with Nirav Bhakta
youtu.be/wca8mGGhjTM
See all UCSF Covid-19 grand rounds, which have been viewed over 3M times, at youtube.com/playlist?list=PLp2l8GCZXFqSgUfwaResQ7rGwKbGIUi_m.
