Uploaded October 2025 | Updated September 2026, 2 weeks ago
In this Huberman Lab Essentials episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging.
We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body's natural longevity pathways. This discussion highlights how lifestyle choices profoundly influence the aging process and may even slow or reverse key aspects of biological aging.
Episode show notes: go.hubermanlab.com/MW6SYCf
Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: youtu.be/n9IxomBusuw
Watch more Huberman Lab Essentials episodes: youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S
*Follow Huberman Lab*
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Threads: threads.net/@hubermanlab
X: twitter.com/hubermanlab
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Website: hubermanlab.com
Newsletter: hubermanlab.com/newsletter
*Timestamps*
00:00:00 David Sinclair
00:00:20 Longevity, Anti-Aging, Aging as a Disease
00:02:27 Causes of Aging; Epigenome & Genes
00:04:53 CD & Scratches Analogy, DNA, Silencing & Expressing Genes
00:06:44 Physical Appearance & Aging
00:07:36 Childhood Development & Aging, Horvath Clock, Accelerate Aging
00:10:13 Rates of Puberty & Aging, Growth Hormone
00:11:20 Body Size & Longevity; Epigenetics
00:11:50 Fasting, Calorie Restriction & Longevity, Sirtuins, Insulin & Glucose
00:15:14 Tool: Skip a Meal
00:15:50 Longer Fasts & Autophagy, “Deep Cleanse”; Fluids, Electrolytes
00:17:28 Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing Behaviors
00:21:37 Breaking a Fast, Tools: Do Your Best; Transitions
00:24:13 Sirtuins, NAD, NMN Supplementation
00:26:18 Iron & Senescent Cells; Personalize Medicine
00:27:48 Tool: Blood Markers, CRP
00:29:57 Tool: Aerobic & Resistance Exercise
00:31:02 Estrogen, Fasting & Fertility; Aging & Rejuvenation
00:33:28 Acknowledgements
Disclaimer & Disclosures: hubermanlab.com/disclaimer
In this Huberman Lab Essentials episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging.
We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body's natural longevity pathways. This discussion highlights how lifestyle choices profoundly influence the aging process and may even slow or reverse key aspects of biological aging.
Episode show notes: go.hubermanlab.com/MW6SYCf
Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: youtu.be/n9IxomBusuw
Watch more Huberman Lab Essentials episodes: youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S
*Follow Huberman Lab*
Instagram: instagram.com/hubermanlab
Threads: threads.net/@hubermanlab
X: twitter.com/hubermanlab
Facebook: facebook.com/hubermanlab
TikTok: tiktok.com/@hubermanlab
LinkedIn: linkedin.com/in/andrew-huberman
Website: hubermanlab.com
Newsletter: hubermanlab.com/newsletter
*Timestamps*
00:00:00 David Sinclair
00:00:20 Longevity, Anti-Aging, Aging as a Disease
00:02:27 Causes of Aging; Epigenome & Genes
00:04:53 CD & Scratches Analogy, DNA, Silencing & Expressing Genes
00:06:44 Physical Appearance & Aging
00:07:36 Childhood Development & Aging, Horvath Clock, Accelerate Aging
00:10:13 Rates of Puberty & Aging, Growth Hormone
00:11:20 Body Size & Longevity; Epigenetics
00:11:50 Fasting, Calorie Restriction & Longevity, Sirtuins, Insulin & Glucose
00:15:14 Tool: Skip a Meal
00:15:50 Longer Fasts & Autophagy, “Deep Cleanse”; Fluids, Electrolytes
00:17:28 Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing Behaviors
00:21:37 Breaking a Fast, Tools: Do Your Best; Transitions
00:24:13 Sirtuins, NAD, NMN Supplementation
00:26:18 Iron & Senescent Cells; Personalize Medicine
00:27:48 Tool: Blood Markers, CRP
00:29:57 Tool: Aerobic & Resistance Exercise
00:31:02 Estrogen, Fasting & Fertility; Aging & Rejuvenation
00:33:28 Acknowledgements
Disclaimer & Disclosures: hubermanlab.com/disclaimer
