Uploaded July 2025 | Updated September 2026, 2 weeks ago
In this Huberman Lab Essentials episode, my guest is Dr. Matthew Johnson, PhD, a senior researcher for the Center of Excellence for Psilocybin Research and Treatment at Sheppard Pratt’s Institute for Advanced Diagnostics and Therapeutics.
We explore the science and therapeutic potential of psychedelic medicine, including psilocybin, MDMA and LSD. We discuss how these substances can profoundly alter perception and self-identity, providing long-lasting relief from depression, addiction and trauma when used in controlled clinical settings. We also discuss microdosing and emerging research on psychedelics’ potential to support recovery from neurological injuries.
Episode show notes: go.hubermanlab.com/yjsDPfV
Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: youtu.be/GzvzWO0NU50
Watch more Huberman Lab Essentials episodes: youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S
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*Timestamps*
00:00:00 Matthew Johnson; Psychedelics
00:01:44 Different Classes of Psychedelics
00:04:33 Psychedelics & Altering Models
00:06:18 LSD, Psylocibin & Serotonin
00:08:44 Psychedelic Clinical Trials
00:12:28 Therapy, Trust, Psychedelics
00:15:36 Letting Go & Psychedelic Experience, Self-Representation, Lasting Changes
00:21:19 MDMA, Dopamine & Serotonin; Bad Trips & Transcendental Experience
00:24:43 Dangers of Psychedelics
00:27:04 Microdosing Psychedelics, Antidepressant
00:31:20 Head Injuries, Psychedelics, Depression
Disclaimer & Disclosures: hubermanlab.com/disclaimer
In this Huberman Lab Essentials episode, my guest is Dr. Matthew Johnson, PhD, a senior researcher for the Center of Excellence for Psilocybin Research and Treatment at Sheppard Pratt’s Institute for Advanced Diagnostics and Therapeutics.
We explore the science and therapeutic potential of psychedelic medicine, including psilocybin, MDMA and LSD. We discuss how these substances can profoundly alter perception and self-identity, providing long-lasting relief from depression, addiction and trauma when used in controlled clinical settings. We also discuss microdosing and emerging research on psychedelics’ potential to support recovery from neurological injuries.
Episode show notes: go.hubermanlab.com/yjsDPfV
Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: youtu.be/GzvzWO0NU50
Watch more Huberman Lab Essentials episodes: youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S
*Follow Huberman Lab*
Instagram: instagram.com/hubermanlab
Threads: threads.net/@hubermanlab
X: twitter.com/hubermanlab
Facebook: facebook.com/hubermanlab
TikTok: tiktok.com/@hubermanlab
LinkedIn: linkedin.com/in/andrew-huberman
Website: hubermanlab.com
Newsletter: hubermanlab.com/newsletter
*Timestamps*
00:00:00 Matthew Johnson; Psychedelics
00:01:44 Different Classes of Psychedelics
00:04:33 Psychedelics & Altering Models
00:06:18 LSD, Psylocibin & Serotonin
00:08:44 Psychedelic Clinical Trials
00:12:28 Therapy, Trust, Psychedelics
00:15:36 Letting Go & Psychedelic Experience, Self-Representation, Lasting Changes
00:21:19 MDMA, Dopamine & Serotonin; Bad Trips & Transcendental Experience
00:24:43 Dangers of Psychedelics
00:27:04 Microdosing Psychedelics, Antidepressant
00:31:20 Head Injuries, Psychedelics, Depression
Disclaimer & Disclosures: hubermanlab.com/disclaimer
