Uploaded March 2025 | Updated September 2026, 4 days ago
In this episode, Drs Trexler and Helms are joined by Dr. Eduardo De Souza to discuss the complexities and misconceptions surrounding high volume training in the context of hypertrophy research. He shares insights from his extensive research background, emphasizing the importance of understanding participant experiences and the nuances of training volume. The conversation also touches on the challenges of research methodology, the need for improved reporting standards, and the future directions of exercise science research.
Time stamps:
0:00 Introducing Dr Eduardo De Souza and some housekeeping
sportsnutritionassociation.com/sna-annual-2025-conference/
4:23 Eduardo’s background and work in high volume training research
Scarpelli 2022 Muscle Hypertrophy Response Is Affected by Previous Resistance Training Volume in Trained Individuals pubmed.ncbi.nlm.nih.gov/32108724/
Enes 2024 Effects of Different Weekly Set Progressions on Muscular Adaptations in Trained Males: Is There a Dose-Response Effect? pubmed.ncbi.nlm.nih.gov/37796222/
19:55 Measurement methods and errors
Barsuhn 2025 Training volume increases or maintenance based on previous volume: the effects on muscular adaptations in trained males pubmed.ncbi.nlm.nih.gov/39665246/
26:00 The participant experience in high volume research and oedema
41:40 Criticisms of research methods
48:29 The applications of Eduardo’s research
59:12 Trained and untrained participants and future research
de Souza 2007 Acute effect of two aerobic exercise modes on maximum strength and strength endurancepubmed.ncbi.nlm.nih.gov/18076237/
1:09:46 The aspects of future research which excites Eduardo (and a sneak peak into some sleep research)
1:21:45 Closing out and where to find Dr Eduardo de Souza
Instagram @dr.desouzaeo https://www.instagram.com/dr.desouzaeo/?hl=en
In this episode, Drs Trexler and Helms are joined by Dr. Eduardo De Souza to discuss the complexities and misconceptions surrounding high volume training in the context of hypertrophy research. He shares insights from his extensive research background, emphasizing the importance of understanding participant experiences and the nuances of training volume. The conversation also touches on the challenges of research methodology, the need for improved reporting standards, and the future directions of exercise science research.
Time stamps:
0:00 Introducing Dr Eduardo De Souza and some housekeeping
sportsnutritionassociation.com/sna-annual-2025-conference/
4:23 Eduardo’s background and work in high volume training research
Scarpelli 2022 Muscle Hypertrophy Response Is Affected by Previous Resistance Training Volume in Trained Individuals pubmed.ncbi.nlm.nih.gov/32108724/
Enes 2024 Effects of Different Weekly Set Progressions on Muscular Adaptations in Trained Males: Is There a Dose-Response Effect? pubmed.ncbi.nlm.nih.gov/37796222/
19:55 Measurement methods and errors
Barsuhn 2025 Training volume increases or maintenance based on previous volume: the effects on muscular adaptations in trained males pubmed.ncbi.nlm.nih.gov/39665246/
26:00 The participant experience in high volume research and oedema
41:40 Criticisms of research methods
48:29 The applications of Eduardo’s research
59:12 Trained and untrained participants and future research
de Souza 2007 Acute effect of two aerobic exercise modes on maximum strength and strength endurancepubmed.ncbi.nlm.nih.gov/18076237/
1:09:46 The aspects of future research which excites Eduardo (and a sneak peak into some sleep research)
1:21:45 Closing out and where to find Dr Eduardo de Souza
Instagram @dr.desouzaeo https://www.instagram.com/dr.desouzaeo/?hl=en
