Uploaded July 2023 | Updated September 2026, 7 hours ago
Today we have the world’s foremost authority on kratom returning to STEM-Talk after five years to give us an update on his research. Shortly after his 2018 interview on episode 61, Dr. Christopher McCurdy and his lab at the University of Florida received two major grants from the National Institute of Drug Abuse to investigate the medical efficacy of kratom and its alkaloids, which we discuss in today’s show.
For more than 25 years, McCurdy has studied the design, synthesis, and development of drugs to treat pain, anxiety, and substance-abuse disorders. For the past 15 years, he and his lab have turned a lot of their attention toward kratom and its chemical components to better understand its potential to treat a multitude of conditions.
McCurdy is a professor in the Medicinal Chemistry Department in the College of Pharmacy at the University of Florida. He also is director of the of school’s Translational Drug Development Core and an Associate Dean for Faculty Development. In today’s interview, we talk about:
-- The numerous studies he has been able to conduct thanks to his lab’s two grants from the National Institute of Drug Abuse.
-- The disparity between the traditional use of kratom and the new often highly concentrated manufactured products sold in the U.S.
-- His lab’s study examining the effects of lyophilized kratom tea and its ability to alleviate withdrawal symptoms of opioid-dependence.
-- The potential of kratom alkaloids to serve as treatment of various substance abuse disorders.
-- The benefits and risks associated with CBD usage.
Shownotes: ihmc.us/stemtalk/episode-155
Today we have the world’s foremost authority on kratom returning to STEM-Talk after five years to give us an update on his research. Shortly after his 2018 interview on episode 61, Dr. Christopher McCurdy and his lab at the University of Florida received two major grants from the National Institute of Drug Abuse to investigate the medical efficacy of kratom and its alkaloids, which we discuss in today’s show.
For more than 25 years, McCurdy has studied the design, synthesis, and development of drugs to treat pain, anxiety, and substance-abuse disorders. For the past 15 years, he and his lab have turned a lot of their attention toward kratom and its chemical components to better understand its potential to treat a multitude of conditions.
McCurdy is a professor in the Medicinal Chemistry Department in the College of Pharmacy at the University of Florida. He also is director of the of school’s Translational Drug Development Core and an Associate Dean for Faculty Development. In today’s interview, we talk about:
-- The numerous studies he has been able to conduct thanks to his lab’s two grants from the National Institute of Drug Abuse.
-- The disparity between the traditional use of kratom and the new often highly concentrated manufactured products sold in the U.S.
-- His lab’s study examining the effects of lyophilized kratom tea and its ability to alleviate withdrawal symptoms of opioid-dependence.
-- The potential of kratom alkaloids to serve as treatment of various substance abuse disorders.
-- The benefits and risks associated with CBD usage.
Shownotes: ihmc.us/stemtalk/episode-155
![Episode 185: Andrew Koutnik discusses metabolic health, athletic performance and growing up with ...
Today we have our good friend and colleague Dr. Andrew Koutnik on the show. Andrew is a research scientist who studies the influence of nutrition and metabolism on health, disease and performance. He specializes in Type 1 diabetes and works with a wide range of people to improve their metabolic health and athletic performance.
Andrew is a visiting research scientist at IHMC and has worked with Harvard, Johns Hopkins, NASA, and the Department of Defense to develop evidence-based strategies for overcoming complex health challenges.
He is a graduate of Florida State University and earned his Ph.D. in medical sciences at the University of South Florida, where he worked with another good friend of ours, Dr. Dominic D’Agostino, who has been a previous STEM-Talk guest.
Show notes:
[00:02:50] Dawn welcomes Andrew to the show and asks him about his website, andrewkoutnik.com (http://andrewkoutnik.com) , the quote on the site’s homepage “Demystifying complex science to help you thrive in your health journey,” and the tagline “Challenging the status quo of metabolic health, human performance, and the management of type1 diabetes.”
[00:05:31] Ken asks Andrew how old he was when he first learned he had Type 1 diabetes.
[00:08:32] Dawn asks why Andrew believes his Type 1 diabetes is one of his life’s ultimate assets?
[00:12:51] Ken mentions that Andrew grew up in Tallahassee and that despite suffering from childhood obesity, he was relatively athletic as a child. Ken asks Andrew to talk about his childhood.
[00:14:20] Dawn asks Andrew to talk about the weight-loss journey he underwent as a teenager.
[00:17:25] Dawn shifts gears to ask Andrew about how he got into science, mentioning that when he was younger, he never saw himself becoming a scientist.
[00:20:19] Dawn asks if it is true that Andrew was the sort of kid who would constantly asked questions.
[00:22:11] Dawn asks Andrew if it is true that after enrolling at Tallahassee Community College, it took him a while to decide on his major.
[00:22:58] Ken asks Andrew to talk about the impact that his undergraduate anatomy and physiology class and professor had on his journey.
[00:24:44] Ken mentions that after graduating from FSU, Andrew went to the University of South Florida where he worked with Dominic D’Agostino, who is both a previous STEM-Talk guest (https://www.ihmc.us/stemtalk/episode-153/) and a current colleague of Andrew’s. Ken asks Andrew how he met Dom.
[00:27:46] Dawn asks Andrew how he came to work in Dom’s lab.
[00:29:00] Dawn asks Andrew if his wife is still in touch with her former roommate, who connected Andrew and Dom.
[00:29:21] Ken asks Andrew to touch on some of the research he did with Dom while he was pursuing his Ph.D.
[00:31:49] Dawn shifts gears to talk about Andrew’s work in metabolic health and Type 1 diabetes. Dawn explains that a study published by the University of North Carolina found only 12 percent of Americans were metabolically healthy. Additionally, researchers from the Friedman School of Nutrition Science and Policy at Tufts University found in 2022 that only 6.8 percent of Americans had good cardiometabolic health. Dawn asks Andrew how he works with people who want to improve their metabolic health.
[00:34:19] Ken asks Andrew for his thoughts on the sentiment that a ketogenic diet is hard to sustain.
[00:36:55] Ken mentions that Andrew was part of a review that looked at carbohydrate restriction for diabetes (https://www.jci.org/articles/view/142246) , which is a practice that had been in use since the 1700s. It fell out of favor once insulin was discovered in the 1920s. Ken goes on to explain that carbohydrate restrictive diets, like the ketogenic diet, have regained popularity for the treatment and management of diabetes, weight-loss and a range of other health issues such as migraines, cancer and depression. Ken asks Andrew to first explain the history of carb-restrictive diets as a treatment of diabetes.
[00:39:43] Ken asks Andrew to talk more about the aforementioned 2021 review and its argument in favor of a medical nutrition therapy for diabetes management.
[00:47:21] Dawn quotes a passage from the American Diabetes Association website that reads, “Before insulin was discovered in 1921, people with diabetes didn’t live for long. There wasn’t much doctors could do for them. The most effective treatment was to put patients with diabetes on very strict diets with minimal carbohydrate intake. This could buy patients a few extra years but couldn’t save them. Harsh diets, some prescribed as little as 450 calories a day, sometimes caused patients to die of starvation.” Dawn asks Andrew if he feels that this quote discourages the use of carb-restriction and medical nutrition therapy for diabetes management.
[00:49:22] Dawn asks Andrew how the treatment of diabetes went from the use of insulin being prescribed along with carbohydrate restriction, to purely pharm... Episode 185: Andrew Koutnik discusses metabolic health, athletic performance and growing up with ...](https://i.ytimg.com/vi/ZTVhJ8h1jmY/mqdefault.jpg)









