Andrew Huberman | Dr. Oded Rechavi: Genes & the Inheritance of Memories Across Generations | Huberman Lab Podcast @hubermanlab | Uploaded February 2023 | Updated October 2024, 2 hours ago.
In this episode, my guest is Oded Rechavi, Ph.D., professor of neurobiology at Tel Aviv University and expert in how genes are inherited, how experiences shape genes and remarkably, how some memories of experiences can be passed via genes to offspring. We discuss his research challenging long-held tenets of genetic inheritance and the relevance of those findings to understanding key biological and psychological processes including metabolism, stress and trauma. He describes the history of the scientific exploration of the “heritability of acquired traits” and how epigenetics and RNA biology can account for some of the passage of certain experience-based memories. He discusses the importance of model organisms in scientific research and describes his work on how stressors and memories can be passed through small RNA molecules to multiple generations of offspring in ways that meaningfully affect their behavior. Nature vs. nurture is a commonly debated theme; Dr. Rechavi’s work represents a fundamental shift in our understanding of that debate, as well as genetic inheritance, brain function and evolution.
Thank you to our sponsors
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Dr. Rechavi
Academic Profile: https://en-lifesci.tau.ac.il/profile/odedrech_66
Lab Website: odedrechavilab.com
Twitter: twitter.com/OdedRechavi
TEDx Talk: ted.com/talks/oded_rechavi_transgenerational_biology?language=en
Articles
Neuronal Small RNAs Control Behavior Transgenerationally: bit.ly/2HZxrzO
Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans: bit.ly/41xRf47
Timestamps
00:00:00 Dr. Oded Rechavi
00:02:08 Sponsors: ROKA, HVMN, Eight Sleep
00:06:04 DNA, RNA, Protein; Somatic vs. Germ Cells
00:14:36 Lamarckian Evolution, Inheritance of Acquired Traits
00:22:54 Paul Kammerer & Toad Morphology
00:28:52 AG1 (Athletic Greens)
00:30:06 James McConnell & Memory Transfer
00:37:31 Weismann Barrier; Epigenetics
00:45:13 Epigenetic Reprogramming; Imprinted Genes
00:50:43 Nature vs. Nurture; Epigenetics & Offspring
00:59:06 Generational Epigenetic Inheritance
01:09:03 Sponsor: InsideTracker
01:10:20 Model Organisms, C. elegans
01:21:50 C. elegans & Inheritance of Acquired Traits, Small RNAs
01:26:02 RNA Interference, C. elegans & Virus Immunity
01:34:13 RNA Amplification, Multi-Generational Effects
01:38:41 Response Duration & Environment
01:47:50 Generational Memory Transmission, RNA
01:59:36 Germ Cells & Behavior; Body Cues
02:04:48 Transmission of Sexual Choice
02:11:22 Fertility & Human Disease; 3-Parent In Vitro Fertilization (IVF); RNA Testing
02:17:56 Deliberate Cold Exposure, Learning & Memory
02:29:26 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac - blabacphoto.com
The Huberman Lab podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.
In this episode, my guest is Oded Rechavi, Ph.D., professor of neurobiology at Tel Aviv University and expert in how genes are inherited, how experiences shape genes and remarkably, how some memories of experiences can be passed via genes to offspring. We discuss his research challenging long-held tenets of genetic inheritance and the relevance of those findings to understanding key biological and psychological processes including metabolism, stress and trauma. He describes the history of the scientific exploration of the “heritability of acquired traits” and how epigenetics and RNA biology can account for some of the passage of certain experience-based memories. He discusses the importance of model organisms in scientific research and describes his work on how stressors and memories can be passed through small RNA molecules to multiple generations of offspring in ways that meaningfully affect their behavior. Nature vs. nurture is a commonly debated theme; Dr. Rechavi’s work represents a fundamental shift in our understanding of that debate, as well as genetic inheritance, brain function and evolution.
Thank you to our sponsors
AG1 (Athletic Greens): athleticgreens.com/huberman
ROKA: roka.com/huberman
HVMN: hvmn.com/huberman
Eight Sleep: eightsleep.com/huberman
InsideTracker: insidetracker.com/huberman
Supplements from Momentous
livemomentous.com/huberman
Huberman Lab Social & Website
Instagram: instagram.com/hubermanlab
Twitter: twitter.com/hubermanlab
Facebook: facebook.com/hubermanlab
TikTok: tiktok.com/@hubermanlab
LinkedIn: linkedin.com/in/andrew-huberman
Website: hubermanlab.com
Newsletter: hubermanlab.com/neural-network
Dr. Rechavi
Academic Profile: https://en-lifesci.tau.ac.il/profile/odedrech_66
Lab Website: odedrechavilab.com
Twitter: twitter.com/OdedRechavi
TEDx Talk: ted.com/talks/oded_rechavi_transgenerational_biology?language=en
Articles
Neuronal Small RNAs Control Behavior Transgenerationally: bit.ly/2HZxrzO
Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans: bit.ly/41xRf47
Timestamps
00:00:00 Dr. Oded Rechavi
00:02:08 Sponsors: ROKA, HVMN, Eight Sleep
00:06:04 DNA, RNA, Protein; Somatic vs. Germ Cells
00:14:36 Lamarckian Evolution, Inheritance of Acquired Traits
00:22:54 Paul Kammerer & Toad Morphology
00:28:52 AG1 (Athletic Greens)
00:30:06 James McConnell & Memory Transfer
00:37:31 Weismann Barrier; Epigenetics
00:45:13 Epigenetic Reprogramming; Imprinted Genes
00:50:43 Nature vs. Nurture; Epigenetics & Offspring
00:59:06 Generational Epigenetic Inheritance
01:09:03 Sponsor: InsideTracker
01:10:20 Model Organisms, C. elegans
01:21:50 C. elegans & Inheritance of Acquired Traits, Small RNAs
01:26:02 RNA Interference, C. elegans & Virus Immunity
01:34:13 RNA Amplification, Multi-Generational Effects
01:38:41 Response Duration & Environment
01:47:50 Generational Memory Transmission, RNA
01:59:36 Germ Cells & Behavior; Body Cues
02:04:48 Transmission of Sexual Choice
02:11:22 Fertility & Human Disease; 3-Parent In Vitro Fertilization (IVF); RNA Testing
02:17:56 Deliberate Cold Exposure, Learning & Memory
02:29:26 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac - blabacphoto.com
The Huberman Lab podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.
