DNA Packaging Animation | chromatin, histone and nucleosome modifications @shomusbiologyacademy874
DNA Packaging Animation | chromatin, histone and nucleosome modifications  @shomusbiologyacademy874
Uploaded March 2016 | Updated September 2026, 2 hours ago
DNA Packaging Animation | chromatin, histone and nucleosome modifications -
This animation will explain the DNA packaging mechanism and the role of histone proteins in condensing chromatin into nucleosome structure. transcript available below-
1st to develop and function properly it must rely on the white jeans of the White House in most of the genes in eukaryotes are located in the nucleus within a tangled material called chromatin researchers are beginning to discover that the structure of chromatin dictates whether or not a gene can be transcribed most of the chromatin in a cell's nucleus is highly ordered and tightly coiled in chromatin DNA is wrapped around several types of proteins called histones each of the many coil units is a nucleosome the histone proteins have an overall positive charge and the DNA has a negative charge these opposite charges attract forming a tight association between the protein and the DNA in this chromatin structure the DNA of the gene is virtually inaccessible and RNA polymerase cannot transcribe it if the DNA is inaccessible is a turnover gene are actually many different triggers for initiating transcription as one example is cell may receive a signal during development that result in the activation or production of the specific title protein called a regular Tory transcription factor the regular Tory transcription factor recognises and binds to exposed sequences in the chromatin of a specific gene is made and work in conjunction with a set of proteins that can change the chromatin structure for example chromatin remodelling may occurred to the function of a title protein called a chromatin remodelling complex the action of this complex is not well understood but the resulting structural changes he exposed regulatory sequences in the DNA of the regulatory sequences may be close or thousands of nucleotides away from the transcription region of the gene for simplicity will examine the naked DNA of the gene about 30 nucleotides upstream of the transcription region is the promoter the core regular Tory sequence of the gene next to the promoter lies the promoter proximal and at promoter proximal elements stimulate transcription through the binding of tissue-specific regulatory transcription factors enhancers are regular Tory sequences that may lie thousands of nucleotides from the transcription start site tissue-specific regulatory transcription factors bind to enhancers to stimulate transcription when regular Tory transcription factors are bound to DNA in Iraq with other transcription factors these basal transcription factors bind to promoters they are required for transcription to occur but they are not cell specific and do not provide much in the way of regulation when all the diesel transcription factors are bound they form a basal transcription complex one of the diesel transcription factors called a total binding protein TDP binds to a specific sequence known as at OtterBox within the promoter batata binding protein allows RNA polymerase to contact DNA the basal transcription complex then recruits RNA polymerase and transcription begins in cell types are lacking the tissue-specific regulatory transcription factors this particular gene would not be transcribed.
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DNA Packaging Animation | chromatin, histone and nucleosome modifications

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