Uploaded July 2023 | Updated September 2026, 2 weeks ago
Therapeutic mRNA is in vitro transcribed mRNA that is delivered to a target cell where the cell translates that mRNA into a protein to effect a therapeutic action. The benefits of using mRNA as a therapeutic were demonstrated during the COVID pandemic. Native and therapeutic mRNA molecules have a 3’ polyadenylation tract, known as a poly(A) tail. This poly(A) tail serves to stabilize the mRNA molecule and facilitate successful protein translation. The importance of this poly(A) tail is recognized by the United States Pharmacopeia (USP), which recommends characterizing 3’ poly(A) tail length and integrity by ion-pair reverse-phase high-performance liquid chromatography (IP-RP-HPLC). However, a 2023 peer review publication demonstrates the use of Droplet Digital™ PCR (ddPCR™) to characterize poly(A) tail content of mRNA samples, thus demonstrating an orthogonal or alternative method to help ensure the quality and consistency of mRNA products. Just one more use of the powerful ddPCR technology!
Learn more: bio-rad.com/polyatail
#digitalPCR #ddPCR #mRNA #biopharma #RNATx
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©2023 Bio-Rad is a trademark of Bio-Rad Laboratories, Inc. in certain jurisdictions. All trademarks used herein are the property of their respective owner.
Music used by permission granted by royalty-free license from Pond5.com
Therapeutic mRNA is in vitro transcribed mRNA that is delivered to a target cell where the cell translates that mRNA into a protein to effect a therapeutic action. The benefits of using mRNA as a therapeutic were demonstrated during the COVID pandemic. Native and therapeutic mRNA molecules have a 3’ polyadenylation tract, known as a poly(A) tail. This poly(A) tail serves to stabilize the mRNA molecule and facilitate successful protein translation. The importance of this poly(A) tail is recognized by the United States Pharmacopeia (USP), which recommends characterizing 3’ poly(A) tail length and integrity by ion-pair reverse-phase high-performance liquid chromatography (IP-RP-HPLC). However, a 2023 peer review publication demonstrates the use of Droplet Digital™ PCR (ddPCR™) to characterize poly(A) tail content of mRNA samples, thus demonstrating an orthogonal or alternative method to help ensure the quality and consistency of mRNA products. Just one more use of the powerful ddPCR technology!
Learn more: bio-rad.com/polyatail
#digitalPCR #ddPCR #mRNA #biopharma #RNATx
Subscribe to the Bio-Rad channel: youtube.com/user/BioRadLifeScience?sub_confirmation=1
We Are Bio-Rad.
Our mission: To provide useful, high-quality products and services that advance scientific discovery and improve healthcare. At Bio-Rad, we are united behind this effort. These two objectives are the driving force behind every decision we make, from developing innovative ideas to building global solutions that help solve our customers' greatest challenges.
Connect with Bio-Rad Online:
Website: bio-rad.com/digital-pcr
LinkedIn: linkedin.com/company/bio-rad
Facebook: facebook.com/BioRadGenomics
Twitter: twitter.com/BioRadGenomics
Instagram: instagram.com/bioradlabs
©2023 Bio-Rad is a trademark of Bio-Rad Laboratories, Inc. in certain jurisdictions. All trademarks used herein are the property of their respective owner.
Music used by permission granted by royalty-free license from Pond5.com
