Uploaded May 2026 | Updated September 2026, 3 weeks ago
How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman
Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level.
-Watch this episode on YouTube for the full video experience: youtube.com/@DaveAspreyBPR
-Explore all of Wonderfeel’s products at: getwonderfeel.com/dave
They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th.
Host Dave Asprey sits down with Professor Andrew Salzman, MD / Chief Medical Officer at Wonderfeel , a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide.
You'll Learn:
-Why NAD declines with age and which two enzymes are primarily responsible for draining it
-How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy
-Why creatine is one of the most underrated anti-aging and brain optimization supplements available
-How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart
-Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade
-How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body
-What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role
-Why most creatine supplements fail to absorb properly and what to look for in a high-quality source
-How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics
-Why walking immediately after a meal may be doing more harm than good to your gut lining
Resources:
• Explore all of Wonderfeel’s products at: getwonderfeel.com/dave
• Order Youngr™: getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode3
• Order ChocoCreatin™: getwonderfeel.com/product/wonderfeel-chococreatin/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode3
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at daveasprey.com/2026-clean-nicotine-roadmap
• Dave Asprey's Latest News | Go to daveasprey.com to join Inside Track today.
Thank you to our sponsors!
- Screenfit | Get your at-home eye training program for 40% off using code DAVE at screenfit.com/dave.
- KILLSwitch | If you’re ready for the best sleep of your life, order now at switchsupplements.com/and use code DAVE for 20% off
- Pique | Go to Piquelife.com/dave for 20% off.
- iRestore | Reverse hair loss at irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
00:00 – Trailer
01:12 – Introduction
04:38 – Free Radicals & Oxidative Stress
11:37 – NAD & Antioxidant Defense
12:34 – CD38 & NAD Depletion
23:31 – The Gut-Aging Hypothesis
30:05 – ATP, Creatine & Energy Distribution
36:41 – Creatine as Energy Shuttle
51:09 – Microbiome & Gut Repair
59:21 – TMAO & Nitric Oxide Interference
1:03:52 – Flagellin & Gut Inflammation Research
1:09:45 – FDA & Pharmaceutical Incentives
1:16:05 – Closing
Website: daveasprey.com
TikTok: tiktok.com/@daveaspreyofficial
Instagram: instagram.com/dave.asprey
Facebook: facebook.com/Daveaspreyofficial
X: https://x.com/daveasprey
The Human Upgrade Podcast: instagram.com/TheHumanUpgradePodcast https://m.facebook.com/Thehumanupgrade
Danger Coffee: dangercoffee.com/discount/dave15?
Dave Asprey’s BEYOND Conference: beyondconference.com
Dave Asprey’s New Book - Heavily Meditated: daveasprey.com/heavily-meditated
Dave's favorite supplements: shopsuppgradelabs.com/discount/DAVE15
Join my Substack: substack.daveasprey.com
Upgrade Labs: upgradelabs.com
40 Years of Zen: 40yearsofzen.com
How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman
Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level.
-Watch this episode on YouTube for the full video experience: youtube.com/@DaveAspreyBPR
-Explore all of Wonderfeel’s products at: getwonderfeel.com/dave
They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th.
Host Dave Asprey sits down with Professor Andrew Salzman, MD / Chief Medical Officer at Wonderfeel , a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide.
You'll Learn:
-Why NAD declines with age and which two enzymes are primarily responsible for draining it
-How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy
-Why creatine is one of the most underrated anti-aging and brain optimization supplements available
-How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart
-Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade
-How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body
-What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role
-Why most creatine supplements fail to absorb properly and what to look for in a high-quality source
-How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics
-Why walking immediately after a meal may be doing more harm than good to your gut lining
Resources:
• Explore all of Wonderfeel’s products at: getwonderfeel.com/dave
• Order Youngr™: getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode3
• Order ChocoCreatin™: getwonderfeel.com/product/wonderfeel-chococreatin/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode3
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at daveasprey.com/2026-clean-nicotine-roadmap
• Dave Asprey's Latest News | Go to daveasprey.com to join Inside Track today.
Thank you to our sponsors!
- Screenfit | Get your at-home eye training program for 40% off using code DAVE at screenfit.com/dave.
- KILLSwitch | If you’re ready for the best sleep of your life, order now at switchsupplements.com/and use code DAVE for 20% off
- Pique | Go to Piquelife.com/dave for 20% off.
- iRestore | Reverse hair loss at irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
00:00 – Trailer
01:12 – Introduction
04:38 – Free Radicals & Oxidative Stress
11:37 – NAD & Antioxidant Defense
12:34 – CD38 & NAD Depletion
23:31 – The Gut-Aging Hypothesis
30:05 – ATP, Creatine & Energy Distribution
36:41 – Creatine as Energy Shuttle
51:09 – Microbiome & Gut Repair
59:21 – TMAO & Nitric Oxide Interference
1:03:52 – Flagellin & Gut Inflammation Research
1:09:45 – FDA & Pharmaceutical Incentives
1:16:05 – Closing
Website: daveasprey.com
TikTok: tiktok.com/@daveaspreyofficial
Instagram: instagram.com/dave.asprey
Facebook: facebook.com/Daveaspreyofficial
X: https://x.com/daveasprey
The Human Upgrade Podcast: instagram.com/TheHumanUpgradePodcast https://m.facebook.com/Thehumanupgrade
Danger Coffee: dangercoffee.com/discount/dave15?
Dave Asprey’s BEYOND Conference: beyondconference.com
Dave Asprey’s New Book - Heavily Meditated: daveasprey.com/heavily-meditated
Dave's favorite supplements: shopsuppgradelabs.com/discount/DAVE15
Join my Substack: substack.daveasprey.com
Upgrade Labs: upgradelabs.com
40 Years of Zen: 40yearsofzen.com
