Coagulopathy | Clinical Medicine @NinjaNerdOfficial

Uploaded April 2025 | Updated September 2026, 2 weeks ago

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Ninja Nerds!
In this lecture, Professor Zach Murphy delivers a comprehensive and high-yield breakdown of Coagulopathy, diving deep into the mechanisms, causes, and clinical significance of bleeding and clotting disorders related to the coagulation cascade. This video explores both congenital and acquired coagulopathies, offering a clear framework for understanding these critical hemostatic abnormalities.

We begin by reviewing the normal physiology of coagulation, including the intrinsic, extrinsic, and common pathways, as well as the roles of vitamin K, calcium, and various coagulation factors. Zach then transitions into detailed discussions on common inherited coagulopathies like hemophilia A and B, and von Willebrand disease, highlighting key differences in pathophysiology, lab findings (such as PT, aPTT, and bleeding time), and clinical manifestations.

The lecture continues with a focused review of acquired coagulopathies, such as liver disease, vitamin K deficiency, anticoagulant use (e.g., warfarin, heparin), and DIC. You’ll also learn how to interpret mixing studies, identify patterns of lab abnormalities, and approach the evaluation of a bleeding patient using real clinical logic.

This lecture concludes with a high-yield comparison of the most commonly tested coagulopathies for exams like USMLE, COMLEX, and PANCE, incorporating memorable clinical pearls and integrative charts to help reinforce your understanding. Whether you’re in the preclinical years or prepping for boards, this video will give you the tools you need to master coagulopathy. Enjoy the lecture and please support us below!

Table of Contents:
0:00 Lab
0:41 Pathophysiology of Coagulopathy
17:43 Causes of Intrinsic Defects
30:25 Causes of Extrinsic Defects
40:13 Causes of Intrinsic/Extrinsic Defects
54:08 Diagnostic Approach to Coagulopathy
1:05:48 Treatment of Coagulopathy
1:13:02 Comment, Like, SUBSCRIBE!

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