Uploaded December 2024 | Updated September 2026, 2 weeks ago

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Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper.

In this video, I discuss some of the best ways to add CF2 and SF5 groups using decent methodology.

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References:
CF2H review - 10.1002/ajoc.201600509
Photoredox CF2H - 10.1002/anie.201807629
SF5 Review - 10.1055/a-1845-9291

Other SF5 Cl to F exchange papers:
HF: patents.google.com/patent/WO2012111839A1/en?oq=WO2012111839A1
ZnF2: dx.doi.org/10.3762/bjoc.8.53IF5: pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc02802dSbF5: dx.doi.org/10.3762/bjoc.8.53AgBF4: dx.doi.org/10.1246/bcsj.20210109KHF2: pubs.acs.org/doi/10.1021/acs.joc.6b02276HF/Pyridine: patents.google.com/patent/WO2010014665A1/en?oq=WO2010014665A1

BONUS - Ag2CO3 also works (thanks to Semp_ukiuki!) - doi.org/10.1039/C7CC07222H (2 equiv of Ar-SF4Cl become 1 equiv of Ar-SF5)
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