Uploaded December 2025 | Updated September 2026, 2 weeks ago
The sequencing of genomes from archaic humans, such as Neanderthals and Denisovans, has transformed our understanding of human evolutionary history. These ancient genomes reveal that modern humans did not evolve in isolation but interbred with now-extinct groups, leaving lasting genetic legacies. To date, genomic sequences from 31 archaic human individuals, including four sequenced to high coverage, have provided unprecedented insights into the population structure, social organization, and adaptation of this now-extinct lineages, allowing us to reconstruct our own evolutionary history and the mechanisms that led to modern human success. Diyendo Massilani of Yale University School of Medicine reviews nearly three decades of research on archaic human DNA and what we have learned about how these groups lived, as well as how admixture between different lineages may have contributed both to the extinction of archaic humans and the thriving of modern humans. Ultimately, ancient genomes show that the success of our species was not predetermined but forged through encounters, exchanges, and adaptations, and that the legacies of archaic humans live on in our biology today, continuing to influence what it means to be human. Recorded on 11/07/2025. [12/2025] [Show ID: 41193]
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Science and technology continue to change our lives. University of California scientists are tackling the important questions like climate change, evolution, oceanography, neuroscience and the potential of stem cells.
UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California -- teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
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The sequencing of genomes from archaic humans, such as Neanderthals and Denisovans, has transformed our understanding of human evolutionary history. These ancient genomes reveal that modern humans did not evolve in isolation but interbred with now-extinct groups, leaving lasting genetic legacies. To date, genomic sequences from 31 archaic human individuals, including four sequenced to high coverage, have provided unprecedented insights into the population structure, social organization, and adaptation of this now-extinct lineages, allowing us to reconstruct our own evolutionary history and the mechanisms that led to modern human success. Diyendo Massilani of Yale University School of Medicine reviews nearly three decades of research on archaic human DNA and what we have learned about how these groups lived, as well as how admixture between different lineages may have contributed both to the extinction of archaic humans and the thriving of modern humans. Ultimately, ancient genomes show that the success of our species was not predetermined but forged through encounters, exchanges, and adaptations, and that the legacies of archaic humans live on in our biology today, continuing to influence what it means to be human. Recorded on 11/07/2025. [12/2025] [Show ID: 41193]
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Learn more about anthropogeny on CARTA's website:
carta.anthropogeny.org
More videos from: CARTA: Ancient DNA - New Revelations
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Explore More Science & Technology on UCTV
(uctv.tv/science)
Science and technology continue to change our lives. University of California scientists are tackling the important questions like climate change, evolution, oceanography, neuroscience and the potential of stem cells.
UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California -- teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
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![Navigating Grief: What the Science of Resilience Teaches about Adaptation to Loss
Danielle K. Glorioso, LCSW, explores the complex nature of grief, emphasizing that it is a lifelong, evolving response to loss rather than something to “get over.” She explains the differences between acute grief, integrated grief, and prolonged grief disorder, highlighting how factors like attachment, personal history, and circumstances of death can influence the grieving process. Glorioso outlines how prolonged grief can impair daily functioning and discusses effective treatments, including a structured therapy program that facilitates adaptation. She also examines resilience as a skill that can be strengthened through emotion regulation, cognitive flexibility, social support, and meaning-making. Drawing on both professional expertise and personal loss, Glorioso offers practical strategies for coping, supporting others, and finding hope while honoring the memory of loved ones. [10/2025] [Show ID: 40332]
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UCTV features the latest in health and medicine from University of California medical schools. Find the information you need on cancer, transplantation, obesity, disease and much more.
UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
(https://www.uctv.tv) Navigating Grief: What the Science of Resilience Teaches about Adaptation to Loss](https://i.ytimg.com/vi/q9heDrGpDZE/mqdefault.jpg)



![How Brain Organoids Model SYNGAP1 in Autism
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https://www.youtube.com/watch?v=qC76ZcSjL94
Human brain organoids help researchers study neurodevelopmental disorders that are difficult to examine directly in developing brain tissue. Giorgia Quadrato, USC, uses cortical organoids derived from human pluripotent stem cells to examine SYNGAP1, an autism risk gene associated in the transcript with intellectual disability, epilepsy, and global developmental delay. Quadrato describes how SYNGAP1 appears in progenitor cells as well as neurons, and how SYNGAP1 haploinsufficiency is linked to disrupted radial glia organization, altered cell division, and faster maturation of cortical projection neurons. She also discusses newer work focused on enteric neurons, gastrointestinal symptoms, and gut motility. By connecting brain development, autism genetics, and the enteric nervous system, this research points to models that may help test therapies and better understand symptoms that affect families. Recorded on 11/07/2025. [7/2026] [Show ID: 41174]
0:00 Modeling Human Brain Development and Disease
0:24 Why Autism Genetics Are Hard to Study
1:49 How Brain Organoids Model the Fetal Cortex
3:59 SYNGAP1 in Progenitor Cells and Rosettes
10:15 Faster Neuron Maturation in SYNGAP1 Organoids
14:46 Autism Genes and Gastrointestinal Symptoms
19:00 Gut Motility Models for Therapy Screening
20:19 Q&A: Migration, Seizures, and Maturation
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UCTV features the latest in health and medicine from University of California medical schools. Find the information you need on cancer, transplantation, obesity, disease and much more.
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Science and technology continue to change our lives. University of California scientists are tackling the important questions like climate change, evolution, oceanography, neuroscience and the potential of stem cells.
UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
(https://www.uctv.tv) How Brain Organoids Model SYNGAP1 in Autism](https://i.ytimg.com/vi/q_pgayjAgOQ/mqdefault.jpg)

![Surgery for the Management of Prostate Cancer
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As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. Carissa Chu discusses surgery for prostate cancer. Recorded on 04/17/2026. [Show ID: 41550]
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UCTV features the latest in health and medicine from University of California medical schools. Find the information you need on cancer, transplantation, obesity, disease and much more.
UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
(https://www.uctv.tv) Surgery for the Management of Prostate Cancer](https://i.ytimg.com/vi/r1GneFWFh4o/mqdefault.jpg)
![PET-Directed Radiation for Oligometastatic Disease
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As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. Will Chen discusses PET-directed radiation for Oligometastatic Disease. Recorded on 04/17/2026. [Show ID: 41559]
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UCTV features the latest in health and medicine from University of California medical schools. Find the information you need on cancer, transplantation, obesity, disease and much more.
UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
(https://www.uctv.tv) PET-Directed Radiation for Oligometastatic Disease](https://i.ytimg.com/vi/rWStmePd5Vs/mqdefault.jpg)
![Sleep in Children with Neurodevelopmental Differences
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As part of the 2026 Developmental Disabilities Conference, Dr. Althea Robinson Shelton, Associate Professor of Neurology and Pediatrics, Vanderbilt University Medical Center, discusses sleep in children with neurodevelopmental differences. Recorded on 03/06/2026. [Show ID: 41466]
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UCTV features the latest in health and medicine from University of California medical schools. Find the information you need on cancer, transplantation, obesity, disease and much more.
UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
(https://www.uctv.tv) Sleep in Children with Neurodevelopmental Differences](https://i.ytimg.com/vi/rakKsTiC4Ss/mqdefault.jpg)
![CARTA: Population Genetics of Latin America and Oceania with Andrés Moreno-Estrada
Genetic data is transforming the understanding of our own species and refining historical chapters at different scales around the globe. However, despite the globalization of biotechnologies to analyze the human genome, indigenous populations from the Americas and Oceania remain underrepresented in large-scale genomic studies. Andrés Moreno-Estrada, Cinvestav, discusses recent efforts to characterize the genetic profile of Indigenous Americans throughout the analysis of ancient and modern DNA, as well as their relationship within and beyond the continent, including the possibility of prehistoric contacts with Pacific Islanders. This topic poses challenges and opportunities to adequately study human diversity not only for the benefit of genetic research and science, but also for the benefit of the local communities, which are bearers of a unique evolutionary history that has been recorded in their DNA. This rapidly evolving field also raises questions about the best practices when studying the DNA of underrepresented ancestries while conducting cutting-edge science in a more equitable way. Recorded on 11/07/2025. [2/2026] [Show ID: 41201]
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Science and technology continue to change our lives. University of California scientists are tackling the important questions like climate change, evolution, oceanography, neuroscience and the potential of stem cells.
UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
(https://www.uctv.tv) CARTA: Population Genetics of Latin America and Oceania with Andrés Moreno-Estrada](https://i.ytimg.com/vi/re4eACBu7iY/mqdefault.jpg)
