Uploaded October 2025 | Updated September 2026, 2 weeks ago

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Sacrifice of Blood is a new Keystone-like mechanic granted by the new Chaos Bloodline's Corruption's Embrace notable. Whilst Sacrifice of Blood isn't a strong leaguestarting spec due to its high corrupted equipment prerequisite, it has incredible potential to beef up lategame life builds in Path of Exile: Keepers of the Flame.

Shepherd of Souls video: youtu.be/uTis0tZldKQ

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0:00 Chaos Bloodline Class
0:24 Corruption's Embrace Notable
0:46 Shepherd of Souls
1:11 Everlasting Sacrifice
1:38 Sacrifice of Blood
3:31 Synergy with Boneshatter/Trauma
4:42 Everlasting Sacrifice with Blood Barrier
5:17 Petrified Blood?
5:44 Dissolution of the Flesh
6:10 Life Stacker Scaling
6:45 Relic of the Pact
7:33 Shadowstitch
7:46 Full Life Wording
8:19 Closing Thoughts