Uploaded November 2025 | Updated September 2026, 10 hours ago
Dan Nicholson on the intention of Schrodinger's What is Life, and the effect it continues to have on modern science outside of physics.
Show notes: braininspired.co/podcast/224
Patreon (full episodes, archive, Discord, more): patreon.com/braininspired
Apple podcasts: itunes.apple.com/us/podcast/brain-inspired/id1428880766?mt=2
Spotify: open.spotify.com/show/2UZj8c8Ap5oc2gh2rJxLLe
Music by @dunovank
The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.
Read more about our partnership: thetransmitter.org/partners
Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released: thetransmitter.org/newsletters
To explore more neuroscience news and perspectives, visit thetransmitter.org.
My guest today is Dan Nicholson, Assistant Professor of Philosophy at George Mason University, here to talk about his little book, What Is Life? Revisited. Erwin Schrödinger's What Is Life is a famous book that people point to as having predicted DNA and influenced and inspired many well-known biologists ushering in the molecular biology revolution. But Schrödinger was a physicist, not a biologist, and he spent very little time and effort toward understanding biology.
What was he up to, why did he write this "famous little book"? Schrödinger had an agenda, a physics agenda. He wanted to save the older deterministic version of quantum physics from the new indeterministic version. When Dan was on the podcast a few years ago, we talked about the machine view of biological systems, how everything has become a "mechanism", and how that view fails to capture what modern science is actually telling us, that organisms are unlike machines in important ways. That work of Dan's led him down this path to Schrödinger's What Is Life, which he argues was a major contributor to that machine metaphor so ubiquitous today in biology. One of the reasons I'm interested in this kind of work is because the cognitive sciences, including neuroscience and artificial intelligence, inherited this mechanistic perspective, and swallowed it so hard that if you don't include the word "mechanism" in your research paper, you're vastly decreasing your chances of getting your work published, when in fact the mechanistic perspective is one super useful perspective among many.
0:00 - Intro
7:27 - Why Schrodinger wrote What is Life
15:13 - Aperiodic crystal and the meaning of code
21:39 - Order-from-order, order-from-disorder
28:32 - Appeal to authority
37:48 - Cell as machine
39:33 - Relation between DNA and organism (development)
44:44 - Negentropy
53:54 - Original contributions
58:54 - Mechanistic metaphor in neuroscience
1:16:05 - What's the lesson?
1:28:06 - Historical sleuthing
1:39:49 - Modern philosophy of biology
Dan Nicholson on the intention of Schrodinger's What is Life, and the effect it continues to have on modern science outside of physics.
Show notes: braininspired.co/podcast/224
Patreon (full episodes, archive, Discord, more): patreon.com/braininspired
Apple podcasts: itunes.apple.com/us/podcast/brain-inspired/id1428880766?mt=2
Spotify: open.spotify.com/show/2UZj8c8Ap5oc2gh2rJxLLe
Music by @dunovank
The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.
Read more about our partnership: thetransmitter.org/partners
Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released: thetransmitter.org/newsletters
To explore more neuroscience news and perspectives, visit thetransmitter.org.
My guest today is Dan Nicholson, Assistant Professor of Philosophy at George Mason University, here to talk about his little book, What Is Life? Revisited. Erwin Schrödinger's What Is Life is a famous book that people point to as having predicted DNA and influenced and inspired many well-known biologists ushering in the molecular biology revolution. But Schrödinger was a physicist, not a biologist, and he spent very little time and effort toward understanding biology.
What was he up to, why did he write this "famous little book"? Schrödinger had an agenda, a physics agenda. He wanted to save the older deterministic version of quantum physics from the new indeterministic version. When Dan was on the podcast a few years ago, we talked about the machine view of biological systems, how everything has become a "mechanism", and how that view fails to capture what modern science is actually telling us, that organisms are unlike machines in important ways. That work of Dan's led him down this path to Schrödinger's What Is Life, which he argues was a major contributor to that machine metaphor so ubiquitous today in biology. One of the reasons I'm interested in this kind of work is because the cognitive sciences, including neuroscience and artificial intelligence, inherited this mechanistic perspective, and swallowed it so hard that if you don't include the word "mechanism" in your research paper, you're vastly decreasing your chances of getting your work published, when in fact the mechanistic perspective is one super useful perspective among many.
0:00 - Intro
7:27 - Why Schrodinger wrote What is Life
15:13 - Aperiodic crystal and the meaning of code
21:39 - Order-from-order, order-from-disorder
28:32 - Appeal to authority
37:48 - Cell as machine
39:33 - Relation between DNA and organism (development)
44:44 - Negentropy
53:54 - Original contributions
58:54 - Mechanistic metaphor in neuroscience
1:16:05 - What's the lesson?
1:28:06 - Historical sleuthing
1:39:49 - Modern philosophy of biology
