Uploaded May 2025 | Updated September 2026, 6 hours ago
📝 Sobetirome (GC-1) Clinical Trials (Withdrawn):
Lin, V.W. et al. (2008) Sobetirome is a TRβ- and liver-selective thyromimetic that can effect substantial LDL-C lowering without significant changes in heart rate or the thyroid axis in euthyroid men. San Francisco: The Endocrine Society, Annual Meeting ENDO 08, OR36-33.
BioSpace (January 29, 2008) Phase 1 Studies Show Promise of QuatRx Pharmaceuticals’ Novel Compound, Sobetirome, for Lowering LDL Cholesterol Levels
biospace.com/phase-1-studies-show-promise-of-quatrx-pharmaceuticals-novel-compound-sobetirome-for-lowering-ldl-cholesterol-levels
Thomas S. Scanlan, Oregon Health and Science University (February 14, 2014) Safety and Pharmacodynamic Study of Sobetirome in X-Linked Adrenoleukodystrophy (X-ALD). NCT01787578
clinicaltrials.gov/study/NCT01787578
Sjouke, B. et al. (June, 2014) Eprotirome in patients with familial hypercholesterolaemia (the AKKA trial): a randomised, double-blind, placebo-controlled phase 3 study. The Lancet Diabetes & Endocrinology, 2(6):455-63. doi: 10.1016/S2213-8587(14)70006-3
pismin.com/10.1016/S2213-8587(14)70006-3
NeuroVia, Inc. (March 7, 2019) Safety, Pharmacokinetics and Pharmacodynamics of NV1205 in Pediatric Male Subjects With Adrenoleukodystrophy. NCT03196765
clinicaltrials.gov/study/NCT03196765
Hartley, P. for Yale University (April 16, 2020) $100,000 Gift Speeds Exploration of Sobetirome as COVID-19 Treatment
https://medicine.yale.edu/news-article/100000-gift-speeds-exploration-of-sobetirome-as-covid-19-treatment/
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KETO-MOJO GK+ Bluetooth Glucose & Ketone Testing Kit: amzn.to/3NLsJG5
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TIMESTAMPS:
00:00 - Intro Teaser
00:38 - Sobetirome (GC-1) Basics
02:18 - Thyroid Hormone Receptor Agonists Compared
04:31 - Function Of Thyroid Hormones T4 & T3
08:04 - Thyroid-Hormone Stimulating Compounds
12:22 - Clinical Trials
16:38 - GC-1 Evidence-Based Unique Characteristics
35:32 - Animal Studies Comparing GC-1 To T3
41:53 - Animal Model To Human Equivalent Dosage Conversion
44:07 - Animal Study Results
48:30 - Effects Of GC-1 And T3 On Heart Function
52:59 - GC-1 And Aromatization And SHBG Production
54:57 - GC-1 Dosing Protocols
57:35 - GC-1 Anecdotal Reports
59:01 - WADA And GC-1
59:21 - Closing Thoughts
#VigorousSteve #Sobetirome #ThyroidHormones
📝 Sobetirome (GC-1) Clinical Trials (Withdrawn):
Lin, V.W. et al. (2008) Sobetirome is a TRβ- and liver-selective thyromimetic that can effect substantial LDL-C lowering without significant changes in heart rate or the thyroid axis in euthyroid men. San Francisco: The Endocrine Society, Annual Meeting ENDO 08, OR36-33.
BioSpace (January 29, 2008) Phase 1 Studies Show Promise of QuatRx Pharmaceuticals’ Novel Compound, Sobetirome, for Lowering LDL Cholesterol Levels
biospace.com/phase-1-studies-show-promise-of-quatrx-pharmaceuticals-novel-compound-sobetirome-for-lowering-ldl-cholesterol-levels
Thomas S. Scanlan, Oregon Health and Science University (February 14, 2014) Safety and Pharmacodynamic Study of Sobetirome in X-Linked Adrenoleukodystrophy (X-ALD). NCT01787578
clinicaltrials.gov/study/NCT01787578
Sjouke, B. et al. (June, 2014) Eprotirome in patients with familial hypercholesterolaemia (the AKKA trial): a randomised, double-blind, placebo-controlled phase 3 study. The Lancet Diabetes & Endocrinology, 2(6):455-63. doi: 10.1016/S2213-8587(14)70006-3
pismin.com/10.1016/S2213-8587(14)70006-3
NeuroVia, Inc. (March 7, 2019) Safety, Pharmacokinetics and Pharmacodynamics of NV1205 in Pediatric Male Subjects With Adrenoleukodystrophy. NCT03196765
clinicaltrials.gov/study/NCT03196765
Hartley, P. for Yale University (April 16, 2020) $100,000 Gift Speeds Exploration of Sobetirome as COVID-19 Treatment
https://medicine.yale.edu/news-article/100000-gift-speeds-exploration-of-sobetirome-as-covid-19-treatment/
✅ Follow Vigorous Steve Here:
Website: vigoroussteve.com
Consultations: vigoroussteve.com/consultations
Advice By Email: vigoroussteve.com/personalized-advice-by-email
eBooks: vigoroussteve.com/shop
YouTube Channel: youtube.com/user/VigorousSteve
YouTube Memberships: youtube.com/user/VigorousSteve/join
Patreon Memberships: patreon.com/vigoroussteve
Clips Channel: youtube.com/@VigorousClips
Instagram: instagram.com/vanilla.vigoroussteve
PodBean: vigoroussteve.podbean.com
Spotify: open.spotify.com/show/2wR0XWY00qLq9K7tlvJ000
Apple Podcast: podcasts.apple.com/us/podcast/vigorous-steve-podcast/id1699523557
🦍 Gorilla Mind (Mode, Nitric, Smooth, Energy, EAAs, Nootropics, Turkesterone & Ecdysterone) 10% Discount Code: VIGOROUS
Affiliate Link: gorillamind.com/vigorous
🐘 Intelligent Shop (Fragrances, Ketoconazole & Minoxidil Shampoo) 10% Discount Code: VIGOROUS
Affiliate Link: https://intelligent.shop/vigorous
👨⚕️ Marek Health (Comprehensive Blood Work Analysis, Professional Medical Guidance & Hormone Optimization) 10% Discount Code: VIGOROUS
Affiliate Link: marekhealth.sjv.io/xLx3LA
🧪 Marek Diagnostics (Comprehensive Blood Work, Budget Panels & Androgen Receptor Sensitivity CAG Repeat Testing) 10% Discount Code: VIGOROUS
Affiliate Link: marekdiagnosis.pxf.io/AgP5Ex
🌿 Marek Supplements (Physician-Formulated Health Support Supplements) 10% Discount Code: VIGOROUS
Affiliate Link: mareksupplements.sjv.io/m4Zyo7
🥤 iHerb (OTC Health Supplements) 5% Discount Code: DTV967 or VIGOROUS
Affiliate Link: https://iherb.prf.hn/l/p3jlQOk/
🍆 Bathmate Penis Pump 10% Discount Link: bathmatedirect.com/VigorousSteve
🏥 Essential Health Monitoring Devices:
RENPHO Digital Bluetooth Body Weight & Fat Scale: amzn.to/4dUVoVj
RENPHO Thermacool Deep-Tissue Massage Gun: amzn.to/3ACSAhe
RENPHO Smart Tape Measure: amzn.to/3WWHZFu
OMRON 7 Series Wireless Wrist Blood Pressure Monitor: amzn.to/3udI3n7
KETO-MOJO GK+ Bluetooth Glucose & Ketone Testing Kit: amzn.to/3NLsJG5
KETO-MOJO GK+ 60x Blood Glucose + 60x Blood Ketone Testing Strips Combo Pack: amzn.to/3LK3ylf
KETOSCAN Mini Breath Ketone Meter: amzn.to/36QOB29
BRAUN ThermoScan 7 Digital Ear Thermometer: amzn.to/3KfvWeP
EMAY Digital Sleep Oxygen Monitor: amzn.to/45RG4FN
FITBIT Charge 5 Advanced Fitness, Stress, Sleep & Health Tracker: amzn.to/3LDU2Qy
🙏 Did A Video Change Your Life For The Better? Feel Free To Donate!
Credit Card: vigoroussteve.com/product/appreciation-or-donation
Bitcoin (BTC): bc1qy79kvq4vupfv90qs0nudpq7k8w6z3jx39ytnp0
TIMESTAMPS:
00:00 - Intro Teaser
00:38 - Sobetirome (GC-1) Basics
02:18 - Thyroid Hormone Receptor Agonists Compared
04:31 - Function Of Thyroid Hormones T4 & T3
08:04 - Thyroid-Hormone Stimulating Compounds
12:22 - Clinical Trials
16:38 - GC-1 Evidence-Based Unique Characteristics
35:32 - Animal Studies Comparing GC-1 To T3
41:53 - Animal Model To Human Equivalent Dosage Conversion
44:07 - Animal Study Results
48:30 - Effects Of GC-1 And T3 On Heart Function
52:59 - GC-1 And Aromatization And SHBG Production
54:57 - GC-1 Dosing Protocols
57:35 - GC-1 Anecdotal Reports
59:01 - WADA And GC-1
59:21 - Closing Thoughts
#VigorousSteve #Sobetirome #ThyroidHormones
