NileRed | Aspirin to Acetaminophen - Part 6 of 6: Acetaminophen from p-aminophenol @NileRed | Uploaded 7 years ago | Updated 1 hour ago
This is the final part of the series, where the p-aminophenol is converted to the acetaminophen.

Using acetic anhydride, the p-aminophenol is going to be acetylated. The reaction is carried out in water at room temperature.

Acetic anhydride does react with water, but it happens slowly. By including an excess of acetic anhydride, we can assure that the acetylation goes to completion.

Procedure (on page 14): goo.gl/2PDLVn

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