Uploaded August 2026 | Updated September 2026, 3 weeks ago
This Week In Startups is made possible by:
Northwest Registered Agent
northwestregisteredagent.com/twistdomain
CLA
claconnect.com/withyou
Rippling
Rippling.ai/twist
Today’s show:
Hugging Face's $399 Microduck and the art of companies taking on side quests. Then, we get into Dwarkesh Patel's "The Rise and Fall of Agent Civilizations," which blew up online this weekend. Jason calls the "secret AI civilization" framing deliberate PR, and thinks it's inflammatory enough that someone might attack a data center over it.
Then, Anders Forslund of Heart Aerospace shows off the X1, a battery-powered electric airliner designed for regional flights that can fly for 30 minutes on just $5 of juice. PLUS, we've got John Yu of Bitsec explaining how his subnet project outperformed Fable 5 in website vulnerability checks.
Guests:
Anders Forslund on X: https://x.com/AndersForslund1?s=2
Heart Aerospace: heartaerospace.com
John Yu on X: https://x.com/yubrew
Bitsec: sentios.io & sentios.io
Relevant Links:
MicroDuck: pollen-robotics.com/microduck
Dwarkesh Patel, "The Rise and Fall of Agent Civilizations," dwarkesh.com/p/openai-huggingface
Dwarkesh's launch thread on X: https://x.com/dwarkesh_sp/status/2093833419377815719
METR's independent investigation of the OpenAI/Hugging Face incident: metr.org/blog/2026-08-26-openai-hugging-face-incident-investigation
X1 first flight announcement — heartaerospace.com/newsroom/heart-aerospace-completes-first-flight-of-world-s-largest-electric-aircraft
JSX (JetSuiteX) — jsx.com
Pilatus PC-12 —pilatus-aircraft.com/en/fly/pc-12
Surf Air — surfair.com
Zcash → https://z.cash/
Timestamps:
0:00 Is Hugging Face's Microduck the greatest side quest ever?
4:48 Jason puts Clem Delangue and Jensen Huang in charge of AI PR
10:37 Northwest Registered Agent - Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! Learn more at northwestregisteredagent.com/twistdomain
18:12 Top story: Dwarkesh Patel's "The Rise and Fall of Agent Civilizations"
18:39 Why agents act like people: they were trained on us
18:47 CLA - Innovation takes balance. CLA's CPAs, consultants, and wealth advisors can help you get from startup to where you want to end up. Get started now at claconnect.com/withyou
21:06 "I know good PR when I see it"
22:28 The prompt Jason says OpenAI should have written instead
26:01 The data center backlash and the politicians who will flip
29:24 Rippling - Don't settle for AI that's all talk. Head to Rippling.ai/twist to get the only AI built to give you full visibility across your startup and take complex actions across your entire business.
32:36 Guest: Anders Forslund, Heart Aerospace, and the X1's first flight
38:57 Turboprops vs. jets and the regional routes America lost
41:50 JSX, Santa Monica Airport, and 5,000 underused airports
44:11 Why Boeing won't build this: the innovator's dilemma
52:31 Guest: John Yu, Bitsec — Bittensor Subnet 60
54:18 How the subnet works: miners, validators, $10K a day
56:34 Bitsec vs. a frontier model: 160+ vulnerabilities to 60
58:54 Was the agent civilization story a pre-IPO PR play?
1:04:27 Sentios.io and continuous coverage
Subscribe to the TWiST500 newsletter: ticker.thisweekinstartups.com
Check out the TWIST500: twist500.com
Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp
Follow Lon:
X: https://x.com/lons
Follow Jason:
X: twitter.com/Jason
LinkedIn: linkedin.com/in/jasoncalacanis
Check out all our partner offers: partners.launch.co
Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland
Check out Jason’s suite of newsletters: substack.com/@calacanis
Follow TWiST:
Twitter: twitter.com/TWiStartups
YouTube: youtube.com/thisweekin
Instagram: instagram.com/thisweekinstartups
TikTok: tiktok.com/@thisweekinstartups
Substack: twistartups.substack.com
This Week In Startups is made possible by:
Northwest Registered Agent
northwestregisteredagent.com/twistdomain
CLA
claconnect.com/withyou
Rippling
Rippling.ai/twist
Today’s show:
Hugging Face's $399 Microduck and the art of companies taking on side quests. Then, we get into Dwarkesh Patel's "The Rise and Fall of Agent Civilizations," which blew up online this weekend. Jason calls the "secret AI civilization" framing deliberate PR, and thinks it's inflammatory enough that someone might attack a data center over it.
Then, Anders Forslund of Heart Aerospace shows off the X1, a battery-powered electric airliner designed for regional flights that can fly for 30 minutes on just $5 of juice. PLUS, we've got John Yu of Bitsec explaining how his subnet project outperformed Fable 5 in website vulnerability checks.
Guests:
Anders Forslund on X: https://x.com/AndersForslund1?s=2
Heart Aerospace: heartaerospace.com
John Yu on X: https://x.com/yubrew
Bitsec: sentios.io & sentios.io
Relevant Links:
MicroDuck: pollen-robotics.com/microduck
Dwarkesh Patel, "The Rise and Fall of Agent Civilizations," dwarkesh.com/p/openai-huggingface
Dwarkesh's launch thread on X: https://x.com/dwarkesh_sp/status/2093833419377815719
METR's independent investigation of the OpenAI/Hugging Face incident: metr.org/blog/2026-08-26-openai-hugging-face-incident-investigation
X1 first flight announcement — heartaerospace.com/newsroom/heart-aerospace-completes-first-flight-of-world-s-largest-electric-aircraft
JSX (JetSuiteX) — jsx.com
Pilatus PC-12 —pilatus-aircraft.com/en/fly/pc-12
Surf Air — surfair.com
Zcash → https://z.cash/
Timestamps:
0:00 Is Hugging Face's Microduck the greatest side quest ever?
4:48 Jason puts Clem Delangue and Jensen Huang in charge of AI PR
10:37 Northwest Registered Agent - Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! Learn more at northwestregisteredagent.com/twistdomain
18:12 Top story: Dwarkesh Patel's "The Rise and Fall of Agent Civilizations"
18:39 Why agents act like people: they were trained on us
18:47 CLA - Innovation takes balance. CLA's CPAs, consultants, and wealth advisors can help you get from startup to where you want to end up. Get started now at claconnect.com/withyou
21:06 "I know good PR when I see it"
22:28 The prompt Jason says OpenAI should have written instead
26:01 The data center backlash and the politicians who will flip
29:24 Rippling - Don't settle for AI that's all talk. Head to Rippling.ai/twist to get the only AI built to give you full visibility across your startup and take complex actions across your entire business.
32:36 Guest: Anders Forslund, Heart Aerospace, and the X1's first flight
38:57 Turboprops vs. jets and the regional routes America lost
41:50 JSX, Santa Monica Airport, and 5,000 underused airports
44:11 Why Boeing won't build this: the innovator's dilemma
52:31 Guest: John Yu, Bitsec — Bittensor Subnet 60
54:18 How the subnet works: miners, validators, $10K a day
56:34 Bitsec vs. a frontier model: 160+ vulnerabilities to 60
58:54 Was the agent civilization story a pre-IPO PR play?
1:04:27 Sentios.io and continuous coverage
Subscribe to the TWiST500 newsletter: ticker.thisweekinstartups.com
Check out the TWIST500: twist500.com
Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp
Follow Lon:
X: https://x.com/lons
Follow Jason:
X: twitter.com/Jason
LinkedIn: linkedin.com/in/jasoncalacanis
Check out all our partner offers: partners.launch.co
Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland
Check out Jason’s suite of newsletters: substack.com/@calacanis
Follow TWiST:
Twitter: twitter.com/TWiStartups
YouTube: youtube.com/thisweekin
Instagram: instagram.com/thisweekinstartups
TikTok: tiktok.com/@thisweekinstartups
Substack: twistartups.substack.com










