Uploaded September 2025 | Updated September 2026, 2 weeks ago
Dr. Dominic D’Agostino is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.
This episode is brought to you by:
Momentous high-quality creatine: livemomentous.com/tim (code TIM for up to 35% off)
Helix Sleep premium mattresses: HelixSleep.com/Tim (27% off all mattress orders)
AG1 all-in-one nutritional supplement: DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs)
Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded 900 million downloads and been selected for “Best of Apple Podcasts” three years running.
Sign up for "5-Bullet Friday" (Tim's free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
Follow the Tim Ferriss Podcast: https://tim.blog/podcast/
Visit the Tim Ferriss Blog: https://tim.blog/
Follow Tim Ferriss on Twitter: twitter.com/tferriss
Follow Tim Ferriss on Instagram: instagram.com/timferriss
Like Tim Ferriss on Facebook: facebook.com/TimFerriss
[00:00] Start
[00:42] Why I'm interested in ketogenic strategies for neurodegenerative prevention.
[02:17] Mary and Steve Newport's ketone-linked temporary cognitive improvements.
[04:31] A mechanisms overview for Alzheimer's/dementia.
[07:45] The immune system as longevity's "fifth horseman" — and why metabolic control is key.
[08:26] How to measure ketones and GKI.
[09:26] Fasting vs. ketogenic diet.
[10:48] There's nothing fishy about sardine fasting.
[15:05] My hiatal hernia discovery and increased cancer risk concerns.
[16:46] HSCRP as a superior biomarker to LDL for cardiovascular risk.
[18:39] Glucose tolerance testing revelations and CGM importance.
[24:12] Upgrading the metabolic machinery through keto without getting bored.
[27:43] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.
[31:43] Dom's day-to-day diet regimen.
[37:29] How Dom optimizes his aging dogs with ketones, SARMs, and supplements.
[41:50] Supplementing for sleep disruption while fasting.
[45:20] Why Dom doesn't have misgivings about melatonin.
[46:09] Shingles prevention through fasting protocols.
[46:32] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.
[50:15] Dom at 50-something: Current meal timing and composition.
[53:35] Blue zone observations: Greek and Sardinian longevity habits.
[54:39] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.
[01:01:49] Ketone metabolic therapy for cancer.
[01:04:54] The metabolic psychiatry revolution.
[01:08:49] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.
[01:15:10] Metformin vs. berberine.
[01:18:29] The low-dose neuroprotective potential of GLP-1 drugs.
[01:21:44] NAD research: MIB-626 and stabilized forms for mitochondrial health.
[01:26:38] Idebenone, CoQ10, and the Deanna protocol for ALS.
[01:28:55] Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.
[01:31:36] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts.
Dr. Dominic D’Agostino is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.
This episode is brought to you by:
Momentous high-quality creatine: livemomentous.com/tim (code TIM for up to 35% off)
Helix Sleep premium mattresses: HelixSleep.com/Tim (27% off all mattress orders)
AG1 all-in-one nutritional supplement: DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs)
Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded 900 million downloads and been selected for “Best of Apple Podcasts” three years running.
Sign up for "5-Bullet Friday" (Tim's free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
Follow the Tim Ferriss Podcast: https://tim.blog/podcast/
Visit the Tim Ferriss Blog: https://tim.blog/
Follow Tim Ferriss on Twitter: twitter.com/tferriss
Follow Tim Ferriss on Instagram: instagram.com/timferriss
Like Tim Ferriss on Facebook: facebook.com/TimFerriss
[00:00] Start
[00:42] Why I'm interested in ketogenic strategies for neurodegenerative prevention.
[02:17] Mary and Steve Newport's ketone-linked temporary cognitive improvements.
[04:31] A mechanisms overview for Alzheimer's/dementia.
[07:45] The immune system as longevity's "fifth horseman" — and why metabolic control is key.
[08:26] How to measure ketones and GKI.
[09:26] Fasting vs. ketogenic diet.
[10:48] There's nothing fishy about sardine fasting.
[15:05] My hiatal hernia discovery and increased cancer risk concerns.
[16:46] HSCRP as a superior biomarker to LDL for cardiovascular risk.
[18:39] Glucose tolerance testing revelations and CGM importance.
[24:12] Upgrading the metabolic machinery through keto without getting bored.
[27:43] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.
[31:43] Dom's day-to-day diet regimen.
[37:29] How Dom optimizes his aging dogs with ketones, SARMs, and supplements.
[41:50] Supplementing for sleep disruption while fasting.
[45:20] Why Dom doesn't have misgivings about melatonin.
[46:09] Shingles prevention through fasting protocols.
[46:32] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.
[50:15] Dom at 50-something: Current meal timing and composition.
[53:35] Blue zone observations: Greek and Sardinian longevity habits.
[54:39] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.
[01:01:49] Ketone metabolic therapy for cancer.
[01:04:54] The metabolic psychiatry revolution.
[01:08:49] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.
[01:15:10] Metformin vs. berberine.
[01:18:29] The low-dose neuroprotective potential of GLP-1 drugs.
[01:21:44] NAD research: MIB-626 and stabilized forms for mitochondrial health.
[01:26:38] Idebenone, CoQ10, and the Deanna protocol for ALS.
[01:28:55] Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.
[01:31:36] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts.
