Uploaded August 2025 | Updated September 2026, 2 weeks ago
Invitation: Alex and I have created an entirely new Fat Loss Strategies webinar that incorporates all of the expertise you hear in this podcast, PLUS new information that Alex has researched over the past year. theenergyblueprint.com/referral.html?p=ari&w=fatlossregister
*YouTube Audio fixed* We were made aware that some of you had issues with the audio quality on the YouTube version of the podcast. We apologize for this, and have corrected it. Please enjoy the episode.
Your cells aren't biochemically broken—they're structurally broken.
In this episode, Alex Leaf and I discuss the startling fact that 94% of adults have some form of metabolic dysfunction and why treating the biochemistry misses the real problem entirely.
In this paradigm-shifting conversation, you'll discover why insulin resistance isn't a glucose problem but a fat cell capacity problem, how hunter-gatherers naturally regulate body fat without counting calories, and even research-backed ways to reverse diabetes.
Invitation: Alex and I have created an entirely new Fat Loss Strategies webinar that incorporates all of the expertise you hear in this podcast, PLUS new information that Alex has researched over the past year. theenergyblueprint.com/referral.html?p=ari&w=fatlossregister
🕒 Chapters:
00:00 – Intro
00:45 – Guest Intro
05:01 - Metabolic health – an overview
11:05 - The potential effects of Diabetes 2 on long term health
23:58 - The conventional view on insulin resistance
31:51 - Are herbal supplements better than pharmaceutical drugs?
38:54 - Carbs have been part of our ancestors diets
44:26 - How the majority of the population view insulin resistance
55:06 - The role of skeletal muscles in metabolic health
1:00:11 - How fat tissue works in the body
1:04:54 - Can you be overweight and metabolically healthy at the same time?
1:13:08 - The link between excess visceral fat and diabetes
1:15:28 - The most common cause of excess body fat
1:29:34 - The most common recommendation to lower your blood pressure
1:32:07 - A note on the MTHFR mutation
1:35:08 - How to solve insulin resistance
1:40:50 - Preliminary findings on ways to restore the pancreas
1:42:03 - The Fat Loss Blueprint
💻 RESOURCES MENTIONED IN THIS EPISODE:
▸ TheEnergyBlueprint.com
theenergyblueprint.com/the-new-paradigm-of-insulin-resistance
Exercise increases glucose transporter expression independent of insulin (pubmed.ncbi.nlm.nih.gov/33166188/)
Glucose moves passively into pancreas and promotes insulin secretion (pubmed.ncbi.nlm.nih.gov/22974359/)
Fat cells can only store so much fat before they shut themselves off from energy (pubmed.ncbi.nlm.nih.gov/25733684/)
Some people can make more and more fat cells and become really obese before metabolic problems occur (pubmed.ncbi.nlm.nih.gov/31357412/)
Metabolically healthy obese people are at an increased risk of developing metabolic diseases years later (pubmed.ncbi.nlm.nih.gov/29381992/)
Evidence for fat loss reversing type 2 diabetes (pubmed.ncbi.nlm.nih.gov/21656330/; https://pubmed.ncbi.nlm.nih.gov/27002059/; https://pubmed.ncbi.nlm.nih.gov/29221645/; https://pubmed.ncbi.nlm.nih.gov/37593846/)
Some can’t restore normal metabolic health after having diabetes for a long time (pubmed.ncbi.nlm.nih.gov/30078554/)
Intermittent fasting allows pancreatic cells to regenerate (pubmed.ncbi.nlm.nih.gov/28235195/)
📌 Want even more tips? Subscribe to This Channel: youtube.com/channel/UCnQo6oCvS6YuvaablyMT_sw?sub_confirmation=1
📖 FREE guide to help boost your energy: theenergyblueprint.com/top-science-backed-supplements-for-energy-brain-and-mood
Invitation: Alex and I have created an entirely new Fat Loss Strategies webinar that incorporates all of the expertise you hear in this podcast, PLUS new information that Alex has researched over the past year. theenergyblueprint.com/referral.html?p=ari&w=fatlossregister
*YouTube Audio fixed* We were made aware that some of you had issues with the audio quality on the YouTube version of the podcast. We apologize for this, and have corrected it. Please enjoy the episode.
Your cells aren't biochemically broken—they're structurally broken.
In this episode, Alex Leaf and I discuss the startling fact that 94% of adults have some form of metabolic dysfunction and why treating the biochemistry misses the real problem entirely.
In this paradigm-shifting conversation, you'll discover why insulin resistance isn't a glucose problem but a fat cell capacity problem, how hunter-gatherers naturally regulate body fat without counting calories, and even research-backed ways to reverse diabetes.
Invitation: Alex and I have created an entirely new Fat Loss Strategies webinar that incorporates all of the expertise you hear in this podcast, PLUS new information that Alex has researched over the past year. theenergyblueprint.com/referral.html?p=ari&w=fatlossregister
🕒 Chapters:
00:00 – Intro
00:45 – Guest Intro
05:01 - Metabolic health – an overview
11:05 - The potential effects of Diabetes 2 on long term health
23:58 - The conventional view on insulin resistance
31:51 - Are herbal supplements better than pharmaceutical drugs?
38:54 - Carbs have been part of our ancestors diets
44:26 - How the majority of the population view insulin resistance
55:06 - The role of skeletal muscles in metabolic health
1:00:11 - How fat tissue works in the body
1:04:54 - Can you be overweight and metabolically healthy at the same time?
1:13:08 - The link between excess visceral fat and diabetes
1:15:28 - The most common cause of excess body fat
1:29:34 - The most common recommendation to lower your blood pressure
1:32:07 - A note on the MTHFR mutation
1:35:08 - How to solve insulin resistance
1:40:50 - Preliminary findings on ways to restore the pancreas
1:42:03 - The Fat Loss Blueprint
💻 RESOURCES MENTIONED IN THIS EPISODE:
▸ TheEnergyBlueprint.com
theenergyblueprint.com/the-new-paradigm-of-insulin-resistance
Exercise increases glucose transporter expression independent of insulin (pubmed.ncbi.nlm.nih.gov/33166188/)
Glucose moves passively into pancreas and promotes insulin secretion (pubmed.ncbi.nlm.nih.gov/22974359/)
Fat cells can only store so much fat before they shut themselves off from energy (pubmed.ncbi.nlm.nih.gov/25733684/)
Some people can make more and more fat cells and become really obese before metabolic problems occur (pubmed.ncbi.nlm.nih.gov/31357412/)
Metabolically healthy obese people are at an increased risk of developing metabolic diseases years later (pubmed.ncbi.nlm.nih.gov/29381992/)
Evidence for fat loss reversing type 2 diabetes (pubmed.ncbi.nlm.nih.gov/21656330/; https://pubmed.ncbi.nlm.nih.gov/27002059/; https://pubmed.ncbi.nlm.nih.gov/29221645/; https://pubmed.ncbi.nlm.nih.gov/37593846/)
Some can’t restore normal metabolic health after having diabetes for a long time (pubmed.ncbi.nlm.nih.gov/30078554/)
Intermittent fasting allows pancreatic cells to regenerate (pubmed.ncbi.nlm.nih.gov/28235195/)
📌 Want even more tips? Subscribe to This Channel: youtube.com/channel/UCnQo6oCvS6YuvaablyMT_sw?sub_confirmation=1
📖 FREE guide to help boost your energy: theenergyblueprint.com/top-science-backed-supplements-for-energy-brain-and-mood
