Chubbyemu | A TikToker Chugged 1 Liter Of Lean. This Is What Happened To His Brain. ft @JustinWhangYt @chubbyemu | Uploaded 3 years ago | Updated 7 seconds ago
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A TikToker Drank 2 Bottles Benadryl ► youtu.be/NaAFOrudj0g
A Man Ate 2 Pounds Licorice Candy ► youtu.be/qg76qIZ4BQ8
Medicine (Playlist) ► youtube.com/playlist?list=PL26HeTCO57qcMQB6CrU6QRzEi9tt9l1FI
Music by @Lifeformed ► lifeformed.bandcamp.com
Music by T4N3 ► soundcloud.com/T4N3
Do not misuse cough syrup.
Codeine metabolism happens in the liver and is mediated primarily in the first pass by CYP 2D6 (to morphine) and CYP 3A4 (norcodeine). Codeine and morphine can be glucuronidated in a second pass of metabolism, but watch for renal function in hospitalized patients as morphine-6-glucuronide is renally excreted. Because it is pharmacologically active as an analgesic as well, use caution in patients with renal failure. Genetic mutations in 2D6 have been observed and result in different pharmacokinetics for codeine. See references below.
This case is 2 cases combined. Both are de-identified. This video is not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet.
Some video imagery supplied by Getty Images
References:
Codeine with Ultrarapid CYP2D6 Metabolism. N Engl J Med 2004; 351:2827-2831. nejm.org/doi/full/10.1056/NEJMoa041888
Codeine after tonsillectomy in North American children. Pediatrics. 2012 May;129(5):e1343-7. pubmed.ncbi.nlm.nih.gov/22492761
UpToDate: Cytochrome P450 3A (including 3A4) inhibitors and inducers
Codeine Therapy and CYP2D6 Genotype. ncbi.nlm.nih.gov/books/NBK100662
Pharmacokinetics of codeine and its metabolite in ultra-rapid metabolizers due to CYP2D6 duplication. The Pharmacogenomics Journal volume 7, pages257–265(2007). nature.com/articles/6500406
Patient BW Portrayed by @JustinWhangYt subscribe!
A TikToker Drank 2 Bottles Benadryl ► youtu.be/NaAFOrudj0g
A Man Ate 2 Pounds Licorice Candy ► youtu.be/qg76qIZ4BQ8
Medicine (Playlist) ► youtube.com/playlist?list=PL26HeTCO57qcMQB6CrU6QRzEi9tt9l1FI
Music by @Lifeformed ► lifeformed.bandcamp.com
Music by T4N3 ► soundcloud.com/T4N3
Do not misuse cough syrup.
Codeine metabolism happens in the liver and is mediated primarily in the first pass by CYP 2D6 (to morphine) and CYP 3A4 (norcodeine). Codeine and morphine can be glucuronidated in a second pass of metabolism, but watch for renal function in hospitalized patients as morphine-6-glucuronide is renally excreted. Because it is pharmacologically active as an analgesic as well, use caution in patients with renal failure. Genetic mutations in 2D6 have been observed and result in different pharmacokinetics for codeine. See references below.
This case is 2 cases combined. Both are de-identified. This video is not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet.
Some video imagery supplied by Getty Images
References:
Codeine with Ultrarapid CYP2D6 Metabolism. N Engl J Med 2004; 351:2827-2831. nejm.org/doi/full/10.1056/NEJMoa041888
Codeine after tonsillectomy in North American children. Pediatrics. 2012 May;129(5):e1343-7. pubmed.ncbi.nlm.nih.gov/22492761
UpToDate: Cytochrome P450 3A (including 3A4) inhibitors and inducers
Codeine Therapy and CYP2D6 Genotype. ncbi.nlm.nih.gov/books/NBK100662
Pharmacokinetics of codeine and its metabolite in ultra-rapid metabolizers due to CYP2D6 duplication. The Pharmacogenomics Journal volume 7, pages257–265(2007). nature.com/articles/6500406
