The Dissenter | #857 Amy Arnsten: The Prefrontal Cortex, and How It Responds to Stress @TheDissenterRL | Uploaded November 2023 | Updated October 2024, 1 hour ago.
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This show is sponsored by Enlites, Learning & Development done differently. Check the website here: enlites.com
RECORDED ON JUNE 27th 2023.
Dr. Amy Arnsten is Albert E. Kent Professor of Neuroscience and Professor of Psychology, and member of the Kavli Institute of Neuroscience at Yale University. Dr. Arnsten is an international expert on the molecular regulation of higher cortical circuits, and a member of the National Academy of Medicine. Dr. Arnsten's research examines the neural basis of higher cognition. Her work has revealed that the newly evolved cortical circuits that underlie higher cognition are uniquely regulated at the molecular level, conferring vulnerability in mental illness and age-related cognitive disorders such as Alzheimer's Disease. Her research has led to new treatments for cognitive disorders in humans, including the successful translation of guanfacine (IntunivTM) for the treatment of ADHD and related prefrontal cortical disorders.
In this episode, we talk about the prefrontal cortex and the role it plays in neurological and mental disorders. We start by talking about the organization and functional properties of the prefrontal cortex. We discuss ADHD, conduct disorder, and the neurological effects of long COVID. We get into the biochemical mechanisms behind stress responses. We talk about PTSD, and how to treat it. We talk about the neurological effects of chronic stress. We discuss why the prefrontal cortex is so vulnerable to stress. We talk about targeting aging itself and the mechanisms of aging to prevent neural disorders. Finally, we discuss how neuroscience can help us become more compassionate.
Time Links:
00:00 Intro
01:10 The organization and functional properties of the prefrontal cortex
14:28 ADHD
22:37 Conduct disorder
33:32 The neurological effects of long-COVID
37:53 Biochemical mechanisms behind stress responses
46:24 PTSD, and how to treat it
53:50 The neurological effects of chronic stress
56:58 Why is the prefrontal cortex so vulnerable to stress?
1:00:04 Targeting aging itself
1:04:56 How neuroscience can help us become more compassionate
1:07:58 Follow Dr. Arnsten’s work!
--
Follow Dr. Arnsten’s work:
Faculty page: bit.ly/3Ip0cVR
ResearchGate profile: bit.ly/3jZ10HQ
--
A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: PER HELGE LARSEN, JERRY MULLER, HANS FREDRIK SUNDE, BERNARDO SEIXAS, OLAF ALEX, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, JOHN CONNORS, FILIP FORS CONNOLLY, DAN DEMETRIOU, ROBERT WINDHAGER, RUI INACIO, ZOOP, MARCO NEVES, COLIN HOLBROOK, PHIL KAVANAGH, MIKKEL STORMYR, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, FERGAL CUSSEN, HAL HERZOG, NUNO MACHADO, JONATHAN LEIBRANT, JOÃO LINHARES, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, ROMAIN ROCH, DIEGO LONDOÑO CORREA, YANICK PUNTER, ADANER USMANI, CHARLOTTE BLEASE, NICOLE BARBARO, ADAM HUNT, PAWEL OSTASZEWSKI, NELLEKE BAK, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, PAULO TOLENTINO, JOÃO BARBOSA, JULIAN PRICE, EDWARD HALL, HEDIN BRØNNER, DOUGLAS FRY, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, SCOTT, ZACHARY FISH, TIM DUFFY, SUNNY SMITH, JON WISMAN, DANIEL FRIEDMAN, WILLIAM BUCKNER, PAUL-GEORGE ARNAUD, LUKE GLOWACKI, GEORGIOS THEOPHANOUS, CHRIS WILLIAMSON, PETER WOLOSZYN, DAVID WILLIAMS, DIOGO COSTA, ANTON ERIKSSON, CHARLES MOREY, ALEX CHAU, AMAURI MARTÍNEZ, CORALIE CHEVALLIER, BANGALORE ATHEISTS, LARRY D. LEE JR., OLD HERRINGBONE, STARRY, MICHAEL BAILEY, DAN SPERBER, ROBERT GRESSIS, IGOR N, JEFF MCMAHAN, JAKE ZUEHL, BARNABAS RADICS, MARK CAMPBELL, TOMAS DAUBNER, LUKE NISSEN, CHRIS STORY, KIMBERLY JOHNSON, BENJAMIN GELBART, JESSICA NOWICKI, LINDA BRANDIN, NIKLAS CARLSSON, ISMAËL BENSLIMANE, GEORGE CHORIATIS, VALENTIN STEINMANN, PER KRAULIS, KATE VON GOELER, ALEXANDER HUBBARD, LIAM DUNAWAY, BR, MASOUD ALIMOHAMMADI, PURPENDICULAR, JONAS HERTNER, URSULA GOODENOUGH, GREGORY HASTINGS, DAVID PINSOF, SEAN NELSON, MIKE LAVIGNE, JOS KNECHT, ERIK ENGMAN, AND LUCY!
A SPECIAL THANKS TO MY PRODUCERS, YZAR WEHBE, JIM FRANK, ŁUKASZ STAFINIAK, TOM VANEGDOM, BERNARD HUGUENEY, CURTIS DIXON, BENEDIKT MUELLER, THOMAS TRUMBLE, KATHRINE AND PATRICK TOBIN, JONCARLO MONTENEGRO, AL NICK ORTIZ, AND NICK GOLDEN!
AND TO MY EXECUTIVE PRODUCERS, MATTHEW LAVENDER, SERGIU CODREANU, BOGDAN KANIVETS, AND ROSEY!
------------------Support the channel------------
Patreon: patreon.com/thedissenter
PayPal: paypal.me/thedissenter
PayPal Subscription 3 Dollars: tinyurl.com/ybn6bg9l
PayPal Subscription 5 Dollars: tinyurl.com/ycmr9gpz
PayPal Subscription 10 Dollars: tinyurl.com/y9r3fc9m
PayPal Subscription 20 Dollars: tinyurl.com/y95uvkao
------------------Follow me on---------------------
Facebook: facebook.com/thedissenteryt
Twitter: twitter.com/TheDissenterYT
Podcast: bit.ly/3FeSNqb
This show is sponsored by Enlites, Learning & Development done differently. Check the website here: enlites.com
RECORDED ON JUNE 27th 2023.
Dr. Amy Arnsten is Albert E. Kent Professor of Neuroscience and Professor of Psychology, and member of the Kavli Institute of Neuroscience at Yale University. Dr. Arnsten is an international expert on the molecular regulation of higher cortical circuits, and a member of the National Academy of Medicine. Dr. Arnsten's research examines the neural basis of higher cognition. Her work has revealed that the newly evolved cortical circuits that underlie higher cognition are uniquely regulated at the molecular level, conferring vulnerability in mental illness and age-related cognitive disorders such as Alzheimer's Disease. Her research has led to new treatments for cognitive disorders in humans, including the successful translation of guanfacine (IntunivTM) for the treatment of ADHD and related prefrontal cortical disorders.
In this episode, we talk about the prefrontal cortex and the role it plays in neurological and mental disorders. We start by talking about the organization and functional properties of the prefrontal cortex. We discuss ADHD, conduct disorder, and the neurological effects of long COVID. We get into the biochemical mechanisms behind stress responses. We talk about PTSD, and how to treat it. We talk about the neurological effects of chronic stress. We discuss why the prefrontal cortex is so vulnerable to stress. We talk about targeting aging itself and the mechanisms of aging to prevent neural disorders. Finally, we discuss how neuroscience can help us become more compassionate.
Time Links:
00:00 Intro
01:10 The organization and functional properties of the prefrontal cortex
14:28 ADHD
22:37 Conduct disorder
33:32 The neurological effects of long-COVID
37:53 Biochemical mechanisms behind stress responses
46:24 PTSD, and how to treat it
53:50 The neurological effects of chronic stress
56:58 Why is the prefrontal cortex so vulnerable to stress?
1:00:04 Targeting aging itself
1:04:56 How neuroscience can help us become more compassionate
1:07:58 Follow Dr. Arnsten’s work!
--
Follow Dr. Arnsten’s work:
Faculty page: bit.ly/3Ip0cVR
ResearchGate profile: bit.ly/3jZ10HQ
--
A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: PER HELGE LARSEN, JERRY MULLER, HANS FREDRIK SUNDE, BERNARDO SEIXAS, OLAF ALEX, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, JOHN CONNORS, FILIP FORS CONNOLLY, DAN DEMETRIOU, ROBERT WINDHAGER, RUI INACIO, ZOOP, MARCO NEVES, COLIN HOLBROOK, PHIL KAVANAGH, MIKKEL STORMYR, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, FERGAL CUSSEN, HAL HERZOG, NUNO MACHADO, JONATHAN LEIBRANT, JOÃO LINHARES, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, ROMAIN ROCH, DIEGO LONDOÑO CORREA, YANICK PUNTER, ADANER USMANI, CHARLOTTE BLEASE, NICOLE BARBARO, ADAM HUNT, PAWEL OSTASZEWSKI, NELLEKE BAK, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, PAULO TOLENTINO, JOÃO BARBOSA, JULIAN PRICE, EDWARD HALL, HEDIN BRØNNER, DOUGLAS FRY, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, SCOTT, ZACHARY FISH, TIM DUFFY, SUNNY SMITH, JON WISMAN, DANIEL FRIEDMAN, WILLIAM BUCKNER, PAUL-GEORGE ARNAUD, LUKE GLOWACKI, GEORGIOS THEOPHANOUS, CHRIS WILLIAMSON, PETER WOLOSZYN, DAVID WILLIAMS, DIOGO COSTA, ANTON ERIKSSON, CHARLES MOREY, ALEX CHAU, AMAURI MARTÍNEZ, CORALIE CHEVALLIER, BANGALORE ATHEISTS, LARRY D. LEE JR., OLD HERRINGBONE, STARRY, MICHAEL BAILEY, DAN SPERBER, ROBERT GRESSIS, IGOR N, JEFF MCMAHAN, JAKE ZUEHL, BARNABAS RADICS, MARK CAMPBELL, TOMAS DAUBNER, LUKE NISSEN, CHRIS STORY, KIMBERLY JOHNSON, BENJAMIN GELBART, JESSICA NOWICKI, LINDA BRANDIN, NIKLAS CARLSSON, ISMAËL BENSLIMANE, GEORGE CHORIATIS, VALENTIN STEINMANN, PER KRAULIS, KATE VON GOELER, ALEXANDER HUBBARD, LIAM DUNAWAY, BR, MASOUD ALIMOHAMMADI, PURPENDICULAR, JONAS HERTNER, URSULA GOODENOUGH, GREGORY HASTINGS, DAVID PINSOF, SEAN NELSON, MIKE LAVIGNE, JOS KNECHT, ERIK ENGMAN, AND LUCY!
A SPECIAL THANKS TO MY PRODUCERS, YZAR WEHBE, JIM FRANK, ŁUKASZ STAFINIAK, TOM VANEGDOM, BERNARD HUGUENEY, CURTIS DIXON, BENEDIKT MUELLER, THOMAS TRUMBLE, KATHRINE AND PATRICK TOBIN, JONCARLO MONTENEGRO, AL NICK ORTIZ, AND NICK GOLDEN!
AND TO MY EXECUTIVE PRODUCERS, MATTHEW LAVENDER, SERGIU CODREANU, BOGDAN KANIVETS, AND ROSEY!
