Uploaded August 2011 | Updated September 2026, 5 days ago

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This is a side-on view of methoxy-XO4-labeled plaques in a volume of brain immediately under the imaging window in an Alzheimer's disease mouse model. The field of view is about 600x600 microns, and 250 microns deep. Multiphoton microscopy allows high-resolution imaging of fluorescence deep within the living brain. Brian Bacskai, Ph.D., Massachusetts General Hospital