Uploaded January 2016 | Updated September 2026, 1 week ago
The knee-jerk reflex, also known as the patellar reflex, is a simple reflex that causes the contraction of the quadriceps muscle when the patellar tendon is stretched. I describe the course of the reflex arc from muscle spindles in the quadriceps muscle to motor neurons that cause movement of the leg. I also discuss the role of inhibitory interneurons in inhibiting the movement of the hamstring muscle, which allows the quadriceps contraction to be unopposed.
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📚Bizarre: The Most Peculiar Cases of Human Behavior and What They Tell Us About How the Brain Works: amazon.com/Bizarre-Peculiar-Cases-Human-Behavior/dp/139980121X
TRANSCRIPT:
Welcome to 2 minute neuroscience, where I simplistically explain neuroscience topics in 2 minutes or less. In this installment I will discuss the knee-jerk reflex.
The knee-jerk reflex, also known as the patellar reflex, is a well-known example of a simple reflex arc that allows us to maintain posture and balance. Most of us have had our knee-jerk reflex tested at a doctor’s visit when the doctor taps the tendon just below your kneecap, which is the patellar tendon, with a small hammer. This causes your lower leg to automatically kick outward. If this doesn’t happen, or if it happens excessively, it can be an indication of a disorder or of damage to the nervous system.
The knee-jerk reflex is a simple reflex arc that occurs at the level of the spinal cord; in other words, the associated movement occurs without the involvement of the brain; the brain receives information about the movement after it has been initiated. When the patellar tendon of the quadriceps muscle is stretched, the stretch is detected by stretch receptors known as muscle spindles that are found in the quadriceps muscle.The muscle spindles stimulate sensory neurons that travel to the spinal cord, where they synapse with motor neurons that control the contraction of the quadriceps muscle. These motor neurons cause immediate contraction of the quadriceps muscle to produce movement of the leg.
The knee-jerk reflex is considered a monosynaptic reflex because it involves direct connections between sensory neurons and motor neurons, without any neurons in between. Although the reflex is often simplified in diagrams to show only one sensory and one motor neuron, in reality the reflex involves many neurons; stretching the quadriceps muscle activates several hundred sensory neurons, each of which makes contact with around 50 motor neurons. Additionally, the sensory neurons traveling from the muscle spindle stimulate interneurons that inhibit the activity of motor neurons that supply opposing muscles like the hamstring muscle. The stimulation of these inhibitory interneurons causes the action of the quadriceps muscle to be unopposed.
REFERENCE:
Nolte J. The Human Brain: An Introduction to its Functional Anatomy. 6th ed. Philadelphia, PA. Elsevier; 2009.
The knee-jerk reflex, also known as the patellar reflex, is a simple reflex that causes the contraction of the quadriceps muscle when the patellar tendon is stretched. I describe the course of the reflex arc from muscle spindles in the quadriceps muscle to motor neurons that cause movement of the leg. I also discuss the role of inhibitory interneurons in inhibiting the movement of the hamstring muscle, which allows the quadriceps contraction to be unopposed.
đź§ Take your learning further with my free, self-paced Introduction to Neuroscience course featuring my videos, articles, and hundreds of quiz questions: neuroscientificallychallenged.com/course
If you're looking for accessible and entertaining ways to learn more about the brain, check out my books:
📚Your Brain, Explained: What Neuroscience Reveals About Your Brain and its Quirks: amazon.com/Your-Brain-Explained-Neuroscience-Reveals/dp/1473696569
📚Bizarre: The Most Peculiar Cases of Human Behavior and What They Tell Us About How the Brain Works: amazon.com/Bizarre-Peculiar-Cases-Human-Behavior/dp/139980121X
TRANSCRIPT:
Welcome to 2 minute neuroscience, where I simplistically explain neuroscience topics in 2 minutes or less. In this installment I will discuss the knee-jerk reflex.
The knee-jerk reflex, also known as the patellar reflex, is a well-known example of a simple reflex arc that allows us to maintain posture and balance. Most of us have had our knee-jerk reflex tested at a doctor’s visit when the doctor taps the tendon just below your kneecap, which is the patellar tendon, with a small hammer. This causes your lower leg to automatically kick outward. If this doesn’t happen, or if it happens excessively, it can be an indication of a disorder or of damage to the nervous system.
The knee-jerk reflex is a simple reflex arc that occurs at the level of the spinal cord; in other words, the associated movement occurs without the involvement of the brain; the brain receives information about the movement after it has been initiated. When the patellar tendon of the quadriceps muscle is stretched, the stretch is detected by stretch receptors known as muscle spindles that are found in the quadriceps muscle.The muscle spindles stimulate sensory neurons that travel to the spinal cord, where they synapse with motor neurons that control the contraction of the quadriceps muscle. These motor neurons cause immediate contraction of the quadriceps muscle to produce movement of the leg.
The knee-jerk reflex is considered a monosynaptic reflex because it involves direct connections between sensory neurons and motor neurons, without any neurons in between. Although the reflex is often simplified in diagrams to show only one sensory and one motor neuron, in reality the reflex involves many neurons; stretching the quadriceps muscle activates several hundred sensory neurons, each of which makes contact with around 50 motor neurons. Additionally, the sensory neurons traveling from the muscle spindle stimulate interneurons that inhibit the activity of motor neurons that supply opposing muscles like the hamstring muscle. The stimulation of these inhibitory interneurons causes the action of the quadriceps muscle to be unopposed.
REFERENCE:
Nolte J. The Human Brain: An Introduction to its Functional Anatomy. 6th ed. Philadelphia, PA. Elsevier; 2009.




![2-Minute Neuroscience: Color Blindness
Color blindness is a condition in which a person has difficulty seeing or distinguishing certain colors. In this video, I explain the biological mechanisms underlying color blindness and how it is inherited.
đź§ Take your learning further with my free, self-paced Introduction to Neuroscience course featuring my videos, articles, and hundreds of quiz questions: https://neuroscientificallychallenged.com/course
If youre looking for accessible and entertaining ways to learn more about the brain, check out my books:
📚Your Brain, Explained: What Neuroscience Reveals About Your Brain and its Quirks: https://www.amazon.com/Your-Brain-Explained-Neuroscience-Reveals/dp/1473696569/
📚Bizarre: The Most Peculiar Cases of Human Behavior and What They Tell Us About How the Brain Works: https://www.amazon.com/Bizarre-Peculiar-Cases-Human-Behavior/dp/139980121X/
TRANSCRIPT
Color blindness is a condition in which a person has difficulty seeing or distinguishing certain colors. It typically does not involve a complete loss of color vision. Color blindness can be due to various causes, but the most common forms are inherited and caused by genetic differences that affect the function of cone photoreceptors in the retina. The most common type of color blindness is red-green color blindness, where individuals have difficulty distinguishing red and green hues.
Normal color vision relies on three types of cones—each sensitive to different ranges of wavelengths corresponding roughly to blue, green, and red. Some individuals have all three cones but have abnormalities in cone sensitivity that cause irregularities in color perception; this is referred to as anomalous trichromacy and is the mildest form of color blindness. When only two of the three cone cells are functional, it results in a type of color blindness known as dichromacy. The rarest and most severe form of color blindness is called monochromacy and involves a complete loss of color vision.
Red-green color blindness is much more common in males because the mutations that typically cause it are found on the x chromosome. If females possess such a mutation on one x chromosome, it is likely to be balanced out by a functional gene on the other x chromosome. Because males only have one x chromosome, a mutation is more likely to result in color blindness.
Color blindness can be diagnosed using color vision tests, and although it cannot be cured, various technologies like color-enhancing lenses can help in some situations.
REFERENCES
Breedlove SM, Watson NV. Behavioral Neuroscience. 10th ed. New York (NY): Oxford University Press; 2023.
Carroll J, Conway BR. Color vision. Handb Clin Neurol. 2021;178:131-153. doi: 10.1016/B978-0-12-821377-3.00005-2. PMID: 33832674.
Meister M, Tessier‑Lavigne M. Low‑Level Visual Processing: The Retina. In: Kandel ER, Koester JD, Mack SH, Siegelbaum SA, editors. Principles of Neural Science. 6th ed. New York (NY): McGraw‑Hill; 2021.
Naifeh N, Kaufman EJ. Color Vision. 2022 Oct 31. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 29261952.
Simunovic MP. Colour vision deficiency. Eye (Lond). 2010 May;24(5):747-55. doi: 10.1038/eye.2009.251. Epub 2009 Nov 20. PMID: 19927164.
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