Uploaded December 2024 | Updated September 2026, 1 week ago
You can view the presentation slides here:
files.wearesrna.org/symposia/2024_rnds/slides/2024RNDS_Schreiner.pdf
At the 2024 RNDS, Drs. Teri Schreiner, Michael Levy, and Grace Gombolay shared their expertise in pediatric and adult neuroimmunology, focusing on diagnosing and managing acute disseminated encephalomyelitis (ADEM) and MOG antibody disease (MOGAD) [00:00:53]. Dr. Schreiner provided a detailed overview of ADEM, including typical symptoms, diagnostic criteria, and treatment options [00:05:24]. Dr. Gombolay then explained MOGAD, comparing its symptoms and progression to those of other neuroimmune disorders such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) [00:17:24]. The session included a segment where panelists addressed audience questions about treatment efficacy, symptom management, and the challenges of insurance coverage for treatments like IVIG [00:28:36]. Please note that the information shared during this session is for informational purposes only and is not medical advice.
00:00 Welcome and Introductions
02:15 Overview of ADEM
12:15 Understanding MOGAD
17:24 Comparing ADEM, MOGAD, and MS
21:22 Treatment and Recovery
28:36 Questions and Discussions
40:21 Understanding Drug Delivery Systems
40:29 Steroid Dosing Mysteries
40:54 Steroid Side Effects and Alternatives
41:41 MRI Findings in Neuroimmunology
42:59 Diagnosing MOGAD vs. NMOSD
46:27 International Perspectives on MOGAD Treatment
49:24 Managing Fatigue in Neuroimmune Disorders
01:02:39 Challenges with Insurance for IVIG Treatment
01:09:58 Navigating Relapses and Treatment Options
You can view the presentation slides here:
files.wearesrna.org/symposia/2024_rnds/slides/2024RNDS_Schreiner.pdf
At the 2024 RNDS, Drs. Teri Schreiner, Michael Levy, and Grace Gombolay shared their expertise in pediatric and adult neuroimmunology, focusing on diagnosing and managing acute disseminated encephalomyelitis (ADEM) and MOG antibody disease (MOGAD) [00:00:53]. Dr. Schreiner provided a detailed overview of ADEM, including typical symptoms, diagnostic criteria, and treatment options [00:05:24]. Dr. Gombolay then explained MOGAD, comparing its symptoms and progression to those of other neuroimmune disorders such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) [00:17:24]. The session included a segment where panelists addressed audience questions about treatment efficacy, symptom management, and the challenges of insurance coverage for treatments like IVIG [00:28:36]. Please note that the information shared during this session is for informational purposes only and is not medical advice.
00:00 Welcome and Introductions
02:15 Overview of ADEM
12:15 Understanding MOGAD
17:24 Comparing ADEM, MOGAD, and MS
21:22 Treatment and Recovery
28:36 Questions and Discussions
40:21 Understanding Drug Delivery Systems
40:29 Steroid Dosing Mysteries
40:54 Steroid Side Effects and Alternatives
41:41 MRI Findings in Neuroimmunology
42:59 Diagnosing MOGAD vs. NMOSD
46:27 International Perspectives on MOGAD Treatment
49:24 Managing Fatigue in Neuroimmune Disorders
01:02:39 Challenges with Insurance for IVIG Treatment
01:09:58 Navigating Relapses and Treatment Options


![2024 RNDS | Transverse Myelitis (TM) and Acute Flaccid Myelitis (AFM)
At the 2024 RNDS, Drs. Leslie Benson, Carlos A. Pardo, and Benjamin Greenberg discussed transverse myelitis (TM) and acute flaccid myelitis (AFM), addressing key questions from the audience [00:00:12]. The session covered symptoms, treatment options, and lifestyle adjustments to manage conditions better [00:02:15]. The experts also emphasized the importance of proper diagnosis, sleep hygiene, and the role of rehabilitation medicine in managing fatigue and spasticity [00:15:03]. Additionally, the panel delved into both the potential and current limitations of stem cell therapy for treating these disorders [00:40:40]. Please note that the information shared during this session is for informational purposes only and is not medical advice.
00:00 Introduction and Session Overview
00:29 Meet the Experts: Dr. Benjamin Greenberg, Dr. Leslie Benson, and Dr. Carlos Pardo
01:10 Interactive Discussion: Your Questions Matter
04:49 Understanding Fatigue in Myelitis
06:34 Managing Fatigue: Strategies and Solutions
10:26 Energy Conservation Techniques
14:51 Medication Management and Side Effects
32:41 Spasticity: Non-Prescription Approaches
40:40 Stem Cell Therapy: Hopes and Realities
47:16 The Challenges of Stem Cell Therapy
48:16 Patient Experiences and Misconceptions
49:06 Scientific Skepticism and Cynicism
51:40 The Role of SRNA in Patient Advocacy
52:37 Managing Long-Term Care for TM
57:48 Muscle Spasticity and Treatment Options
01:14:39 Understanding Myelitis: Diagnosis and Root Causes
01:26:30 Final Q&A and Closing Remarks 2024 RNDS | Transverse Myelitis (TM) and Acute Flaccid Myelitis (AFM)](https://i.ytimg.com/vi/yC0WJfnLNjo/mqdefault.jpg)





![Ask the Expert | Research Edition 1406. Q Study Updates | Expanded Inclusion Criteria & What’s Next
Krissy Dilger of SRNA hosted Dr. Benjamin Greenberg of UT Southwestern to share updates on the Q Study, a Phase 1 trial assessing the safety and feasibility of transplanting human glial restricted progenitor cells into the spinal cord of people who have been diagnosed with transverse myelitis (TM). Dr. Greenberg cautioned the audience against stem cell tourism [00:03:03]. He described the decades-long development of the cell line and safety monitoring for this study [00:01:35]. He reported no safety signals prompting a trial pause and noted the FDA-approved expansion of eligibility from non-ambulatory participants to those who can walk with assistance, while efficacy results were not yet being shared [00:08:31]. Finally, Dr. Greenberg outlined potential next steps, including Phase 2 studies and expanded populations (e.g., MOGAD and NMOSD diagnoses), as well as future targets [00:17:02].
Benjamin M. Greenberg, MD, MHS is a Professor and the Cain Denius Scholar in Mobility Disorders in the Department of Neurology [https://utswmed.org/why-utsw/departments/neurology/] at UT Southwestern Medical Center in Dallas, Texas. He currently serves as the Vice Chair of Translational Research and Strategic Initiatives for the Department of Neurology. He is also the interim Director of the Multiple Sclerosis Center [https://utswmed.org/locations/aston/multiple-sclerosis-and-neuroimmunology-clinic/] and the Director of the Neurosciences Clinical Research Center. In addition, he serves as Director of the Transverse Myelitis and Neuromyelitis Optica Program and the Pediatric Demyelinating Disease Program at Children’s Medical Center [https://www.childrens.com/specialties-services/specialty-centers-and-programs/neurology/demyelinating-disease-program].
Dr. Greenberg earned his medical degree at Baylor College of Medicine before completing an internal medicine internship at Chicago’s Rush Presbyterian-St. Luke’s Medical Center. He performed his neurology residency at the Johns Hopkins School of Medicine. He also holds an M.H.S. in molecular microbiology and immunology from the Bloomberg School of Public Health, as well as a bachelor’s degree in the history of medicine – both from Johns Hopkins. Prior to his recruitment to UT Southwestern in 2009, Dr. Greenberg was on the faculty of the Johns Hopkins Division of Neuroimmunology, serving as the Director of the Encephalitis Center and Co-Director of the nation’s first dedicated Transverse Myelitis Center.
Dr. Greenberg splits his clinical time between adult and pediatric patients at William P. Clements Jr. and Zale Lipshy University Hospitals, Parkland, and Children’s Medical Center. His research focuses on better diagnosing, prognosticating, and treating demyelinating diseases and nervous system infections. He also coordinates clinical trials to evaluate new treatments to prevent neurologic damage and restore function to affected patients.
00:00 Welcome and Guest Intro
01:35 Origins of Q Study
02:46 Getting Cells Into Cord
04:49 Phase One Trial Design
06:31 Safety and Efficacy Measures
08:31 Eligibility Expanded Criteria
11:39 Screening and Selection
14:05 Travel and Site Logistics
15:15 Early Safety Findings
17:02 Next Steps After Phase One
19:01 Beyond Idiopathic Myelitis
23:07 Damage Differences by Disease
25:20 Optic Nerve and Brain Targets
27:29 Expected Outcomes and Vision
28:58 Final Thanks Ask the Expert | Research Edition 1406. Q Study Updates | Expanded Inclusion Criteria & What’s Next](https://i.ytimg.com/vi/zs6w6dtqr3U/mqdefault.jpg)