Uploaded February 2026 | Updated September 2026, 3 weeks ago
Virus being experimented on in China.
researchgate.net/publication/377199018_Lethal_Infection_of_Human_ACE2-Transgenic_Mice_Caused_by_SARS-CoV-2-related_Pangolin_Coronavirus_GX_P2Vshort_3UTR
biorxiv.org/content/10.1101/2024.01.03.574008v1.full.pdf
theepochtimes.com/health/chinese-scientists-reveal-experiments-with-virus-100-percent-fatal-to-mice-5560854?utm_source=atcn&utm_content=hw1016multicomp&utm_medium=email&utm_campaign=atc&utm_term=hws1comp
SARS-CoV-2-related pangolin coronavirus GX_P2V,
can cause 100% mortality in human ACE2-transgenic mice,
potentially attributable to late-stage brain infection.
Paper Authors
Beijing Advanced Innovation Center
Beijing University of Chemical Technology,
The Fifth Medical Center of PLA General Hospital, Beijing, China.
Medical School, Nanjing University, China
(including a doctor trained by the Chinese military, Yigang Tong)
Purpose of study
Assessed virus pathogenicity
Risk
100% IFR underscores a spillover risk of GX_P2V into humans,
and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses.
Details
GX_P2V isolate was actually a cell culture-adapted mutant
In this study, we cloned this mutant
This is not a wild type virus
It is possible that GX_P2V C7 has undergone a virulence-enhancing mutation.
GX_P2V is capable of rapid mutation rates.
High viral loads detected in both lung and brain tissues.
Surprisingly, all the mice that were infected with the live virus succumbed to the infection within 7-8 days post-inoculation,
Resulted in 100% mortality in the hACE2 mice.
Clinical features
Weight loss, Piloerection, hunched posture, sluggish movements, and their eyes turned white.
Significant amounts of viral RNA in the brain, lung, turbinate, eye, trachea, reducing with time
Infection did not lead to significant inflammatory reactions or cytokine storm
Brain with high viral counts increasing during infection
ACE2 receptors are found in the human brain
Brainstem (especially areas regulating breathing and cardiovascular control)
Hypothalamus
Substantia nigra
Cortex (low levels)
Endothelial cells lining cerebral blood vessels
Some neurons and glial cells
The choroid plexus
Justin Kinney, associate professor, Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, U.S.
“I am especially concerned that the paper does not say what biosafety level the work was performed at.
Coronavirus research in China is often done at a biosafety level (BSL-2) that is inadequate for working with potential pandemic pathogens that might be transmitted by air.
“Indeed, coronavirus research done at BSL-2 may have caused the COVID-19 pandemic.
And by showing that the coronavirus has a surprisingly high pathogenicity, the work underscores the need for extreme caution when working with novel coronaviruses.”
Justin Goodman, senior vice president of the White Coat Waste Project, a U.S. nonprofit
China-based scientists have been conducting “dangerous and deadly tests on mice.”
“This is why shipping U.S. tax dollars to foreign adversaries’ unaccountable animal labs is a recipe for disaster ……
Virus being experimented on in China.
researchgate.net/publication/377199018_Lethal_Infection_of_Human_ACE2-Transgenic_Mice_Caused_by_SARS-CoV-2-related_Pangolin_Coronavirus_GX_P2Vshort_3UTR
biorxiv.org/content/10.1101/2024.01.03.574008v1.full.pdf
theepochtimes.com/health/chinese-scientists-reveal-experiments-with-virus-100-percent-fatal-to-mice-5560854?utm_source=atcn&utm_content=hw1016multicomp&utm_medium=email&utm_campaign=atc&utm_term=hws1comp
SARS-CoV-2-related pangolin coronavirus GX_P2V,
can cause 100% mortality in human ACE2-transgenic mice,
potentially attributable to late-stage brain infection.
Paper Authors
Beijing Advanced Innovation Center
Beijing University of Chemical Technology,
The Fifth Medical Center of PLA General Hospital, Beijing, China.
Medical School, Nanjing University, China
(including a doctor trained by the Chinese military, Yigang Tong)
Purpose of study
Assessed virus pathogenicity
Risk
100% IFR underscores a spillover risk of GX_P2V into humans,
and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses.
Details
GX_P2V isolate was actually a cell culture-adapted mutant
In this study, we cloned this mutant
This is not a wild type virus
It is possible that GX_P2V C7 has undergone a virulence-enhancing mutation.
GX_P2V is capable of rapid mutation rates.
High viral loads detected in both lung and brain tissues.
Surprisingly, all the mice that were infected with the live virus succumbed to the infection within 7-8 days post-inoculation,
Resulted in 100% mortality in the hACE2 mice.
Clinical features
Weight loss, Piloerection, hunched posture, sluggish movements, and their eyes turned white.
Significant amounts of viral RNA in the brain, lung, turbinate, eye, trachea, reducing with time
Infection did not lead to significant inflammatory reactions or cytokine storm
Brain with high viral counts increasing during infection
ACE2 receptors are found in the human brain
Brainstem (especially areas regulating breathing and cardiovascular control)
Hypothalamus
Substantia nigra
Cortex (low levels)
Endothelial cells lining cerebral blood vessels
Some neurons and glial cells
The choroid plexus
Justin Kinney, associate professor, Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, U.S.
“I am especially concerned that the paper does not say what biosafety level the work was performed at.
Coronavirus research in China is often done at a biosafety level (BSL-2) that is inadequate for working with potential pandemic pathogens that might be transmitted by air.
“Indeed, coronavirus research done at BSL-2 may have caused the COVID-19 pandemic.
And by showing that the coronavirus has a surprisingly high pathogenicity, the work underscores the need for extreme caution when working with novel coronaviruses.”
Justin Goodman, senior vice president of the White Coat Waste Project, a U.S. nonprofit
China-based scientists have been conducting “dangerous and deadly tests on mice.”
“This is why shipping U.S. tax dollars to foreign adversaries’ unaccountable animal labs is a recipe for disaster ……
