Kendrew Lecture 2021 pt1 - Using AI to accelerate scientific discovery - Demis Hassabis MRC Laboratory of Molecular Biology 2024-10-22 | Kendrew Lecture 2021 pt1 - Using AI to accelerate scientific discovery - Demis Hassabis
Pat Edwards - LMB Through the Years MRC Laboratory of Molecular Biology 2023-07-25 | Technician extraordinaireInterview with Pat EdwardsPat discusses the 40 years she has spent as a research assistant at the LMB, including her early days working with Hugh Huxley, prepping human brain tissue with Claude Wischik, long periods in the dark room trying to crystallise rhodopsin, and the many Nobel Prize celebrations she has attended over the years.This interview is part of the LMB Through the Years project celebrating the LMB's 60th anniversary. A selection of twelve staff and alumni, from across the decades, were interviewed by science writer Kathy Weston about their time at the LMB and what it has meant to them. Each interviewee has also chosen an object to represent their time at the LMB, giving an unusual insight into the many facets of life at the LMB.--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Meet the Electronics Workshop - LMB@60 MRC Laboratory of Molecular Biology 2023-07-10 | We're continuing our tours of the LMB's scientific facilities - today we invite you to meet our Electronics Workshop team: Andy Howe, Ryan Usher, Martin Kyte, David Cattermole and Abby Chisnall.Here the team discuss some of their projects they're working on, including custom LED panels with varying wavelengths, a linear motor-controlled cryo-plunger for electron cryo-microscopy sample preparation and a plasma system with radio frequency heating coils.Check out our Mechanical Workshop in this video: youtu.be/JEahUKEkCtkOr find the rest of our facility videos in this playlist: youtube.com/playlist?list=PLQbPquAyEw4fAxY9TxezoPpbi7fxykiQ4--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
John Walker - LMB Through the Years MRC Laboratory of Molecular Biology 2023-06-22 | An unexpected cellular revolutionInterview with John WalkerHere, John discusses how a chance meeting with Fred Sanger changed the course of his career, life in the LMB's PNAC Division in its early years, and how his decision to focus on ATP synthase wasn't entirely popular.This interview is part of the LMB Through the Years project celebrating the LMB's 60th anniversary. A selection of twelve staff and alumni, from across the decades, were interviewed by science writer Kathy Weston about their time at the LMB and what it has meant to them. Each interviewee has also chosen an object to represent their time at the LMB, giving an unusual insight into the many facets of life at the LMB.--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Wheres Wally? How does the immune system identify cancer cells? By Patrycja Kozik MRC Laboratory of Molecular Biology 2023-06-12 | Where's Wally? How does the immune system identify cancer cells?By Patrycja KozikLMB Seminar for Non-ScientistsCambridge Biomedical Campus on Virtual Tour-In this seminar for non-scientists, Patrycja Kozik, Group Leader in the LMB's Protein and Nucleic Acid Chemistry (PNAC) Division, discusses her group's goal to understand how the immune system eliminates cancer cells. Specifically, they focus on dendritic cells, key orchestrators of the immune responses. In this talk, Patrcyja covers their attempts to uncover how dendritic cells detect tumours and how they drive tumour-specific T lymphocytes to differentiate into powerful effectors that can kill unwanted cells.Patrycja's group page: www2.mrc-lmb.cam.ac.uk/group-leaders/h-to-m/patrycja-kozik-Want to watch more of our seminars for non-scientists? Check out this playlist: youtube.com/playlist?list=PLQbPquAyEw4cL38rgPGkUC46QJWngG--r-About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
John White - LMB Through the Years MRC Laboratory of Molecular Biology 2023-06-09 | Mapping the mind of a wormInterview with John WhiteIn this interview, John describes the early years working with Sydney Brenner, reveals why Eileen Southgate was so amazingly good at her job, and goes on to talk about how he got together with Brad Amos, Richard Durbin and Mick Fordham to design one of the most useful bits of kit that the LMB has ever produced: the beam scanning confocal microscope, workhorse of literally thousands of labs.This interview is part of the LMB Through the Years project celebrating the LMB's 60th anniversary. A selection of twelve staff and alumni, from across the decades, were interviewed by science writer Kathy Weston about their time at the LMB and what it has meant to them. Each interviewee has also chosen an object to represent their time at the LMB, giving an unusual insight into the many facets of life at the LMB.Accompanying article: www3.mrc-lmb.cam.ac.uk/sites/lmbthroughtheyears/john-white-mapping-the-mind-of-a-wormVideo transcript: www3.mrc-lmb.cam.ac.uk/sites/lmbthroughtheyears/transcripts/shortened-transcript-of-interview-with-john-white-jw-27-june-2022--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Greg Winter - LMB Through the Years MRC Laboratory of Molecular Biology 2023-06-09 | The genesis of therapeutic antibodiesInterview with Greg WinterIn this interview for the LMB’s 60th birthday celebrations, Greg looks back on his time as a PhD student, postdoc and then Group Leader in the LMB’s Division of Protein and Nucleic Acid Chemistry (PNAC). Throughout his career, Greg's main focus was on the practical applications of genetic and protein engineering, and following his development of humanised mouse antibodies, he pioneered the use of phage display libraries to make entirely human therapeutic antibodies. For this achievement, Greg was awarded the 2018 Nobel Prize in Chemistry.This interview is part of the LMB Through the Years project celebrating the LMB's 60th anniversary. A selection of twelve staff and alumni, from across the decades, were interviewed by science writer Kathy Weston about their time at the LMB and what it has meant to them. Each interviewee has also chosen an object to represent their time at the LMB, giving an unusual insight into the many facets of life at the LMB.Accompanying article: www3.mrc-lmb.cam.ac.uk/sites/lmbthroughtheyears/greg-winterVideo transcript: www3.mrc-lmb.cam.ac.uk/sites/lmbthroughtheyears/transcripts/shortened-transcript-of-interview-with-greg-winter-gw-4-april-2022--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
The Extraordinary Life and Legacy of Sir John C. Kendrew by Paul Wassarman MRC Laboratory of Molecular Biology 2023-06-05 | The Extraordinary Life and Legacy of Sir John C. KendrewLMB Lecture by Paul WassarmanJohn Kendrew (1917-1997) was a pioneer in structural biology and a catalyst for the emergence of molecular biology in the second half of the twentieth century. He was the first person to determine the three-dimensional structure of a protein at atomic resolution and, for this, was awarded the Nobel Prize in Chemistry in 1962. John Kendrew ultimately became an international organizer, administrator, and unwavering advocate for British and European science, and his expansive legacy lives on today. In this talk, Paul Wassarman will delve into aspects of John Kendrew’s personal and scientific life and discuss some of the background, traits, and experiences of the man responsible for so many achievements within science and beyond.Paul Wassarman is a Professor in Cell, Developmental and Regenerative Biology at the Ichan School of Medicine at Mount Sinai, where he researches the molecular mechanisms behind mammalian fertilisation.In 2020, Paul published ‘A Place in History: The Biography of John C. Kendrew’ where he discussed the scientific and personal life of John Kendrew, a key figure in the LMB’s history. Paul’s lecture will cover several of the key insights from his book.--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Panel Discussion – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-05-02 | Panel DiscussionChair: Maria LeptinWith Yanlan Mao, Liz Miller, Marta Shahbazi and Ruth SperlingSpeaking at Ahead of the Curve: Women Scientists at the LMB on Friday 11th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Kelly Nguyen – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-05-02 | Kelly NguyenSpeaking at Ahead of the Curve: Women Scientists at the LMB on Friday 11th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Cynthia Kenyon – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-05-02 | Cynthia KenyonSpeaking at Ahead of the Curve: Women Scientists at the LMB on Friday 11th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Maria Leptin – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-05-02 | Maria LeptinSpeaking at Ahead of the Curve: Women Scientists at the LMB on Friday 11th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Madeline Lancaster – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-05-02 | Madeline LancasterSpeaking at Ahead of the Curve: Women Scientists at the LMB on Friday 11th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Sarah Teichmann – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-05-02 | Sarah TeichmannSpeaking at Ahead of the Curve: Women Scientists at the LMB on Friday 11th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Suzanne Cory – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-05-02 | Suzanne CorySpeaking at Ahead of the Curve: Women Scientists at the LMB on Friday 11th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Laura Machesky – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-05-02 | Laura MacheskySpeaking at Ahead of the Curve: Women Scientists at the LMB on Friday 11th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Anne Bertolotti – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-05-02 | Anne BertolottiSpeaking at Ahead of the Curve: Women Scientists at the LMB on Friday 11th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Meet the Mechanical Workshop – LMB@60 MRC Laboratory of Molecular Biology 2023-04-03 | To mark the LMB’s 60th anniversary, we’re continuing our video tours of our scientific facilities. Today we invite you to meet our Mechanical Workshop team: Steve Scotcher, Adam Fowle, Chris Palmer, Alex Haslett-Saunders, Andras Bukkosi.Here the team discuss how machine techniques have changed over the years, how they work with scientists to create bespoke equipment and some of their favourite projects.Find the rest of our facility videos in this playlist: youtube.com/playlist?list=PLQbPquAyEw4fAxY9TxezoPpbi7fxykiQ4Read Alex Haslett-Saunders’ account of completing an apprenticeship in the LMB’s Mechanical Workshop: www2.mrc-lmb.cam.ac.uk/apprenticeship-success-in-the-lmb-workshopsRead Steve Scotcher’s recollections from his 40 year career at the LMB: www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/share-your-memories/steve-scotcher--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Elizabeth Blackburn – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-03-08 | Elizabeth BlackburnSpeaking at Ahead of the Curve: Women Scientists at the LMB on Thursday 10th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Lori Passmore – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-03-08 | Lori PassmoreSpeaking at Ahead of the Curve: Women Scientists at the LMB on Thursday 10th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Julie Ahringer – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-03-08 | Julie AhringerSpeaking at Ahead of the Curve: Women Scientists at the LMB on Thursday 10th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Susan Taylor – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-03-08 | Susan TaylorSpeaking at Ahead of the Curve: Women Scientists at the LMB on Thursday 10th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Gillian Griffiths - Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-03-08 | Gillian GriffithsSpeaking at Ahead of the Curve: Women Scientists at the LMB on Thursday 10th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Joan Steitz – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-03-08 | Joan SteitzSpeaking at Ahead of the Curve: Women Scientists at the LMB on Thursday 10th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Philippa Marrack – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-03-08 | Philippa MarrackSpeaking at Ahead of the Curve: Women Scientists at the LMB on Thursday 10th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Margaret (Scottie) Robinson – Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-03-08 | Margaret (Scottie) RobinsonSpeaking at Ahead of the Curve: Women Scientists at the LMB on Thursday 10th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Daniela Rhodes - Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-03-08 | Daniela RhodesSpeaking at Ahead of the Curve: Women Scientists at the LMB on Thursday 10th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Mariann Bienz - Ahead of the Curve: Women Scientists at the LMB MRC Laboratory of Molecular Biology 2023-03-08 | Mariann BienzIntroducing Ahead of the Curve: Women Scientists at the LMB on Thursday 10th November 2022.--Ahead of the Curve: Women Scientists at the LMB was a symposium held on 10th-11th November 2022, celebrating women scientists who work or have worked at the LMB, many of whom have gone on to careers at some of the world’s foremost scientific institutions. Many of the women featured in Kathy Weston’s book “Ahead of the Curve” spoke about their career to date, including how the LMB influenced them.Ahead of the Curve by Kathy Weston: aheadofthecurve.org.uk--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Investigating the molecular basis of nuclei remodelling by Matteo Allegretti with Pirating Science MRC Laboratory of Molecular Biology 2023-02-09 | Matteo Allegretti, Group Leader in the LMB’s Structural Studies Division, discusses his group’s research on the macromolecular basis of how the nucleus is remodelled in shape during differentiation processes or in response to environmental cues.This video was produced by Pirating Science: youtube.com/@piratingscience7333Find out more about Matteo’s research here: www2.mrc-lmb.cam.ac.uk/group-leaders/a-to-g/matteo-allegretti--Like this video? Check out more videos from our Structural Studies Division here: youtube.com/playlist?list=PLQbPquAyEw4edDbQPPhYtkhUPZ_QBx9vD--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
From the scientists view: a conversation with Anne Bertolotti MRC Laboratory of Molecular Biology 2023-01-17 | “It's very hard to think about other work or other professions that could bring the level of excitement that science does.”Anne has been a Group Leader in the Neurobiology Division since2006. Her group investigates the molecular basis of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s and Huntington’s diseases. These diseases share a common molecular origin; the deposition of proteins in abnormal conformation. Anne’s research seeks to better understand the mechanisms which underlie the deposition of these proteins and elucidate ways to prevent this.Find out more about Anne's group here: www2.mrc-lmb.cam.ac.uk/group-leaders/a-to-g/anne-bertolottiOther playlists you might be interested in:Meet our Scientists: youtube.com/playlist?list=PLQbPquAyEw4cCCUMIgzoMJ_IGTm7fGP7tResearch Highlights from our Neurobiology Division: youtube.com/playlist?list=PLQbPquAyEw4eKZsoOGJBTT1KK6vezDm-r--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
From the scientists view: a conversation with Chris Tate MRC Laboratory of Molecular Biology 2023-01-17 | “You can have the craziest idea in science, and you can always find somebody to discuss it with and people really give you the time.”Chris joined the LMB in 1992, as researcher in Richard Henderson’s Group. He started his own group in the Structural Studies Division in 2010, investigating the structure and function of G protein-coupled receptors (GPCRs).Find out more about Chris Tate's group here: www2.mrc-lmb.cam.ac.uk/group-leaders/t-to-z/chris-tateOther playlists you might be interested in:Meet our Scientists: youtube.com/playlist?list=PLQbPquAyEw4cCCUMIgzoMJ_IGTm7fGP7tResearch Highlights in our Structural Studies Division: youtube.com/playlist?list=PLQbPquAyEw4edDbQPPhYtkhUPZ_QBx9vD--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Sjors Scheres - LMB Through the Years MRC Laboratory of Molecular Biology 2022-12-15 | From blobology to the resolution revolutionInterview with Sjors ScheresIn this interview, Sjors discusses why moving to the LMB put him in the right place at the right time, explains how he developed the ideas that eventually produced RELION, and talks about the importance of open-access software for rapid scientific progress. Since 2018, Sjors has been Joint Head of the Structural Studies Division, and we learn about his strategy for recruiting new Group Leaders, as well as what his lab is doing these days, and the collaborative project that has rekindled his passion for wet-lab biology: his work on Alzheimer’s Disease and other tauopathies with fellow LMB Group Leader Michel Goedert.This interview is part of the LMB Through the Years project celebrating the LMB's 60th anniversary. A selection of twelve staff and alumni, from across the decades, were interviewed by science writer Kathy Weston about their time at the LMB and what it has meant to them. Each interviewee has also chosen an object to represent their time at the LMB, giving an unusual insight into the many facets of life at the LMB.Accompanying article: www3.mrc-lmb.cam.ac.uk/sites/lmbthroughtheyears/sjors-scheres-from-blobology-to-the-resolution-revolutionVideo transcript: www3.mrc-lmb.cam.ac.uk/sites/lmbthroughtheyears/transcripts/shortened-transcript-of-interview-with-sjors-scheres-ss-25-july-2022-About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Lesley Drynan - LMB Through the Years MRC Laboratory of Molecular Biology 2022-12-15 | Essential services: Running the Biological Services GroupInterview with Lesley DrynanIn this interview, Lesley tells us how she came to the LMB as a research assistant and what it was like to switch into a different career track, and gives us a behind the scenes look at how a top-ranked animal facility works to take the best possible care of its inhabitants, both furry and otherwise.This interview is part of the LMB Through the Years project celebrating the LMB's 60th anniversary. A selection of twelve staff and alumni, from across the decades, were interviewed by science writer Kathy Weston about their time at the LMB and what it has meant to them. Each interviewee has also chosen an object to represent their time at the LMB, giving an unusual insight into the many facets of life at the LMB.Accompanying article: www3.mrc-lmb.cam.ac.uk/sites/lmbthroughtheyears/lesley-drynan-essential-services-running-the-biological-services-groupVideo transcript: www3.mrc-lmb.cam.ac.uk/sites/lmbthroughtheyears/transcripts/transcript-of-interview-with-lesley-drynan-ld-23-may-2022-About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Mark Bretscher - LMB Through the Years MRC Laboratory of Molecular Biology 2022-12-15 | Solving the genetic code with Crick and BrennerInterview with Mark BretscherIn this interview, Mark discusses many topics including some of his work on the triplet code, the move into the new Laboratory of Molecular Biology (including a little “light burglary” on his part), and finally, the epic series of parties following the announcement of Kendrew and Perutz’s Nobel Prize for Chemistry and Crick and Watson’s Nobel Prize for Physiology or Medicine in October 1962.This interview is part of the LMB Through the Years project celebrating the LMB's 60th anniversary. A selection of twelve staff and alumni, from across the decades, were interviewed by science writer Kathy Weston about their time at the LMB and what it has meant to them. Each interviewee has also chosen an object to represent their time at the LMB, giving an unusual insight into the many facets of life at the LMB.Accompanying article: www3.mrc-lmb.cam.ac.uk/sites/lmbthroughtheyears/solving-the-genetic-code-with-crick-and-brennerVideo transcript: www3.mrc-lmb.cam.ac.uk/sites/lmbthroughtheyears/transcripts/shortened-transcript-of-interview-with-mark-bretscher-mb-7-march-2022How the Genetic Code was Solved by Mark Bretscher: www3.mrc-lmb.cam.ac.uk/sites/lmbthroughtheyears/how-the-genetic-code-was-solved-About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Understanding Hidden Disabilities and Conditions - Ted Smith MRC Laboratory of Molecular Biology 2022-12-06 | For this talk marking Disability History Month our speaker, Ted Smith, will help us to understand the burdens and challenges faced by those with disabilities and hidden conditions. On average, every fifth person you meet will have a disability, and eighty percent of these disabilities are not immediately obvious to others yet can have a significant impact on the individual.During lockdown Ted interviewed over seventy people about their hidden disabilities and conditions and specifically asked what accommodations their employers could make for them. He then wrote a book using the information he gathered. Ted will illustrate his talk using the real life examples from his book, and will help us to think about how we can make the workplace more inclusive and supportive for those with disabilities.Ted Smith was Group HR Director at the MRC for five years, and at the Wellcome Trust for three years, during which he helped set up a £5m diversity and inclusion project. After leaving Wellcome he set up as an HR consultant, just as Covid struck, which inspired him to write his latest book on ‘Hidden Disabilities and Conditions’.-About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Lessons for Tuberculosis Treatment from the Zebrafish by Lalita Ramakrishnan MRC Laboratory of Molecular Biology 2022-11-23 | Lessons for Tuberculosis Treatment from the ZebrafishBy Lalita RamakrishnanLMB Seminar for Non-ScientistsCambridge Biomedical Campus on Virtual Tour-Join Professor Lalita Ramakrishnan to discover how zebrafish are helping researchers understand and develop treatments for tuberculosis (TB), a major infectious killer to this day.Lalita is a pioneer of research into the pathogenesis of TB. Her work uses zebrafish to study tuberculosis. The zebrafish larvae are particularly useful as they are transparent for several weeks, which enables Lalita and her team to manipulate and monitor infection in real-time. In this talk, Lalita will share how these tools have proven to be powerful when trying to understand tuberculosis, and how her team have also translated this work to human tuberculosis and discovered new drugs for tuberculosis.Professor Lalita Ramakrishnan is Head of the University of Cambridge’s Molecular Immunity Unit, located within the MRC Laboratory of Molecular Biology (LMB), a Group Leader in the LMB’s Cell Biology Division, and also works as an Infectious Diseases Consultant at Cambridge University Hospital.After completing her medical training in India, Lalita completed a PhD, medical residency training and postdoctoral research in the US. In 2001, Lalita joined the faculty of the University of Washington where she pioneered the zebrafish as a model for tuberculosis (TB) pathogenesis, before moving to Cambridge in 2014. Lalita is a member of US National Academy of Sciences and EMBO, and a Fellow of The Royal Society, the Academy of Medical Sciences and the American Academy of Microbiology.Lalita's group page: www2.mrc-lmb.cam.ac.uk/group-leaders/n-to-s/lalita-ramakrishnan-About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Meet the NMR Facility – LMB@60 MRC Laboratory of Molecular Biology 2022-11-14 | To mark the LMB’s 60th anniversary in 2022, we are taking you on a tour to see behind the scenes of our scientific facilities. Today we invite you to meet our NMR team.The NMR facility is made up of Stefan Freund, Trevor Rutherford, Jane Wagstaff and Conny Yu. Here the team discuss how NMR spectroscopy works, why it is useful for numerous molecular research projects, and how they first became interested in NMR.Find the rest of our facility videos in this playlist: youtube.com/playlist?list=PLQbPquAyEw4fAxY9TxezoPpbi7fxykiQ4 --About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
Excitement in Science by Hans Boye (1962-1964) MRC Laboratory of Molecular Biology 2022-11-09 | Between 1962 and 1964, LMB Student, Hans Boye took some amateur film of the LMB, in its new Hills Road building. The film, which is without sound, captures some of the key people in the Lab and one of the earliest LMB Nobel Parties.The film has been edited and released to celebrate the 60th Anniversary of the LMB.Read more about our exhibitions here: www2.mrc-lmb.cam.ac.uk/news-and-events/lmb-exhibitions--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
NGBS2022 Talk 11: Protein design using deep learning – David Baker MRC Laboratory of Molecular Biology 2022-10-26 | Protein design using deep learningTowards a mechanistic understanding of genome regulationSpeaker: David Baker, University of Washington, USAChair: Stephen McLaughlin, MRC Laboratory of Molecular Biology, UK Co-Chair: David Rueda, Imperial College, London and MRC-LMS UKDavid Baker describes de novo protein design via two methods using physically-based Rosetta and using deep learning neural networks. Using the first method, he shows how proteins can be designed for potential therapeutic use and to understand the photophysics of chlorophyll or create a transmembrane beta-barrel protein that can function as ion channel. This approach has also generated a set designed a set of protein building blocks that can be used for formations of larger structures not found in nature. In the second half of this talk, David describes how using a deep-learning approach can be used to find a protein sequence that will fold into a designed structure. This has been used to generate large symmetric rings, novel selective catalysts and stable epitopes for vaccine development. Read more about David Bakers’s work here: bakerlab.orgYou can find more about the Next Generation Biophysics Symposium 2022 here:www3.mrc-lmb.cam.ac.uk/sites/nextgen--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
NGBS2022 Talk 10: RNA modelling and design - Rhiju Das MRC Laboratory of Molecular Biology 2022-10-26 | RNA modelling and designSpeaker: Rhiju Das, Stanford University, USAChair: Chris Johnson, MRC Laboratory of Molecular Biology, UKCo-Chair: Maria Flocco, AstraZeneca, UKRhiju Das describes a software pipeline to construct and visualize the three-dimensional structure of RNA from resolvable cryo-EM maps. The method combines technology based on chemical mapping strategies to determine the secondary structure of RNA which is fed into the program DRRAFTER to trace the RNA coordinates into the cryo-EM map. This approach has determined the structures of ribozymes, aptamers, riboswitches and confirmed the predicted structure of designed sequences. The discovery of a new RNA fold in the genome of SARS-CoV2-RNA opened up a potential new therapeutic avenue and the prevalence of RNA structure throughout other genomes. Read more about Rhiju Das’s work here:https://daslab.stanford.edu/You can find more about the Next Generation Biophysics Symposium 2022 here:www3.mrc-lmb.cam.ac.uk/sites/nextgen--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
NGBS2022 Talk 9: Dynamics and mechanism of CRISPR-Cas9 using computational methods - Giulia Palermo MRC Laboratory of Molecular Biology 2022-10-26 | Dynamics and mechanism of CRISPR-Cas9 through the lens of computational methods Speaker: Giulia Palermo, University of California Riverside, USA:Chair: Chris Johnson, MRC Laboratory of Molecular Biology, UKCo-Chair: Maria Flocco, AstraZeneca, UKGiulia Palermo describes how she has used computational methods to probe the biology of the Cas9 system. She has used a combination of different computation approaches including QM/MM and classical force fields to push simulations beyond the normal timescale limits. Simulations on binding and conformational change correlate with recent cryo-EM structures. Construction of a nodal interaction network within the protein has identified how key residues and defined pathways control dynamics within the protein and lead to allostery. This has allowed the effect of mutations to be probed and compared with NMR data. Computation methods have also predicted residues involved in catalysis and also the presence of Mg2+ which were confirmed by a recent structure. Read more about Giulia Palermo’s work here: palermolab.comYou can find more about the Next Generation Biophysics Symposium 2022 here:www3.mrc-lmb.cam.ac.uk/sites/nextgen--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
NGBS2022 Talk 8: AlphaFold and its implications for understanding biology- John Jumper MRC Laboratory of Molecular Biology 2022-10-26 | AlphaFold and its implications for understanding biologySpeaker: John Jumper, DeepMind, London, UKChair: Chris Johnson, MRC Laboratory of Molecular Biology, UKCo-Chair: Maria Flocco, AstraZeneca, UKJohn Jumper describes how AlphaFold predicts highly accurate protein structures from amino acid protein sequence. He highlights the role of the critical assessment in structure prediction (CASP) in stimulating development. He gives an overview of how AlphaFold predicts structures through a process of deep-learning using a neural network. He looks forward to the major challenges in further developments of prediction especially interactomes, conformation states, and the effect of mutation.Read more about John Jumper and DeepMinds’s work here:deepmind.com/researchYou can find more about the Next Generation Biophysics Symposium 2022 here:www3.mrc-lmb.cam.ac.uk/sites/nextgen--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
NGBS2022 Talk 7: Single cell electrical characterization in bacteria - Ashley Nord MRC Laboratory of Molecular Biology 2022-10-26 | Single cell electrical characterization in bacteriaSpeaker: Ashley Nord, CNRS, Montpellier, FranceChair: David Rueda, Imperial College, London/MRC-LMS, UKCo-Chair: Geoff Holdgate, AstraZeneca, UKAshley Nord describes how she has engineered the bacterial flagellar motor to read-out the proton motive force (PMF) across the bacterial membrane. For this she has constructed a simple circuit model that describes PMF perturbations via laser induced activation of proteorhodospin. This shows that the PMF travels fast with little loss and is homogeneous on the scale of a single bacterium and is due to the rapid propagation of membrane voltage.Read more about Ashley Nord’s work here: sites.google.com/view/sm-angular-dynamicsYou can find more about the Next Generation Biophysics Symposium 2022 here:www3.mrc-lmb.cam.ac.uk/sites/nextgen--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
NGBS2022 Talk 6: Atomic force microscopy uncovers invisible complexities of the genome - Alice Pyne MRC Laboratory of Molecular Biology 2022-10-26 | Uncovering the invisible complexities of the genome using atomic force microscopySpeaker: Alice Pyne, University of Sheffield, UKChair: David Rueda, Imperial College, London/MRC-LMS, UKCo-Chair: Geoff Holdgate, AstraZeneca, UKAlice Pyne describes how she investigates the conformational dynamics of DNA using AFM. Working with manufacturers, she has driven improvements in commercial AFM cantilevers so they are uniform in size and softer which enables a step-change in the resolution and reproducibility of imaging. This has allowed her to examine the structure and dynamics of small DNA mini-circles and the effect of supercoiling and G-quadraplexes. She has also developed an automated processing pipeline software to generate quantitative AFM data that has both informed and validated MD simulations. Read more about Alice Pyne’s work here: pyne-lab.ukYou can find more about the Next Generation Biophysics Symposium 2022 here:www3.mrc-lmb.cam.ac.uk/sites/nextgen--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
NGBS2022 Talk 5: Dynamic motion during loading and activation of the yeast Replisome - Nynke Dekker MRC Laboratory of Molecular Biology 2022-10-26 | Dynamic motion during loading and activation of the yeast Replisome Speaker: Nynke Dekker, Delft University of Technology, NetherlandsChair: David Rueda, Imperial College, London/MRC-LMS, UKCo-Chair: Geoff Holdgate, AstraZeneca, UKNynke Dekker describes her work on the DNA replication in yeast at the single molecule level. She used optical tweezers to trap DNA between the beads and then visualizes assembly of the fluorescently labelled replication proteins on the DNA. Alternatively, she captures pre-assembled DNA-protein complexes between the beads. This has enabled quantitation of both binding and diffusion of proteins on DNA. This has led to the first successful analysis of CMG motion on DNA and the effect of nucleotide state on this process. Read more about Nynke Dekker’s work here: https://www.tudelft.nl/en/faculty-of-applied-sciences/about-faculty/departments/bionanoscience/about-the-department/prof-dr-nynke-dekkerYou can find more about the Next Generation Biophysics Symposium 2022 here:www3.mrc-lmb.cam.ac.uk/sites/nextgen--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
NGBS2022 Talk 4: Imaging cholesterol & its enriched domains - Jorge Bernadino de la Serna MRC Laboratory of Molecular Biology 2022-10-26 | Imaging cholesterol and its enriched domains spatiotemporally across scalesSpeaker: Jorge Bernadino de la Serna, Imperial College London, UKChair: Geoff Holdgate, AstraZeneca, UKCo-Chair: Chris Johnson, MRC Laboratory of Molecular Biology, UKJorge Bernadino de la Serna describes novel imaging techniques using raster imaging correlation spectroscopy with polarization sensitive fluorescence dye imaging and STED microscopy to examine the lateral packing and mobility of lipids in real time in cells. Using this he has been able to examine the number and dynamics of cholesterol at vesicles and membrane.Read more about Jorge Bernadino de la Serna’s work here: imperial.ac.uk/people/j.bernardino-de-la-sernaYou can find more about the Next Generation Biophysics Symposium 2022 here:www3.mrc-lmb.cam.ac.uk/sites/nextgen--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
NGBS2022 Talk 3: Cryo-EM to Understand physiological processes in bacterial cells - Tanmay Bharat MRC Laboratory of Molecular Biology 2022-10-26 | Understanding physiological processes in bacterial cells using cryo-EM Speaker: Tanmay Bharat, Laboratory of Molecular Biology, MRC, UKChair: Geoff Holdgate, AstraZeneca, UKCo-Chair: Chris Johnson, MRC Laboratory of Molecular Biology, UKTanmay Bharat describes his work elucidating the structure of S-layer proteins that envelope many prokaryotic cells. He shows through a combination of cryo-EM and cryo-ET, X-ray crystallography and MD simulations the S-layer is made of units of self-oligomerizing proteins that form a large array on the surface. His work shows how this layer is connected the underlying structure of the cells and also points towards the mechanism of their assembly and transport to the outer layer in the dividing prokaryotic cell. Read more about Tanmay Bharat’s work here: www2.mrc-lmb.cam.ac.uk/groups/bharatYou can find more about the Next Generation Biophysics Symposium 2022 here:www3.mrc-lmb.cam.ac.uk/sites/nextgen
NGBS2022 Talk 2: Focal molography analysis in complex samples - Andreas Frutiger MRC Laboratory of Molecular Biology 2022-10-26 | Label-free interaction analysis in complex samples – focal Molography enables novel applications in bioprocessing, drug discovery and diagnosticsSpeaker: Andreas Frutiger, Lino Biotech, Zurich, Switzerland Chair: Geoff Holdgate, AstraZeneca, UKCo-Chair: Chris Johnson, MRC Laboratory of Molecular Biology, UKAndreas Frutiger describes the application of a novel type of biosensor based on changes in the diffraction patterns resulting from scattering of biomolecules arranged in an array of closely spaced stripes. He discusses the physics behind the instrument method and its application to a variety of interaction biological molecules and cells.Read more about Lino Biotech’s work here: lino-biotech.com/#companyYou can find more about the Next Generation Biophysics Symposium 2022 here:www3.mrc-lmb.cam.ac.uk/sites/nextgen--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
NGBS2022 Talk 1: The extent of RNA catalysis – are there any limits? - David Lilley MRC Laboratory of Molecular Biology 2022-10-26 | The extent of RNA catalysis – are there any limits?Speaker: David Lilley, University of Dundee, UKChair: Maria Flocco, AstraZeneca. UKCo-Chair: Stephen McLaughlin, MRC Laboratory of Molecular Biology, UKDavid Lilley explores RNA-catalysed chemistry including acid/base or metal ion mechanisms involved in P-O bond chemistry and relatively sophisticated mechanisms in methyl and alkyl transfer reactions revealed in quantum mechanical calculations. He also looks at the potential of co-factors in future design of RNA-based catalytic reactions.Read more about David’s work here: lifesci.dundee.ac.uk/groups/nasgYou can find more about the Next Generation Biophysics Symposium 2022 here:www3.mrc-lmb.cam.ac.uk/sites/nextgen--About the MRC Laboratory of Molecular Biology (LMB):The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.More links:Official Site: www2.mrc-lmb.cam.ac.ukFacebook: facebook.com/MRC.LMBTwitter: twitter.com/MRC_LMBInstagram: instagram.com/mrc_lmbLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyClick here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
The making of Inside the LMB: One take fly through MRC Laboratory of Molecular Biology 2022-10-12 | Take a look behind the scenes on the day we filmed the LMB’s single-shot drone film, ‘Inside LMB: One-take fly through’. The 4 minute 39 second continuous film, which shares a snippet of everyday life in our institute, was made entirely by members of the LMB. There was a lot of effort behind this one shot, with months of planning, many hours of practice and more than a hundred members of the LMB involved on the day. Here you can see behind-the-scenes footage to show how we coordinated everything on the day. Read more on the story behind this video project here:www2.mrc-lmb.cam.ac.uk/the-making-of-inside-the-lmb-one-take-fly-throughCredits:Video and footage: Shraddha Nayak; Paul Hart for Drone and Michael’s video; Grace Massucci for scone footage.Tape illustration: Starline (Freepik).Crash audio: “Destruction, Wooden, A.wav” by InspectorJ (Freesound).With thanks to all members of the LMB who contributed to this project. Subscribe: youtube.com/user/LMBCambridge Follow us on socials: Twitter: twitter.com/MRC_LMB Facebook: facebook.com/MRC.LMB LinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biology Instagram: instagram.com/mrc_lmb
Inside the LMB: One take fly through MRC Laboratory of Molecular Biology 2022-08-10 | Filmed in a single shot, we flew a drone around the inside of the MRC Laboratory of Molecular Biology (MRC LMB) to share a snippet of everyday life in our institute. At the MRC LMB, we work together to solve key problems in human health by understanding life at the level of atoms, molecules, cells and organisms. www2.mrc-lmb.cam.ac.uk This 4m 39s single continuous film, taken with a first-person view (FPV) drone, was made entirely by members of the MRC LMB.Credits: Concept: Michael HastingsDrone pilot and edit: Paul HartProduction: Lydia Melville, Liz Pryke and Shraddha NayakWith thanks to all members of the LMB who contributed to this project. Subscribe: youtube.com/user/LMBCambridge?sub_confirmation=1Follow us on socials: Twitter: twitter.com/MRC_LMBFacebook: facebook.com/MRC.LMBLinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biologyInstagram: instagram.com/mrc_lmb
