CANN D8 Panel Discussion CANN - Cannabis Chemistry Subdivision of ACS 2021-08-02 | A Delta-8 Discussion: The conversion of CBD into Delta-8-THC and other isomers has recently gone mainstream due to the abundance of hemp on the market. There are a number of concerns surrounding its production and questions regarding its legality. This panel discussion will explore the chemistry involved in D8 production, its legality & pharmacology, as well as the various challenges seen when testing D8 products.SpeakersMark Scialdone, PhD (Founder & President, Betterchem Consulting)Greg Gerdeman, PhD (President and CEO, NASHCX)Richard Sams, PhD (Scientific Director, KCA Laboratories)Yvonne DePorre, PhD (Scientific Advisor, Orion GMP)Chelsie Spencer (Founding Member, Ritter Spencer PLLC)
Medical Cannabis for Migraines with Michelle Sexton ND CANN - Cannabis Chemistry Subdivision of ACS 2025-09-11 | Michelle Sexton ND has extensive clinical research experience helping patients fine-tune their endocannabinoid systems since 2008. Ms.Sexton received her degree at Bastyr University and then eventually began working at UCSD working in the pain division. She presents research from a recent publication that she worked on titled "Efficacy of vaporized cannabis vs. placebo for acute treatment of migraine: a randomized, double-blind, placebo- controlled, crossover trial"Paper link: pubmed.ncbi.nlm.nih.gov/38405890Dr.Sexton's website: msextonnd.comYou can also read or get more info on her book "Eat, Sleep, Relax, Protect, Forget: An Endocannabinoid Guide to Systems Wholeness for Women" at her website
a Neurodivergent-affirming Perspective of a Marginalized Subset of Medical Cannabis Users CANN - Cannabis Chemistry Subdivision of ACS 2025-05-29 | Dr. Miyabe Shields (@miyabephd ) of the Network of Applied Pharmacognosy (@AppliedPharmacognosy) is hosted by Twinkle Paryani of the CANN subdivision of ACS in this months journal club collaboration with the Cannaclub at UCLA. Dr. Shields presents their recent work a perspective and re-analysis on publicly available data with a neurodivergent-affirming lens. The journal article is available publicly and for free here: appliedpharmacognosy.org/journal
Review and Implications of Fungal and Mycotoxin Contaminants in Cannabis and Hemp with Kyle Boyar CANN - Cannabis Chemistry Subdivision of ACS 2025-02-07 | Kyle Boyar of Bio-Rad Labs presents a review on Fungal and Mycotoxin Contaminants in Cannabis and Hemp. Kyle also presents some new data on previously unexamined fungal species, shedding light on their impact on product safety.
Percolation vs Maceration with Jason Wilson MS from Curious about Cannabis CANN - Cannabis Chemistry Subdivision of ACS 2024-11-05 | Jason Wilson, MS, from Curious About Cannabis, discusses his recent publication on CBD extraction for at-home patients with host Twinkle Paryani. Together, they explore the differences between maceration and percolation efficiency.Video edited by scalemarketingandsales.com
How to Dissect Scientific Literature - ACS CANN Journal Club - Jason Wilson M.S CANN - Cannabis Chemistry Subdivision of ACS 2024-06-24 | Presenter Jason Wilson M.S from Curious about Cannabis shares information about utilizing AI tools to assist with research along with host Twinkle Paryani from the CANN subdivision of ACS. They discuss the ethical implications and the utility and downside to using AI tools with research as well as how to critically analyze scientific literature.Jason shares several AI tools geared specifically towards chemistry.
Genetic vs Aroma Consistency in Cannabis with Dr. Anna Schwabe CANN - Cannabis Chemistry Subdivision of ACS 2024-03-29 | Dr.Schwabe presents her research on how genetic differences make each strain unique, but this research shows that even genetically identical samples from different sources have different scents and chemical profiles. Moderated by Twinkle Paryani through CANN Journal Club
Exploring the anxiolytic potential of CBG, a case study on CBG and CBD - Dr. Riley Kirk CANN - Cannabis Chemistry Subdivision of ACS 2024-01-30 | CBG is a major cannabinoid found in Cannabis Sativa L. that has well documented analgesic effects. The polypharmacological activity at receptors TRPV1, TRPV2, alpha2, adrenoceptor, serotonin, 5HT1A receptor, and more provide additional evidence that there may be further implications for this compound for anxiolytic purposes. Dr. Riley Kirk is a cannabis research scientist, educator, and advocate. She received her PHD from the university of Rhode Island in pharmaceutical sciences specializing in chemistry and pharmacology of medicinal plants and fungi. She is the founder of The Network for Applied Pharmacognosy, and adjunct professor in the college of pharmacy at University of Rhode Island and the host of the Bioactive podcast. She is an advocate for science communication and education. Follow Riley @cannabichem on most social medial platforms, where she attempts to destigmatize and inform patients and consumers with her educational cannabis content.
Short Cut to Avoiding Quality Issues in Cannabis - Emily Kirkham - Hosted by CANN CANN - Cannabis Chemistry Subdivision of ACS 2022-12-22 | Emily is founder and President at National Laboratory Services, a Canadian companyfocusing on analytical laboratory consulting for the Cannabis industry. She specializes inmethod validation, quality control and training for Licensed Producers and cannabistesting laboratories. National Laboratory Services has recently partnered with RudraSolutions Inc, to further diversify their consulting services.After obtaining her Bachelor’s degree in Chemistry from McGill University, Emilymanaged method development and analysis in environmental and governmentlaboratories. Recently she managed the Cannabis Division at CARO Analytical Services,a Canadian Cannabis Testing Laboratory. In 2014, Emily founded her own qualitycontrol and laboratory development business, tailoring to the budding cannabis industryin North America. As a registered Professional Chemist Emily brings over 22 years oflaboratory expertise to the NLS Team.
The Matrix Effect – Why Cannabis Testing is Complicated - Jini Curry CANN - Cannabis Chemistry Subdivision of ACS 2022-10-27 | Cannabis is an extremely complex matrix that has chemical properties which can make the quantitation of various analytes within the product difficult. As such, laboratories must develop methods that will account for the matrix effect and interferences that naturally occur in everyday samples. While all analyses can be impacted by matrix effect, the analyses for pesticides and mycotoxins are impacted the most. This indicates that laboratories must take the matrix and resulting interferences into consideration when processing samples. If a laboratory wants to accurately identify and quantify compounds of interest, matrix calibrations, the use of internal standards, and robust method development are essential. This presentation will provide data and evidence regarding the impact that a matrix can play on pesticide and mycotoxin results and why the lack of matrix calibrations can be detrimental to the accurate quantitation of the analytes of interest. Additionally, tools for identifying matrix interferences and how to combat these issues will be discussed in further detail. Jini Curry is the Chief Scientific Officer at Modern Canna Labs in Lakeland, Florida. She received her bachelor’s degree with honors in Biochemistry from the University of West Florida and her master’s degree in Medical Cannabis Science and Therapeutics from the University of Maryland, Baltimore, becoming one of less than 350 people with this prestigious degree. Before entering the cannabis industry, Jini gained valuable research experience at several well-respected institutes, including Emory University, the National Institute of Aging, and the University of Florida. She began working with Modern Canna in 2016, moved into the laboratory director position in January 2018, and was recently promoted to chief scientific officer in August of 2022. Jini is extremely involved in the cannabis industry and currently serves on the Scientific Advisory Board for Analytical Cannabis, is a member of the CASP Proficiency Testing Advisory Task Force with AOAC International and is a member of the CannMed 2023 Advisory Board.
Novel Prenylated Volatile Sulfur Compounds in Cannabis - Twinkle Paryani CANN - Cannabis Chemistry Subdivision of ACS 2022-07-28 | Twinkle holds a Bachelor’s of Science in Chemistry from Colorado State University and currently works at Abstrax Tech team as a research and development scientist, utilizing experience gained from working at the Center for Disease Control and at a California compliance analytical testing lab. She is presenting on a research paper that sought to uncover the chemical origins of the “skunk-like” aroma in cannabis. The authors measured the aromatic properties of cannabis flowers and concentrated extracts using 2D GC-MS-TOF, flame ionization detection, and sulfur chemiluminescence. They discovered a new family of volatile sulfur compounds (VSCs) containing the prenyl (3-methylbut-2-en-1-yl) functional group that is responsible for this scent. These results shed light on the chemical origins of the characteristic aroma of cannabis and how volatile sulfur compound production evolves during plant growth.
Glutamate, GABA & the Ouroboros of the Cannabinoids CANN - Cannabis Chemistry Subdivision of ACS 2022-07-07 | The ability of the endocannabinoids to regulate glutamate & GABA may underlie much of their ability to heal. As the brain's primary excitatory & inhibitory neurotransmitters respectively, glutamate & GABA are workhorses of homeostasis in the mind. In today's talk, we'll look at how the phytocannabinoids & endocannabinoids interact with these two key neurotransmitters as well as how this relates to a number of medical & mental health conditions.About the speaker: With a background in biochemistry, Lex Pelger writes about the science of psychoactives with his company White Whale Creations. He's written three graphic novels about the endocannabinoid system based on Moby-Dick & hosts the Lex Files podcast about spirituality & psychoactives. Follow him on Twitter or join his weekly cannabinoid science newsletter 'Cannabinoids & the People'.
A Science and Technology Approach to Packaging in Cannabis and Hemp Products. - Dr. Jerry King CANN - Cannabis Chemistry Subdivision of ACS 2022-06-08 | Dr. King has over 57 years of experience in the field of chemistry, chemical engineering and food technology. He has published over 277 documents, including government reports and holds 3 patents. He is world renown for his expertise and contributions to supercritical fluid (CO2) technology in the fields of food, botanical and natural product processing, as well as contributions to analytical chemistry and materials science. He is a recognized multi-disciplinary expert in the fields of extraction engineering &, chemistry, particularly using critical fluid technology and has made numerous presentations at many science & engineering conferences. Since 2012, he has been an R&D Consultant with a focus on applying the above technologies in the cannabis and hemp industries as well as other natural products. In 2021, he was awarded both the ElSohly Award and the Kenneth Spencer Award from the American Chemical Society.
Heavy Metals In Cannabis: The Lastest Developments In Testing Protocols- Jennly Nelson, PhD. CANN - Cannabis Chemistry Subdivision of ACS 2021-11-06 | The legalization of hemp, medicinal cannabis, and recreational marijuana has driven demand for cannabis products worldwide. There is a lack of federal regulations to ensure the quality and safety of these products. Among these missing regulations are testing protocols for toxic heavy metals. In this webinar, we will share an AOAC First Action Method and efforts towards an ASTM method. We will cover the preparation of multi-elemental analysis of plant material, cannabis-containing foods, and cannabis-containing personal care products. This method utilizes microwave digestion sample preparation and analysis by inductively coupled plasma-mass spectrometry (ICP-MS).Jenny Nelson, PhD. Jenny Nelson received her Ph.D. in Analytical Chemistry from the University of Cincinnati in 2007, and her MBA from Saint Mary’s College of California in 2011. Currently, Jenny is an Application Scientist at Agilent Technologies, joining in 2012. Jenny is also an Adjunct Professor in the Department of Viticulture and Enology at the University of California, Davis, since 2013. Jenny has been very active with AOAC and ASTM over the past eight years, serving on expert review panels, chairing committees, and volunteering to develop new methods needed by the industry. Jenny has extensive experience in operating and method development for Inductively Coupled Plasma Mass Spectroscopy (ICP-MS), Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES), and Microwave Plasma Atomic Emission Spectroscopy (MP-AES).
General Safety Measures for Extraction Facilities and How to Prevent Workplace Incidents CANN - Cannabis Chemistry Subdivision of ACS 2021-10-05 | -Saman RazaniFor extraction equipment operators and laboratory technicians, the day-to-day work can often be dangerous and complex. From hazardous processes using volatile, flammable chemical solvents, to glassware exploding under pressure – safety is always of utmost priority and should be taken very seriously. The extraction lab is the most opportune place for accidents to occur. Lab technicians and extraction equipment operators should ensure they are always prepared with the most up-to-date training and with appropriate personal protective equipment (PPE) for the tasks they are performing. This presentation will review: building requirements surrounding commercial scale extraction facilities and operations, common laboratory mishaps & catastrophic failures, and accident prevention.BIO:Saman is a lean-minded pioneer of the regulated cannabis industry. He has more than 12 years of experience in the regulated cannabis extraction and manufacturing sector, with a wide range of skills including research & development, chemical & biological sciences, facility design, operations, employee training, marketing & branding. Saman’s extraction expertise includes volatile extraction technologies and methods, including hydrocarbons like butane, propane, and heptane, as well as non-volatile extraction methods including ice, water, and more.Saman’s is known in the industry for building, executing, and managing the manufacturing arms of some of the largest and most successful cannabis companies across the country including The Green Solution, Sweet Leaf Marijuana Centers, Grow Healthy (FL), INSA (MA), and Glass House Group (CA). Saman has also served as an expert, giving testimony, in McRory’s Nursery vs. The State of Florida Department of Public Health and Office of Compassionate Use, an unprecedented cannabis case in the state of Florida as well as executed launches and production in California for companies such as Wonderbrett, Cresco Labs, Team Elite Genetics, Field Extracts, and Hello Again Products.
Markus Roggen - The Roach Isnt That Bad CANN - Cannabis Chemistry Subdivision of ACS 2021-06-14 | "In this talk we will present our findings from our latest vape and joint experiment and answer the longstanding question: Which part of a joint is the best to smoke?"Complex Biotech Discovery Ventures (CBDV), Vancouver, Canada Cannabis testing focuses on harm reduction, by testing for unwanted pesticides, heavy metals and biological contamination. On one side, cannabinoid levels are precisely measured in the product. Although these final product tests miss one important aspect of cannabis consumption. The actual process of consumption. For inhalable products, like joints and vape cartridges, the dosing of cannabinoids and chemical changes during burning/vaporization are mostly unknow. We have developed a testing platform to quantify cannabinoid and terpene levels on a puff per puff basis. This setup also allows us to screen the aerosol and gas phase for potential toxicants present. We also looked at cannabinoid concentrations puff by puff, how those compare between joints and vapes, and how those levels change over the lifecycle of a product. In this talk we will present our findings from our latest vape and joint experiment and answer the longstanding question: Which part of a joint is the best to smoke?Dr. Markus Roggen founded Complex Biotech Discovery Ventures, a fundamental researchlaboratory and CRO for the cannabis, hemp and psychedelic mushroom industries. His research interests lie in the metabolite composition and behavior throughout the production cycle, extraction optimization, and development of innovative therapeutic formulations. His company was acquired by Delic Corp in spring 2021. Dr. Roggen received his M/Sci degree from Imperial College, London, UK in 2008. He then pursued his graduate degree in organic chemistry at the Federal Institute of Technology in Zürich (ETHZ), where he received his PhD in 2012. Dr. Roggen was awarded an DAAD postdoctoral fellowship to pursue further training in physical organic chemistry at The Scripps Research Institute in La Jolla from 2013-2014. He then entered the cannabis industry, at first as laboratory director for Davinci Laboratories of California, an analytical laboratory from 2014 to 2016. In 2016, he moved into an executive position overseeing production, R&D and process optimization for OutCo, a vertically integrated cannabis company. Dr. Roggen is also a trusted advisor and mentor to multiple startups, startup accelerators and organizations. Positions include advisory positions at Bloom Automation, a cannabis robotics company, and former SAB member at MediPharm Labs, a Canadian LP, and co-chair of the NCIA Scientific Advisory Committee.
Cannabis Inflorescence for Medical Purposes: USP Considerations for Quality Attributes⠀ CANN - Cannabis Chemistry Subdivision of ACS 2021-06-09 | Dr. Nandakumara (Nandu) Sarma is the Director for the Dietary Supplements and Herbal Medicines program at US Pharmacopeia (USP) responsible for strategy and external stakeholder engagement for new and innovative projects, working with global stakeholders and expert volunteers in the development of quality standards (monographs and general chapters) for dietary supplements and herbal medicines that are published in the USP Dietary Supplements Compendium and the Herbal Medicine Compendium.⠀⠀Before joining USP 2006, he was a post-doctoral fellow at National Cancer Institute, Bethesda, and Thomas Jefferson University, Philadelphia and was a Senior Scientific Officer at The Himalaya Drug Company, India. His research experience includes isolation and analysis of active components of botanicals and their biologic activity. He published more than 25 scientific articles in peer-reviewed journals. Dr. Sarma holds a Pharmacist degree and a Ph.D. in pharmaceutical sciences (pharmacognosy) from Banaras Hindu University, India.⠀
The Importance of Solubility in Cannabis/Hemp Extraction, Processing, Formulation, and Packaging CANN - Cannabis Chemistry Subdivision of ACS 2021-06-09 | Jerry King, PhD, a CANN member and sponsor, presents "The Importance of Solubility in Cannabis/Hemp Extraction, Processing, Product Formulation,and Packaging"
Amber Wise - Cannabis Vaporizer Aerosols: Nonpolar Methods for Collection and Analysis of Ten Metals CANN - Cannabis Chemistry Subdivision of ACS 2021-06-02 | Cannabis Vaporizer Aerosols: Nonpolar Methods for Collection and Analysis of Ten Metals
An In Depth Overview of California Cannabis Compliance Testing - CANN CANN - Cannabis Chemistry Subdivision of ACS 2021-02-08 | CANN Vice Chair Kyle Boyar visits a Southern California testing facility and walks through the lifecycle of a cannabis sample being tested for compliance. The video provides a high level overview of the required tests and the instrumentation involved.cann-acs.org
Monica Vialpando, PhD - Cannabis For Athletes CANN - Cannabis Chemistry Subdivision of ACS 2020-11-29 | This talk will provide a scientific rationale for the integration of cannabis to enhance a range of sports. Emphasis will be placed on lung function and inhalation safety using a variety of product examples and cannabinoid types to support athletic performance and recovery.
Kevin Boehnke, PhD-Pills to Pot? Investigating the evidence for cannabinoids as an opioid substitute CANN - Cannabis Chemistry Subdivision of ACS 2020-11-11 | Kevin Boehnke is a Research Investigator in the Department of Anesthesiology and the Chronic Pain and Fatigue Research Center at the University of Michigan. He is also a yoga instructor. His current research interests include cannabinoid analgesia, cannabis as an opioid substitute in chronic pain, and self-management strategies for pain, such as yoga. Kevin completed his BS in Biology at the University of Michigan, and received his doctorate from the University of Michigan School of Public Health in Environmental Health Sciences in 2017. He joined the CPFRC in 2017, and currently leads several studies examining the effects of cannabis and cannabinoids on chronic pain.
Robert Strongin- The Chemistry of Cannabis Vaping CANN - Cannabis Chemistry Subdivision of ACS 2020-11-04 | Robert M. Strongin, PhD is a Professor of Organic Chemistry at Portland State University. He has studied the chemistry of vaping since 2013. Dr. Strongin is interested in determining how vape constituents behave when heated and aerosolized. In 2017 he began to investigate cannabis vaping and has published the first peer-reviewed report on the specific byproducts formed when dabbing terpenes, and more recently on the reactions and products that form upon vaping and dabbing concentrated cannabis oil mixtures. Dr. Strongin runs an internationally recognized research program, is a founder of two biotech startup companies, and is known for his contributions to STEM education and diversity. In addition to tobacco control and cannabis science, he is an expert in the field of biosensors and targeted molecular probes for imaging cancer tissue.
Shannon Swantek- Cannabis Supply Chain Best Practices:Adding Value and Controlling Risk CANN - Cannabis Chemistry Subdivision of ACS 2020-11-04 | This presentation will detail best practices in supply chain processes witha risks and opportunity data-based approach. It will cover supplier evaluationand qualification, supply chain sampling and testing considerations, and setting supply specifications in contracts.Shannon Swantek is the principal scientist and CEO of Enlightened QualityAnalytics who holds broad knowledge of the cannabis, natural medicine,and environmental industries. Shannon drafted some of the first cannabislegislation and significantly contributed to laboratory regulations in bothOregon and Massachusetts. She was also responsible for the creation andmanagement of Oregon’s Cannabis Laboratory Accreditation Program.In this position, she was the main point of contact for Oregon cannabislaboratories and provided extensive training on good practices to preparefor the new regulations in addition to advising on cannabis policy, legisla-tion, and education nationwide in recent years. These early efforts led toShannon’s passion for industry education and providing diverse supportto license-holders. She strives to reduce product risk and ensure accu-rate data for clients in developing technical and quality systems solutionsthroughout the maturing industry. Shannon also brings extensive regula-tory and private experience in auditing to ISO 9001, ISO 17025, TNI, andcGMP requirements.
Rod Kight, JD - Cannabis and Cars - A Discussion of the Scientific and Legal Issues CANN - Cannabis Chemistry Subdivision of ACS 2020-11-03 | Cannabis and Cars - A Discussion of the Scientific and Legal Issues Raised by Driving and Cannabis UseRod is a cannabis business law attorney who represents legal cannabis businesses throughout the world. He is a prolific author serving as editor and chief writer of the Kight on Cannabis law blog, contributing legal perspective to the American Journal of Endocannabinoid Medicine, and publishing the book “Cannabis Business Law-What You Need to Know”, in 2015. He is frequently interviewed on cannabis matters by major media outlets including the Wall Street Journal, Time, Business Insider, and Business Insurance. Rod is an attorney advocate for NORML. He is also a member of the International Cannabis Bar Association, the National Cannabis Industry Association, Women Grow, the Hemp Industries Association, and the North Carolina Industrial Hemp Association. Rod has been a presenter on cannabis legal issues at seminars across the country. He has also drafted and presented cannabis legislation to a foreign head of state.
Monica Taing, PharmD- Balancing Cannabis with Complementary & Alternative Medicine During COVID-19 CANN - Cannabis Chemistry Subdivision of ACS 2020-11-03 | Monica Taing, PharmD presenting: “Balancing Cannabis with Complementary & Alternative Medicine (CAM) Considerations During COVID-19”This session will review the basics of cannabis pharmacology & types of CAM, outline important safety points for optimizing immune system function & mental health, and will detail harm reduction strategies for dosing considerations.Monica Taing, PharmD, RPh graduated from Northeastern University where she gained academic experience in Endocannabinoid Receptor System research. Dr. Taing is a clinical cannabis consultant for licensed dispensaries, hospital systems, and academic medical institutions in multiple states. She is a spokesperson, and the first pharmacist, appointed to the Board of Directors of Doctors for Cannabis Regulation (DFCR), the National Director of Research & Clinical Education for Minorities for Medical Marijuana (M4MM), a clinical consultant specialist for Columbia University's Northeast/Caribbean AIDS Education Training Center (NEC-AETC), and sits on the Editorial Board of the American Journal of Endocannabinoid Medicine (AJEM). Dr. Taing is passionate about clinical research, patient counseling, public health education, multidisciplinary clinical outreach, and harm reduction advocacy for underserved patient populations.
Susan Audino - Bringing Clarity to Under-Appreciated Numbers CANN - Cannabis Chemistry Subdivision of ACS 2020-09-28 | ...
Linda Klumpers- Cannabis Antagonists: Disgraceful Downfall, Promising Prospects CANN - Cannabis Chemistry Subdivision of ACS 2020-09-28 | "Wonder Pills" against obesity and substance abuse abruptly disappeared from the market over a decade ago, researchers now try to revive them for new applications.Dr. Linda Klumpers grew up in the Netherlands and completed a PhD in Clinical Pharmacology at Leiden University Medical Center. Her research focused on Clinical Pharmacology of Cannabinoids. Dr. Klumpers has been studying cannabinoids in humans since 2006 and has authored various peer-reviewed cannabinoid publications including primary literature and book chapters. Her work received five honors and awards, including the BJCP Prize, handed out by the British Journal of Clinical Pharmacology. In 2016 Dr. Klumpers founded Cannify to help patients and clinicians with product and science matching via an online tool as well as customized cannabis education. In 2018, Dr. Klumpers formed Verdient Science in partnership with Clinical Pharmacologist Dr. Michael Tagen.
Julia Bramante- Cannabis & Professionalism Meet at the Worlds Largest Scientific Society CANN - Cannabis Chemistry Subdivision of ACS 2020-03-09 | February Journal club we have our incredible Chairwoman Julia Bramante revealing the advances of CANN within the largest scientific society; latest advances in other societies and organizations to drive legitimacy and scientific developments in cannabis. Julia Bramante is the Chair of the Cannabis Chemistry Subdivision at the American Chemical Society, a position she has held since January 2019. She also serves as Lead Scientist at the Colorado Department of Public Health and Environment’s Marijuana Reference Laboratory. Prior to entering that role Julia was instrumental to the success of Gobi Labs, one of the first three certified marijuana testing labs to open in Colorado following recreational legalization in 2014. Additionally, she serves as Chair of the CASP Microbial Contaminants Working Group at AOAC International.CANN’s Journal Club is the only international cannabis chemistry webinar of its kind. Journal club focuses on recent peer reviewed publications in the cannabis science space and is open to the public free of charge. Presentations are often made by publication authors themselves. This provides an excellent opportunity for audience members to learn from and interact with leading cannabis scientists.
Mahmoud A. ElSohly, Ph.D- Analytical Methods Used at ElSohly Labs, Inc. CANN - Cannabis Chemistry Subdivision of ACS 2020-01-30 | Analytical Methods Used at ElSohly Labs, Inc., for the Quantitation of Various Cannabinoids in Cannabis Biomass and ExtractsMahmoud A. ElSohly, Ph.D., is President and Laboratory Director of ElSohly Laboratories, Inc. He serves as Research Professor at the National Center for Natural Products Research and Research Institute of Pharmaceutical Sciences, and Professor of Pharmaceutics at the School of Pharmacy at the University of Mississippi. Dr. ElSohly is also the Director of the Marijuana Project at the University of Mississippi, which is funded by the National Institute on Drug Abuse. He holds over 30 patents and has authored over 250 scholarly articles.CANN’s Journal Club is the only international cannabis chemistry webinar of its kind. Journal club focuses on recent peer reviewed publications in the cannabis science space and is open to the public free of charge. Sessions are held monthly and broadcast via webinar on Zoom. Presentations are often made by publication authors themselves. This provides an excellent opportunity for audience members to learn from and interact with leading cannabis scientists.
Why the Entourage Effect Matters for Cannabis Vapor Regulations- Brad Douglass, PhD CANN - Cannabis Chemistry Subdivision of ACS 2019-12-16 | November 7th, 2019“Cannabis vapor [flavor] additives can be evaluated using a similar framework and structure (both administrative & scientific) that was created by the Food Extract Manufacturer’s Ass’n (FEMA) to assess food flavor ingredients for safety over a half-century ago”.CANN’s Journal Club is the only international cannabis chemistry webinar of its kind. Journal club focuses on recent peer reviewed publications in the cannabis science space and is open to the public free of charge. Presentations are often made by publication authors themselves. This provides an excellent opportunity for audience members to learn from and interact with leading cannabis scientists.
Alexandros Makriyannis, PhD- Cannabinoid Receptors: Structures, Functions and History CANN - Cannabis Chemistry Subdivision of ACS 2019-12-16 | October 17th, 2019Although a number of cannabinoid analogs had been synthesized beginning in the 1960’s, the discovery of the first cannabinoid receptor (CB1) took several decades. This happened through the joint efforts of a number of laboratories, and it involved the use of photoaffinity labelling of radioligands and imaging. The need for obtaining structural information on both CB1 and CB2 to serve as templates in target-based discovery led to computational efforts based on mutational studies for receptor modeling. More extended structural work involving the use of covalent ligands, targeted mutations and proteomic approaches in our laboratory, under the designation of Ligand Assisted Protein Structure (LAPS), provided more detailed experimental data and identified helix 6 in both receptors as being a key site involved in their activation/deactivation, validating some of the earlier computational efforts. An intensive effort involving Scripps, iHuman in Shanghai, and our laboratory, the Center for Drug Discovery led to the crystal structure of the CB1 receptor, first in its inactive form using a suitably designed antagonist for crystallization and subsequently in its activated form, using two irreversible agonists. This work provided detailed information on the binding motif of CB1 ligands . It also validated the concept of a double-toggle (HX6 – Hx3) mechanism of activation. These first two successes were followed by the very recent crystallization of the CB2 receptor, which provided some initial evidence for the complementarity of the two receptors and introduced the activation/deactivation(ying-yang)receptor concept, which now serves as a basis for the development of CB2 agonist/CB1 antagonist therapeutic medications.The availability of detailed structural information of a number of CB1 and CB2 ligand complexes, coupledwith data on ligand-receptor dynamics, opens the door for the design of cannabinergic drugs with greater structural and functional specificity.
Ethan Russo, MD: No Strain, No Gain September 2019 CANN Journal Club CANN - Cannabis Chemistry Subdivision of ACS 2019-09-23 | September 19th, 2019“The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No 'Strain', No Gain”, featuring Dr. Ethan Russo.Dr. Ethan Russo is a board-certified neurologist with specialization in child neurology and 20 years of experience in clinical practice. In 2003 Dr. Russo began work with GW Pharmaceuticals developing prescription pharmaceuticals from the cannabis plant. In 2015 he became medical director of PHYTECS, a company focused on optimizing the function of the endocannabinoid system. Currently Dr. Russo serves as the Director of Research and Development at the International Cannabis and Cannabinoids Institute. He is also a prolific writer and is commonly published cannabis related research in peer reviewed journals.
