What is Kinesin? Ron Vale Explains UC San Francisco (UCSF) 2018-04-02 | Ron Vale explains the inner workings of the motor protein called kinesin (“kin-EE-sin”) that transports vital components within cells and also separates chromosomes during cell division. He discovered kinesin when he was at Woods Hole, MA and continued his kinesin research at UCSF.
Treating Rare Genetic Diseases - In Utero UC San Francisco (UCSF) 2022-11-09 | A UCSF clinical trial to treat patients with certain genetic diseases prenatally is showing success.The trial aims to determine the the maternal and fetal safety and feasibility of in utero enzyme replacement therapy in fetuses with Lysosomal Storage Diseases.The trial is being led by Dr. Tippi MacKenzie, a pediatric and fetal surgeon who is focused on developing better ways to diagnose and treat genetic diseases before birth.Diseases included in this trial:Mucopolysaccharidosis type 1Mucopolysaccharidosis type 2 - (Hunter syndrome)Mucopolysaccharidosis type 4aMucopolysaccharidosis type 6Mucopolysaccharidosis type 7Infantile-onset Pompe disease (IOPD)Neuronopathic Gaucher disease (types 2 and 3)Wolman diseaseFor more info about the trial or to enroll:https://clinicaltrials.ucsf.edu/trial/NCT04532047UCSF Center for Maternal-Fetal Precision Medicine:https://mfprecision.ucsf.edu/UCSF Lysosomal Storage Disease Center:ucsfhealth.org/clinics/lysosomal-storage-disease-center
Breaking Barriers: Pioneering of Artemis-SCID Gene Therapy UC San Francisco (UCSF) 2022-11-04 | Artemis-SCID is a severe form of immunodeficiency caused by mutations in a specific gene. A simple infection can easily kill children with Artemis-SCID in their first year of life if it is left untreated. Even with a bone marrow transplant – the current standard treatment – children with SCID often fail to develop a normal immune system and require repeated infusions to stay alive.UCSF Pediatrics professors Morton Cowan, MD, and Jennifer Puck, MD, are leading a clinical trial that involves transferring a normal copy of the mutated gene into patients’ own stem cells. The study aims to determine whether the procedure is safe, feasible and results in a normal immune system up to 15 years later.For more info: https://clinicaltrials.ucsf.edu/trial/NCT03538899
UCSF - San Joaquin Valley Program in Medical Education UC San Francisco (UCSF) 2022-11-03 | SJV PRIME offers medical students the opportunity to work in the San Joaquin Valley with highly underserved populations at the individual and community levelsIt incorporates the unique expertise of UCSF, UC Merced, and UCSF faculty at UCSF Fresno, as researchers, educators and leaders in the field of health care in the Valley.— more info — https://meded.ucsf.edu/ucsf-san-joaquin-valley-prime-sjv-prime
2022 State of the University Address || Science + Service UC San Francisco (UCSF) 2022-11-03 | UCSF Chancellor Sam Hawgood delivers his ninth annual State of the University Address. The chancellor will reflect upon and highlight accomplishments from 2022 and frame his remarks around UCSF's four priorities: fostering innovation, forging partnerships, ensuring financial resiliency and empowering our people.
Bark to Peak - Connecting Golden Gate Park to Mt. Sutro Open Space Reserve UC San Francisco (UCSF) 2022-10-04 | More information about the Comprehensive Parnassus Heights Plan can be found here:https://www.ucsf.edu/cphp
2022 UCSF Medals || The Black Caucus UC San Francisco (UCSF) 2022-09-22 | UC San Francisco has bestowed its highest honor, the UCSF Medal, to Freeman Bradley, Charles Edgar Clary, and David Johnson — Three co-founders of the Black Caucus who fought for racial equality. We honor three Black men who co-founded the Black Caucus in May 1968 to advocate for equal opportunity and treatment at UCSF. The janitors strike they organized was a catalyst for institutional change that resulted in improved recruitment and retention of historically underrepresented faculty, staff and students. Current leaders of the Black Caucus strive to uphold the legacy of its founding members.Freeman Bradley worked at UCSF’s Cardiovascular Research Institute, where he conducted research on respiratory issues concerning anesthesia and eventually became director of the Research and Development Lab at UCSF.Charles Edgar Clary joined UCSF as a radiologic technician, served as educator during the HIV/AIDS epidemic and became a leader in his profession and spokesperson for the American Cancer Society as a prostate cancer survivor.David Johnson was a longtime activist and public servant who worked in UCSF’s personnel department, learned photography from Ansel Adams and was recognized for this work by the NAACP.Learn more here:www.ucsf.edu/news/2022-ucsf-medals
2022 UCSF Medals || David Julius UC San Francisco (UCSF) 2022-09-22 | We recognize the accomplishments of a UCSF scientist who has contributed to the understanding of key mechanisms of how people sense heat, cold and touch. His work epitomizes the very best of UCSF science, using his curiosity about the natural world to remarkable success. His award-winning work confirms the importance of basic research — work that strives to understand the basic underpinnings of human physiology — to ultimately advance health.David Julius, PhD, is professor and chair of the Department of Physiology and Morris Herzstein Chair in Molecular Biology and Medicine and shared the 2021 Nobel Prize in Physiology or Medicine for co-discovering receptors for temperature and touch.www.ucsf.edu/news/2022-ucsf-medals
2022 UCSF Medals || Jennie Chin Hansen UC San Francisco (UCSF) 2022-09-22 | Jennie Chin Hansen, RN, MSN, FAAN, has been a dedicated advocate for the care of older adults, an alumna of the UCSF School of Nursing and a national leader in geriatric care, serving as president of AARP.We salute an influential national leader dedicated to improving the health and care of older adults. Her contributions include serving as CEO of the American Geriatric Society and president of the AARP and advancing holistic care for seniors in San Francisco. She led a pioneering a program that made it possible for older adults to receive comprehensive medical and social services at home instead of a nursing home. This program is now a federally established Medicare benefit that has been replicated in 31 states.https://www.ucsf.edu/news/2022-ucsf-medals
Why Do Chili Peppers Make You Sweat? UC San Francisco (UCSF) 2022-08-02 | Learn more about how David Julius and Ardem Patapoutian’s Nobel-winning discoveries are illuminating how we sense the world in UCSF Magazine: http://tiny.ucsf.edu/Nobel
UCSF Weill Institute for Neurosciences Overview UC San Francisco (UCSF) 2022-06-28 | Learn more at https://weill.ucsf.edu
Community Construction Outreach Program: Christopher Quinteros Story UC San Francisco (UCSF) 2022-05-04 | Since the program’s inception in 2011, The Community Construction Outreach Program (CCOP) has placed over 1,600 local hires on 15 capital projects across all UCSF campuses.C The program was created to provide job opportunities for individuals in our community who are skilled in or want to learn more about construction trades. This is one story of a participant in the program.You can learn more about the program here: https://www.ucsf.edu/cgr/cgr-projects/workforce-development
Community Construction Outreach Program: Lynna Vongs Story UC San Francisco (UCSF) 2022-05-04 | Since the program’s inception in 2011, The Community Construction Outreach Program (CCOP) has placed over 1,600 local hires on 15 capital projects across all UCSF campuses.C The program was created to provide job opportunities for individuals in our community who are skilled in or want to learn more about construction trades. This is one story of a participant in the program.You can learn more about the program here: https://www.ucsf.edu/cgr/cgr-projects/workforce-development
2022 Last Lecture with Dr. D’Anne Duncan UC San Francisco (UCSF) 2022-04-07 | D'Anne Duncan, PhD is UCSF’s first Assistant Dean for Diversity and Learner Success in the Graduate Division and is an adjunct assistant professor in the Department of Social and Behavioral Sciences. She has advocated for and worked closely with students to advance institutional change at UCSF since 2017. In 2020-21, Dr. Duncan conceived of, designed, and launched the first-ever Justice, Equity, Diversity, and Inclusion (JEDI) Academic Leadership course, aimed at educating and training students on the value and implications of centering diversity, equity, inclusion, and justice in education and research. Dr. Duncan’s research at UCSF transforms the student experience – with an emphasis on supporting graduate students from historically marginalized and underrepresented backgrounds – through institutional interventions founded upon personal and professional identity alignment, and principles of mentorship, community building and belonging.Dr. Duncan earned her PhD in neuroscience from Northwestern University and pursued her postdoctoral training in visual neuroscience at Vanderbilt University. Dr. Duncan has an established history of designing and offering professional development opportunities to advance PhD education and training for biomedical scientists. Dr. Duncan draws on her training in neuroscience and expertise in academic administration to identify the intersections of biological systems and apply them in an academic administrative capacity, with a goal of creating tangible and deliberate systemic changes capable of improving the student experience at UCSF and throughout academia. She specifically utilizes the science of how to cultivate relationships with students in order to advocate for and train a new generation of leaders, and to challenge academia’s status quo. Dr. Duncan is the 2021 recipient of the ImmunoDiverse Community Award. She is nationally recognized for her work at UCSF, and has been featured in Science Careers “A Day in the Life of an Assistant Dean.”
UCSF Management of Mount Sutro UC San Francisco (UCSF) 2022-01-19 | UCSF is moving into the fourth year of its Mount Sutro Vegetation Management Plan. UCSF’s top priority is to ensure the safety of the Reserve for our residents, patients, visitors, campus buildings and neighboring homes.Learn more: https://www.ucsf.edu/about/locations/mount-sutro-open-space-reserve
Documenting Asylum Seekers Stories UC San Francisco (UCSF) 2021-12-21 | The UCSF Human Rights Collaborative provides free forensic medical evaluations for people who have fled extreme violence or persecution in their home countries and are seeking asylum in the United States.To learn more, visit https://magazine.ucsf.edu/body-tells-story
How To Identify the Scars of Torture UC San Francisco (UCSF) 2021-12-21 | Asylum-seekers' scars often are the only material evidence they possess of the torture they endured. UCSF's Coleen Kivlahan, MD, MSPH, describes how clinicians use forensic science to tell the stories behind the scars.To learn more, visit magazine.ucsf.edu/body-tells-story
Topological Network Analysis of Blood Pressure in Spinal Cord Injuries UC San Francisco (UCSF) 2021-11-16 | Using machine intelligence, UCSF researchers found that patients with new spinal cord injuries whose blood pressure is maintained within a newly defined range might stand a better chance of regaining some mobility. Video credit: Adam Ferguson, PhD, and Abel Torres-Espin, PhD
UCSF Partnerships to Vaccinate the Bay Area UC San Francisco (UCSF) 2021-11-08 | During the COVID-19 pandemic, UCSF has partnered with public health agencies, nonprofit groups and the community, to drive vaccination efforts across the Bay Area, especially to underserved populations and communities.
Hope for a Cure: Treating Sickle Cell Disease with CRISPR UC San Francisco (UCSF) 2021-11-08 | UCSF Benioff Children’s Hospital Oakland has one of the premiere centers in the nation for Sickle Cell treatment and has been at the forefront of advancing the research for better treatments and a cure for over 45 years. A sickle cell-CRISPR gene therapy clinical trial – a partnership with UCSF, UCLA and UC Berkeley – will be the first human trial using CRISPR gene editing technology to replace mutated blood cells with edited cells – a potential cure for sickle cell.
UCSF 2021 State of the University Address UC San Francisco (UCSF) 2021-10-21 | In his address titled “Catalyst,” Chancellor Hawgood will describe how the UCSF community has continued to pursue innovation across research, education, care delivery, and public service despite the challenges of the pandemic.
Nobel Laureate David Julius: Behind the Scenes and Celebrations UC San Francisco (UCSF) 2021-10-08 | There were early-morning phone calls, media interviews, celebrations with his lab and champagne toasts for UCSF's David Julius after receiving the 2021 Nobel Prize in Physiology or Medicine jointly with Ardem Patapoutian, PhD, a professor in the Department of Neuroscience at Scripps Research.On Oct. 4, 2021, the researchers received the prize “for their discoveries of receptors for temperature and touch,” according to the Nobel committee in Stockholm, Sweden.Read more about David Julius and his work: https://www.ucsf.edu/news/2021-nobel-prize-physiology-or-medicine-david-julius
What is Whole Genome Sequencing? UC San Francisco (UCSF) 2021-10-08 | UCSF’s 3D Health study heralds a future where we'll be able to predict and prevent the vast majority of human diseases. Information from your genome, your environment, your gut microbiome, and other factors will create a knowledge network that will advance new scientific discoveries and help predict disease risk.Learn more at http://tiny.ucsf.edu/mYS79N.
UCSF Chancellor Hawgood in Conversation with US Senator Padilla UC San Francisco (UCSF) 2021-10-07 | UCSF Chancellor Sam Hawgood welcomes special guest U.S. Senator Alex Padilla to a conversation with UCSF about recent tenure as the first Latino to serve California in the U.S. Senate, leadership during his longstanding service to California, policy implications of health and other disparities magnified by COVID-19, how to promote diversity in STEM and science policy advocacy. Alicia Fernandez, MD, with the Latinx Center of Excellence and Anuvir Singh with the UCSF School of Medicine PRIME-Urban Underserved pose questions on behalf of the greater UCSF community.
Personalized Deep Brain Stimulation Therapy (DBS) UC San Francisco (UCSF) 2021-10-04 | UCSF Health physicians have successfully treated a patient with severe depression by tapping into the specific brain circuit involved in depressive brain patterns and resetting them using the equivalent of a pacemaker for the brain.
“Neuroprosthesis” Restores Words to Man with Paralysis UC San Francisco (UCSF) 2021-07-14 | Researchers at UC San Francisco have successfully developed a “speech neuroprosthesis” that has enabled a man with severe paralysis to communicate in sentences, translating signals from his brain to the vocal tract directly into words that appear as text on a screen.
UCSF Earth Day Town Hall UC San Francisco (UCSF) 2021-07-01 | In honor of Earth Day 2021, UCSF hosted its first ever town hall highlighting its commitment to environmental sustainability and how the UCSF community can support UC's carbon neutrality goal. Chancellor Sam Hawgood and other leaders discussed current initiatives to reduce carbon emissions, address climate health equity, improve environmental health, and incorporate greener designs in existing and new campus construction. Panelists also shared unexpected environmental silver linings from UCSF’s response to the COVID-19 pandemic in business travel, telehealth and energy savings.
Next-Generation T-Cell Therapeutics Set Sights on Cancers, Autoimmune Disorders and More UC San Francisco (UCSF) 2021-07-01 | T cells – immune cells that patrol our bodies in search of trouble -- have become a central focus for UC San Francisco scientists working on living cell therapies, an approach that views cells themselves as a form of medicine.T cells actually include a diverse group of cells with specialized roles. So-called killer T cells attack foreign invaders, while helper T cells release signals to orchestrate the overall immune response. Once a threat is neutralized, another subset — the regulatory T cells, produce anti-inflammatory factors that shut down the immune response. T cells’ range of behaviors and their ability to survive for years in our bodies have made them attractive candidates for living cell therapies. UCSF researchers are finding ways to modify T cells to enhance our immune response against cancers and viral infection and to quiet our immune response in autoimmune disorders. Harnessing the power of the body’s own systems to create adaptive therapeutics is at the core of the University’s new Living Therapeutics Initiative, which will provide new facilities, resources and leadership in this area.Additional video provided by Alex Ritter
The Body’s ‘Bugs’ as Medicine UC San Francisco (UCSF) 2021-07-01 | Plenty of probiotic yogurts, pickles, and kombuchas claim to boost our digestive health with armies of microbes, but some scientists have more ambitious therapeutic plans for the “bugs” that colonize us. They hope to leverage these microbes as “living therapeutics” for a range of health conditions, including ulcerative colitis, multiple sclerosis, eczema, and asthma. Our guts, skin, and other regions of the body harbor trillions of microbes, as many as we have cells of our own. Each of these microbes – bacteria, viruses, microscopic fungi, and others – that make up the human microbiome brings with it a unique genome. The composition of our microbiome – and its microbial pan-genome – is shaped by diet and environment, which in turn affect its important influences on human physiology, from digestion to brain health to immune function.
馬鎮邦醫學教授敦促接種新冠疫苗 UC San Francisco (UCSF) 2021-06-14 | 加州大學舊金山分校的外科醫生馬鎮邦教授敦促市民盡快接種新冠疫苗，提醒別被許多詆毀該疫苗的不實社交媒體信息誤導https://coronavirus.ucsf.edu/vaccines/psas
Living Therapeutics Initiative Will Accelerate Revolutionary Treatments UC San Francisco (UCSF) 2021-06-10 | UC San Francisco is launching a new initiative to propel the development of living therapeutics – a category of treatments broadly defined as living cells and microbes that are selected, modified, or engineered to treat or cure disease – and bring them quickly to patients.The Living Therapeutics Initiative (LTI) will bring together UCSF’s vast scientific and clinical expertise to accelerate research and quickly advance promising therapies to clinical trials for patients who have few, if any, good treatment options. As a federation of previously established UCSF initiatives, disciplines, and departments, the LTI will allow disparate research and patient-care programs to share information, tools, and platforms. As early as this fall, the initiative will make $50 million in philanthropic funding available, in the form of competitive grants, to UCSF faculty pursing living-therapeutics projects.
UCSF: 40 Years of AIDS UC San Francisco (UCSF) 2021-06-10 | In 1981, a mysterious illness began overwhelming the San Francisco community. Since those early days of the epidemic, UCSF has steadfastly been at the forefront of patient care, research and community partnerships in the battle against HIV and AIDS.Read more: http://tiny.ucsf.edu/AIDS40
2021 UCSF Founders Day Virtual Awards Celebration UC San Francisco (UCSF) 2021-05-25 | Chancellor Sam Hawgood celebrated the outstanding efforts of the 2021 Founders Day Award recipients, recognizing these individuals who embody our UCSF PRIDE values and demonstrate a strong dedication to advancing health, community and diversity. For more information about the awards, recipients and event details, read the story on UCSF.edu: http://tiny.ucsf.edu/XjuhpP.
Brain wave recording reveals potential for new Parkinson’s disease treatments UC San Francisco (UCSF) 2021-05-03 | Pioneering long-term wireless neural recordings in patients with Parkinson’s disease by UC San Francisco scientists lays the groundwork for personalized brain stimulation to treat Parkinson’s and other neurological disorders. In a study published today online in Nature Biotechnology, UCSF Weill Institute for Neurosciences researchers implanted novel neurostimulation devices that monitor brain activity for many months, with and without deep brain stimulation therapy. Pairing the brain recordings with wearable monitors of movement, they identified patterns of brain activity corresponding to specific movement abnormalities. Their research provides the first evidence, during normal activities of daily living, for a long-held hypothesis that Parkinson’s symptoms are related to erratic brain wave patterns, and demonstrate how DBS restores order to patient brain waves.
Smart Cell Therapies for Solid Cancers UC San Francisco (UCSF) 2021-04-28 | Immunotherapies that fight cancer have been a life-saving advancement for many patients, but the approach only works on a few types of malignancies, leaving few treatment options for most cancer patients with solid tumors. Now, in two related papers published in Science Translational Medicine on April 28, 2021, researchers at UCSF have demonstrated how to engineer smart immune cells that are effective against solid tumors, opening the door to treating a variety of cancers that have long been untouchable with immunotherapies. By “programming” basic computational abilities into immune cells designed to attack cancers, the researchers have solved three major concerns that have kept these strategies out of the clinic up to now. The two new papers show that the resulting smart therapies are more precise, flexible and thorough than previous approaches, and the researchers say they’re convinced that the system is ready for clinical trials.
Smart Immune Cells for Glioblastoma UC San Francisco (UCSF) 2021-04-28 | Lim Lab video showing smart immune cells hunting brain cancer cells.
