Grape seed extract - new senolytic extends lifespan? The Sheekey Science Show 2021-12-15 | “Here we show that procyanidin C1 (PCC1), a polyphenolic component of grape seed extract (GSE), increases the healthspan and lifespan of mice through its action on senescent cells.”So, in this video, we take a look at the research in this recent publication regarding a potential new senolytic compound to add to the others including fisetin and dasatinib & quercetin. As well as my thoughts.. is this the next new senolytic? Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Senescent cells - 00:30New senolytic from grape seed extract - 02:20Thoughts - 06:10REFERENCES:Xu, Q., Fu, Q., Li, Z. et al. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nat Metab (2021). https://doi.org/10.1038/s42255-021-00491-8 Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Follistatin - why is this the new longevity trend? The Sheekey Science Show 2024-02-13 | Muscle loss, also known as sarcopenia, is a natural part of aging that occurs due to various factors, such as reduced physical activity, hormonal changes, and protein deficiency. Muscle loss can lead to weakness, mobility problems, falls, fractures, and increased risk of chronic diseases.There are also various genetic diseases that result in muscle loss and reduced function and hence much research has been conducted to find therapeutic solutions focusing on myostatin and follistatin. We'll take a look at a mouse study that saw longevity benefits following follistatin gene therapy and some clinical trials in development.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPSIntro - 00:00Myostatin - 00:55Follistatin - 02:11References:McPherron, A., Lawler, A. & Lee, SJ. Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member. *Nature* **387**, 83–90 (1997). https://doi-org.ezp.lib.cam.ac.uk/10.1038/387083a0New intranasal and injectable gene therapy for healthy life extension - https://doi.org/10.1073/pnas.2121499119Follistatin-induced muscle hypertrophy in aged mice improves neuromuscular junction innervation and function - https://doi.org/10.1016/j.neurobiolaging.2021.03.005 Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates - https://doi.org/10.1126/scitranslmed.3000112Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Should we be measuring biological age? - Aaron King (Complete interview) The Sheekey Science Show 2024-01-06 | In this video, I spoke with Aaron King who recently built AgeRank, a tool that shows how various biomarkers change with age. From here we discuss the use-case of biological age, the implications of aging research, and the possibility of reversing aging in the future.AgeRank - https://agerank.com/ Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTimestamps:Intro - 00:00AgeRank - 00:36Biological Age - 14:20Bryan Johnson - 17:45Reversing Aging - 23:00Germline - 28:00Knowledge collection - 37:30Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
This years biggest breakthroughs in longevity (2023 edition) !!! The Sheekey Science Show 2023-12-31 | Every year I compile what I think were some important contributions to longevity research. Here is my list for 2023.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowIntro - 00:00What causes aging? - 00:32Hallmarks Of Aging: An Expanding Universe The DREAM Complex Functions As Conserved Master Regulator Of Somatic DNA-Repair Capacities Biomarkers - 02:00The Aging Biomarker Consortium Represents A New Era For Aging Research In ChinaLongitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clockA Foundation Model For Generalizable Disease Detection From Retinal ImagesCellular reprogramming - 04:30Chemically induced reprogramming to reverse cellular agingLoss of epigenetic information as a cause of mammalian agingIn vivo reprogramming leads to premature death linked to hepatic and intestinal failureLifespan extension - 07:30Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules usedTaurine deficiency as a driver of agingDietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female miceOptogenetic Rejuvenation Of Mitochondrial Membrane Potential Extends C. Elegans LifespanReversal Of Biological Age In Multiple Rat Organs By Young Porcine Plasma FractionMulti-Omic Rejuvenation And Life Span Extension On Exposure To Youthful CirculationBiotechnology - 13:50Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissuesIntradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapyWhy we age - 15:15Ageing as a software design flawThe Longevity Bottleneck Hypothesis: Could Dinosaurs Have Shaped Ageing In Present‐Day Mammals?Reconsidering Life History Theory Amid Infectious DiseasesBlood Group A Enhances SARS-CoV-2 InfectionWhat's next? - 16:50There are many items missing from this list - these are only the papers I found time to read. Please post below any I missed! ICYMI2022 longevity papers2021 longevity papersPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
The Power of Language - how communication influence our lives (Viorica Marian) The Sheekey Science Show 2023-12-24 | Here I spoke with Viorica Marian, Professor of Psychology at Northwestern University, and is the Principal Investigator of the Northwestern Bilingualism and Psycholinguistics Research Laboratory. Most recenetly Prof Marian published her excellent book “The power of language” which i read earlier this year that discusses how languages change the way we percieve the world as well as the benefits of bilingualism. Here we discuss many of these topics and more. I hope you enjoy.Find out about Viorica's book here - https://www.poweroflanguagebook.com/ Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPSIntro - 00:00Languages - 01:00Benefits of bilingualism - 07:15Creativity - 22:30Language learning - 28:30Psycholinguistics - 37:00Scientific progress - 43:00Large language models (LLMs) & AI - 49:30Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
what i read this year (2023 edition) The Sheekey Science Show 2023-12-19 | Here are my quick thoughts on all the books i read this year, both fiction & non-fiction.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Can taurine and vitamin B12 improve your health? - Vijay Yadav The Sheekey Science Show 2023-12-16 | In this video I spoke with Vijay Yadav, Assistant Professor at the Department of Genetics and Development at Columbia university researching functional connections between human metabolism and disorders. Earlier this year his team published on the role of taurine and how supplementation in a mouse models improved many markers of health. Here we discuss Vijay’s interest and research further.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Early work in reproductive endocrinology - 01:00Vitamin B12 - 08:00Taurine - 19:00Human clinical trials - 41:30Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
ResearchHub - The future of science publishing and funding? - Cole Delyea The Sheekey Science Show 2023-12-09 | In this discussion i spoke with Cole Delyea, a fellow youtuber @InvestigateExploreDiscover , with a background in immunology. However, here we discuss Cole’s involvement with ResearchHub - a platform that is changing the way in which scientific research can be accessed and funded, as you will shortly find out.ResearchHub - https://www.researchhub.com/ Follow Cole's progress - https://www.researchhub.com/hubs/lettuce-growth-and-music-data?sort=newFind me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00ResearchHub - 01:30Independent Science - 10:00Funding science - 17:30Peer review - 22:30Future of science publishing - 25:00Reputation - 30:00Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Win $101,000,000 if you solve aging? The Sheekey Science Show 2023-12-02 | Friend: Hey Sheekey, have you heard the news?Sheekey: No, what news?Friend: About the XPrize…if you find a solution to aging, you get a really big prize!Sheekey: Oh really, you’ve told the right person, tell me more!Friend: Well, it’s called the Healthspan Prize, and it’s the largest competition in history with a prize of $101,000,000 if you win. It’s running for **7-years aiming to revolutionize the way we approach human aging.**whether i form a team or only facilitate connections with viewers, fill out this form if you want to join - https://forms.gle/1uDRErvDKo6fGiic9 😊More details on the XPrize website:Video clips from @peterdiamandis https://www.youtube.com/watch?v=whV2P53qm_U Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Solving global problems with synthetic biology - Tae Seok Moon (full interview) The Sheekey Science Show 2023-11-25 | Tae Seok Moon is an associate professor of energy, environmental and chemical engineering at Washington University in St. Louis. He is an expert in synthetic biology, metabolic engineering, and protein engineering. Using synthetic biology, Tae Seok has been engineering probiotic bacteria for medical applications, bacteria to consume plastic and building biocontainment circuits and other global problems.Find Tae Seok on Twitter - https://twitter.com/Moon_Synth_Bio Tae Seok runs a YouTube channel hosting symposiums - https://www.youtube.com/@UCTkyl4Uw1NlpuLCeP4Zi8aA Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Synthetic biology - 01:30Plastic - 10:00Probiotics - 25:00Biocontainment - 40:00Advice - 56:00Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Would you live in a state prioritizing longevity? The Sheekey Science Show 2023-11-18 | Would you live somewhere if the central mission of the state is to “make death optional”? Vitalia is a movement to start a longevity network society—a multi-jurisdiction society built around the idea that “life is good, death is bad”. The movement aims to create a new kind of society that is focused on extending human lifespan and improving the quality of life for everyone.https://wiki.vitalia.city/ https://www.vitalia.city/ Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Network States - 01:15What is Vitalia? - 02:00Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
How social isolation can impact your health. The Sheekey Science Show 2023-11-11 | At times we can feel lonely and social isolation can affect you at any age at any time. While I often focus on the physical and mental links to health, today we will look at the third component to my BBC bitesize definition of health - social connection. While the evidence regarding humans and health is limiting, the same detrimental effects have been seen in eusocial species like ants. Here, we also look at some data where social isolation in the ants was linked to increased reactive oxygen species and how melatonin helped rescue the decrease in lifespan.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Why it impacts health - 04:24Solutions? - 05:58ReferencesKoto, A., Tamura, M., Wong, P.S. et al. Social isolation shortens lifespan through oxidative stress in ants. Nat Commun 14, 5493 (2023). https://doi.org/10.1038/s41467-023-41140-wKeller, L., Genoud, M. Extraordinary lifespans in ants: a test of evolutionary theories of ageing. Nature 389, 958–960 (1997). https://doi.org/10.1038/40130Social relationships and physiological determinants of longevity across the human life span - https://www.pnas.org/doi/full/10.1073/pnas.1511085112The PLoS Medicine Editors (2010) Social Relationships Are Key to Health, and to Health Policy. PLoS Med 7(8): e1000334. https://doi.org/10.1371/journal.pmed.1000334Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
The future of cancer therapies? - Ryan Murray The Sheekey Science Show 2023-11-04 | Here, I chat with Ryan Murray, a current PhD student at North Eastern University who has been using an innovative form of gene editing, called base editing, to engineer T-cells to target cancer cells. His editing approach involves making the T-cells allogeneic, more effective and stealthier! Ryan's Twitter - Ryan's preprint - https://www.biorxiv.org/content/10.1101/2023.08.03.551705v1.full Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Engineering CAR T cells - 01:00Next steps - 28:00Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Who is @agingdoc1? The Sheekey Science Show 2023-10-28 | Here, I speak with agingdoc1 about who he is, why he started his Twitter page and his interests in aging and longevity.agingdoc1 links:https://twitter.com/agingdoc1 https://www.barzilaiconsulting.com/49 Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Can we cure cancer with CRISPR? The Sheekey Science Show 2023-10-21 | CRISPR these days refers to the suite of technologies that can edit the DNA of living cells by adding, removing, or changing segments of it.. Cancer, by definition, is a genetic disease caused by DNA mutations, changes within the sequence of DNA. So, can we cure cancer with CRISPR? That is the hope of many researchers, but a current promising solution that we’ll take a look at in this video, is perhaps not the straightforward solution you were thinking of. Let’s investigate.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Cancer - 00:00CRISPR is - 03:30CAR T cells - 04:45References:https://asheekeyscienceblogcom.wordpress.com/2017/09/16/cars-designed-to-tackle-cancer/ Comprehensive genome editing confers ‘off-the-shelf’ CAR-T cells superior efficacy against solid tumors - https://doi.org/10.1101/2023.08.03.551705 Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Does your blood type impact your longevity? The Sheekey Science Show 2023-10-14 | The discovery of the ABO blood group system is now considered one of the most important discoveries in the history of medicine. As I’ve been reading more about blood, its importance and links with longevity, along with the ABO blood group , it got me thinking - does blood group have an impact for health? Well, before we get to that, we first need to address what is the molecular underpinnings of the blood groups.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00ABO blood system explained - 01:30Blood type and disease risk - 04:00Blood type and longevity? - 06:45References:Evolutionary aspects of ABO blood groups in humans - https://doi.org/10.1016/j.cca.2015.02.016 Landsteiner paper - https://www.scienceheroes.com/images/stories/AcademicPapers/LandsteinerPages_merged.pdf Blood group A enhances SARS-CoV-2 infection - https://ashpublications.org/blood/article/142/8/742/496471/Blood-group-A-enhances-SARS-CoV-2-infection Press release of above - https://www.hematology.org/newsroom/press-releases/2023/study-uncovers-direct-link-between-blood-group-a-and-a-higher-risk-for-covid-19-infection https://www.nobelprize.org/prizes/medicine/1930/landsteiner/biographical/ Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Pig plasma to live longer? The Sheekey Science Show 2023-10-07 | Hello, i am back! Blood, sweat and tears have been shed these past months of absence. But enough sweating was done during the summer, tears have already been shed, so that just leaves me with blood. And whether taking a part of blood (plasma) and injecting it into old animals is enough for rejuvenation. That’s right, many of you may remember, earlier this year i made a video on the oldest living rat.- and now we have some updates: in particular, (i) what actually were the rats given, and (ii) what changes were seen, showing both some DNAm and glycan age data. Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro and recap - 00:00New results - 02:45What were the rats given? - 05:05References:https://doi.org/10.1016/j.tcb.2023.01.002 - Extracellular vesicles and nanoparticles: emerging complexitiesReversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction - https://doi.org/10.1101/2023.08.06.552148 I took clips of an interview with Dr Harold Katcher from @ModernHealthspan 's channelPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Bioelectricity as an longevity intervention - Benjamin Anderson The Sheekey Science Show 2023-07-15 | Today’s discussion features Benjamin Anderson, a friend of mine from St. Louis and who i would consider a life long learner. He has previously built WAND, an Uber-like platform for booking housekeepers and more recently is an executive producer for the Vance Crowe podcast. However, here i talk with Ben about his independent research in aging and bioelectric networks through independent research and why he thinks this may be a good intervention point for longevity. Links:Benjamin's Website: https://www.thebenjam.in/Find Benjamin on Twitter: https://twitter.com/BenAnderson421Bioelectricity & Aging Paper: https://www.liebertpub.com/doi/10.1089/bioe.2023.0013Open Source PrePrint: https://www.thebenjam.in/research/bioelectricity-causal-factor-aging/Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:0:00 Introduction1:34 Background and Discovering Bioelectricity8:49 Most Compelling Examples of Bioelectricity16:38 Advantages of Top-Down Controls in Biology22:50 What's needed for progress29:40 Challenges of doing research as an independent33:51 Starting an independent lab39:22 Speculating in public on bioelectricity for cellular reprogramming43:34 Intervention strategies in complex systems46:45 Advantages of a generalist mindset49:54 A place to work without constraintsPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Taurine - a supplement for longevity? The Sheekey Science Show 2023-07-01 | Today we’ll spill the T on taurine. You’ll learn that it is an unusual Amino-acid, that is Used not for proteins but has other Responsibilities. From their we’ll look at this recent INvestigation that found taurine supplementation Extended lifespan in some models and delays aging. Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPSIntro - 00:00What is taurine - 00:30Taurine and aging - 03:25Thoughts - 07:00References:https://doi.org/10.1038/d41586-023-01910-4 - Taurine supplement makes animals live longer — what it means for people is unclearTaurine linked with healthy aging - https://doi.org/10.1126/science.adi3025Taurine deficiency as a driver of aging - https://doi.org/10.1126/science.abn9257 Taurine, energy drinks, and neuroendocrine effects - https://doi.org/10.3949/ccjm.83a.15050 https://books.google.co.jp/books?hl=en&lr=&id=0AxIEAAAQBAJ&oi=fnd&pg=PP1&ots=4dmXXyFHQ0&sig=V7c_U3Um8OioUB83W0_D0kPqJd8&redir_esc=y#v=onepage&q&f=false Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Philosophy of Biology - Samir Okasha The Sheekey Science Show 2023-06-17 | In this video I spoke with Samir Okasha, Professor of Philosophy of Science at University of Bristol. He has interests in the 'levels of selection' question in evolutionary biology, and the related issue of individual versus group conflicts of interest. Here, we discuss these interests and the broader role that philosophy of biology plays.Samir's profile - https://research-information.bris.ac.uk/en/persons/samir-okasha Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPSIntro - 00:00Philosophy of Biology - 01:00Levels of selection - 15:00Cell fitness & cancer - 33:30Applications - 48:00Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Evolution of aging - could it be adaptive? - Peter Lidsky The Sheekey Science Show 2023-06-03 | In this video I chat with Peter Lidsky, a postdoctoral fellow at the University of California, San Francisco (UCSF), where he works on his interests in the role of viruses in aging and evolution.Before that, Peter studied enteroviruses and then moved to Switzerland, where he joined the laboratory of Christian Lehner at the University of Zurich. There, he switched his focus to Drosophila melanogaster, a model organism for studying gene regulation and development. In 2017, Lidsky moved to the US and joined the laboratory of Raul Andino at UCSF. He has been involved in several projects but here we chat predominantly about his 'Pathogen Control Strategy' to explain why aging evolved.Peter's Twitter: https://twitter.com/LidskyPeter Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTimestamps:Intro - 00:00Aging as a paradox - 02:30Theories of aging - 03:45Pathogen control strategy - 09:30Advice - 47:00Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Is aging adaptive? The Sheekey Science Show 2023-05-27 | Aging is a paradox when one considers evolutionary biology. Evolution is driven by natural selection, where advantageous traits are favoured over time and passed onto the next generation. But does aging fit into this equation?Aging is a natural phenomenon that affects all living organisms and can essentially be defined as an increase in mortality with age. As we grow older, our bodies undergo various changes, both internally and externally. But what is the purpose of aging? Is it simply a side effect of our biological processes, or does it serve a greater purpose? In this video we’ll do just that and deeply consider a more recent proposal that aging evolved as a pathogen control strategy. there will be 3 parts: a primer on evolution and theories of aging, why they could, most likely be wrong while i introduce this newer theory, and three, evidence for the pathogen control strategy and why we should even care about all this.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Theories of aging - 01:09Pathogen control strategy - 03:45Thoughts - 07:00References:Lidsky, P.V., Yuan, J., Rulison, J.M. et al. Is Aging an Inevitable Characteristic of Organic Life or an Evolutionary Adaptation?. Biochemistry Moscow 87, 1413–1445 (2022). https://doi.org/10.1134/S0006297922120021Could aging evolve as a pathogen control strategy? - https://doi.org/10.1016/j.tree.2022.08.003 Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Engineering cells to live longer The Sheekey Science Show 2023-05-06 | You’re playing a game. You’re in a boat that has to keep moving when you come to a two way junction. Steer left and you will fall of a cliff face and die, steer right and you will come across some very hungry bears. It’s not looking great. So, what will it be? left or right? Well, it turns out both paths are gated and the other closes once you make your decision…but it takes a bit of time for the gate to close. You have an idea. What if you go one way, then immediately turn around and chose the other side - you can do this decision flipping faster than the gates can close and so by oscillating between you effectively remain perpetuating in a state of indecision.What if we could apply similar logic to prevent two paths of aging within a cell? Would that even be possible? What would that tell us if it was possible?The story starts with an observation that was published in 2020. In this paper, they presented that yeast cells show two different forms of aging - either they slow down the biosynthesis of heme which results in mitochondrial dysfunction, or they lose the ability to cause silencing of ribosomal DNA. For now, you don’t need to fully understand how the yeast, just appreciate that there are these two mechanisms, and two key protein players involved in there regulation: Sir2 controls the gene silencing, while Hap4 controls heme production - so, like how you could go left or right in the game example at the start of the video and that either event occurs and the cell is committed to it. How clever to have mentioned it at the start.So, like in the game, the question was raised? What controls which path is taken, and can you manipulate yeast such that they prolong this decision and live longer?Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Aging circuits in yeast - 01:30Engineering yeast cells to live longer - 03:45Insights - 07:44References:Engineering longevity—design of a synthetic gene oscillator to slow cellular aging - https://doi.org/10.1126/science.add7631 Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Are we programmed to age? The Sheekey Science Show 2023-04-22 | Why do we age? It’s a simple question, without, of yet, a simple answer.Now there are many theories of aging - its DNA damage, its free radicals, it cross-linking, its nutrient sensing, its the endocrines, its programmed, its epigenetics and loss of information, its immune decline, it’s the mitochondria, it’s good old wear and tear, it’s p53, telomere shortening, it’s antagonistic pleiotropy, its senescence accumulation... well.Three things i have found myself doing a lot these past few weeks include reading very rare and old biology books, thinking about how different scientists are defining aging and thinking of silly things to write in a YouTube script. In this video, we’ll stick with the first two, the latter being a given. Now there are many theories of why we age, i have an entire playlist of videos talking about many of them, but i felt like we needed an update in light of some recent not-so-light reading i’ve been doing. So, in this video, we’ll consider what is the current major thoughts regarding why we age and consider whether aging is programmed or if aging is loss of entropy . So, we’ll cover a lot, so “brace yourselves”. Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Theories of aging - 01:00Why we age - 05:00What's the solution - 13:20References:de Magalhães, J.P. Ageing as a software design flaw. Genome Biol 24, 51 (2023). https://doi.org/10.1186/s13059-023-02888-yPoljsak B, Dahmane R, Adamič M, et al. THE (A)SYMMETRY OF THE MALE GRAYING BEARD HAIRS AS AN INDICATION OF THE PROGRAMMED AGING PROCESS. Acta Clin Croat. 2020;59(4):650-660. doi:10.20471/acc.2020.59.04.11Bujarrabal-Dueso, A., Sendtner, G., Meyer, D.H. et al. The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. Nat Struct Mol Biol 30, 475–488 (2023). https://doi.org/10.1038/s41594-023-00942-8Lakatta EG. The reality of aging viewed from the arterial wall. Artery Res. 2013 Jun 1;7(2):73-80. doi: 10.1016/j.artres.2013.01.003. PMID: 23667404; PMCID: PMC3646655.Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
What they thought of aging in 1931. The Sheekey Science Show 2023-04-08 | What did scientists think about aging in 1931? That’s right. 1931. because that is the year the first biological textbook was published “The Science of Life”. I managed to get my hands on the first edition of this textbook. This was my face when i first received it. As you can see i was quite excited. And this textbook is made up of separate books. I bought book i last year and i read it. Having enjoyed it and discovered that it was part of this massive ensemble piece - well, i’ve read the first “book” - there are, if my roman numerals are correct, 9 books in total. And in this first book, penned “The Living Body”, the authors, most famously, H.G.Wells, Sir Julian Huxley and G.P.Wells, H.G’s son discusses the body as a machine and that"For the present it is enough to remember that all animals (including men) are combustion engines of an intricate and curious kind, which live by oxidising their food"I bought first The Living Body and then discovered it was part of this massive ensemble piece and decided i needed to read it. Now, besides being surprised to find out that H.G.Wells wrote not just non-fiction, but biology non-fiction, i was also surprised to hear how both similar & dissimilar their views were back in 1931 compared to today and i wasnt sure if that was good or terrifying. So, how did they think of human aging. Well, in the last chapter of this 1st book titled “The wearing out of the machine and its reproduction”, they discuss it.Sheekey bookmarks - https://www.contrado.co.uk/stores/the-sheekey-science-show/classic-theme/classic-sheekey-leather-bookmark-1999569 Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Pro-aging factors in the blood - 01:35Circulatory defects & Vascular aging - 02:50Tissues age at different rates - 04:05Immortality? - 05:19Hormones - 05:48References:Novel imaging markers for altered cerebrovascular morphology in aging, stroke, and Alzheimer's disease - https://doi.org/10.1111/jon.13023 Steinach vs. Voronoff - https://journals.co.za/doi/pdf/10.10520/AJA20785135_4424 Distinct biological ages of organs and systems identified from a multi-omics study - https://doi.org/10.1016/j.celrep.2022.110459Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Psychedelics: a trip from mechanism to therapeutic potential? The Sheekey Science Show 2023-03-25 | "People are trying them. The media is touting them. But scientists say we need to know more about how they work and when they can help." This quote comes from the March Stanford Magazine edition, titled 'Falling for psychedelics'. So is there hope or is it all hype?Well, in this video we will give an overview to classic psychedelics with some essential neuroanatomy, and then we’ll look at this recent study that has identified a possible therapeutic mechanism that involves activation of pathways involved with dendritic growth. As we’ll come to conclude studies like these are imperative for with providing a foundation with which to guide optimal dosing and to identify individuals who could benefit from psychedelics. and other challenges ahead.So, firstly, what are psychedelics and why are people excited about them?Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPSIntro - 00:00What are psychedelics - 00:48Mechanism of action - 04:00Hope or hype? - 08:30References:Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors - https://doi.org/10.1126/science.adf0435 Kwan, A.C., Olson, D.E., Preller, K.H. et al. The neural basis of psychedelic action. Nat Neurosci 25, 1407–1419 (2022). https://doi.org/10.1038/s41593-022-01177-4A High-Resolution In Vivo Atlas of the Human Brain's Serotonin SystemJournal of Neuroscience 4 January 2017, 37 (1) 120-128; DOI: 10.1523/JNEUROSCI.2830-16.2016Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression - https://www.nejm.org/doi/pdf/10.1056/NEJMoa2206443https://www.science.org/doi/full/10.1126/science.abn5486Stanford Mag - https://project-orion-production.s3.amazonaws.com/uploads/issue/182/StanfordMagazine_March2023.pdf Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Mushrooms: fungal biology to medicinal & psychedelic effects - Prof Nik Money The Sheekey Science Show 2023-03-18 | Nik Money is Professor of Biology and Western Program Director at Miami University in Oxford, Ohio. Referring to himself as “The mycologist”, Nik is indeed an expert on mycology and has authored a number of books that celebrate the diversity of the microbial world. In his research at Miami, he has pioneered the use of high-speed video microscopy to understand the explosive mechanisms used by fungi to launch their spores into the air. In this discussion we discuss what fungi are, whether they are intelligence and how compounds found within mushrooms could affect our health and our brain. Hope you enjoy. Nik's website - https://www.themycologist.com/ Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTimestamps:Intro - 00:00What are fungi/mushrooms? - 01:45Nik's interests - 06:15Fungal intelligence/consciousness - 14:14Genetic engineering - 25:00Health (microbiome) - 29:15Health & nutrition - 34:20Psychedelics - 46:00Other uses - 56:00Advice - 1:06:30Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
What does epigenetics really mean? The Sheekey Science Show 2023-03-11 | There’s a phrase that get’s thrown around a lot these days, particularly in the longevity space. And that phrase is Sheekey Science. But there’s another word you may also hear about and that is epigenetic reprogramming. I am guilty myself of throwing this word around without really explaining what i mean by this. I’ve discussed reprogramming before, but i want to discuss in this video what is really meant by the phrase epigenetics, as And it goes beyond me, do you really know what they means by that term. Well, by the end of this video, you will have my interpretation of the term which has come from the science literature that i;ve read, and for fun, i’ll throw in other scientists definitions too. In particular i will focus mainly on the link between epigenetics, gene expression and cell identity - what makes a happy healthy cell do what it does best. And i think by the end of it you will have 3 main take homes;(i) an appreciation of genome organisation & cell identity - with some shocking surprises(ii) an overview of the different classes of epigenetics(iii) modern day & epigenetic reprogrammingTIMESTAMPS:Intro - 00:00DNA packing & chromatin organisation - 01:05Histone marks - 05:15DNA methylation - 06:20RNA - 07:57Epigenetic reprogramming - 09:45References:https://asheekeyscienceblogcom.wordpress.com/2017/09/13/time-to-re-write-the-textbooks-how-dna-is-really-packed-inside-the-nucleus/ Holoch, D., Moazed, D. RNA-mediated epigenetic regulation of gene expression. Nat Rev Genet 16, 71–84 (2015). https://doi.org/10.1038/nrg3863Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
How scientists made this rat the oldest living lab rat - E5 rejuvenation? The Sheekey Science Show 2023-02-25 | Rats are also useful for aging research and for cooking ratatouille. But in all seriousness, take a look at this recent headline article - “We have the oldest living female Sprague Dawley rat,” said Dr Harold Katcher, a former biology professor at the University of Maryland, now chief scientific officer at Yuvan Research, a California-based startup.So, Rejuvenation & rats. That’s what we’re talking about today, and how this rat has apparently become the longest living rat for its species following concentrated plasma injections from young blood plasma, and what this could mean for human therapeutics, along my perspectives. But, before we get there we must go back, back to the late 1950s and early 1960...to a time when The Sheekey Science Show did not exist, but when researchers, such as Clive McKay did, and these researchers were conducting a procedure called heterochronic parabiosis.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowConference i mentioned - https://www.curing-aging.com/ TIMESTAMPS:Intro - 00:00Plasma & rejuvenation - 00:45E5 Rat plasma experiments - 04:00Discussion - 09:44References:https://www.theguardian.com/science/2023/feb/08/anti-ageing-scientists-extend-lifespan-of-oldest-living-lab-ratPatent - https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2022150818&_cid=P12-LDLTHI-23678-1 Reversing age: dual species measurement of epigenetic age with a single clock. Steve Horvath bioRxiv 2020.05.07.082917; doi: https://doi.org/10.1101/2020.05.07.082917Villeda, S., Plambeck, K., Middeldorp, J. et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med 20, 659–663 (2014). https://doi.org/10.1038/nm.3569i took the video interview clips from @yuvanresearch2749 Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Could collagen gene delivery reverse skin aging? The Sheekey Science Show 2023-02-11 | Collagen. It’s a protein. And a pretty cool one at that. Due to it’s structure it possesses many functions within the body that exploits it’s strength, firmness, and elasticity. Collagen is found in your skin, cartilage, tendons, ligaments, blood vessels, eyes, and well, many parts of the body as collagen is one of the most abundant proteins in the body. And along with it’s abundance in our bodies, there is a growing abundance of research papers on collagen - one of which we’ll discuss today; a new collagen replacement therapy that was applied to the skin of mice and improved long-term treatment of photoaged skin. So, first we’ll look in more detail at both the structure of collagen and where it is found in the skin. then i’ll show there method of collagen delivery and the data they present showing whether it worked, then we’ll have a discussion. Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPSIntro - 00:00Collagen & Skin - 00:50Restore skin? EVs vs. LNPs - 02:55Discussion - 08:15ReferencesYou, Y., Tian, Y., Yang, Z. et al. Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy. Nat. Biomed. Eng (2023). https://doi.org/10.1038/s41551-022-00989-w Yang, Z., Shi, J., Xie, J. et al. Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. Nat Biomed Eng 4, 69–83 (2020). https://doi.org/10.1038/s41551-019-0485-1The Extracellular Matrix in Skin Inflammation and Infection - https://doi.org/10.3389/fcell.2021.682414 Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Healing tissue from the inside out - infusible biomaterial. The Sheekey Science Show 2023-02-04 | A recent paper describes how infusing biomaterial can potentially treat inflamed and injured tissue such as the brain, heart and lungs from the inside out. So, like the biomaterial used in this study, let me digest the key findings from this paper for you - starting with what these biomaterials are, how it was tested in the paper and look at how these findings can be therapeutically translated as regenerative medicines.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Biomaterial - 00:15Study results - 03:40Clinical translation? - 08:00References:Spang, M.T., Middleton, R., Diaz, M. et al. Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues. Nat. Biomed. Eng (2022). https://doi.org/10.1038/s41551-022-00964-5 Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Aging reversed? Testing the information theory of aging. The Sheekey Science Show 2023-01-28 | Aging. It’s what we do. And what i’m here to talk about today. In particular, addressing a recent paper that claims to test the information theory of aging that has come out from David Sinclair’s lab at Harvard Medical School and claims to drive aging both forwards and backwards.In this paper they generate a mouse model (ICE-mice) where additional DNA damage can be controlled to induce, they hope, epigenetic changes to test their theory that loss of epigenetic information drives aging. Let's find out.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPSIntro - 00:00Information theory of aging - 00:45The results - 05:00The thoughts - 10:45References:Loss of epigenetic information as a cause of mammalian aging - https://doi.org/10.1016/j.cell.2022.12.027 https://www.science.org/content/article/two-research-teams-reverse-signs-aging-mice Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Mitochondria-ON - Optogenetics & Aging The Sheekey Science Show 2023-01-17 | You asked. I deliver. So i recently spoke with Dr Brandon Berry about his work using the tool mitochondria-ON. Here, i will explain how this worksIn our cells, we have organelles, you have likely heard of called mitochondria. Primarily these organelles are responsible for the generation of ATP. The way ATP is generated is through the generation of a proton motive force - essentially a high concentration of protons - hydrogen ions - in the space between the membranes of this organelle. When these protons move down their concentration gradient out of the space between the membranes they go through a protein called ATP synthase. The movement of protons through this protein facilitates the generation of ATP - the energy source of the cell. Mitochondria-ON, is a tool that also moves protons across the membrane. But it can only do this is the presence of a cofactor - all-trans-retinal and light. In this paper, Brandon activated this tool using light during adulthood of the worms - so it kept this high proton motive force. He showed it extended their lifespan. Listen to our full conversation here; https://youtu.be/twke5yKQbvk Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Extending lifespan by rejuvenating mitochondrial membrane potential - Dr Brandon Berry The Sheekey Science Show 2023-01-14 | In this video i spoke with Dr Brandon Berry, a current Post-Doctoral fellow at the University of Washington, where he is developing and using tools to understand the function of mitochondria and their link with diseases and aging. Here, we discuss these interests further and the results from his latest publication one tool, termed 'mitochondria-ON', extended worm lifespan. 'Mitochondria-ON' rejuvenates the mitochondrial membrane potential when exposed to light and all-trans-retinal using optogenetics.Find Brandon on Twitter - https://twitter.com/mitobrandon Research papers - Berry, B.J., Vodičková, A., Müller-Eigner, A. et al. Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan. Nat Aging (2022). https://doi.org/10.1038/s43587-022-00340-7 Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance https://www.embopress.org/doi/full/10.15252/embr.201949113 Berry, B.J., Kaeberlein, M. An energetics perspective on geroscience: mitochondrial protonmotive force and aging. GeroScience 43, 1591–1604 (2021). https://doi.org/10.1007/s11357-021-00365-7Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPSIntro - 00:00Mitochondria and proton motive force - 01:10Optogenetic tools manipulate membrane potential - 08:45Lifespan studies - 17:55Consequences of recharging - 30:00Cellular senescence - 36:30Academia & advice - 38:30Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Will ChatGPT help longevity breakthroughs? The Sheekey Science Show 2023-01-07 | You have most likely heard about ChatGPT - the new AI chatbot tool from OpenAI . [ChatGPT](https://chat.openai.com/chat), which was released at the end of last year, is trained on OpenAI’s family of large language models and creates surprisingly intelligent-sounding text in response to user prompts. More than one million people tried it out in the first week - including me - and me being the normal person that i am and took full advantage of it, Now, besides entertaining myself while procrastinating my thesis, or for doing basic info searches or writing science essays - I was keen to know, as you may be too, will ChatGPT actually help us make science discoveries faster in particular in biological research such as coming up with drug solutions to cancer, aging, alzheimers?Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
This years biggest breakthroughs in longevity research - 2022!! The Sheekey Science Show 2022-12-31 | What a year 2022 has been for longevity research. Take a trip down memory lane with me in this video as we chat from rapamycin, cellular reprogramming, CRISPR to cellular senescence.SPONSOR: Come and join the discussion of research papers (in particular longevity) over at ResearchHub: https://www.researchhub.com/referral/8ea63e48-05fd-4907-a4d7-b8737173edcb Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPSIntro - 00:00Lifespan regulation - 00:45Rejuvenation & Regeneration - 04:00Cellular senescence - 08:05Technology, CRISPR, microscopy - 11:15Lifestyle - diet & supplements - 13:50Aging is... - 15:50Sponsor - 18:25References: Jeon, O.H., Mehdipour, M., Gil, TH. et al. Systemic induction of senescence in young mice after single heterochronic blood exchange. Nat Metab 4, 995–1006 (2022). https://doi.org/10.1038/s42255-022-00609-6An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory - https://www.nature.com/articles/s41556-022-00991-z Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration - https://doi.org/10.1126/sciadv.abj2164 Moiseeva, V., Cisneros, A., Sica, V. et al. Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration. Nature (2022). https://doi.org/10.1038/s41586-022-05535-xOrally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - https://doi.org/10.1016/j.ebiom.2022.103912 Selenium mediates exercise-induced adult neurogenesis https://doi.org/10.1016/j.cmet.2022.01.005A rare human centenarian variant of SIRT6 enhances genome stability - https://doi.org/10.15252/embj.2021110393 Multi-omic rejuvenation of human cells by maturation phase transient reprogramming https://doi.org/10.7554/eLife.71624Papandreou, ME., Konstantinidis, G. & Tavernarakis, N. Nucleophagy delays aging and preserves germline immortality. Nat Aging (2022). https://doi.org/10.1038/s43587-022-00327-4 Kriebs, A. Body temperature not metabolic rate modulates lifespan. Nat Aging 2, 368 (2022). https://doi.org/10.1038/s43587-022-00227-7Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases - https://doi.org/10.1101/2021.11.01.466786Snyder, J.M., Casey, K.M., Galecki, A. et al. Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice. GeroScience (2022). https://doi.org/10.1007/s11357-022-00641-0Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus - https://doi.org/10.15252/embr.202255299Browder, K.C., Reddy, P., Yamamoto, M. et al. In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice. Nat Aging 2, 243–253 (2022). https://doi.org/10.1038/s43587-022-00183-2Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Why do reindeer antlers regenerate? The Sheekey Science Show 2022-12-23 | Different organisms respond differently to injury. Axolotls can regenerate entire limbs, planaria can regrow heads from a single cell. But if we get even a small skin wounds as adults, like most other adult mammalian tissue, we get scars, not regeneration of the tissue. But why? How come some tissues can regenerate, while others form scar tissue? How is that decision mediated & why ultimately would it be useful to have this information? Well, that brings us to the item on my head. Reindeer, also known as caribou, are known for their distinctive antlers, like the ones on my head, that are covered in a soft, velvety skin, which are used for fighting, mating, and display. The interesting point of relevance for this video is that reindeer antlers also have the ability to regenerate after being damaged or broken? In this video, we will talk through this latest paper about reindeer, regeneration and wound response.#SheekeySleighs #reindeer #regeneration Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPSIntro - 00:00Regeneration of antler velvet - 01:00Wound response - 01:30Molecular mechanism - 03:00Senescence & open questions - 05:40ReferencesFibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer - https://doi.org/10.1016/j.cell.2022.11.004 Reindeer light the way to scarless wound healing - https://doi.org/10.1016/j.cell.2022.11.013 Gurtner, G., Werner, S., Barrandon, Y. et al. Wound repair and regeneration. Nature 453, 314–321 (2008). https://doi.org/10.1038/nature07039 Wound repair and regeneration: Mechanisms, signaling, and translation - https://doi.org/10.1126/scitranslmed.3009337 Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
what i read in 2022 (non-fiction book recommendations) The Sheekey Science Show 2022-12-17 | So, i read actually quite a lot of non-fiction books this year. Well, 12 to be precise. Here are my thoughts on each of them. as maybe you’d be interested in reading them too, or to gift to your science friends for xmas. Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPSIntro - 00:00The Case Against Reality - Donald Hoffman - 00:20The Music of Life - Denis Noble - 01:10Short introduction to Systems Biology - Eberhard Voit - 02:00The Contact Paradox - Keith Cooper - 02:30How Spies Think - David Omand - 03:05Fundamentals - Frank Wilczek - 03:50The Future of the Mind - Michio Kaku - 04:30The End of Everything - Katie Mack - 05:05Biological Weapons - Jeanne Guillemin - 05:50Cryobiology - Cherie Winner - 07:00BioFuture - Burke Zimmerman - 07:35The Biological Timebomb - Gordon Rattray Taylor - 08:25Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Memory molecules, Neural Computation & the ECM - Prof Ben Goult The Sheekey Science Show 2022-12-10 | In this video I speak with Ben Goult, Professor of Biochemistry at the University of Kent, where his lab researches the mechanical basis of memory and the role of the protein Talin as an information storing molecule. This, Ben refers to as the MeshCODE theory. We discuss this theory of memory and more in our discussion. Enjoy! Find Ben on Twitter: https://twitter.com/bengoult & YouTube: https://www.youtube.com/playlist?list=PLPZo4lO_YLXZkDAdo-9dlrBNHg-R3llFc Here they are.MeshCODE to Scale https://www.frontiersin.org/articles/10.3389/fncel.2022.1014629/fullMeshCODE https://www.frontiersin.org/articles/10.3389/fnmol.2021.592951/fullBen's channel: https://www.youtube.com/channel/UCJPBBfsUOdehD4ISfrZl4mQFind me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?coun... through Patreon - https://www.patreon.com/TheSheekeySci...TIMESTAMPS:Intro - 00:00Mechanobiology - 1:00Talin - 4:00The mechanical basis of memory - 8:00Biomolecules as molecular memory storage - 22:00Testing the MeshCODE theory - 28:15Neural networks and energy input - 38:30Memory location & ethical issues - 43:00Extracellular Matrix & Aging - 48:00Protein shock absorbers - 55:00Advice - 59:15Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-v..."Background vector created by freepik - www.freepik.com
Cryobiology & Cryogenics - cool stuff? The Sheekey Science Show 2022-12-03 | Why are people interested in “freezing” as a way of life preservation. Well, it is super cool for two reasons. It is (i) super cool in terms of temperature, and (ii) cool, for the ingenious ways researchers have found to alleviate ice crystal formation and for the many potential applications. This is the field of cryobiology and/or cryopreservation. In this video, we will have a beginner’s intro to cryobiology and cryogenics: why, what, the hmmm the how and the what if and the potential.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Cryobiology - 01:00Challenges - 02:50Lessons from animals - 05:10Would it affect memory? - 08:15Cryogenics - 10:00References:Murray, K.A., Gibson, M.I. Chemical approaches to cryopreservation. Nat Rev Chem 6, 579–593 (2022). https://doi.org/10.1038/s41570-022-00407-4Dein, S. Cryonics: Science or Religion. J Relig Health 61, 3164–3176 (2022). https://doi.org/10.1007/s10943-020-01166-6Hibernation Effects on Memory in European Ground Squirrels (Spermophilus citellus) - https://doi.org/10.1177/074873040101600309Blackiston DJ, Shomrat T, Levin M. The stability of memories during brain remodeling: A perspective. Commun Integr Biol. 2015 Aug 27;8(5):e1073424. https://doi.org/10.1080%2F19420889.2015.1073424 Gillett CR, Brame T, Kendziorra EF (2021) Correction: Comprehensive survey of United States internet users’ sentiments towards cryopreservation. PLOS ONE 16(4): e0251225. https://doi.org/10.1371/journal.pone.0251225Persistence of Long-Term Memory in Vitrified and Revived Caenorhabditis elegans - https://doi.org/10.1089%2Frej.2014.1636 Aldehyde-stabilized cryopreservation - https://doi.org/10.1016/j.cryobiol.2015.09.003 Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Are we in a fertility crisis? The Sheekey Science Show 2022-11-26 | Last month, the global population hit 8 billion people. Now, like me, that is a number i can say, but cannot really comprehend. It’s big. Basically. And the number of people on the planet are projected to keep growing to 9.7 B by 2050 and 10.4B by the end of the century. But, the rate of population growth is declining.Now, there are obviously many reasons for this, but one factor that comes into this is the trends of declining fertility. Last week, a meta-analysis study showed that sperm count is declining. But why is this happening and what can be done about it?Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Fertility - 01:11Sperm count decline - 01:45Genetics - 04:00Epigenetics - 05:00Environment - 05:55Outlook - 06:50References:UN data - https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/wpp2022_summary_of_results.pdf Skakkebæk, N.E., Lindahl-Jacobsen, R., Levine, H. et al. Environmental factors in declining human fertility. Nat Rev Endocrinol 18, 139–157 (2022). https://doi.org/10.1038/s41574-021-00598-8Hagai Levine, Niels Jørgensen, Anderson Martino-Andrade, Jaime Mendiola, Dan Weksler-Derri, Maya Jolles, Rachel Pinotti, Shanna H Swan, Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries, Human Reproduction Update, 2022;, dmac035, https://doi.org/10.1093/humupd/dmac035 Body fluid concentrations of bisphenol A and their association with in vitro fertilization outcomes - https://doi.org/10.1080/14647273.2019.1612104 Exposure to modern, widespread environmental endocrine disrupting chemicals and their effect on the reproductive potential of women: an overview of current epidemiological evidence - https://doi.org/10.1080/14647273.2017.1358828 Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women - https://doi.org/10.1080/03009734.2020.1727073 Xu, H., Wang, X., Wang, Z. et al. MicroRNA expression profile analysis in sperm reveals hsa-mir-191 as an auspicious omen of in vitro fertilization. BMC Genomics 21, 165 (2020). https://doi.org/10.1186/s12864-020-6570-8Ruth, K.S., Day, F.R., Hussain, J. et al. Genetic insights into biological mechanisms governing human ovarian ageing. Nature 596, 393–397 (2021). https://doi.org/10.1038/s41586-021-03779-7Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Lifespan extending compounds: from mice to mechanism - Prof Rich Miller The Sheekey Science Show 2022-11-19 | In this video I spoke with Rich Miller, Professor of Pathology at the University of Michigan and the Director of Michigan’s Paul F. Glenn Center for Biology of Aging Research. He also contributes to the Interventions Testing Program (ITP), created in the early 2000s to study the effect of various drugs on lifespan in mice. The ITP has produced evidence for anti-aging drugs, such as rapamycin, and, in contrast, has shown a lack of effectiveness for several agents, such as metformin. We discuss the ITP findings, the biology of aging and the important questions still to address.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTimestamps:Intro - 00:00Interests in aging - 01:00Mice as a model organism - 04:00Lessons from the ITP - 06:00Rapamycin, mTOR & cap-independent translation - 21:00Combining therapies - 32:30Brain health & glucose - 35:30Theories of aging - 44:00DNA methylation - 49:00Advice - 53:00Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Misconduct in biomedical research, science publishing & fake papers - Elizabeth Bik The Sheekey Science Show 2022-11-05 | In this video I had a great discussion with Elizabeth Bik, a former microbiologist who has worked at the Dutch National Institute of Health and the School of Medicine at Stanford university, who is now a science integrity consultant where she searches the biomedical literature for inappropriately duplicated or manipulated photographic images, plagiarized text, or poor study design and data analysis. Elizabeth's work has been featured in Nature, Science, the New York Times, Le Monde, Wall Street Journal, and now The Sheekey Science Show. Let’s get on with the conversation!Find Elizabeth on Twitter - https://twitter.com/MicrobiomDigesthttps://scienceintegritydigest.com/about/ Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Scientific Misconduct - 01:30 Alzheimer's - 16.10Reporting misconduct & Science Journals - 19:30Future of Publishing & Peer Review - 22:30What makes a good paper - 36:30Fake papers & Paper Mills - 38:30Microbiome - 48:30Dealing with critics & advice - 52:30Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
When is the best time to eat? The Sheekey Science Show 2022-10-29 | Food. We need it to survive. So maybe it's not surprising that many fix there daily routine and work schedule around it. While many like to discuss the quantity and quality of your diet, one factor i also think is important is when. So given some recent randomized controlled crossover trial looked into this, i thought it was time to talk about time in food consumption. They all seem to reach the same conclusion; so let’s take a quick look through them to see what, address the limitations and discuss what this all means. But firstly, why might timing of food consumption be important?Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPS:Intro - 00:00Circadian Rhythms - 00:45Studies - 04:30Discussion - 08:35References:Takahashi, J. Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet 18, 164–179 (2017). https://doi.org/10.1038/nrg.2016.150Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity - https://doi.org/10.1016/j.cmet.2022.09.007 Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity - https://doi.org/10.1016/j.cmet.2022.08.001 Xie, Z., Sun, Y., Ye, Y. et al. Randomized controlled trial for time-restricted eating in healthy volunteers without obesity. Nat Commun 13, 1003 (2022). https://doi.org/10.1038/s41467-022-28662-5Circadian Integration of Metabolism and Energetics - https://doi.org/10.1126/science.1195027Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Senolytic peptides, p53 and Aging - Peter de Keizer The Sheekey Science Show 2022-10-15 | In this video I had a great conversation with Peter de Keizer, Associate Professor of Senescence in Cancer and Aging at UMC Utrecht, who is also at the same time an entrepreneur as founder of Cleara Biotech, where they are focused on senescence and senolytic peptides which you’ll learn more about during our discussion. Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTimestampsIntro - 00:00Senescence & disease - 00:45p53 - 05:45Senolytic FOXO4 peptide - 07:30Cell penetrating peptides - 16:00Cleara Biotech & clinical trials - 18:45Senolytics - 25:00Aging and future healthcare - 33:00Advice for young people - 40:00ReferencesTargeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging - https://doi.org/10.1016/j.cell.2017.02.031 Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Fasting mimicking diets & health (2022 updates) The Sheekey Science Show 2022-10-08 | There has been a series of papers that have come out in the last year showing how following a fasting mimicking diet (FMD) affected patients with advanced cancers, and just last week, early Alzheimer’s. So, in this video we will go through what FMDs are and what this latest studies tell us.Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowTIMESTAMPSIntro - 00:00What is FMD - 00:20Cancer - 03:20Alzheimer's disease - 06:10Outro - 08:30References:Nardon, M., Venturelli, M., Ruzzante, F. et al. Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial. Eur J Appl Physiol 122, 651–661 (2022). https://doi.org/10.1007/s00421-021-04867-2Exceptional tumour responses to fasting-mimicking diet combined with standard anticancer therapies: A sub-analysis of the NCT03340935 trialhttps://doi.org/10.1016/j.ejca.2022.05.046 Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer’s models - https://doi.org/10.1016/j.celrep.2022.111417 Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
NR & Fertility - Charles Brenner (CLIP) The Sheekey Science Show 2022-10-02 | In this clip I asked Prof Charles Brenner about studies that have investigated nicotinamide riboside, NAD+ metabolism and fertility.Full interview here - https://youtu.be/opMijdJ6z9QFind me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Limb Regeneration - Michael Levin (CLIP) The Sheekey Science Show 2022-10-01 | In this clip I spoke with Dr Michael Levin about limb regeneration with biodomes and whether it can ever be applied as human therapeutics.Full interview here - https://youtu.be/-Bwq1oOST7wFind me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Rejuvenation vs. aging - Vadim Gladyshev (CLIPS) The Sheekey Science Show 2022-09-30 | In this clip I spoke with Prof Vadim Gladyshev about different potential rejuvenation strategies and current progress with them.FULL LENGTH INTERVIEW HERE - https://youtu.be/zp3Nvwz4F3U Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Sirtuins are not longevity genes - Charles Brenner (CLIP) The Sheekey Science Show 2022-09-29 | In this clip I asked Prof Charles Brenner "what is aging" which led to a conversation about longevity and sirtuins.Full interview here - https://youtu.be/opMijdJ6z9QFind me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
Levels of intelligence in biology - Michael Levin (CLIP) The Sheekey Science Show 2022-09-28 | In this clip I spoke with Dr Michael Levin about defining intelligence and how that can be explored at different levels in biological systems using xenobots as an example.Full interview here - https://youtu.be/-Bwq1oOST7wFind me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShowPlease note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
