Sequencing at Speed yourgenome 2020-06-02 | This 3D animation gives a simple overview of next generation DNA sequencing, known as massively parallel sequencing. This 3D animation shows how scientists read the letters in DNA, a process called DNA sequencing. The method shown is known as Next Generation Sequencing or Massively Parallel Sequencing. This is one of the main methods used in sequencing labs around the world. We start by seeing the DNA being chopped up and modified so that it sticks to the surface if a flow cell. Lots of copies of the DNA fragments are made resulting in millions of small clusters of single stranded DNA. The DNA is then sequenced by adding primers, DNA polymerase enzymes and fluorescently-labelled DNA bases. Lasers pass of the DNA clusters causing the bases causing the fluorescently labelled bases to glow. This fluorescent glow is then detected by a digital camera. Once this colour has been recorded, the fluorescent terminator tag is removed from the base, allowing a new fluorescently labelled terminator base to be added. The process is repeated and the data exported from the sequencing machine for assembly and analysis.For more information, please view the video and explore related resources on our site: http://www.yourgenome.org/video/sequencing-at-speed---Animated by Polymime Animation Company Ltd.http://www.polymime.comhttp://www.instagram.com/polymimestudio
What does DNA do? yourgenome 2020-05-27 | This animation explains what DNA does in our bodies and how it makes us the unique individuals we are. With all the billions of people in the world it is amazing to think that we are all different. When we are born, each of us grows according to a unique set of instructions that are inside every cell in our body. All living things are made of cells - they’re like small packets of life.Inside each cell is a nucleus where the instructions are stored. This instruction manual is called DNA and contains all the information needed to make you, you. DNA provides the instructions to make proteins which are the building blocks of life and carry out lots of different functions to make us work! Animation by Bob Banks (Bob Banks animation studio)Script developed by Maria A Duque-Correa, Susanna Repo and the students of Great and Little Shelford Primary school.
Extracting DNA from fruit yourgenome 2019-01-07 | This video shows how to extract DNA from strawberries using everyday items.Materials:- 5 ml washing-up liquid- 50 ml water- 5 g salt- 3-4 strawberries- 10 ml vodka (ice cold!)- Spoon- Glass or plastic cup- Plastic bag- Sieve- Kitchen jug- Small cup- ToothpickNotes:1) Mixing the washing-up liquid, the water and the salt we create a mixture that will help break up the strawberry cells when we squash them, and release the DNA contained inside of each cell.2) By passing it all through the sieve we get rid of the solid debris.3) The vodka is used to pull the DNA out of the mixture. DNA is not soluble in alcohol, so it precipitates out in the white clumps that we can see in the top layer.** Keep vodka in the freezer, it works best when it is very cold! And gently pour it down the side of the cup.For more information about DNA, please explore related resources on our site: http://www.yourgenome.org
Life in the Lab: A DNA sequencing pipeline yourgenome 2017-12-05 | Louise Aigrain is a senior staff scientist, working in DNA Pipelines Research and Development group at the Wellcome Trust Sanger Institute. In this film she outline all the process involved in sequencing a DNA sample, from receiving a prepared sample to releasing the assembled data to the scientists. She discusses how to working safely and efficiently in the lab as well as how to track samples and carry out quality control checks.The R & D group develop new and improved methods to sequence DNA samples using a range of different technologies at the Wellcome Trust Sanger Institute.This is one of a series of Life in the lab films providing a more in-depth insight to some of the laboratory processes used by different teams at the Wellcome Trust Sanger Institute. The film has been developed to help support the OCR Cambridge Technical Level 3 in laboratory skills.
Life in the Lab: A malaria genome modification pipeline yourgenome 2017-12-05 | Frank Schwach is a senior computational biologist, working in the malaria group at the Wellcome Trust Sanger Institute. In this film he gives an overview of the main processes involved in developing and creating malaria vectors as part of the PlasmoGEM project. Frank discusses how he develops software to create DNA sequences used to modify the DNA of malaria parasites. He also outlines some of the processes involved in creating the vectors in the lab, ready for use by scientists around the world. The Malaria programme uses a variety of different research methods to understand the biology of the Plasmodium parasite, its mosquito vector and the human host. This scientific approach aims to find solutions to malaria control such as discovering new drugs and vaccines. This is one of a series of Life in the lab films providing a more in-depth insight to some of the laboratory processes used by different teams at the Wellcome Trust Sanger Institute. The film has been developed to help support the OCR Cambridge Technical Level 3 in laboratory skills.
Life in the Lab: Working with malaria parasites yourgenome 2017-11-28 | Alena Pance is a senior staff scientist in the malaria group at the Wellcome Trust Sanger Institute. In this film she introduces malaria as a parasitic disease and describes how to work safely in the lab with malaria parasites including culturing them using human blood and preparing them on microscope slides. The Malaria programme uses a variety of different research methods to understand the biology of the Plasmodium parasite, its mosquito vector and the human host. This scientific approach aims to find solutions to malaria control such as discovering new drugs and vaccines. This is one of a series of Life in the lab films providing a more in-depth insight to some of the laboratory processes used by different teams at the Wellcome Sanger Institute. The film has been developed to help support the OCR Cambridge Technical Level 3 in laboratory skills.
Life in the Lab: Working with human gut microbiota yourgenome 2017-11-22 | Hilary Browne is a PhD student, working in the infection genomics group at the Wellcome Trust Sanger Institute. In this film he describes how to work safely in the lab with bacteria from the human gut including culturing them on agar plates and extracting the DNA for genome sequencing. The infection genomics programme uses a variety of different research approaches to study the biology and evolution of disease-causing organisms such as viruses, bacteria and parasites and understand how they cause disease in humans and other animals. This is one of a series of Life in the lab films providing a more in-depth insight to some of the laboratory processes used by different teams at the Wellcome Sanger Institute. The film has been developed to help support the OCR Cambridge Technical Level 3 in laboratory skills.
DNA Sequencing - 3D yourgenome 2016-09-28 | This 3D animation shows the basic steps in the method of DNA sequencing that was used during the Human Genome Project.For more information, please view the video and explore related resources on our site: http://www.yourgenome.org/video/dna-sequencing---Animated by Polymime Animation Company Ltd.http://www.polymime.comhttp://www.instagram.com/polymimestudio
DNA replication - 3D yourgenome 2015-06-26 | This 3D animation shows you how DNA is copied in a cell. It shows how both strands of the DNA helix are unzipped and copied to produce two identical DNA molecules. To download the subtitles (.srt) for this video, please use the following link: drive.google.com/file/d/0B1CbdfY31ykoZlhrcXUtcVIyNEU/view?usp=sharing&resourcekey=0--VxJZWBrWoXLJUPbQ8cttgFor more information, download the video, and explore related resources on our site: http://www.yourgenome.org/video/dna-replication---Animated by Polymime Animation Company Ltd.http://www.polymime.comhttp://www.instagram.com/polymimestudio
My career in genomics: cancer biology yourgenome 2015-04-22 | For more information about this film, as well as links to other related content, please view our page on yourgenome: http://www.yourgenome.org/video/my-career-in-genomics-cancer-biologyIn this film Niki Patel talks about her research at the Wellcome Trust Sanger Institute looking at the genetics of cancer. This is one of a series of films providing a unique insight into different careers in the field of genomics.
My career in genomics: immune diseases yourgenome 2015-04-22 | For more information about this film, as well as links to other related content, please view our page on yourgenome: http://www.yourgenome.org/video/my-career-in-genomics-immune-diseases In this film Gosia Trynka talks about her research at the Wellcome Trust Sanger Institute looking at the effect of genetic changes on the immune system. This is one of a series of films providing a unique insight into different careers in the field of genomics.
My career in genomics: antibiotic resistance yourgenome 2015-04-22 | For more information about this film, as well as links to other related content, please view our page on yourgenome: http://www.yourgenome.org/video/my-career-in-genomics-antibiotic-resistanceIn this film Christine Boinett talks about her research at the Wellcome Trust Sanger Institute looking at antibiotic resistance in bacteria. This is one of a series of films providing a unique insight into different careers in the field of genomics.
My career in genomics: evolution yourgenome 2015-04-22 | For more information about this film, as well as links to other related content, please view our page on yourgenome: http://www.yourgenome.org/video/my-career-in-genomics-evolutionIn this film Roland Schwarz talks about his research at the European Bioinformatics Institute (EBI) using computers to model and understand evolution. This is one of a series of films providing a unique insight into different careers in the field of genomics.
Direct-to-consumer genetic testing: interpreting risk yourgenome 2015-02-26 | A clip from the full Direct-to-consumer testing film at http://youtu.be/fkTNhHh8Fts
Direct-to-consumer genetic testing: supplying a sample and getting the results yourgenome 2015-02-26 | A clip from the full Direct-to-consumer testing film at http://youtu.be/fkTNhHh8Fts
Direct-to-consumer genetic testing: considering genetic test results yourgenome 2015-02-26 | A clip from the full Direct-to-consumer testing film at http://youtu.be/fkTNhHh8Fts
Direct-to-consumer genetic testing: looking at your ancestry yourgenome 2015-02-26 | A clip from the full Direct-to-consumer testing film at http://youtu.be/fkTNhHh8Fts
From DNA to protein - 3D yourgenome 2015-01-07 | This 3D animation shows how proteins are made in the cell from the information in the DNA code. To download the subtitles (.srt) for this site, please use the following link: goo.gl/Ew7l69 and for more information, please view the video and explore related resources on our site: http://www.yourgenome.org/video/from-dna-to-protein---Animated by Polymime Animation Company Ltd.http://www.polymime.comhttp://www.instagram.com/polymimestudio
Role of cancer genes yourgenome 2014-12-19 | This animation shows you how DNA mutations are involved in the development of cancer.
Francis Collins: Involvement with the Human Genome Project yourgenome 2014-12-19 | A short film where Dr. Francis Collins, director of the NIH, reminisces about his role during the Human Genome Project.
Francis Collins: Surprises in the human genome sequence yourgenome 2014-12-19 | A short film where Dr. Francis Collins, director of the NIH and one of the leaders during the Human Genome Project, talks about the surprise Human Genome Project scientists had when they examined the sequence of the human genome for the first time.
Phil Butcher: The early days of IT yourgenome 2014-12-19 | A short film where Phil Butcher, head of IT at the Wellcome Trust Sanger Institute during the Human Genome Project, discusses the huge developments in IT since 1993 and how it has enabled scientific progress.
Alec Jeffreys: What use is a national DNA database? yourgenome 2014-12-19 | A short film where Professor Sir Alec Jeffreys, a British geneticist who developed techniques for DNA fingerprinting, discusses the importance of national DNA databases for helping to solve crime.
Francis Collins: Building on the human genome sequence yourgenome 2014-12-19 | A short film where Dr. Francis Collins, director of the NIH and one of the leaders during the Human Genome Project, talks about how the completed human genome sequence has been used to tell us more about how to prevent and treat human disease.
The Human Genome Project: Personal Stories yourgenome 2014-12-19 | This video features personal accounts from key US and UK scientists involved in the Human Genome Project between 1990 and 2003. Including stories from Francis Collins, John Sulston, Cordelia Langford, David Lloyd, Mike Quail, Tim Hubbard and Sarah Sims.
John Burton: Scaling up for the Human Genome Project yourgenome 2014-12-19 | A short film where John Burton, a group leader at the Wellcome Trust Sanger Institute during the Human Genome Project, talks about how DNA sequencing technologies have changed over time to cope with increasingly large genomes, such as the human genome.
John Sulston: How did I become involved in the Human Genome Project? yourgenome 2014-12-19 | A short film where Sir John Sulston, former director of the Wellcome Trust Sanger Institute, talks about sequencing the nematode worm C. elegans, his role in the Human Genome Project and the importance of sharing data.
Francis Collins: The importance of the human genome sequence yourgenome 2014-12-19 | A short film where Dr. Francis Collins, director of the NIH and one of the leaders during the Human Genome Project, discusses how the completed human genome sequence has enabled the development of more personalised approaches to medicine.
Ewan Birney: Surprises in the human genome sequence yourgenome 2014-12-19 | A short film where Dr. Ewan Birney, Joint Associate Director and Senior Scientist at the European Bioinformatics Institute (EBI), talks about the surprise Human Genome Project scientists had when they first found out the number of protein-coding genes in the human genome was much lower than they had originally predicted.
John Sulston: Whats the benefit of sharing data? yourgenome 2014-12-19 | A short film where Sir John Sulston, former director of the Wellcome Trust Sanger Institute, discusses the importance of sharing genome sequence data to enable scientific progress.
About the disease yourgenome 2014-07-10 | In this film scientists describe how Devil Facial Tumour Disease develops in Tasmanian devils. This cancer is spreading through the Tasmanian devil population and leading to a massive reduction in the numbers of devils in the wild. This video is from 'Saving the Devil' -- a multimedia resource that tells the story of the Tasmanian devil and how science, in particular genomics, is playing a role in trying to save the species from extinction.You can explore 'Saving the Devil' at http://www.yourgenome.org/interactives/saving-the-devil/.
A contagious cancer yourgenome 2014-07-10 | In this film scientists explain how they identified Devil Facial Tumour Disease as a transmissible cancer that is spread when Tasmanian devils bite each other. This cancer is spreading through the Tasmanian devil population and leading to a massive reduction in the numbers of devils in the wild. This video is from 'Saving the Devil' -- a multimedia resource that tells the story of the Tasmanian devil and how science, in particular genomics, is playing a role in trying to save the species from extinction.You can explore 'Saving the Devil' at http://www.yourgenome.org/interactives/saving-the-devil/.
Sequencing the cancer yourgenome 2014-07-10 | This film introduces how DNA sequencing can be used to find mutations that cause cancer. It describes how it is being used to understand a transmissible cancer affecting the Tasmanian devil. This video is from 'Saving the Devil' -- a multimedia resource that tells the story of the Tasmanian devil and how science, in particular genomics, is playing a role in trying to save the species from extinction.You can explore 'Saving the Devil' at http://www.yourgenome.org/interactives/saving-the-devil/.
The devil genome yourgenome 2014-07-10 | In this film scientists describe what has been revealed by sequencing the DNA of Tasmanian devils. It describes what this DNA sequencing has uncovered about Devil Facial Tumour Disease, a transmissible cancer that is affecting Tasmanian devils in the wild. This video is from 'Saving the Devil' -- a multimedia resource that tells the story of the Tasmanian devil and how science, in particular genomics, is playing a role in trying to save the species from extinction.You can explore 'Saving the Devil' at http://www.yourgenome.org/interactives/saving-the-devil/.
Finding cancer genes yourgenome 2014-07-10 | In this film scientists explain how looking at the genes of the Tasmanian devil has uncovered mutations that may be driving a cancer that is affecting devils in the wild. Some of these mutations may be targets for drugs to treat devils with the cancer. This video is from 'Saving the Devil' -- a multimedia resource that tells the story of the Tasmanian devil and how science, in particular genomics, is playing a role in trying to save the species from extinction.You can explore 'Saving the Devil' at http://www.yourgenome.org/interactives/saving-the-devil
The devils defences yourgenome 2014-07-10 | In this film scientists describe how the immune system works and how it can go wrong in cancer. In Tasmanian devils affected by a transmissible cancer the body's natural immune system is unable to detect the cancer. This video is from 'Saving the Devil' -- a multimedia resource that tells the story of the Tasmanian devil and how science, in particular genomics, is playing a role in trying to save the species from extinction.You can explore 'Saving the Devil' at http://www.yourgenome.org/interactives/saving-the-devil/.
Saving the devil yourgenome 2014-07-10 | This film outlines how scientists from across the world are trying to understand the biology and evolution of a transmissible cancer affecting Tasmanian devils. Together they hope to find a way of saving the Tasmanian devil from extinction in the wild.This video is from 'Saving the Devil' -- a multimedia resource that tells the story of the Tasmanian devil and how science, in particular genomics, is playing a role in trying to save the species from extinction.You can explore 'Saving the Devil' at http://www.yourgenome.org/interactives/saving-the-devil/.
Captive breeding yourgenome 2014-07-10 | This film describes how Tasmanian devils are being bred in captivity to establish a series of insurance populations. Devils are kept in a semi-wild environment where they are protected from wild devils with the deadly Devil Facial Tumour Disease. This video is from 'Saving the Devil' -- a multimedia resource that tells the story of the Tasmanian devil and how science, in particular genomics, is playing a role in trying to save the species from extinction.You can explore 'Saving the Devil' at http://www.yourgenome.org/interactives/saving-the-devil/.
Evolving devils yourgenome 2014-07-10 | In this film, scientists describe how Tasmanian devils are changing in the wild. They describe how evolution may play a role in preventing the devils becoming extinct as a result of a transmissible cancer that is spreading through the population. This video is from 'Saving the Devil' -- a multimedia resource that tells the story of the Tasmanian devil and how science, in particular genomics, is playing a role in trying to save the species from extinction.You can explore 'Saving the Devil' at http://www.yourgenome.org/interactives/saving-the-devil/.
Treating the cancer yourgenome 2014-07-10 | This film outlines how scientists are working to develop drugs and vaccines that may be used to treat Devil Facial Tumour Disease in Tasmanian devils. This video is from 'Saving the Devil' -- a multimedia resource that tells the story of the Tasmanian devil and how science, in particular genomics, is playing a role in trying to save the species from extinction.You can explore 'Saving the Devil' at http://www.yourgenome.org/interactives/saving-the-devil/.
Another transmissible cancer yourgenome 2014-06-16 | This film describes a transmissible cancer that affects dogs. This cancer has spread around the world over several thousands of years and can be successfully treated with chemotherapy.This video is from 'Saving the Devil' -- a multimedia resource that tells the story of the Tasmanian devil and how science, in particular genomics, is playing a role in trying to save the species from extinction.You can explore 'Saving the Devil' at http://www.yourgenome.org/interactives/saving-the-devil/.
Devils in decline yourgenome 2014-06-02 | This film introduces you to the Tasmanian devil and how its numbers are being decimated by a cancer that is spreading across the population. This video is from 'Saving the Devil' -- a multimedia resource that tells the story of the Tasmanian devil and how science, in particular genomics, is playing a role in trying to save the species from extinction.You can explore 'Saving the Devil' at http://www.yourgenome.org/interactives/saving-the-devil
Zoom in on your genome - female yourgenome 2014-02-28 | 'Zoom in on your genome' allows you to take a journey into the body to see where the genome is found and how DNA is packaged in the cell nucleus. Your journey will start outside the body and take you into the liver and a liver cell. You will then travel to the cell nucleus and unwind the chromosomes to reveal the DNA itself. You will see the various levels of DNA packaging and the four basic building blocks of DNA.This animation and many others are available from http://www.yourgenome.org.
Zoom in on your genome - male yourgenome 2014-02-28 | 'Zoom in on your genome' allows you to take a journey into the body to see where the genome is found and how DNA is packaged in the cell nucleus. Your journey will start outside the body and take you into the liver and a liver cell. You will then travel to the cell nucleus and unwind the chromosomes to reveal the DNA itself. You will see the various levels of DNA packaging and the four basic building blocks of DNA.This animation and many others are available from http://www.yourgenome.org.
Monitoring disease spread yourgenome 2014-02-10 | This film illustrates how a transmissible cancer affecting Tasmanian devils has spread in the wild since it was first seen in 1996. The disease has spread across most of Tasmania and has reduced the population of wild Tasmanian devils in some areas by 80-95%. This video is from 'Saving the Devil' -- a multimedia resource that tells the story of the Tasmanian devil and how science, in particular genomics, is playing a role in trying to save the species from extinction.You can explore 'Saving the Devil' at http://www.yourgenome.org/interactives/saving-the-devil/.
The challenges of drug resistance with targetted cancer therapies yourgenome 2013-06-26 | Wellcome Trust Sanger Institute researcher Ultan McDermott discusses the challenges of drug resistance with targeted cancer therapies. This video has been produced to accompany a classroom activity: BRAF: from gene to cancer therapy that has been developed by the Public Engagement team at the Wellcome Trust Sanger Institute. The activity is available at www.yourgenome.org
BRAF: from gene to cancer therapy yourgenome 2013-06-26 | Wellcome Trust Sanger Institute scientist Ultan McDermott tells the story of BRAF. This gene was discovered to be mutated in 40% of malignant melanoma by researchers who sequenced cancer genomes. As a result drugs have been developed to target a particular mutation in BRAF prolonging the life of people with this form of cancer.This video has been produced to accompany a classroom activity: BRAF: from gene to cancer therapy that has been developed by the Public Engagement team at the Wellcome Trust Sanger Institute. The activity is available at www.yourgenome.org
Malaria: an introduction yourgenome 2012-01-10 | This video provides an introduction to the topic of malaria. It describes what malaria is, why it is a complex disease, where malaria is a problem and who is affected. It also describes the symptoms of the disease, how to treat it and how to prevent transmission. The video also addresses the topic of drug resistance and explains why this is a constant challenge to the eradication of malaria and how current research is developing new solutions to tackling the disease.
