A 3D Map of the Human Genome Cell Press 2014-12-11 | Suhas Rao and Miriam Huntley (of the Aiden Lab) describe a 3D map of the human genome at kilobase resolution, revealing the principles of chromatin looping. Guest Origami Folding: Sarah Nyquist.Suhas S.P. Rao*, Miriam H. Huntley*, Neva C. Durand, Elena K. Stamenova, Ivan D. Bochkov, James T. Robinson, Adrian L. Sanborn, Ido Machol, Arina D. Omer, Eric S. Lander, Erez Lieberman Aiden. (2014). A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping. Cell 159, 1665–1680.
Inclusive language in scientific publishing: Age and aging Cell Press 2024-10-17 | Cell Press and @TheLancetTV are excited to host this thought-provoking webinar, part of our Inclusive Language in Scientific Publishing series. This event aims to unite researchers and experts to explore essential perspectives that will make science and scientific publishing more inclusive and accurate.Our panel will focus on the theme of age and aging, shedding light on how we describe these concepts in research. We will delve into ways to avoid stigmatizing language and prevent the perpetuation of stereotypes. This is a unique opportunity to gain valuable insights and contribute to a more inclusive scientific community.We are honored to have distinguished speakers for this panel, including Professor Paula Rochon from the University of Toronto and Professor Desmond O’Neill from Trinity College Dublin. Following their presentations, there will be a Q&A session, providing a platform for engaging discussions.This webinar is a key component of the Cell Press 50th anniversary celebrations. By participating, you will be part of our ongoing efforts to broaden the reach of our speakers' perspectives and reinforce our commitment to advocating for science and scientists.
Theoretical insights into rotary mechanism of MotAB in the bacterial flagellar motor Cell Press 2024-10-09 | Typical animation of [(A, C, E), ()] from "Theoretical insights into rotary mechanism of MotAB in the bacterial flagellar motor" by Kubo et al. See the full article at Biophysical Journal at cell.com/biophysj/fulltext/S0006-3495(24)00602-7.
Therapeutic advances for cardiometabolic diseases: a webinar from Cell Press and The Lancet Cell Press 2024-09-30 | Watch this engaging joint webinar with Cell Press and @TheLancetTV featuring expert speakers who will offer their valuable insights into the epidemiology and pathophysiology of cardiometabolic diseases, and the latest therapeutic advancements. We will explore the mechanism of action and clinical evidence of current and emerging treatments, focusing on their impact on cardiorenal outcomes and weight management. Our expert panel will discuss the challenges in availability and access to these treatments and the crucial role of disease prevention in managing cardiometabolic conditions. Engage with our speakers in a Q&A session at the end of the webinar to deepen your understanding and gain valuable insight into this important topic. Don’t miss this opportunity to be part of a transformative discussion that will inspire action towards better cardiometabolic health.
Improving the peer review experience for reviewers and authors Cell Press 2024-09-17 | In today’s landscape of increasing publication volumes and large amounts of information, peer review is more important than ever. Insightful and constructive peer reviewer comments can reduce confusion within scientific communities by helping authors identify errors, avoid over-interpretation, and ensure that their work is presented at its best. However, when the process is not working optimally, authors may find the process time-consuming and unproductive, and reviewers may feel overwhelmed by the task.Please join Ruth Zearfoss from Cell Reports Methods and panelists Iain Cheeseman and Yadira Soto-Feliciano from the Massachusetts Institute of Technology for “Improving the peer review experience for reviewers and authors.” In this free interactive webinar, we will discuss what goes into peer review, how to prepare a review that will ultimately benefit the authors and the scientific community, and answer questions about issues that may arise during the process.
One Earth Voices on Living with Fire Cell Press 2024-08-29 | One Earth Voices is a series of invited perspectives on topics of socio-economic importance. This Voices, on fire risk in a warming world, comes from the June 2024 issue of One Earth. It features experts Sofia Taylor, Line Roald, Paula Villagra, Pauline Dube, and Francesca Di Giuseppe who each answer the question, "What are the risks of fire and how might they be better understood and mitigated?"Read the full Voices article here: cell.com/one-earth/abstract/S2590-3322(24)00263-X
Navigating the Pyrocene: Managing fire risk in a warming world Cell Press 2024-07-16 | Ecosystems across the world have evolved with fire as an essential process, and many cultures have traditionally used fire to manage landscapes in their favor. The last century, however, has seen expanding human infrastructure and altered land management practices. In North America, a legacy of fire suppression, coupled with a drastic expansion of the wildland-urban interface, means that fire now poses a greater risk to both ecosystems and human systems. More recently, the impacts of climate change have altered fire regimes still further. As fires become more intense, the annual burned area expands, and the fire season grows longer across parts of the continent, human systems will need to adapt to achieve resilience to wildfire. However, “adaptation” is easier said than done given the many components of fire risk—from smoke that lowers air quality across national borders, to the compounding challenges of socioeconomic inequality, to vulnerable essential infrastructure like water and energy. Further, adaptation will also require collective action spanning scales from individual backyards to across international borders. This complexity calls for transdisciplinary expertise and collaboration among different management agencies. This Cell Press Forum on Sustainability will feature a wide-ranging discussion on what contributes to fire risk and what is needed to mitigate those risks for a more fire-resilient future.
Trish Simner Lablinks (Johns Hopkins University) Cell Press 2024-06-28 | Translating an understanding of antimicrobial resistance mechanisms among gram-negatives to optimize patient care
Chloe Loiseau (Swiss Tropical and Public Health Institute) Cell Press 2024-06-28 | Ecology and Evolution of MultiDrug-Resistant M. tuberculosis
Etienne Ruppe (University of Paris) Cell Press 2024-06-28 | Antibiotic resistance detection in clinical metagenomics
Gaud Catho (Geneva University Hospital) Cell Press 2024-06-28 | Fighting antimicrobial resistance: Current insights in infection control and antimicrobial stewardship
Haileyesus Getahun (WHO) Cell Press 2024-06-28 | From metagenome to policy and practice: How to bridge the gap for AMR?
Patrice Nordmann (University of Fribourg) Cell Press 2024-06-28 | Emergence of antibiotic resistance in gram negatives
Spatial heterogeneity in tumor adhesion qualifies collective cell invasion Cell Press 2024-06-17 | Video from "Spatial heterogeneity in tumor adhesion qualifies collective cell invasion," by Prasanna et al. See the full article at Biophysical Journal at cell.com/biophysj/fulltext/S0006-3495(24)00319-9#%20
Data-driven classification of individual cells by their non-Markovian motion Cell Press 2024-05-20 | From "Data-driven classification of individual cells by their non-Markovian motion" by Klimek et al. See the full Biophysical Journal article at cell.com/biophysj/fulltext/S0006-3495(24)00203-0
Inclusive language in scientific publishing: Neurodiversity Cell Press 2024-04-17 | A discussion exploring neurodiversity in science and the scientific community, presented by Cell Press and The Lancet. Beginning with a short introduction to the concepts of neurodiversity and the social model of disability, speakers Mary Doherty (University College Dublin), Hari Srinivasan (Vanderbilt University), and Axelle Ahanhanzo (LAUDACE) offer insights into making spaces safer for neurodivergent people, discuss intersectionality and neurodivergence, and unpack the importance of evolving scientific language to reflect lived experiences while ensuring rigorous scientific investigation. Cell Press’s virtual event series on inclusive language in publishing brings together researchers and experts with the key perspectives needed to make science and the language of scientific publishing more inclusive and accurate. We’re now proud to offer these events—begun in 2023 as an internal Cell Press series to educate and support our editors and staff—to the broader scientific community. As an integral part of our 50th anniversary celebrations (cell.com/cell-press-50), these events seek to expand the reach of our speakers’ insightful perspectives and support our commitment to advocating for science and scientists.00:00:00 - Welcome from Sri Narasimhan, deputy editor, Cell00:03:32 - Talk from Mary Doherty, PhD, University College Dublin00:20:22 - Talk from Hari Srinivasan, Vanderbilt University00:36:06 - Talk from Axelle Ahanhanzo, MSc, LAUDACE01:01:38 - Discussion
Rising lake levels threaten Lesser Flamingos / Curr. Biol., Apr. 12, 2024 (Vol. 34, Issue 8) Cell Press 2024-04-12 | More than three-quarters of the world’s Lesser Flamingos feed on the cyanobacterial blooms present in the productive soda lakes of East Africa. However, rising lake levels are diluting the alkaline-saline waters required for the cyanobacteria to grow. Lesser Flamingos are losing suitable feeding habitats, particularly in Kenya and Tanzania, further threatening a species already in decline. With increasing rainfall predicted under climate change, the iconic birds, as well as other unique soda lake biodiversity adapted to these extreme environments, could be lost from the region. Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(24)00302-6.A. Byrne, E.J. Tebbs, P. Njoroge, A. Nkwabi, M.A. Chadwick, R. Freeman, D. Harper, and K. Norris (2024). Productivity declines threaten East African soda lakes and the iconic Lesser Flamingo. Curr. Biol. 34.And read more great research at http://www.cell.com/current-biology/home.
Unlocking larval settlement in marine invertebrates / Curr. Biol., Feb. 8, 2024 (Vol. 34, Issue 6) Cell Press 2024-04-11 | Ciona is a marine invertebrate with a freely swimming larva that settles and metamorphoses to a sessile adult. Hoyer et al. identified a set of chemical cues that control settlement and metamorphosis of Ciona larvae. These cues are detected by polymodal sensory cells, which determine the attractive or repulsive nature of these chemical stimuli. This information is relayed to the larva's brain to elicit robust behavioral actions.Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(24)00075-7.J. Hoyer, K. Kolar, A. Athira, M. van den Burgh, D. Dondorp, Z. Liang, and M. Chatzigeorgiou (2024). Polymodal sensory perception drives settlement and metamorphosis of Ciona larvae. Curr. Biol. 34.And read more great research at http://www.cell.com/current-biology/home.
Mechanical control of cell proliferation patterns in growing epithelial monolayers Cell Press 2024-04-02 | Read the full Biophysical Journal article by Carpenter et al. at cell.com/biophysj/abstract/S0006-3495(24)00167-X
Bad, but how bad? Assessing the impacts of plastic pollution on human and ecosystem health Cell Press 2024-03-27 | Plastics have rapidly come to shape life on earth, with their versatility and durability revolutionizing healthcare, food storage, technology, and beyond. At the same time, the explosion in plastic production and consumption has led to billions of tons of waste. During the last few decades, researchers have confirmed that plastic waste degrades slowly, is widespread but accumulates heterogeneously across the land and oceans, and exists in almost all organisms on earth. As public consciousness grasps the scale of this problem, research is turning to the unanswered questions to inform concrete policies and effective actions: What is the fate of the smallest plastics and the unknown additives we have been historically unable to detect? How exactly and to which degree does the widespread plastic waste affect the health and functionality of our ecosystems? What are the direct and indirect consequences of plastic pollution on human health? This forum highlights the gaps in our understanding of how plastics affect human and ecosystem health and explore what needs to be done to close them – a prerequisite for devising meaningful solutions.Keynote speaker Nanna Hartmann (Technical University of Denmark) is joined by an interdisciplinary panel featuring Philip J. Landrigan (Boston College and Centre Scientifique de Monaco) and Imari Walker-Franklin (RTI International).Forums on Sustainability bring together speakers from across disciplines and around the world to drive conversations on key sustainability challenges forward. Be sure to suggest a question for our distinguished panel to discuss during the session when you register.
Disambiguating vision with sound / Curr. Biol., Mar. 25, 2024 (Vol. 34, Issue 6) Cell Press 2024-03-25 | Vision often operates on weak and ambiguous information, as exemplified by bistable illusions, where two clear percepts alternate stochastically. Here, Gori et al. show that concurrently listening to appropriate soundtracks disambiguates these illusions almost completely, while verbal instructions have little effect.Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(24)00078-2.M. Gori, D. Burr, and C. Campus (2024). Disambiguating vision with sound. Curr. Biol. 34.And read more great research at http://www.cell.com/current-biology/home.
Dogs understand words as we do / Curr. Biol., Mar. 22, 2024 (Vol. 34, Issue 8) Cell Press 2024-03-22 | Researchers at Eötvös Loránd University, Hungary, find a human N400-like semantic mismatch effect in dogs’ ERPs to objects primed with matching or mismatching object words, revealing that object words can evoke mental representations of the referred objects in dogs. The referential understanding of object words is thus not a distinctive feature of the human language faculty.Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(24)00171-4.M. Boros, L. Magyari, B. Morvai, R. Hernández-Pérez, S. Dror, and A. Andics (2024). Neural evidence for referential understanding of object words in dogs. Curr. Biol. 34.And read more great research at http://www.cell.com/current-biology/home.
Session 2: Downstream decommissioning and circularity Cell Press 2024-03-14 | In this session, three talks and a panel discussion explore the importance of and potential for battery sustainability through the lens of battery decommissioning and circularity.This virtual Cell Press LabLinks, “Batteries: Designing a safe and sustainable future,” held on February 21, 2024, brings together diverse stakeholders for a discussion-focused event around the emerging notion of Safe-and-Sustainable-by-Design.00:00:00 - Introduction from moderator Shanshan Zhang, One Earth00:01:43 - Lifecycle footprint of battery recycling | Dr. Annick Anctil, Michigan State University00:19:50 - Designing lithium ion batteries for recycle | Prof. Andrew Abbott, University of Leicester00:38:19 - Labs to markets for sustainable batteries | Prof. Yet-Ming Chiang, Form Energy00:57:01 - Panel discussion
Session 1: Upstream design and manufacturing Cell Press 2024-03-14 | In this session, four talks and a panel discussion explore the design, manufacturing, and monitoring of new battery chemistries and devices for battery sustainability.This virtual Cell Press LabLinks, “Batteries: Designing a safe and sustainable future,” held on February 21, 2024, brings together diverse stakeholders for a discussion-focused event around the emerging notion of Safe-and-Sustainable-by-Design. 00:00:00 - Introduction from moderator Andy Wadsworth, Joule00:00:11 - Chemistry design for metal-free batteries | Prof. Yan Yao, University of Houston00:17:44 - Battery electrodes and cell design | Dr. Franco Zanotto, LRCS, Université de Picardie Jules Verne & CNRS00:34:24 - Sustainable battery manufacturing | Dr. Jenny Baker, Swansea University00:50:02 - Smart battery management for sustainable systems | Dr. Dhammika Widanalage, University of Warwick01:13:32 - Panel discussion
Plenary: Sustainable batteries: Oxymoron or pleonasm? Cell Press 2024-03-14 | In this plenary talk, Professor Magda Titirici, Chair of Sustainable Energy Materials at Imperial College London, provides an overview of sustainable batteries and the complex, interdisciplinary questions that go into defining and engineering them.This virtual Cell Press LabLinks, “Batteries: Designing a safe and sustainable future,” held on February 21, 2024, brings together diverse stakeholders for a discussion-focused event around the emerging notion of Safe-and-Sustainable-by-Design. 00:00:00 - Event introduction from Andy Wadsworth, editor at Joule00:02:13 - Plenary talk from Prof. Magda Titirici
Hippocampal decision-predictive time cells / Curr. Biol., Feb. 6, 2024 (Vol. 34, Issue 4) Cell Press 2024-02-26 | Ma et al. show that stimulus divergence of neural activity of cells in dorsal CA1 takes place at discrete times during a mouse’s response in a go-no go associative learning task. The sequential neural dynamics of these “decision-predicting time cells” in dorsal CA1 would provide a cognitive time map for decision making in associative learning.Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(24)00021-6.M. Ma, F.S.d. Souza, G.L. Futia, S.R. Anderson, J. Riguero, D. Tollin, A. Gentile-Polese, J.P. Platt, K. Steinke, N. Hiratani, et al. (2024). Sequential activity of CA1 hippocampal cells constitutes a temporal memory map for associative learning in mice. Curr. Biol. 34.And read more great research at http://www.cell.com/current-biology/home.
Microenvironmental stiffness induces metabolic reprogramming in glioblastoma Cell Press 2024-01-29 | In this episode of Research in Action, Dr. Stephanie Seidlits of the University of Texas at Austin discusses how the mechanical microenvironment of brain tissue cells can affect the metabolism and invasive behavior of brain cancer cells.
Permissive females facilitate spread of new signal / Curr. Biol., Dec. 22, 2023 (Vol. 34, Issue 2) Cell Press 2024-01-22 | Zhang et al. test how new animal signal variants evolve. In Hawaiian crickets, males evolved higher-pitch courtship songs under selection from eavesdropping enemies. However, males singing songs at these abnormal frequencies suffer no mating disadvantage. Permissive females may buffer against the loss of new signal variants.Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(23)01651-2.R. Zhang, J.G. Rayner, and N.W. Bailey (2024). Rapid sexual signal diversification is facilitated by permissive females. Curr. Biol. 34.And read more great research at http://www.cell.com/current-biology/home.
Curious caracaras: The puzzle-solving wild falcons / Curr. Biol., Nov. 20, 2023 (Vol. 34, Issue 1) Cell Press 2024-01-08 | Striated caracaras, wild falcons from the remote Falkland Islands, quickly learn to solve an unfamiliar puzzle with eight distinct food challenges—and they do it faster each time they try. These curious falcons performed as well as tool-using parrots on the same tasks, and even better on some tasks. Striated caracaras’ remarkable flexibility in approaching the puzzle, coupled with their eagerness to participate and unwariness of humans, highlights these birds as a promising new model for studies of avian cognition.Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(23)01462-8.K.J. Harrington, R. Folkertsma, A.M.I. Auersperg, L. Biondi, and M.L. Lambert (2023). Innovative problem solving by wild falcons. Curr. Biol. 34.And read more great research at http://www.cell.com/current-biology/home.
Celebrating science that inspires new directions Cell Press 2024-01-04 | In 1974, the journal of “exciting biology” was launched. Fifty years later Cell continues to pave the way with ground-breaking, game-changing research across the life and health sciences. Today, as part of Cell Press, Cell is one of almost 60 journals spanning the sciences, all focused on our mission to engage and enable scholars and practitioners in all disciplines with passion, and integrity.An anniversary is an opportunity to reflect on the past, look toward the future and, importantly, to celebrate with the community of scientists – including authors, reviewers, and readers – who choose Cell Press. It has been an honor and a privilege. Thank you. We believe, to meet our greatest challenges, the world needs science that inspires. Science across all disciplines, all geographies, and at all stages of research. Throughout 2024 and beyond, we will focus on the real-world impact of the science we publish and launch initiatives to inspire new directions in research all with the goal of making the world a better place. We hope that you’ll join us in promoting better outcomes, driving innovation, bringing communities together, and advocating for science and scientists. We can’t do it without you.
Fast or slow: How motoneurons get precise / Curr. Biol., Dec. 28, 2023 (Vol. 34, Issue 2) Cell Press 2023-12-28 | Some animals move slow, while others move fast. This imposes different constraints on the precision of motoneurons governing different behaviors. We asked how neurons can adapt to such different behaviors by investigating spinal motoneurons controlling locomotion and rattling in the western diamondback rattlesnake. We show that the modulation of a single specific ion channel, the KV7 potassium channel, alters the ability of these neurons to transmit motor commands with high temporal precision.Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(23)01650-0.M.S. Bothe, T. Kohl, F. Felmy, J. Gallant, and B.P. Chagnaud (2023). Timing and precision of rattlesnake spinal motoneurons are determined by the KV72/3 potassium channel. Curr. Biol. 34.And read more great research at http://www.cell.com/current-biology/home.
Meeting the Paris Agreement goals: Where are we and where do we need to head? | Forum Cell Press 2023-12-20 | Forums on Sustainability bring together speakers from across disciplines and around the world to drive conversations on key sustainability challenges. This year, both states and non-state actors have taken stock of the progress made towards the Paris Agreement goals. The outcomes of this will inform decision-making at the UN Climate Change Conference (COP28). Incidentally, this year also marks the mid-term review of the progress on achieving the Sustainable Development Goals (SDGs).This virtual forum on November 21 from Cell Press brought together four experts to provide perspectives on mitigation, adaptation, finance, and the possibility of integrating climate action and sustainable development. The event featured speakers Mengye Zhu of the University of Maryland, Nella Canales of the Stockholm Environment Institute, Charlene Watson of ODI, and Lukas Hermwille of the Wuppertal Institute for Climate, Environment, and Energy and moderator Ninad Bondre, Senior Sustainability Editor at Cell Press.
Inclusive language in scientific publishing: Health and disability Cell Press 2023-12-06 | Cell Press’s inclusive language speaker series brings together researchers with various perspectives on inclusive language in science and seeks to provide our editors and employees the perspectives needed to make the language of scientific publishing more accurate and inclusive. We're proud to now be able to share this series with the broader scientific community. This session focused on the language we use to describe the spectrum of health, disease, and disability in scientific research and beyond. The panel featured three speakers: Amy Oulton, a Tedx speaker and advocate, Dr. Fatima Cody Stanford, a physician and public health expert, and Vicki Mooney, Executive Director of the European Coalition for People living with Obesity. The talk was moderated by Amber Mueller, editor of Cell Metabolism.For a transcript of the talk, please contact diversity@cell.com.
Inclusive language in scientific publishing: Race, ethnicity, and ancestry Cell Press 2023-12-06 | Cell Press’s inclusive language speaker series brings together researchers with various perspectives on inclusive language in science and seeks to provide our editors and employees the perspectives needed to make the language of scientific publishing more accurate and inclusive. We're proud to now be able to share this series with the broader scientific community. This session focused on the use of the terms “race,” “ethnicity,” and “ancestry” in scientific research and featured three speakers: Sonia Anand, Alice Popejoy, and Courtney Bonam. Sonia Anand is a Professor of Medicine at McMaster University. She also serves as the Canada Research Chair in Ethnic Diversity and Cardiovascular Health and the Heart and Stroke Foundation of Canada in Population Health. Alice Popejoy is an Assistant Professor of Epidemiology at the University of California, Davis Health and a member of the NIH ClinGen Ancestry and Diversity Working Group. Courtney Bonam is an Assistant Professor of Psychology and Critical Race and Ethnic Studies at the University of California, Santa Cruz where she also works with the Student Success Equity Research Center. The talk was moderated by Shankar Iyer, editor of Trends in Microbiology.For a transcript of the talk, please contact diversity@cell.com.
One Earth Voices on the Plastics Treaty Cell Press 2023-12-04 | One Earth Voices is a series of invited perspectives on topics of socio-economic importance. This Voices, on the upcoming Plastics Treaty, comes from the June 2023 issue of One Earth. It features international plastic pollution experts Anja Brandon, Kumar Raja Vanapalli, Olwenn V. Martin, Hanna Dijkstra, Gabriel Enrique De la Torre, Nanna B. Hartmann, Michael A.R. Meier, Gauri Pathak, Per-Olof Busch, Ding Ma, Eleni Iacovidou, Carolyn Deere Birkbeck, and Henrique Pacini, who each answer the question, "What is needed for the Plastics Treaty to meaningfully address the plastics crisis?"Read the full article here: cell.com/one-earth/fulltext/S2590-3322(23)00256-7
Barbastelles and the bat-moth arms race / Curr. Biol., Oct. 27, 2023 (Vol. 33, Issue 23) Cell Press 2023-12-04 | The quiet barbastelle bat is highlighted as the prime example of a bat that struck back at insect hearing—by emitting calls too quiet for the insects to hear. However, we show that barbastelle echolocation evolved from a quiet gleaning ancestor and reflects limitations imposed by nasal sound emission. So, while barbastelle stealth echolocation circumvents moth hearing, it did not evolve specifically to counter it.Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(23)01372-6.D. Lewanzik, J.M. Ratcliffe, E.A. Etzler, H.R. Goerlitz, L. Jakobsen (2023). Stealth echolocation in aerial hawking bats reflects a substrate gleaning ancestry. Curr. Biol. 33.And read more great research at http://www.cell.com/current-biology/home.
From food cues to food consumption / Curr. Biol., Oct. 16, 2023 (Vol. 33, Issue 22) Cell Press 2023-11-20 | How food cues influence consumption remains elusive. In their research, Li et al. have pinpointed a cluster of inhibitory CRH neurons within the lateral hypothalamic area that play a pivotal role in regulating appetite triggered by food cues. This video shows that these neurons exhibit varying responses to food cues under diverse physiological conditions, and intervening in their activities also has a positive effect on regulating feeding behavior. Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(23)01299-X.S.-Y. Li, J.-J. Cao, K. Tan, L. Fan, Y.-Q. Wang, Z.-X. Shen, S.-S. Li, C. Wu, H. Zhou, and H.-T. Xu (2023). CRH neurons in the lateral hypothalamic area regulate feeding behavior of mice. Curr. Biol. 33.And read more great research at http://www.cell.com/current-biology/home.
Excess pancreatic elastase in diabetes / Cell Metab., June 19, 2023 (Vol. 35, Issue 7) Cell Press 2023-11-14 | Giorgio Basile, Rohit Kulkarni, and colleagues have observed CELA3B genes to be upregulated in acinar cells linked to augmented CELA3B protein within the islet milieu of type 2 diabetes patients, resulting in reduced β cell homeostasis secondary to impairment of two signaling hubs: mechano-signaling and PAR2 pathways. PE inhibitors rescue β cell homeostasis and point to anti-PE therapies for diabetes.Check out the paper at http://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00184-5.G. Basile, A. Vetere, J. Hu, O. Ijaduola, Y. Zhang, K.-C. Liu, A.M. Eltony, D.F. De Jesus, K. Fukuda, G. Doherty, et al. (2023). Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways. Cell Metab. 35.And read more great research at http://www.cell.com/cell-metabolism/home.
Pancreatic plasticity at work by dynamic scRNA-seq / Cell Metab., Oct. 27, 2023 (Vol. 35, Issue 11) Cell Press 2023-11-14 | Mayur Doke, Juan Domínguez-Bendala, and colleagues report that the integration of scRNA-seq datasets obtained from human pancreatic slices at different time points, with or without the regenerative factor BMP-7, reveals distinct differentiation waves where the barriers between the various compartments of the pancreas seem to blur along a ductal-to-acinar-to-endocrine axis. Following differentiation from an acinar-like transitional stage, neogenic insulin-producing cells are detected in slices of type 1 diabetes donors, exhibiting full beta cell-like functionality in response to glucose stimulation. These results open the door to the design of pharmacological approaches to restore beta cell mass in patients, bypassing the need for transplantation.Check out the paper at http://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00370-4.M. Doke, S. Álvarez-Cubela, D. Klein, I. Altilio, J. Schulz, L. Mateus Gonçalves, J. Almaça, C.A. Fraker, A. Pugliese, C. Ricordi, et al. (2023). Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage. Cell Metab. 35.And read more great research at http://www.cell.com/cell-metabolism/home.
Neddylation of PCK1 controls glucose metabolism / Cell Metab., Aug. 3, 2023 (Vol. 35, Issue 9) Cell Press 2023-11-14 | María Gonzalez-Rellan, Uxía Fernández, Ruben Nogueiras, and colleagues have discovered that the neddylation of PCK1 at three key lysine residues plays a physiological role in glucose homeostasis by inducing the synthesis of glucose in conditions of nutrient deficiency and by being a common mechanism shared by the counter-regulatory hormones glucagon, adrenaline, and glucocorticoids in the counter-regulatory response to increase glucose availability.Check out the paper at http://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00263-2.M.J. Gonzalez-Rellan, U. Fernández, T. Parracho, E. Novoa, M.F. Fondevila, N. da Silva Lima, L. Ramos, A. Rodríguez, M. Serrano-Maciá, G. Perez-Mejias, et al. (2023). Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism. Cell Metab. 35.And read more great research at http://www.cell.com/cell-metabolism/home.
A GLP-1/GDF15 dual agonist / Cell Metab., Jan. 26, 2023 (Vol. 35, Issue 2) Cell Press 2023-11-14 | Yuanyuan Zhang, Alexei Kharitonenkov, and colleagues have developed QL1005, a GLP-1/GDF15 hybrid molecule with balanced pathway activation, which can effectively lower body weight via reductions in caloric intake in multiple animal models. In a non-human primate model of obesity, QL1005’s safety and tolerability are similar to that of incretin-based therapies.Check out the paper at http://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00001-3.Y. Zhang, X. Zhao, X. Dong, Y. Zhang, H. Zou, Y. Jin, W. Guo, P. Zhai, X. Chen, and A. Kharitonenkov (2023). Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates. Cell Metab. 35.And read more great research at http://www.cell.com/cell-metabolism/home.
Palmitoylation and β cell failure in diabetes / Cell Metab., Jan. 11, 2023 (Vol. 35, Issue 2) Cell Press 2023-11-14 | Guifang Dong, Clay Semenkovich, and colleagues have discovered that the depalmitoylation enzyme acyl-protein thioesterase 1 (APT1) is altered in pancreatic islets from people with type 2 diabetes and in nondiabetic islets exposed to hyperglycemia. APT1 deficiency in mice increases insulin secretion that promotes β cell failure in the setting of metabolic stress, suggesting involvement of palmitoylation in diabetes pathogenesis.Check out the paper at http://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00549-6.G. Dong, S. Adak, G. Spyropoulos, Q. Zhang, C. Feng, L. Yin, S.L. Speck, Z. Shyr, S. Morikawa, R.A. Kitamura, et al. (2023). Palmitoylation couples insulin hypersecretion with β cell failure in diabetes. Cell Metab. 35.And read more great research at http://www.cell.com/cell-metabolism/home.
Two major epigenetic subtypes of β cells / Cell Metab., Mar. 21, 2023 (Vol. 35, Issue 5) Cell Press 2023-11-14 | β cells, the sole providers of insulin, are highly specialized, long-lived cells that rely on specific epigenetic systems to maintain their identity. By leveraging distinct differences in the histone modification H3K27me3, Erez Dror, Andrew Pospisilik, and colleagues identified and characterized two subtypes of β cells that are distinctive by their morphology, epigenomes, transcriptomes, and function.Check out the paper at http://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00086-4.E. Dror, L. Fagnocchi, V. Wegert, S. Apostle, B. Grimaldi, T. Gruber, I. Panzeri, S. Heyne, K.D. Höffler, V. Kreiner, et al. (2023). Epigenetic dosage identifies two major and functionally distinct β cell subtypes. Cell Metab. 35.And read more great research at http://www.cell.com/cell-metabolism/home.
Optical mapping of cardiac electromechanics in beating in vivo hearts Cell Press 2023-11-06 | See the full article by Zhang et al. at cell.com/biophysj/fulltext/S0006-3495(23)00620-3
Snow flies amputate their legs to survive in cold / Curr. Biol., Sept. 26, 2023 (Vol. 33, Issue 21) Cell Press 2023-11-06 | The snow fly, Chionea, is one of the only insects that remains active through the winter in snowy environments. Using thermal imaging, Golding et al. show that snow flies walk at sub-zero temperatures that incapacitate other insects. They also discovered that snow flies detect internal ice formation and self-amputate legs to avoid death by freezing.Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(23)01215-0.D. Golding, K.L. Rupp, A. Sustar, B. Pratt, and J.C. Tuthill (2023). Snow flies self-amputate freezing limbs to sustain behavior at sub-zero temperatures. Curr. Biol. 33.And read more great research at http://www.cell.com/current-biology/home.
Inclusive language in scientific publishing: Sex & gender Cell Press 2023-11-01 | Cell Press’s inclusive language speaker series brings together researchers with various perspectives on inclusive language in science and seeks to provide our editors and employees the perspectives needed to make the language of scientific publishing more accurate and inclusive. We're proud to now be able to share this series with the broader scientific community. This first session focused on improving the language of sex and gender in research and featured three speakers: Sarah S. Richardson, Professor of the History of Science & Studies of Women, Gender, and Sexuality at Harvard University; Paisley Currah, a Professor of Political Science and Women’s & Gender Studies at Brooklyn College and the Graduate Center of the City University of New York; and Kendra Albert, a clinical instructor at the Cyberlaw Clinic at Harvard Law School and the founder and director of the Initiative for a Representative First Amendment. The panel was moderated by Isabel Goldman, inclusion and diversity officer at Cell Press. 00:00:00 - Welcome from Isabel Goldman 00:00:31 - Short talk from Kendra Albert 00:15:38 - Short talk from Paisley Currah 00:32:28 - Short talk from Sarah S. Richardson 00:49:43 - Discussion Read Kendra Albert's paper in the journal Patterns, "Sex trouble: Sex/gender slippage, sex confusion, and sex obsession in machine learning using electronic health records," here: cell.com/patterns/fulltext/S2666-3899(22)00131-3 Read Sarah S. Richardson's paper in the journal Cell Reports Medicine, "Why 'sex as a biological variable' conflicts with precision medicine initiatives," here: cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00056-8 Learn more about Paisley Currah's work here: paisleycurrah.com For a transcript of the talk, please contact diversity@cell.com.
Length and strength in a male weapon / Curr. Biol., Sept. 20, 2023 (Vol. 33, Issue 20) Cell Press 2023-10-23 | Male rhinoceros beetles wield long “pitchfork”-shaped horns in battles over access to females. Usually males with the longest weapons win. Occasionally, fights escalate into pitched contests of strength where males use their horn as a lever to pry an opponent off the tree. When this happens, longer weapons might be weaker than shorter ones, unless other aspects of the lever system compensate. Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(23)01146-6.J.N. Weber, W. Kojima, R.P. Boisseau, T. Niimi, S. Morita, S. Shigenobu, H. Gotoh, K. Araya, C.-P. Lin, C. Thomas-Bulle, et al. (2023). Evolution of horn length and lifting strength in the Japanese rhinoceros beetle Trypoxylus dichotomus. Curr. Biol. 33.And read more great research at http://www.cell.com/current-biology/home.
Inclusive language in scientific publishing: Visual communication Cell Press 2023-10-12 | Cell Press’s inclusive language speaker series brings together researchers with various perspectives on inclusive language in science and seeks to provide our editors and employees the perspectives needed to make the language of scientific publishing more accurate and inclusive. We're proud to now be able to share this series with the broader scientific community.This session focused on understanding how visual representation (or the lack, thereof) impacts various communities, learning how to make our journals’ visuals more inclusive and precise, and protecting against unintended harm from the use of inaccurate and exclusionary imagery. The panels featured expert speakers Dr. Esmita Charani and Sabrina J. Ashwell and was moderated by Phillip Krzeminski, Cell Press’s Illustration and Design Program manager.Esmita Charani is an Associate Professor at the University of Cape Town where she is undertaking a Wellcome Trust Career Development Fellowship investigating intersectionality and AMR (2023-2027). She is also the author of “The use of imagery in global health: an analysis of infectious disease documents and a framework to guide practice”: thelancet.com/journals/langlo/article/PIIS2214-109X(22)00465-X/fulltextSabrina J. Ashwell is the senior copyeditor at Chemical & Engineering News, the independent news organization of the American Chemical Society. Sabrina led the creation of the ACS Inclusivity Style Guide and leads updates to that guide: acs.org/about/diversity/inclusivity-style-guide.html. She also worked with The Coalition for Diversity and Inclusion in Scholarly Communications to develop their guidelines on inclusive image usage: c4disc.pubpub.org/guidelines-on-inclusive-language-and-images-in-scholarly-communication. For a transcript of the talk, please contact diversity@cell.com.
Neurons in the visual cortex look outside the box / Curr. Biol., Aug. 28, 2023 (Vol. 33, Issue 18) Cell Press 2023-09-25 | A new study from the Netherlands Institute for Neuroscience shows that individual neurons that do not receive visual input still represent scene information through their connections with cells.Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(23)01053-9.P. Papale, F. Wang, A.T. Morgan, X. Chen, A. Gilhuis, L.S. Petro, L. Muckli, P.R. Roelfsema, and M.W. Self (2023). The representation of occluded image regions in area V1 of monkeys and humans. Curr. Biol. 33.And read more great research at http://www.cell.com/current-biology/home.
Worms sense sound pressure gradients / Curr. Biol., Aug. 28, 2023 (Vol. 33, Issue 18) Cell Press 2023-09-25 | How the earless roundworm C. elegans senses airborne sound to initiate phonotaxis behavior is not well understood. Here, Wang et al. show that worms sense sound pressure gradients rather than absolute sound pressure. Interestingly, the cochlea of the human inner ear and some insect ears also sense sound pressure gradients, revealing a common mechanism in auditory sensation.Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(23)01048-5.C. Wang, E.A. Ronan, S.-K. Kim, P. Kitsopoulos, A.J. Iliff, K. Grosh, G.-H. Kim, J. Liu, and X.Z.S. Xu (2023). Sensing of sound pressure gradients by C. elegans drives phonotaxis behavior. Curr. Biol. 33.And read more great research at http://www.cell.com/current-biology/home.
