Split brain behavioral experiments Neuroslicer 2007-04-19 | To reduce the severity of his seizures, Joe had the bridge between his left and right cerebral hemisphers (the corpus callosum) severed. As a result, his left and right brains no longer communicate through that pathway. Here's what happens as a result:
Triple transgenic GCaMP6f mouse Neuroslicer 2017-11-10 | Two-photon imaging of auditory activity in awake mouse during 1 Hz sound stimuli. Triple transgenic mouse expresses GCaMP6f fluorescent protein in Layer 4 excitatory pyramidal neurons. (Ai93 mouse from Jackson Labs crossed with Scnn1a-Cre mouse)
Layer 4 auditory cortex activity of awake mouse Neuroslicer 2017-11-09 | GCaMP6f fluorescence signaling from an awake mouse listening to tone stimuli. from Blundon et al., Science vol. 356, p. 1352 (2017).
Spontaneous activity in the awake mouse auditory thalamus Neuroslicer 2017-06-27 | Recorded 3 mm deep within the mouse brain, speed up 4 times normal speed.
Mauthe art deco clock.... two tone chimes Neuroslicer 2016-01-16 | Up for auction on eBay is this 1930's Mauthe art deco clock. Runs very well and has a lovely sounding chime.
Brain activity: visualized! Neuroslicer 2013-10-11 | Neuroscientists used to learn about patterns of neuron activity by recording their electrical signals directly, but that was usually done one or two cells at a time. Now, with advanced laser microscopes that can penetrate deep into the living brain, coupled with fluorescent probes that are ultra sensitive to neuron activity, we can explore neural network activity of ensembles of many neurons,
Memphis Kings Scooter Club: Dead Elvis III Scooter Rally (part deux) Neuroslicer 2010-01-10 | More pics from our third scooter rally. Scooterists interested in club activity should visit www.memphiskings.net and subscribe to our newsletter.
Visual cortex Neuroslicer 2009-03-29 | David Hubel and Torsten Wiesel recorded from neurons in the visual cortex of cats and mapped out their receptive fields. They found many neurons were excited by particular patterns of light or darkness, patterns such as dots, circles and bars. They also found neurons that were sensitive to shape orientation and movement. In this video they project these patterns of light onto a screen placed in front of the animal while recording from neurons in the visual cortex. The popping clicking sounds you hear correspond to electrical activity from these recorded nerve cells played over an audio monitor.
Dendritic spine activity in the auditory cortex Neuroslicer 2009-03-22 | This is a small dendritic branch from a Layer 3 neuron in the mouse auditory cortex. The neuron has been filled with a red fluorescent dye (Alexa 594), which is why it appears red on the video. It has also been filled with a calcium sensitive green fluorescent dye (Fluo 5F). When neurons from the thalamus are stimulated (during the yellow dot on the video), you will see that one of the dendritic spines (shown by the arrow) glows green, showing that it is being activated by thalamic stimulation. Using this mapping technique, we now know that thalamic neurons synapse very close to the cell body of these auditory neurons, helping to guarantee that they reliably receive sound information from the environment.
Cerebellar purkinje neuron Neuroslicer 2009-03-20 | This purkinje neuron from a mouse cerebellum was imaged with the fluorescent dye Alexa 594, injected into the cell with a microelectrode. The high resolution image was captured with a two photon laser scanning microscope. The microscope took two dimensional images of the neuron, and then advanced deeper into the tissue, one micron at a time, taking many more scans. The computer took the stack of images and reconstructed the 3D video you see here.
Aging & Alzheimers Disease, Part 2 Neuroslicer 2007-05-02 | There is substantial evidence that an active mind helps increase the survival of neurons in the brain that are at risk of Alzheimer's Disease. Chemicals in the brain called trophic factors, released during activity, may be at the heart of this saving effect.
Aging & Alzheimers Disease, Part 1 Neuroslicer 2007-05-02 | Senile dementia is not a direct consequence of aging. Alzheimer's Disease is more prevalent in the elderly, but the healthy aging brain and mind can be as vital as it was decades before.
Deep Brain Stimulation for Parkinsons Disease Part 1 Neuroslicer 2007-04-24 | Sybil's Parkinson's Disease can no longer be effectively treated with drug therapy. Deep brain stimulation is an alternative treatment that can re-establish quality of life in such patients.
Deep brain stimulation for Parkinsons Disease Part 2 Neuroslicer 2007-04-23 | Sybil's Parkinson's Disease can no longer be effectively treated with drug therapy. Deep brain stimulation is an alternative treatment that can re-establish quality of life in such patients.
Pallidotomy Part 2 Neuroslicer 2007-04-23 | Fred can no longer lead a quality life with Parkinson's disease, even with medication. Brain surgery called pallidotomy is an alternative to alleviate symptoms.
Pallidotomy Part 1 Neuroslicer 2007-04-23 | Fred can no longer lead a quality life with Parkinson's disease, even with medication. Brain surgery called pallidotomy is an alternative to alleviate symptoms.
Electroconvulsive shock therapy Neuroslicer 2007-04-19 | Mary has severe depression to the point of suicide. She does not respond to drug therapy. She and people like her are often helped with electroconvulsive shock therapy.
Amnesia Neuroslicer 2007-04-19 | Clive suffers from amnesia as a result of damage to his hippocampus. He cannot incorporate current experiences into his short term or long term memory.
Mania can resemble schizophrenia or even a crack high! Neuroslicer 2007-04-19 | Patients showing a manic episode often have delusions common in schizophrenia, and euphoria common during cocaine usage.
Bipolar Depression / Rapid cycling Neuroslicer 2007-04-19 | Kathy has bipolar depression and cycles frequently between highs and lows.
Morris water maze Neuroslicer 2007-04-18 | This is a wild type mouse showing spatial learning over a 5 day period in a Morris water maze.
Schizophrenia: Gerald, Part 1 Neuroslicer 2007-04-18 | Gerald shows all the signs of class schizophrenia
Learning and Memory: Radial arm maze Part 1 Neuroslicer 2007-04-18 | This wild type mouse has been trained to find the hidden treats at the end of the arms in this 8 arm radial maze.
Schizophrenia: Heather Neuroslicer 2007-04-18 | Heather shows disordered unorganized thoughts in her conversations. The odd facial expressions she displays when she speaks is a side effect of the antipsychotic medication she is on. While some antipsychotic meds do not produce such side effects, not all schizophrenics response well to such medication.
Learning and Memory: Radial arm maze Part 2 Neuroslicer 2007-04-18 | This mouse has been genetically engineered without a protein in its brain that we believe is important in learning and memory. It is having trouble remembering where the treats are in this radial maze.
Neuroanatomy of the brain Neuroslicer 2007-04-18 | For all you pre-medical, medical and neuro grad students who need to brush up on their neuroanatomy, this video will help!
Schizophrenia: Gerald, Part 2 Neuroslicer 2007-04-18 | Schizophrenia has a huge impact on the family of those afflicted, as well.
