Ep. 4: Jayne Rees Buxton on The Great Plant Based Con—With Dr Brian Kerley @TuckerGoodrich0

Tucker Goodrich: Debugging Life Jayne Rees Buxton, author
thegreatplantbasedcon.com/books

Amazon: "The Great Plant-Based Con"
amzn.to/3PdeV7A
Using these Amazon link suppports this podcast, so thank you!

Amazon hardcover link (UK site):
amazon.co.uk/dp/1408717441

Twitter
twitter.com/JayneReesBuxton
_______________________________________

Co-host Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Blog: http://yelling-stop.blogspot.com
Youtube: youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg
Podcast: sites.libsyn.com/408758
Twitter: twitter.com/TuckerGoodrich
_______________________________________
Show Notes
**these are points we mention that I think people might want to read more about, or to explain or correct a point made. I don't inlude material from the book that we discuss, you'll have to get a copy to follow up on that information!

Colourful conman
mcgill.ca/oss/article/controversial-science-health-news/colourful-conman

Obituary—Jay Dinshah, 66, American Vegan Society Leader
ivu.org/news/oct2000/dinshah.html

"The Game Changers" movie
amzn.to/3o3bu7n

Clark, M. A., Springmann, M., Hill, J., & Tilman, D. (2019). Multiple health and environmental impacts of foods. Proceedings of the National Academy of Sciences, 116(46), 23357–23362.
doi.org/10.1073/pnas.1906908116

Banta, J. E., Lee, J. W., Hodgkin, G., Yi, Z., Fanica, A., & Sabate, J. (2018). The Global Influence of the Seventh-Day Adventist Church on Diet. Religions, 9(9), 251.
doi.org/10.3390/rel9090251

O, ’Hearn Meghan, Lauren, B. N., Wong, J. B., Kim, D. D., & Mozaffarian, D. (2022). Trends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018. Journal of the American College of Cardiology, 80(2), 138–151. doi.org/10.1016/j.jacc.2022.04.046

"Oatly ads banned by UK watchdog over ‘misleading’ green claims"
theguardian.com/media/2022/jan/26/oatly-ads-banned-by-uk-watchdog-over-misleading-green-claims

"Tesco plc"
ethicalconsumer.org/company-profile/tesco-plc

"Protein content claims and methylcellulose in the spotlight as Beyond Meat hit with new lawsuits"
foodnavigator-usa.com/Article/2022/06/03/Protein-content-claims-and-methylcellulose-in-the-spotlight-as-Beyond-Meat-hit-with-new-lawsuits

Physician's Committee for Responsible Medicine is run by Neal Barnard, not David Katz.
pcrm.org/about-us

There are ~1 million physicians in the U.S. (statista.com/topics/1244/physicians/#topicHeader__wrapper), according to PCRM, they have 17,000 physician members (see link above), so that's 1.7% of practicing physicians as members. Of course the vast majority of the rest are *also* in favor of responsible medicine, so the name is a bit of a slander.

BBC Radio 4 interview (twitter.com/JayneReesBuxton/status/1525798657919963137) "Eating Meat, Inclusive Rents and Business Going Bust"
bbc.co.uk/sounds/play/m0017cp5

(Thanks to David Wyant for the link! twitter.com/wyadvd/status/1548002099518091264)

"Honest Burgers is to convert its all-vegan V Honest site close to London's Leicester Square back to its core concept in July, just six months after launching the spin-off brand."
bighospitality.co.uk/Article/2022/06/23/Honest-Burgers-to-convert-V-Honest-site-back-to-core-concept-after-just-six-months

updated 4 years ago

Ep. 4: Jayne Rees Buxton on The Great Plant Based Con—With Dr Brian Kerley

Tucker Goodrich: Debugging Life 2022-07-16 | Jayne Rees Buxton, author
thegreatplantbasedcon.com/books

Amazon: "The Great Plant-Based Con"
amzn.to/3PdeV7A
Using these Amazon link suppports this podcast, so thank you!

Amazon hardcover link (UK site):
amazon.co.uk/dp/1408717441

Twitter
twitter.com/JayneReesBuxton
_______________________________________

Co-host Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Blog: http://yelling-stop.blogspot.com
Youtube: youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg
Podcast: sites.libsyn.com/408758
Twitter: twitter.com/TuckerGoodrich
_______________________________________
Show Notes
**these are points we mention that I think people might want to read more about, or to explain or correct a point made. I don't inlude material from the book that we discuss, you'll have to get a copy to follow up on that information!

Colourful conman
mcgill.ca/oss/article/controversial-science-health-news/colourful-conman

Obituary—Jay Dinshah, 66, American Vegan Society Leader
ivu.org/news/oct2000/dinshah.html

"The Game Changers" movie
amzn.to/3o3bu7n

Clark, M. A., Springmann, M., Hill, J., & Tilman, D. (2019). Multiple health and environmental impacts of foods. Proceedings of the National Academy of Sciences, 116(46), 23357–23362.
doi.org/10.1073/pnas.1906908116

Banta, J. E., Lee, J. W., Hodgkin, G., Yi, Z., Fanica, A., & Sabate, J. (2018). The Global Influence of the Seventh-Day Adventist Church on Diet. Religions, 9(9), 251.
doi.org/10.3390/rel9090251

O, ’Hearn Meghan, Lauren, B. N., Wong, J. B., Kim, D. D., & Mozaffarian, D. (2022). Trends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018. Journal of the American College of Cardiology, 80(2), 138–151. doi.org/10.1016/j.jacc.2022.04.046

"Oatly ads banned by UK watchdog over ‘misleading’ green claims"
theguardian.com/media/2022/jan/26/oatly-ads-banned-by-uk-watchdog-over-misleading-green-claims

"Tesco plc"
ethicalconsumer.org/company-profile/tesco-plc

"Protein content claims and methylcellulose in the spotlight as Beyond Meat hit with new lawsuits"
foodnavigator-usa.com/Article/2022/06/03/Protein-content-claims-and-methylcellulose-in-the-spotlight-as-Beyond-Meat-hit-with-new-lawsuits

Physician's Committee for Responsible Medicine is run by Neal Barnard, not David Katz.
pcrm.org/about-us

There are ~1 million physicians in the U.S. (statista.com/topics/1244/physicians/#topicHeader__wrapper), according to PCRM, they have 17,000 physician members (see link above), so that's 1.7% of practicing physicians as members. Of course the vast majority of the rest are *also* in favor of responsible medicine, so the name is a bit of a slander.

BBC Radio 4 interview (twitter.com/JayneReesBuxton/status/1525798657919963137) "Eating Meat, Inclusive Rents and Business Going Bust"
bbc.co.uk/sounds/play/m0017cp5

(Thanks to David Wyant for the link! twitter.com/wyadvd/status/1548002099518091264)

"Honest Burgers is to convert its all-vegan V Honest site close to London's Leicester Square back to its core concept in July, just six months after launching the spin-off brand."
bighospitality.co.uk/Article/2022/06/23/Honest-Burgers-to-convert-V-Honest-site-back-to-core-concept-after-just-six-months

Ep. 26: How To Lie With Science (Nick Jikomes Livestream)

Tucker Goodrich: Debugging Life 2026-03-16 | Introduction
Nick asked me to do a YouTube livestream to go over some research he had been doing. He drilled down on a reference in a high-profile cardiology guideline article and discovered that the authors had inverted the research finding in the referenced paper to claim the inverse of what it actually showed.

We discussed this, and then I gave some more context about the matter and one of the authors.

“Nick Jikomes is a neuroscientist, plant chemistry researcher, data scientist, and podcast host. He received a PhD in Neuroscience from Harvard University and a Bachelor of Science in Genetics from the University of Wisconsin. Nick currently works in the legal cannabis industry in the US.”

nickjikomes.com/about

Home page, with links to writing and podcasts.

nickjikomes.com

@MindAndMatter
_______________________________________

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes
TK

If you have any questions about sources for things discussed please ask in the comments.

Ep. 25: Is Mikhail Shchepinov Breaking The Chains of Aging?

Tucker Goodrich: Debugging Life 2026-03-02 | Introduction
It's well-known that lipid peroxidation is involved in aging and longevity. But what can we do about it? Dr. Shchepinov has been researching using deuterium to 'shore up' the PUFAs like those in seed oils to prevent them become toxic metabolites. He's had some interesting successes, and we discuss at length his new book: “Breaking the Chains of Aging”.

Amazon link:
amzn.to/46A29KX

Book website
breakingaging.com

Research:
scholar.google.com/citations?user=0kQp8lEAAAAJ&hl=en

Biography:
Mikhail Shchepinov trained in Moscow (PhD, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 1994), then moved to Oxford to work on DNA microarray technology, combinatorial chemistry, and oligonucleotide dendrimers.
He worked in academia and biotech in Oxford, UK and San Diego, USA, and is affiliated with several universities.

From: breakingaging.com/author
_______________________________________

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
If you have any questions about sources for things discussed please ask in the comments.

Ep. 24: Does Deuterium Cause Chronic Disease? With Prof. John Speakman

Tucker Goodrich: Debugging Life 2026-02-23 | There's an idea going around that increased deuterium in the diet is what's wrong with seed oils, and is what is causing chronic disease.

In this video, we talk to a world expert on deuterium and metabolism to see if the idea holds any water.

Ep. 23 Debate: Ep 23 Doctors Should Tell Patients that High Linoleic Acid Seed Oils are Unhealthy

Tucker Goodrich: Debugging Life 2024-05-17 | Introduction
So apparently there is some demand for discussion/debate on the topic of seed oils and health. Dave Feldman (Ep. 9) had considered doing this at his recent conference, but couldn’t fit in the time.
He’s since regained interest in the idea, and reached out to Andreas Eenfeldt and Ted Naiman, who have expressed skepticism. They replied:
“We decline as we feel this debate is a distraction. The reason is that we see no good scientific evidence for replacing any source of added pure fat with another. It's not the right question.”
Since there’s so much interest, and clearly that opinion is not defensible—probably why they avoided the debate!—Raphael Sirtoli volunteered to take the con side of a debate, topic:
“Doctors Should Tell Patients that High Linoleic Acid Seed Oils are Unhealthy”
This was a debate proposition that Raphi had suggested recently, and it had also been declined. (More about that in a future episode.)
So, here we are. Please enjoy, and as always, post questions or comments in the comments below.
The debate on Dave’s YouTube channel is here:
youtube.com/live/JDsbpAJ28U4?si=4n7mSt56JiQDXTGN
_______________________________________

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes

See Substack for the notes, too long for Youtube:

open.substack.com/pub/tuckergoodrich/p/ep-23-ep-23-doctors-should-tell-patients

If you have any questions about sources for things discussed please ask in the comments.

Ep 22 Preview: Food Reward and Obesity

Tucker Goodrich: Debugging Life 2024-05-09 | See the full episode here or Substack for more info.

open.substack.com/pub/tuckergoodrich/p/ep-22-john-speakmanwhat-causes-obesity

Ep. 22: John Speakman—What Causes Obesity?

Tucker Goodrich: Debugging Life 2024-05-09 | Introduction
I am honored to be joined by John Speakman, a leading authority on energy balance in animals, and in the use of the doubly-labeled water method of determining energy balance. This has led him into the study of obesity, among other topics, where he has become a recognized expert.
Our discussion was prompted by his recent paper, “Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure”, which casts a new light onto the world pandemic of obesity.
In addition to discussing a few of the papers that give some background to that one, and his future research plans in light of that paper, we have an enlightening discussion on the potential role of deuterium in obesity and chronic disease.
Biography:
“John Roger Speakman (born 1958) FRS FRSE FRSB FRSA FMedSci FRSS is a British biologist working at the University of Aberdeen, Institute of Biological and Environmental Sciences, for which he was Director from 2007 to 2011. He leads the University's Energetics Research Group, which is one of the world's leading groups using doubly labeled water (DLW) to investigate energy expenditure and balance in animals. Between 2011-2020, he was a '1000 talents' Professor at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, in Beijing, China, where he ran the molecular energetics group. In 2020 he moved to the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences in Shenzhen, China where he works at the Center for Energy Metabolism and Reproduction and Head of the Shenzhen Key laboratory of Metabolic Health.”
en.wikipedia.org/wiki/John_Speakman
_______________________________________

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes
Too many to fit here, see Substack..

open.substack.com/pub/tuckergoodrich/p/ep-22-john-speakmanwhat-causes-obesity

If you have any questions about sources for things discussed please ask in the comments.

Ep TK: Discussions I would like to have: Seed Oils vs Sugar Carbs with Dr. Robert Lufkin

Tucker Goodrich: Debugging Life 2024-05-02 | ...

Ep. 21: How Seed Oils Promote Cancer—with Matt Quinn and Dr. Brian Kerley

Tucker Goodrich: Debugging Life 2024-05-02 | Introduction
Cancer is the second-leading killer of Americans, and is increasing both around the world and increasingly affecting younger and younger people.
It’s obviously important to understand what environmental factors might affect our susceptibility to the various cancers.
Here we discuss what I think is a key paper showing a link between our environment, genetic mutation, and metabolic dysfunction in cancer cells.
“The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in Hepatocellular Carcinoma” (Hu et al., 2002)

Guest info
Matt Quinn
twitter.com/Mqsley
https://www.mquinn.online/

Biography:
TL;DR Here's what I am working on:
I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here
I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this
I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here
In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here
I have failed at so so so many things - read about them here
https://www.mquinn.online/
_______________________________________
Co-host
Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes
Hu, W., Feng, Z., Eveleigh, J., Iyer, G., Pan, J., Amin, S., Chung, F.-L., & Tang, M. (2002). The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in Hepatocellular Carcinoma. Carcinogenesis, 23(11), 1781–1789.
doi.org/10.1093/carcin/23.11.1781

Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection
amzn.to/3Unn39b

Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
amzn.to/44pbz9C

Goodrich, T. D. (2021, July 8). Interview: Thomas Seyfried on Glioblastoma, Metabolic Cancer Breakthroughs, with David Gornoski on A Neighbor’s Choice [Blog]. Yelling Stop.
yelling-stop.blogspot.com/2021/07/podcast-interview-thomas-seyfried-with.html

Soussi, T. (2000). The P53 Tumor Suppressor Gene: From Molecular Biology to Clinical Investigation. Annals of the New York Academy of Sciences, 910, 121–137; discussion 137-139.
doi.org/10.1111/j.1749-6632.2000.tb06705.x

Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006). P53 Regulates Mitochondrial Respiration. Science, 312(5780), 1650–1653.
doi.org/10.1126/science.1126863
The American Oil Chemists’ Society. (2004, June). Wilhelm Normann (1870-1939). INFORM Magazine.
lipidlibrary.aocs.org/resource-material/the-history-of-lipid-science-and-technology/wilhelm-normann-(1870-1939)
Goodrich, T. D. (2016, January 14). Thyroid and Low-Carb: What Do Thyroid Hormones Do? [Blog]. Yelling Stop.
open.substack.com/pub/tuckergoodrich/p/thyroid-and-low-carb-what-do-thyroid

If you have any questions about sources for things discussed please ask in the comments.

Ep. 20: Are Seed Oils a Problem?—with Jacob Hands (Ep. 19 Excerpt)

Tucker Goodrich: Debugging Life 2024-04-19 | Introduction
Dr. Brian Kerley, my co-host (although not on this episode) requested that I break out the seed oil discussion that Jacob and I had in episode 19. I had been thinking this would be a good idea as well, as it was a bit out of place in that episode, although I am glad Jacob wanted to discuss it.
So if you have already listened to ep. 19, this will be redundant. We’ll have a new episode out soon.
If you haven’t listened to ep. 19, then this was a discussion that Jacob requested we have about some weaknesses that he perceived in the idea that seed oils are causal in chronic disease.
Unfortunately, we only touched the tip of the iceberg, but he brought up a number of excellent points, which are well worth discussing.
Enjoy!
Guest info
Jacob Hands, MD candidate and consultant for Consumer Lab on quality control and testing of supplements, and consultant to Rhonda Patrick, MD, of Found my Fitness.
Consumer Lab consumerlab.com
Found my Fitness foundmyfitness.com

Biography:
“Medical student passionate about patient care, research, and emerging therapeutics.
“M.D. Candidate at The George Washington University School of Medicine and Health Sciences.”
linkedin.com/in/jacob-hands-3622619b

_______________________________________
Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes
See the notes in the previous episode:

tuckergoodrich.substack.com/p/ep-19-jacob-m-handswhats-wrong-with

Ep. 19: Jacob M. Hands—Whats Wrong With Fish Oil (Chocolate too!?!)?

Tucker Goodrich: Debugging Life 2024-04-11 | Introduction
What about fish oil? Is it a problem due to oxidation and contamination? Is it beneficial to health as many claim or is it a PUFA that’s bad for your health?
Jacob recently published an analysis of various fish oils with the team at Consumer Labs, looking at oxidative toxicity and purity of a wide variety of commercially available fish oils.
We discuss omega-3 and health, fish oils and oxidation, the science of seed oils and health, and, as a bonus, the problem with chocolates.
This is definitely a bit of a geek fest, so let me know if you have any questions.
Guest info
Jacob Hands, MD candidate and consultant for Consumer Lab on quality control and testing of supplements, and consultant to Rhonda Patrick, MD, of Found my Fitness.
Consumer Lab consumerlab.com
Found my Fitness foundmyfitness.com

Biography:
“Medical student passionate about patient care, research, and emerging therapeutics.
“M.D. Candidate at The George Washington University School of Medicine and Health Sciences.”
linkedin.com/in/jacob-hands-3622619b

_______________________________________
Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes
Hands, J. M., Anderson, M. L., Cooperman, T., & Frame, L. A. (2023). A Multi-Year Rancidity Analysis of 72 Marine and Microalgal Oil Omega-3 Supplements. Journal of Dietary Supplements, 0(0), 1–12. doi.org/10.1080/19390211.2023.2252064
This is the only human study I’m aware of showing harm from eating marine foods. The Japanese and the Eskimos do not suffer from infertility, so I think this gentleman must have been doing something wrong.
“I lived for 100 days on nothing but marine animal food (seal, fish, crustaceans and molluscs) and water; weights of all food were recorded….”
“In seminal fluid, the total amount of prostaglandins decreased significantly and small amounts of the [Ω-]3-series appeared; spermatozoa became immobile and then disappeared.”
Sinclair, H. M. (1981). The Relative Importance of Essential Fatty Acids of the Linoleic and Linolenic Families: Studies with an Eskimo Diet. Progress in Lipid Research, 20, 897–899. doi.org/10.1016/0163-7827(81)90167-3
Goodrich, T. D. (2022, April 13). The Folate Experiment [Blog]. Yelling Stop. open.substack.com/pub/tuckergoodrich/p/the-folate-experiment
Goodrich, T. (2021, October 19). What Is The Most Fattening Food? [Blog]. Yelling Stop. tuckergoodrich.substack.com/p/what-is-the-most-fattening-food
Mozaffarian, D., Hao, T., Rimm, E. B., Willett, W. C., & Hu, F. B. (2011). Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and Men. New England Journal of Medicine, 364(25), 2392–2404. doi.org/10.1056/NEJMoa1014296
Zong, G., Liu, G., Willett, W. C., Wanders, A. J., Alssema, M., Zock, P. L., Hu, F. B., & Sun, Q. (2019). Associations Between Linoleic Acid Intake and Incident Type 2 Diabetes Among U.S. Men and Women. Diabetes Care, 42(8), 1406–1413. doi.org/10.2337/dc19-0412
Johns, D. M. (2023, April 13). Nutrition Science’s Most Preposterous Result: Could Ice Cream Possibly Be Good for You? The Atlantic, 5/2023. theatlantic.com/magazine/archive/2023/05/ice-cream-bad-for-you-health-study/673487
Pearce, N. (2011). Epidemiology in a Changing World: Variation, Causation and Ubiquitous Risk Factors. International Journal of Epidemiology, 40(2), 503–512. doi.org/10.1093/ije/dyq257
Huang, Z., Sun, S., Lee, M., Maslov, A. Y., Shi, M., Waldman, S., Marsh, A., Siddiqui, T., Dong, X., Peter, Y., Sadoughi, A., Shah, C., Ye, K., Spivack, S. D., & Vijg, J. (2022). Single-Cell Analysis of Somatic Mutations in Human Bronchial Epithelial Cells in Relation to Aging and Smoking. Nature Genetics, 54(4), Article 4. doi.org/10.1038/s41588-022-01035-w

Jacob’s Discussion Notes

See Substack: open.substack.com/pub/tuckergoodrich/p/ep-19-jacob-m-handswhats-wrong-with?r=1g2jpl&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

If you have any questions about sources for things discussed please ask in the comments.

Ep. 18: What Causes Insulin Resistance?—with Matt Quinn and Dr. Brian Kerley

Tucker Goodrich: Debugging Life 2024-04-04 | Diabetes, broadly defined, afflicts greater than 50% of the U.S. population. The hallmark of type 2 diabetes is insulin resistance.

While many are unable to answer the question of why a formerly rare disease now afflicts the majority of the population, we go over research dating back to 1964 that makes it clear that we have a pretty good idea of what causes insulin resistance.

Scientists can easily induce insulin resistance in humans. How do they do it, and what might it tell us about what has caused our epidemic of diabetes?

Guest info
Matt Quinn
twitter.com/Mqsley
https://www.mquinn.online/

Biography:
TL;DR Here's what I am working on:
I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here
I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this
I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here
In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here
I have failed at so so so many things - read about them here
https://www.mquinn.online/

_______________________________________
Co-host
Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes
Felber, J. P., & Vannotti, A. (1964). Effects of Fat Infusion on Glucose Tolerance and Insulin Plasma Levels. Medicina Experimentalis: International Journal of Experimental Medicine, 10, 153–156. doi.org/10.1159/000135410
Nowotny, B., Zahiragic, L., Krog, D., Nowotny, P. J., Herder, C., Carstensen, M., Yoshimura, T., Szendroedi, J., Phielix, E., Schadewaldt, P., Schloot, N. C., Shulman, G. I., & Roden, M. (2013). Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans. Diabetes, 62(7), 2240–2248. doi.org/10.2337/db12-1179
Attia, P. (2020, December 7). #140 - Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications (140) [Mp3]. peterattiamd.com/geraldshulman
Koch, S., Cohen, D., & Carroll, L.. (2013, June 7). Drug treatment Omegaven that could save infants’ lives not yet approved by FDA [Mp4]. In NBC News. NBC. http://www.nbcnews.com/nightly-news/drug-treatment-omegaven-could-save-infants-lives-not-yet-approved-flna6C10249250

If you have any questions about sources for things discussed please ask in the comments.

Ep. 17: Making Better Meat—Autumn Smith and John Etchart (v2)

Tucker Goodrich: Debugging Life 2024-03-29 | Introduction
We’re honored to be joined today by Autumn Smith of Paleovalley and John Etchart of Wild Pastures. These related companies (John is Autumn’s brother-in-law) work to deliver healthy, regeneratively-farmed foods to their customers.
“At Paleovalley, our mission is to help people reclaim vibrant health. We provide products that prioritize nutrient density in an industry that prioritizes everything else. We believe that every dietary choice and every added ingredient is a powerful opportunity to love and care for oneself.”
paleovalley.com/about
Wild Pastures:
“Turning The Page To A Healthier You & A Healthier Planet
“We provide healthy, rotationally grazed, pasture-raised meats without hormones or antibiotics. Rotational grazing helps restore soil and sequester carbon from the atmosphere. We use no chemicals on our pastures... ever.
“We only work with small family farmers located in the USA using regenerative farming practices.
wildpastures.com
As I mention in the episode, Autumn sent me a sample box of the various products they offer, include meat from Wild Pastures and beef sticks and other products from Paleovalley.
Guest info
Wild Pastures
wildpastures.com
Paleovalley
paleovalley.com
Wild Pastures Burger Company
wildpasturesburger.com
Biography:
“Autumn Smith suffered from debilitating digestive issues and crippling anxiety for most of
her life. Specialist after specialist told her nothing could be done, and she was ready to give up.
But as one final attempt at a life free of health issues, Autumn decided to harness the power of
whole foods. She cleaned up her diet and in just 30 days, her IBS was cured. But that was just
the beginning. She also had less anxiety, was mentally sharper, and a bubbly side of her that she
forgot existed came back. Since then, Autumn has dedicated her life to helping others harness
the power of whole foods to live vibrant lives.
“In 2013, she and her husband Chas launched Paleovalley, a company dedicated to helping
people get the essential nutrients they need, without added sugars, grains, and other harmful
ingredients. But they didn’t stop there. After learning about the healing powers of grass fed,
pasture raised meat - both for our bodies and the planet - Autumn and Chas started their next
venture. In 2018, they launched Wild Pastures, a regenerative meat delivery service that sends
100% grass fed pasture raised meat directly to your doorstep.”
_______________________________________

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes
Autumn’s podcast interview of Tucker Goodrich
EP286: Seed Oils: History, Science and Negative Health Impacts with Tucker Goodrich
paleovalley.com/articles/ep286-seed-oils-history-science-and-negative-health-impacts-with-Tucker-Goodrich
Our Robb Wolf interview:
Podcast Ep. 3: Robb Wolf on 'Sacred Cow', His Health Issues, Beyond Paleo, and More... with Co-host Dr. Brian Kerley
yelling-stop.blogspot.com/2022/06/podcast-ep-3-robb-wolf-on-sacred-cow.html
van Vliet paper on fake meat:
“Despite apparent similarities based on Nutrition Facts panels, our metabolomics analysis found that metabolite abundances between the plant‑based meat alternative and grass‑fed ground beef differed by 90% (171 out of 190 profiled metabolites; false discovery rate adjusted p lt 0.05). Several metabolites were found either exclusively (22 metabolites) or in greater quantities in beef (51 metabolites) (all, p lt 0.05).”
van Vliet, S., Bain, J. R., Muehlbauer, M. J., Provenza, F. D., Kronberg, S. L., Pieper, C. F., & Huffman, K. M. (2021). A Metabolomics Comparison of Plant-Based Meat and Grass-Fed Meat Indicates Large Nutritional Differences Despite Comparable Nutrition Facts Panels. Scientific Reports, 11(1), 13828. doi.org/10.1038/s41598-021-93100-3
Bareburger
bareburger.com

If you have any questions about sources for things discussed please ask in the comments.

Ep 16 Understanding HNE

Tucker Goodrich: Debugging Life 2024-03-11 | Introduction
We look at a paper about the process of how the fats in seed oils become toxic, and what effects those toxins can have.
This paper is a broad overview of the related disease processes, which we will discuss to further understand how one thing can be driving many different disease processes.
“The study of lipid peroxidation (LPO) processes has become a rapidly growing ﬁeld in medicine and biology, based on increasing evidence that LPO is involved in the development of many chronic diseases, e.g. [references removed]
(1) Asthma
(2) Atherosclerosis
(3) Alzheimer’s disease
(4) Rheumatoid arthritis
(5) Burn injury
(6) Cataractogenesis
(7) Diabetes
(8) Endotoxin liver injury
(9) Multiple sclerosis
(10) Myocardial infarction
(11) Organ transplantation
(12) Parkinson disease
(13) Psoriasis
(14) Reperfusion injury
(15) Stroke
(16) Aging
“The obvious involvement of LPO processes in the majority of severe diseases stimulated worldwide efforts to elucidate the mechanisms of their generation.
“These efforts are expressed in the exploding ﬂood of papers, conference reports, review articles (see above) and books dealing with LPO. This paper is, therefore, not intended to add to these reviews but rather to address aspects previously overlooked: the dominant role of linoleic acid (LA) in LPO and the application of a combination of modern separation and identiﬁcation techniques to isolate LPO products. Knowledge of these products provides insight into the mechanisms of their generation and offers a better understanding of the diseases in which LPO is involved.” (Spiteller 1998)
Guest info
Matt Quinn
twitter.com/Mqsley
https://www.mquinn.online/

Biography:
TL;DR Here's what I am working on:
I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here
I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this
I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here
In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here
I have failed at so so so many things - read about them here
https://www.mquinn.online/
_______________________________________
Co-host
Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes
Episode 14 Post Script: Matt Has a Surprising Easter Egg
youtu.be/1D17vUvbHhk

Spiteller, G. (1998). Linoleic Acid Peroxidation—The Dominant Lipid Peroxidation Process in Low Density Lipoprotein—And Its Relationship to Chronic Diseases. Chemistry and Physics of Lipids, 95(2), 105–162. doi.org/10.1016/S0009-3084(98)00091-7

If you have any questions about sources for things discussed please ask in the comments.

Ep 16 Preview

Tucker Goodrich: Debugging Life 2024-03-09 | ...

Ep. 14 PS: Matt Has a Surprising Easter Egg

Tucker Goodrich: Debugging Life 2024-03-07 | Matt has a surprising Easter egg after we filmed this episode.

(This was while we were recording episode 16, coming soon...)

The paper referenced:

Chen, W. J., Chen, C.-C., Yu, J.-M., & Cheng, A. T. A. (1998). Self-Reported Flushing and Genotypes of ALDH2, ADH2, and ADH3 among Taiwanese Han. Alcoholism: Clinical and Experimental Research, 22(5), 1048–1052. doi.org/10.1111/j.1530-0277.1998.tb03697.x

Ep. 15 clip: How to Make Yourself Diabetic

Tucker Goodrich: Debugging Life 2024-02-23 | A short description of an n=1 experiment of how to make yourself insulin resistant in a week.

Might have some light to shed on how we all became diabetic...

Ep 15 AJ Hulbert on The Omega Balance

Tucker Goodrich: Debugging Life 2024-02-22 | Introduction
We are honorored to be joined by Prof. A. J. Hulbert, noted zoologist and author of Omega Balance: Nutritional Power for a Happier, Healthier Life.
“In Omega Balance, noted scientist Anthony J. Hulbert explains how the balance between [Omega-3 and omega-6 fatty acids] in the human food chain has changed over the last half-century and the very serious negative health impacts this imbalance has created.
An imbalance of these omega fats contributes to increased rates of obesity, diabetes, cardiovascular diseases, allergies, asthma, as well as cancer and a variety of other inflammatory diseases. Omega balance is also important for normal brain function, and an imbalance in these fatty acids is associated with depression, mood disorders, and neurodegenerative diseases.
Hulbert provides extensive information on the omega balance of different foods and discusses fascinating details about human evolution, dietary changes throughout history, the effect of diet on human development and physiological processes, and more. He investigates the paleo diet of our ancestors and describes the dramatic changes that have accompanied the increased ultra-processing of modern foods. Omega Balance is an essential guide to understanding a significant problem in our modern food chain and will make us rethink the food we eat.
https://press.jhu.edu/books/title/12823/omega-balance

Amazon link to benefit this podcast: amzn.to/49JHXFo

This book won a “Best Book” award from the American Book Fest in the category “Health: Diet and Exercise”.
americanbookfest.com/2023bbafullresults.html

Guest info
I was introduced to Prof. Hulbert by Prof. Tom Brenna, our guest in Ep. 5: Prof. Tom Brenna, Omega-3 and Omega-6 in Human Health.

Biography:
“Anthony John Hulbert (UNSW, AUS), PhD, DSc, is an internationally renowned researcher on metabolism, longevity, and nutrition. He is emeritus professor in Science, Medicine, and Health at the University of Wollongong, Australia.”
https://press.jhu.edu/books/title/12823/omega-balance#book__authors
_______________________________________
Co-host
Co-host Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes

In order of discussion.

Borchman, D., Stimmelmayr, R., & George, J. C. (2017). Whales, Lifespan, Phospholipids, and Cataracts. Journal of Lipid Research, 58(12), 2289–2298. doi.org/10.1194/jlr.M079368

Hulbert, A. J., & Else, P. L. (1999). Membranes as Possible Pacemakers of Metabolism. Journal of Theoretical Biology, 199(3), 257–274. doi.org/10.1006/jtbi.1999.0955

Abbott, S. K., Else, P. L., Atkins, T. A., & Hulbert, A. J. (2012). Fatty Acid Composition of Membrane Bilayers: Importance of Diet Polyunsaturated Fat Balance. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818(5), 1309–1317. doi.org/10.1016/j.bbamem.2012.01.011

McCollum, E. V. (1919). The Newer Knowledge of Nutrition. Macmillan Company. ia801302.us.archive.org/28/items/cu31924104225937/cu31924104225937.pdf

Speakman, J. R., De Jong, J. M. A., Sinha, S., Westerterp, K. R., Yamada, Y., Sagayama, H., Ainslie, P. N., Anderson, L. J., Arab, L., Bedu-Addo, K., Blanc, S., Bonomi, A. G., Bovet, P., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Cooper, J. A., Cooper, R., … Wong, W. W. (2023). Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure. Nature Metabolism, 5(4), 579–588. doi.org/10.1038/s42255-023-00782-2

Allport, S. (2010, November). One Person’s Response to a High Omega-6 Diet [Magazine]. American Oil Chemists’ Society. aocs.org/stay-informed/inform-magazine/featured-articles/one-persons-response-to-a-high-omega-6-diet-november-2010?SSO=True

If you have any questions about sources for things discussed please ask in the comments.

Ep. 14: How a Common Asian Genetic Mutation Leads to Chronic Disease, and What to Do

Tucker Goodrich: Debugging Life 2024-02-12 | Introduction
We look at a paper enlightening what causes chronic disease, in the context of a huge population of people who suffer from the most common human mutation, to the aldehyde dehydrogenase enzyme that detoxifies both alcohol and seed oil metabolites, the ALDH2*2 mutation. We discuss how this mutation is thought to affect the people who have it through the lens of the paper at hand.
This was a difficult video for me to edit, as both Matt and Brian share their experiences with the topic we are discussing in their own families.
I thought this was excellent, and hope many others can learn from it.
Here’s this paper: “A Common East Asian-Specific ALDH2 Mutation Causes Obesity and Insulin Resistance: Therapeutic Effect of Reducing Toxic Aldehydes by ALDH2 Activation”
Preprint:
Chang, Y.-C., Lee, H.-L., Yang, W., Hsieh, M.-L., Liu, C.-C., Lee, T.-Y., Huang, J.-Y., Nong, J.-Y., Li, F.-A., Chuang, H.-L., Ding, Z.-Z., Su, W.-L., Chueh, L.-Y., Tsai, Y.-T., Chen, C.-H., Mochly-Rosen, D., & Chuang, L.-M. (2020). A Common East Asian-Specific ALDH2 Mutation Causes Obesity and Insulin Resistance: Therapeutic Effect of Reducing Toxic Aldehydes by ALDH2 Activation. doi.org/10.21203/rs.3.rs-104384/v1
Published:
Chang, Y.-C., Lee, H.-L., Yang, W., Hsieh, M.-L., Liu, C.-C., Lee, T.-Y., Huang, J.-Y., Nong, J.-Y., Li, F.-A., Chuang, H.-L., Ding, Z.-Z., Su, W.-L., Chueh, L.-Y., Tsai, Y.-T., Chen, C.-H., Mochly-Rosen, D., & Chuang, L.-M. (2023). A Common East-Asian ALDH2 Mutation Causes Metabolic Disorders and the Therapeutic Effect of ALDH2 Activators. Nature Communications, 14(1), Article 1. doi.org/10.1038/s41467-023-41570-6

Guest info
Matt Quinn
twitter.com/Mqsley
https://www.mquinn.online/

Biography:
TL;DR Here's what I am working on:
I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here
I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this
I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here
In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here
I have failed at so so so many things - read about them here
https://www.mquinn.online/
_______________________________________
Co-host
Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes
Previous paper:
Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 Pufa. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. doi.org/10.1152/ajpheart.00480.2004

Discussed in this episode:
Ep. 12 Study: What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet—with Dr. Brian Kerley and Matt Quinn
tuckergoodrich.substack.com/p/ep-115-study-whats-worsecarbs-or
HNE/4-HNE in Wikipedia
en.wikipedia.org/wiki/4-Hydroxynonenal

Gomes, K. M. S., Campos, J. C., Bechara, L. R. G., Queliconi, B., Lima, V. M., Disatnik, M.-H., Magno, P., Chen, C.-H., Brum, P. C., Kowaltowski, A. J., Mochly-Rosen, D., & Ferreira, J. C. B. (2014). Aldehyde Dehydrogenase 2 Activation in Heart Failure Restores Mitochondrial Function and Improves Ventricular Function and Remodelling. Cardiovascular Research, 103(4), 498–508. doi.org/10.1093/cvr/cvu125

If you have any questions about sources for things discussed please ask in the comments.

Ep. 14 Preview: Half a Billion People

Tucker Goodrich: Debugging Life 2024-02-11 | ...

Ep. 13: Chef Andrew Gruel: Learning to Cook Again—with Dr. Brian Kerley

Tucker Goodrich: Debugging Life 2024-02-01 | Introduction
Brian and I are honored to be joined by the illustrious Chef Andrew Gruel. He tells us the story of how he got into cooking, how he had to learn to cook again after discovering that his academic chef training left out natural fats, and the impact using proper fats has had on his health, the health of his staff, and his customers in his latest restaurant venture.
We also have an extensive and very interesting discussion on fish, fish farming, and the health benefits of eating fish.

Guest info
Web: www.chefgruel.com (It throws a security error…)
X: twitter.com/ChefGruel
Substack: “The Food Porn Master”! substack.com/@andrewgruel
Instagram: instagram.com/andrewgruel
Calico Fish House: calico-restaurant.com

Biography:
“Andrew Gruel, a graduate of Johnson & Wales University, is a food entrepreneur and television personality – he is the Founder of Slapfish Restaurant Group (27 locations), the award-winning food truck turned international brick and mortar, based out of Huntington Beach, CA and currently CEO and founder of American Gravy Restaurant Group which comprises Calico Fishhouse, Big Parm Pizza, Two Birds Chicken, Butterleaf, Lolo’s Tacos and 101 Burger.
“Andrew has appeared on multiple television series including his most recent role as a judge on Food Network’s “Chopped Junior” with Megan Markle. He was the Host of FYI Series “Say It To My Face”, as well as a judge on Food Network’s “Food Truck Face Off.” He has made appearances on the TODAY show, Fox News, CNN, NBC Nightly News, PBS, Cooking Channel, and has been featured in numerous publications including The Wall Street Journal, Forbes, Men’s Health, Food & Wine magazine, USA Today, Entrepreneur and Nation’s Restaurant News. He was named Top 25 Business Executives for Fast Casual magazine as well as featured in Nation’s Restaurant News’ 2017 Power List. In 2013 he was named top 40 under 40 entrepreneurs in Orange County. He and his wife Lauren Gruel were named Pandemic Heroes by Restaurant Business Magazine alongside Guy Fieri and Jose Andres. He is currently the Co-Host of The SoCal Restaurant Show on AM 830 and a regular contributor on various national news channels.”
http://www.chefgruel.com/index.php/about-us.html
_______________________________________
Co-host
Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes
Slapfish: slapfishrestaurant.com
Nina Planck, “Real Food” amzn.to/3OhJBG8
Callico Fish House Restaurant: calico-restaurant.com
Tom Brenna ep. 5: tuckergoodrich.substack.com/p/podcast-ep-5-prof-tom-brenna-on-omega
Cargill & McDonalds: “Removing Trans Fats from McDonald’s® Famous Fries” cargill.com/history-story/en/HIGH-OLEIC.jsp
“Podcast Ep. 0: What VICE Left Out: Bitcoin and Seed Oils—Starting a Podcast” yelling-stop.blogspot.com/2022/04/what-vice-left-out-bitcoin-and-seed.html

If you have any questions about sources for things discussed please ask in the comments.

Ep 13 (Preview): Seed Oil is Junk

Tucker Goodrich: Debugging Life 2024-01-29 | Why Chef Gruel's restaurant smells like doughnuts...

Ep 13 (Preview): Blown an Episode

Tucker Goodrich: Debugging Life 2024-01-26 | ...

Ep. 12: Whats Worse—Carbs or Seed Oils? Understanding a Hi-PUFA Diet—w/ Brian Kerley & Matt Quinn

Tucker Goodrich: Debugging Life 2024-01-25 | Introduction
We’re trying something a bit different today. Dr. Brian Kerley and I have found a victim, Matt Quinn. Matt’s a smart guy but he’s not as immersed in these topics as we are, and so he’s going to play our straight man, the every-day guy who can hopefully come to easily-digested conclusions about the papers we discuss.
In our inaugural episode we discuss “Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 PUFA”.
Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 Pufa. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. doi.org/10.1152/ajpheart.00480.2004
Guest info
Matt Quinn
twitter.com/Mqsley
https://www.mquinn.online/

Biography:
TL;DR Here's what I am working on:
I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here
I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this
I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here
In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here
I have failed at so so so many things - read about them here
https://www.mquinn.online/
_______________________________________
Co-host
Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes
Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 Pufa. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. doi.org/10.1152/ajpheart.00480.2004
I discussed this in a blog post. I won’t be doing this for most of the studies we discuss, but I figured it was handy to start with one where I had already done some work!
What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet.
tl;dr: The one study I'm aware of that shows conclusively that excess glucose acts as an accelerant for excess omega-6 fat, but it not nearly so harmful without the omega-6, in vivo.
tuckergoodrich.substack.com/p/whats-worsecarbs-or-seed-oils-understanding
If you have any questions about sources for things discussed please ask in the comments.

Ep 11 clip: Raw Vegan Cavities

Tucker Goodrich: Debugging Life 2024-01-22 | Dr. Saladino describes his experience with getting cavities on a raw vegan diet, and how he fixed them.

Ep. 11: Paul Saladino, MD: The Intellectual Journey of a Physician—with Dr. Joshua Durham

Tucker Goodrich: Debugging Life 2024-01-22 | We interview Paul Saladino MD about his intellectual journey from being a raw vegan with rotting teeth as a physician’s assistant, through becoming the “Carnivore MD”, to where he is today. We discuss the training a physician receives in medical school about nutrition, and how he filled that gap with his own experience and research. And how it impacted his health and his ideas about being a physician.
Josh Durham, my personal physician, joins me as co-host today to recount his personal health journey as well and how it changed his practice. (He recently quit his job at a large hospital to go independent!)

Paul Saladino, MD:
paulsaladinomd.co

Dr. Saladino’s "The Carnivore Code" book:
amzn.to/47OCjAt

Biography of Paul Saladino:
I’m a double board certified MD, host of the Fundamental Health podcast, and author of The Carnivore Code and The Carnivore Code Cookbook.
I believe in questioning our assumptions about health and nutrition, which makes me controversial in modern medicine. I'm much more interested in optimal health than in dogmatic adherence to a mainstream narrative.
I graduated from medical school at the University of Arizona in Tucson, and completed my residency at the University of Washington in Seattle. After residency, I attained a board certification as a Physician Nutrition Specialist.
Throughout my medical training, I came to one very saddening conclusion: our Western medical system isn’t helping people lead richer lives.
Western medicine fails to treat the root cause of chronic illness, and doctors are only taught to treat symptoms with medications, rather than trying to understand the roots of illness.
I firmly believe that nutritional choices lie at the ROOT of so many chronic illnesses that western medicine deems irreversible.
And I also believe that most chronic illnesses are preventable AND reversible.
paulsaladinomd.co/about
_______________________________________
Co-host Joshua Durham, DO:
drdurham.org

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Twitter: twitter.com/TuckerGoodrich
Youtube: youtube.com/tuckergoodrich0
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
_______________________________________
Show Notes
Jordan Petersen on Joe Rogan discussing carnivore diet:
youtube.com/watch?v=HLF29w6YqXs

Farley Mowat "People of the Deer" book:
amzn.to/3Uc42bh

Amgen: "8 Things to Know About Lipoprotein(a)"
amgen.com/stories/2023/02/8-things-to-know-about-lipoproteina

"AMGEN ANNOUNCES POSITIVE TOPLINE PHASE 2 DATA FOR INVESTIGATIONAL OLPASIRAN IN ADULTS WITH ELEVATED LIPOPROTEIN(a)":
amgen.com/newsroom/press-releases/2022/05/amgen-announces-positive-topline-phase-2-data-for-investigational-olpasiran-in-adults-with-elevated-lipoproteina

"Seed oils are BS" t-shirt: bunkerbranding.com/collections/paul-saladino-md-shirts/products/seed-oils-are-bs?variant=42776441782403

If you have any questions about sources for things discussed please ask in the comments.

Ep. 10: Dalton Graham: How to Induce Fatty Liver—with Dr. Brian Kerley

Tucker Goodrich: Debugging Life 2023-10-26 | Dr. Kerley and I are joined by Dalton Graham, a student who found himself in a liver pathology lab at Tulane. He had the interesting idea to test if a high-linoleic acid diet could be shown to produce fatty liver disease at the same time it was causing obesity.
The scientists in the lab required a little convincing that this was a worthy experiment, but one day he arrived to find all the materials he need waiting for him.
Be careful what you wish for! Find out how it turned out.
Graham, D. S., Liu, G., Arasteh, A., Yin, X.-M., & Yan, S. (2023). Ability of High Fat Diet to Induce Liver Pathology Correlates with the Level of Linoleic Acid and Vitamin E in the Diet. PLOS ONE, 18(6), e0286726. doi.org/10.1371/journal.pone.0286726

Biography:
• Dalton is currently a PhD student at University of Florida, studying Biochemistry with a focus on metabolism. When he wrote the paper we are discussing, he was an undergrad, and then grad student at Tulane University, studying Biochemical Engineering and Pathology.
_______________________________________
Co-host Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Substack: tuckergoodrich.substack.com
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com
Youtube: youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg
Apple podcast: podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Podcast: sites.libsyn.com/408758
Twitter: twitter.com/TuckerGoodrich
_______________________________________
Show Notes
“Alvheim papers out of the NIH”
Alvheim, A. R., Malde, M. K., Osei‐Hyiaman, D., Hong, Y. H., Pawlosky, R. J., Madsen, L., Kristiansen, K., Frøyland, L., & Hibbeln, J. R. (2012). Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity. Obesity, 20(10), 1984–1994. doi.org/10.1038/oby.2012.38
Alvheim, A. R. (2012). Dietary linoleic acid induces obesity through excessive endocannabinoid activity [Doctor of Philosophy, The University of Bergen]. https://bora.uib.no/bora-xmlui/handle/1956/5962

See the Substack post for the rest of the show notes.

open.substack.com/pub/tuckergoodrich/p/ep-10-dalton-graham-how-to-induce?r=1g2jpl&utm_campaign=post&utm_medium=web

Ep 9: Dave Feldman, Citizen Scientist—What Causes Heart Disease

Tucker Goodrich: Debugging Life 2023-10-16 | Dave Feldman and I discuss the what causes heart disease, specifically focusing on the consensus view and how it differs from what the science actually shows.

Topics:
Basic theory of CVD causation:

• High ApoB/LDL/Cholesterol
• Gradient causes penetration of arterial wall
• Cholesterol/lipid oxidation in wall
• Progression through stages of atherosclerosis
• Blockage/rupture of plaque
• Ischemia of blood to heart
• Death/morbidity via MI

Electro-negative LDL
Aggregated LDL
TG-rich Lipoproteins
Risk and factor models
FH mortality—implications for causality
ApoB48
Albumin
Vasa vasorum
'Atherosclerosis' in veins

_______________________________________
Dave Feldman

Biography:
“I’m a senior software engineer and entrepreneur.
“I began a Low Carb, High Fat diet in April 2015 and have since learned everything I could about it with special emphasis on cholesterol given my lipid numbers spiked substantially after going on the diet. As an engineer, I spotted a pattern in the lipid system that’s very similar to distributed objects in networks.
“I’ve since learned quite a bit on the subject both through research and experimentation which has revealed some very powerful data. With this new general theory, I’ve shifted around my cholesterol substantially without any drugs or special supplements of any kind.
From: cholesterolcode.com/about

Blog: cholesterolcode.com
Twitter: twitter.com/realDaveFeldman

Citizen Science Foundation:
Site: citizensciencefoundation.org
Twitter: twitter.com/realCSF
DONATE: citizensciencefoundation.org/donate

Own Your Labs: ownyourlabs.com

Tucker Goodrich
Blog: http://yelling-stop.blogspot.com
Substack: tuckergoodrich.substack.com
Youtube: youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg
Podcast: sites.libsyn.com/408758
Twitter: twitter.com/TuckerGoodrich

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

_______________________________________
Show Notes
Notes
See the canine LMHR study:

Kronfeld, D. S., Hammel, E. P., Ramberg, C. F., & Dunlap, H. L. (1977). Hematological and metabolic responses to training in racing sled dogs fed diets containing medium, low, or zero carbohydrate. The American Journal of Clinical Nutrition, 30(3), 419–430. doi.org/10.1093/ajcn/30.3.419

Lipid-Energy Model

Norwitz, N. G., Feldman, D., Soto-Mota, A., Kalayjian, T., & Ludwig, D. S. (2022). Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a “Lean Mass Hyper-Responder” Phenotype. Current Developments in Nutrition, 6(1), nzab144. doi.org/10.1093/cdn/nzab144

Norwitz, N. G., Soto-Mota, A., Kaplan, B., Ludwig, D. S., Budoff, M., Kontush, A., & Feldman, D. (2022). The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets. Metabolites, 12(5), Article 5. doi.org/10.3390/metabo12050460

PubMed for Dave's other papers:

pubmed.ncbi.nlm.nih.gov/?term=norwitz+feldman&sort=pubdate

See Substack for full show notes—They don't fit here

tuckergoodrich.substack.com

Ep 8: Paul Hart—In the Belly of the Beast: Life in a Processed Food Company

Tucker Goodrich: Debugging Life 2023-06-29 | Discussion with Paul Hart, formerly of Unilever and currently a consultant to the processed food industry, on the pros and cons are of processed foods, and what the food industry is hoping to accomplish.

Ep. 7: Drs. Tro Kalayjian, Brian Lenzkes, Joshua Durham—How to Save Medicine, One Practice at a Time

Tucker Goodrich: Debugging Life 2023-06-15 | Medicine needs to be fixed:
“The New Crisis of Increasing All-Cause Mortality in US Children and Adolescents”
• jamanetwork.com/journals/jama/article-abstract/2802602

Dr. Tro Kalayjian
Dr. Tro’s Medical Weight Loss
• doctortro.com
Research:
• scholar.google.com/citations?user=ByYma7sAAAAJ
Twitter:
• twitter.com/DoctorTro

Dr. Brian Lenzkes
Metabolic Health:
• San Diego: sandiegometabolichealth.com
• Arizona: arizonametabolichealth.com/brian-lenzkes-md
Twitter:
• twitter.com/BrianLenzkes

Dr. Joshua Durham
Twitter:
• twitter.com/JoshuaD81699641

Dr. Eric Westman
• ericwestmanmd.com
New Atkins for a New You: The Ultimate Diet for Shedding Weight and Feeling Great by Eric C. Westman, Stephen D. Phinney, Jeff S. Volek
• amzn.to/3qd9fzy (this link benefits the podcast!)

Philip Ovadia
• ovadiahearthealth.com

Alessio Fassano
• https://nutrition.hms.harvard.edu/people/alessio-fasano
Research:
• scholar.google.com/citations?user=8IxzUn0AAAAJ&hl=en&oi=ao

Whole30
• whole30.com

Virta
• virtahealth.com

Dr. Tro app
• apps.apple.com/us/app/doctor-tro/id1588693888

Lenzkes & Kalayjian’s podcast: Low-Carb MD Podcast
• lowcarbmd.com
_______________________________________
Co-host Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Blog: http://yelling-stop.blogspot.com
Youtube:

/ @tuckergoodrich0
Podcast: sites.libsyn.com/408758
Twitter: twitter.com/TuckerGoodrich
_______________________________________

Ep. 6: Dr. Joshua Durham; Family Doc Gets Red-pilled by Seed Oils—with Dr Brian Kerley

Tucker Goodrich: Debugging Life 2022-09-08 | Dr. Durham is a Family Physician in Boise, Idaho; and is Tucker's doctor.

We discuss how his practice has changed since he figured out how to solve his own chronic health problems, how this has changed his practice, some successes, and more.

Joshua Durham, DO
• saintalphonsus.org/provider/joshua-durham
Blog comment:
Dr. Durham: “If you need a family Dr. here in Boise hit me up. I went from 235lbs to keto to carnivore and then finally came across your info. Now at 195 I feel comfortable knowing what I can and can't have and why I was so sick. Felt great on carnivore but can't live that way forever. Thank you for your work.”
• http://yelling-stop.blogspot.com/2021/04/experts-do-as-we-say-not-as-we-do.html?showComment=1620609617154#c416429453974276542
“Doctor of Osteopathy vs. Medical Doctor- What are the Differences?”
• https://hecec.human.cornell.edu/2016/02/12/doctor-of-osteopathy-vs-medical-doctor-what-are-the-differences/
Dr. Eric Westman
• ericwestmanmd.com
New Atkins for a New You: The Ultimate Diet for Shedding Weight and Feeling Great by Eric C. Westman, Stephen D. Phinney, Jeff S. Volek
• amzn.to/3qd9fzy (this link benefits the podcast!)
Dr. Durham: “Good fat/bad fat” I wrote a post about this: “Good Keto vs. Bad Keto”
• http://yelling-stop.blogspot.com/2021/09/good-keto-vs-bad-keto.html
Dr. Durham: “Then I saw your interview with Paul Saladino…”
• “How Seed Oils Destroy Your Mitochondria and Lead To Chronic Disease, with Tucker Goodrich” carnivoremd.com/how-seed-oils-destroy-your-mitochondria-and-lead-to-chronic-disease-with-tucker-goodrich
“…and then I watched Brad Marshall…”
• Brad’s blog is here: fireinabottle.net
Drs. Kerley and Durham compare “elevator pitches” to patients.
Dr. Durham: “I needed 4 pills based on the guidelines, and I was 38 years old.”
Tucker: “Lean-Mass Hyper Responder”:
Norwitz, N. G., Soto-Mota, A., Kaplan, B., Ludwig, D. S., Budoff, M., Kontush, A., & Feldman, D. (2022). The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets. Metabolites, 12(5), 460. doi.org/10.3390/metabo12050460
Dr. Durham: 40:02 “American College of Cardiology article…”
Astrup, A., Magkos, F., Bier, D. M., Brenna, J. T., de Oliveira Otto, M. C., Hill, J. O., King, J. C., Mente, A., Ordovas, J. M., Volek, J. S., Yusuf, S., & Krauss, R. M. (2020). Saturated Fats and Health: A Reassessment and Proposal for Food-based Recommendations: JACC State-of -the-Art Review. Journal of the American College of Cardiology, 76(7), 844–857. doi.org/10.1016/j.jacc.2020.05.077
See Episode 5, in which we interview Tom Brenna, one of the co-authors of that article: youtube.com/watch?v=rrQ8q_ctGUQ
Tucker: “The AGEs, same thing—Chris Masterjohn did a great post years ago looking into it:
Masterjohn, C. (2011, October 7). Where Do Most AGEs Come From? O Glycation, How Thy Name Hast Deceived Me! | [Blog]. Chris Masterjohn, PhD. chrismasterjohnphd.com/blog/2011/10/07/where-do-most-ages-come-from-o
Tucker: “Polyunsaturated fats are about 10x as effective in producing advanced glycation end products [than glucose]…”
Fu, M.-X., Requena, J. R., Jenkins, A. J., Lyons, T. J., Baynes, J. W., & Thorpe, S. R. (1996). The Advanced Glycation End Product, N-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions. Journal of Biological Chemistry, 271(17), 9982–9986. doi.org/10.1074/jbc.271.17.9982
Tucker: Lp(a):
• Hazard ratio 16.8: Tsimikas, S., Brilakis, E. S., Miller, E. R., McConnell, J. P., Lennon, R. J., Kornman, K. S., Witztum, J. L., & Berger, P. B. (2005). Oxidized Phospholipids, Lp(a) Lipoprotein, and Coronary Artery Disease. New England Journal of Medicine, 353(1), 46–57. doi.org/10.1056/NEJMoa043175
• Hazard ratio 1 in Africa: Paré, G., Çaku, A., McQueen, M., Anand, S. S., Enas, E., Clarke, R., Boffa, M. B., Koschinsky, M., Wang, X., Yusuf, S., & null, null. (2019). Lipoprotein(a) Levels and the Risk of Myocardial Infarction Among 7 Ethnic Groups. Circulation, 139(12), 1472–1482. doi.org/10.1161/CIRCULATIONAHA.118.034311
• 2 sure-fire ways to raise Lp(a):
1. Statins: Yeang, C., Hung, M.-Y., Byun, Y.-S., Clopton, P., Yang, X., Witztum, J. L., & Tsimikas, S. (2016). Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a). Journal of Clinical Lipidology, 10(3), 594–603. doi.org/10.1016/j.jacl.2016.01.005

See the blog for the rest!

_______________________________________
Co-host Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Blog: http://yelling-stop.blogspot.com
Youtube: youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg
Podcast: sites.libsyn.com/408758
Twitter: twitter.com/TuckerGoodrich

Ep. 5: Prof. Tom Brenna, Omega-3 and Omega-6 in Human Health—with Dr Brian Kerley

Tucker Goodrich: Debugging Life 2022-09-01 | Human results of a low-linoleic diet with adequate omega-3 on neurodevelopment.
The WHO change their guidelines to favor a low-linoleic diet for starving children
How to protect against blindness.
Why the Dietary Guidelines can’t get it right, and where they do.
Fish vs fish oil for omega-3 DHA benefits.
Fish consumption and mercury, is it a problem?
Farmed vs. wild-caught fish.
On the essentiality of linoleic acid.
Linoleic acid impairs fertility
Biography:
Tom Brenna, Ph.D., Professor, Department of Pediatrics, Dell Medical School, UT Austin;
• https://dellmed.utexas.edu/directory/tom-brenna
“Tom Brenna is a professor of pediatrics at Dell Medical School. He moved to Austin after 28 years as a professor of human nutrition, chemistry, chemical biology and food science at Cornell University in Ithaca, New York. His group’s basic research into the chemical, biochemical, metabolic, genetic and ecological aspects of fatty acids have had a decisive influence on modern knowledge of these key nutrients.
“Brenna’s research couples nutrition and chemistry in a broadly interdisciplinary program. His research group has been funded by institutes and centers at the National Institutes of Health (National Institute of General Medical Sciences, National Eye Institute, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Center for Complementary and Integrative Health) since 1992. Most of the work of the Brenna Lab is translational, tying basic research to biomedicine and human nutrition….”
Professor Emeritus, Division of Nutritional Sciences, Cornell University.
• https://www.human.cornell.edu/people/jtb4
_______________________________________
Co-host Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Blog: http://yelling-stop.blogspot.com
Youtube: youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg
Podcast: sites.libsyn.com/408758
Twitter: twitter.com/TuckerGoodrich
_______________________________________

Show notes
For full show notes see my blog. (They won't fit here!)

Ep. 3: Robb Wolf on Sacred Cow, His Health Issues, Beyond Paleo, and More... co-host Brian Kerley

Tucker Goodrich: Debugging Life 2022-06-06 | Brian and I have an engaging chat with famed Paleo Diet advocate Robb Wolf on his recent book 'Sacred Cow', how his own health issues have kept him engaged in continuing to explore the relationship between diet and health, how he's going beyond Paleo with his new enterprise LMNT, and more. I hope you all enjoy!

Robb Wolf
robbwolf.com

"Sacred Cow"
amzn.to/39bzKAe

Diana Rodgers, RD (co-author of Sacred Cow)
sustainabledish.com
twitter.com/SustainableDish

"The Paleo Solution"
amzn.to/3x4TKwn

T. Colin Campbell's "The China Study"
amzn.to/39azaml

Zero Acre Farms
zeroacre.com

*Fermentation, not "fertilization"!

Carbon cycle
education.nationalgeographic.org/resource/carbon-cycle

EAT-Lancet Commission Summary Report
eatforum.org/eat-lancet-commission/eat-lancet-commission-summary-report

Omega Initiative
TK

Mat Lalonde
fatburningman.com/mat-lalonde-why-nutrient-density-matters-paleo-fails-what-to-eat-for-dinner

Amber O'Hearn
mostly-fat.com

Ketogains
ketogains.com

LMNT
drinklmnt.com
Products: amzn.to/3Q211pk

Tim Noakes' "Waterlogged: The Serious Problem of Overhydration in Endurance Sports"
amzn.to/38MxY8L

Stan Efferding
stanefferding.com

LMNT make your own sodium supplement: "11 Homemad Electrolyte Drink Recipes"
- Includes the Norcal Margarita I mentioned!
drinklmnt.com/blogs/health/the-best-homemade-electrolyte-drink-for-dehydration

Roam Free Bison Ranch
goroamfree.com

"Restoring the land with the Savory Institute"
youtube.com/watch?v=yVxLQtSqvbQ

_____________________________________________________

Co-host Dr. Brian Kerley
seedoilrebellion.com
twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
seedyapp.com

Tucker Goodrich
Blog: http://yelling-stop.blogspot.com
Youtube: youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg
Podcast: sites.libsyn.com/408758
Twitter: twitter.com/TuckerGoodrich

Ep. 2: Professor Ameer Taha on Lipid Oxidation, Linoleic Acid, OXLAMS

Tucker Goodrich: Debugging Life 2022-05-05 | I interview Prof. Ameer Taha of U.C. Davis on linoleic acid, lipid peroxidation, oxLAMs, and neurodegeneration.

A great discussion going over some of the seminal research he has done during his career.

We also discuss his surprising dream research project, one I think would yield major benefits if he were able to pursue it...

This was originally released on David Gornoski's A Neighbor's Choice podcast:

aneighborschoice.com/professor-ameer-taha-on-lipid-oxidation-linoleic-acid-oxlams

My thanks to David for permission to re-release it here.

Please subscribe to this channel if you find this topic interesting!

My audio podcast link is here:
sites.libsyn.com/408758

Here is Prof. Taha's page at U.C. Davis:

https://foodscience.ucdavis.edu/people/ameer-taha#/

Here's his PubMed research:
pubmed.ncbi.nlm.nih.gov/?term=ameer+taha%5BAuthor%5D&sort=date

And his most recent (one I will be reading as soon as I finish posting this!):

Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions
pubmed.ncbi.nlm.nih.gov/35508275

Blog:
yelling-stop.blogspot.com

Twitter:
twitter.com/TuckerGoodrich

Ep. 1: Seed Oil Disrespecter Revealed

Tucker Goodrich: Debugging Life 2022-04-21 | Meet the Seed Oil Disrespecter and his wife, Ashley. We talk about how and why they started doing what they are doing, and what they hope to accomplish, with a focus on how avoiding seed oils affected their family health even after eating a mostly healthy diet for many years.

Some news at the end, so stick around!

Seed Oil Disrespecter on Twitter:
twitter.com/SeedOilDsrspctr

On Instagram:
instagram.com/seedoildisrespecter

Healthy Oil Respecter (Ashley) on Twitter:
twitter.com/RealOilRspctr

On Instagram:
instagram.com/seed_oil_rebellion

Seed Oil Rebellion:
seedoilrebellion.com

My blog:
yelling-stop.blogspot.com

Twitter:
twitter.com/TuckerGoodrich

Podcast:
sites.libsyn.com/408758

Ep. 0: What VICE Left Out: Bitcoin and Seed Oils

Tucker Goodrich: Debugging Life 2022-04-01 | [Blog post with lots more links is here: yelling-stop.blogspot.com/2022/04/what-vice-left-out-bitcoin-and-seed.html ]

Back in February, Dr. K, the Seed Oil Disrespecter on Twitter, was contacted by Audrey Carleton, a reporter for the news website VICE. She had some questions about why the seed oil topic had become a 'big thing' in the bitcoin world. He mentioned me as being knowledgeable about the seed oil and health topic, and suggested I reach out to her.

I did, and we had a nice chat, although it probably went on longer than she was expecting. I've often heard it's wise to record conversations with journalists, and we did so via Zoom, to which she agreed.

We had a pleasant enough conversation, and she listened to me at length (~48 minutes).

I followed up with a bunch of references to some of the scientific evidence we had discussed (see that link for the file I sent her, references below), and offered to send more.
drive.google.com/file/d/14CWTc-KSlgnZ3VJlmg_ndQv5Hl2tQCPV/view?usp=sharing

She didn't get back to me for any follow-up discussion, and then finally the article came out:

"The Newest Bitcoin Diet Trend Is Hating ‘Seed Oils’"
vice.com/en/article/v7djay/the-newest-bitcoin-diet-trend-is-hating-seed-oils

I'll not editorialize about the many problems with that article, but the major one is they never addressed the research from institutions like the NIH and the AHA showing that there are credible reasons to think that the benefits of seed oils are oversold, and that there are real reasons to fear harmful effects.

"Misinformation is a two-edged sword in the seed oil debate, however. Figureheads like Shanahan, after all, believe that most mainstream dietary guidance around fat consumption is built on lies, the kind that have quietly fueled America’s major health epidemics for decades. Like Bitcoin itself, the anti-seed oil stance reflects a skepticism of authority, one that is often not unfounded in the least but which can quickly snowball, echoed and amplified online."

It's rather routine at this time for journalists to spread misinformation while pretending to be preventing it, and this is a perfect example of that.

So I am presenting here the full discussion I had with VICE, so you can be the judge yourself of the value of what they elected to leave out while claiming that being concerned about seed oils is "misinformation".

Journalists have editors, and many publications have clear—often unadmitted—editorial biases. I have no particular reason to think that Audrey wrote the bias into this story, so I won't blame her for it. I appreciate the time that she took to speak to me.

I do blame VICE, however, which I think is fair. They printed a biased, misleading article, while ignoring that there are valid scientific reasons to think seed oils are problematic.

I'm glad they left my name out of it.

Podcast version (audio only) here: sites.libsyn.com/408758/what-vice-left-out-bitcoin-and-seed-oils