Uploaded January 2025 | Updated September 2026, 2 weeks ago
In this Complex Care Journal Club podcast episode, Dr. Kathleen C. Thomas discusses a cross-sectional study of associations between neighborhood context with psychotropic polypharmacy and psychotherapy among children with high-needs for medical or psychiatric care. She describes the inclusion of parent advisors on the study team, the inclusion of children with medical complexity in the study population, key insights including the importance of non-medical supports, and the next steps from this work.
SPEAKER
Kathleen C. Thomas, PhD, MPH
Professor and Vice Chair of Research and Graduate Education
Division of Pharmaceutical Outcomes and Policy
Eshelman School of Pharmacy
University of North Carolina at Chapel Hill
HOST
Kristina Malik, MD
Assistant Professor of Pediatrics,
University of Colorado School of Medicine
Medical Director, KidStreet
Pediatrician, Special Care Clinic,
Children's Hospital Colorado
DATE
Initial publication date: January 13, 2025.
ARTICLE REFERENCED
Thomas KC, Annis IE, deJong NA, Christian RB, Davis SA, Hughes PM, Prichard BA, Prichard JR, Allen PS, Gettinger JS, Morris DN, Eaker KB. Association Between Neighborhood Context and Psychotropic Polypharmacy Use Among High-Need Children. Psychiatr Serv. 2024 Sep 11:appips20230639. doi: 10.1176/appi.ps.20230639. Epub ahead of print. PMID: 39257315.
TRANSCRIPT
cdn.bfldr.com/D6LGWP8S/as/3rffshwp3q2km53w7xckq38/011025_CCJCP__Where_You_Live_Matters
Clinicians across healthcare professions, advocates, researchers, and patients/families are all encouraged to engage and provide feedback! You can recommend an article for discussion using this form: forms.gle/Bdxb86Sw5qq1uFhW6
Please visit: openpediatrics.org
OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access, thus at no expense to the user.
For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu
Please note: OPENPediatrics does not support or control any related videos in the sidebar; these are placed by YouTube. We apologize for any inconvenience this may cause.
CITATION
Thomas KC, Malik KE. Where You Live Matters: Psychotropic Polypharmacy and Psychotherapy in Children with High-Needs. 01/2025. OPENPediatrics. Online Podcast. youtu.be/hEPsDVRxx0I.
In this Complex Care Journal Club podcast episode, Dr. Kathleen C. Thomas discusses a cross-sectional study of associations between neighborhood context with psychotropic polypharmacy and psychotherapy among children with high-needs for medical or psychiatric care. She describes the inclusion of parent advisors on the study team, the inclusion of children with medical complexity in the study population, key insights including the importance of non-medical supports, and the next steps from this work.
SPEAKER
Kathleen C. Thomas, PhD, MPH
Professor and Vice Chair of Research and Graduate Education
Division of Pharmaceutical Outcomes and Policy
Eshelman School of Pharmacy
University of North Carolina at Chapel Hill
HOST
Kristina Malik, MD
Assistant Professor of Pediatrics,
University of Colorado School of Medicine
Medical Director, KidStreet
Pediatrician, Special Care Clinic,
Children's Hospital Colorado
DATE
Initial publication date: January 13, 2025.
ARTICLE REFERENCED
Thomas KC, Annis IE, deJong NA, Christian RB, Davis SA, Hughes PM, Prichard BA, Prichard JR, Allen PS, Gettinger JS, Morris DN, Eaker KB. Association Between Neighborhood Context and Psychotropic Polypharmacy Use Among High-Need Children. Psychiatr Serv. 2024 Sep 11:appips20230639. doi: 10.1176/appi.ps.20230639. Epub ahead of print. PMID: 39257315.
TRANSCRIPT
cdn.bfldr.com/D6LGWP8S/as/3rffshwp3q2km53w7xckq38/011025_CCJCP__Where_You_Live_Matters
Clinicians across healthcare professions, advocates, researchers, and patients/families are all encouraged to engage and provide feedback! You can recommend an article for discussion using this form: forms.gle/Bdxb86Sw5qq1uFhW6
Please visit: openpediatrics.org
OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access, thus at no expense to the user.
For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu
Please note: OPENPediatrics does not support or control any related videos in the sidebar; these are placed by YouTube. We apologize for any inconvenience this may cause.
CITATION
Thomas KC, Malik KE. Where You Live Matters: Psychotropic Polypharmacy and Psychotherapy in Children with High-Needs. 01/2025. OPENPediatrics. Online Podcast. youtu.be/hEPsDVRxx0I.

![Immunoparalysis and the Future of Personalized Immunotherapy for Critically Ill Children by M. Hall
In this World Shared Practice Forum Podcast, Dr. Mark Hall discusses immunology and inflammation in pediatric sepsis treatment, using immune phenotyping to personalize treatment for pediatric sepsis.
LEARNING OBJECTIVES
Upon listening to this presentation, learners will be able to:
- Recall the history of understanding the inflammatory response in critically ill children
- Identify the distinction between the pro-inflammatory response and the immune paralysis phenomenon
- Describe the study of immune phenotyping to personalize treatment for pediatric sepsis
AUTHORS
Mark W. Hall, MD, FAAP, FCCM
Chief, Division of Critical Care Medicine
Nationwide Childrens Hospital
Professor in the Department of Pediatrics
Division of Critical Care Medicine
Nationwide Childrens Hospital and The Ohio State University College of Medicine
Jeffrey Burns, MD, MPH
Chief and Shapiro Chair, Division of Critical Care Medicine; Executive Chair, International Health Services
Senior Associate in Critical Care Medicine; Department of Anesthesiology, Critical Care and Pain Medicine
Boston Childrens Hospital
Professor of Anesthesia
Harvard Medical School
DATES
Initial publication: November 27, 2023.
ARTICLES REFERENCED
15:48: Cornell TT, Sun L, Hall MW, et al. Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2012;143(5):1160-1166.e1. doi:10.1016/j.jtcvs.2011.09.011
16:10 Collaborative Pediatric Critical Care Research Network, https://www.cpccrn.org/
17:04 VanBuren JM, Hall M, Zuppa AF, et al. The Design of Nested Adaptive Clinical Trials of Multiple Organ Dysfunction Syndrome Children in a Single Study [published online ahead of print, 2023 Jul 27]. Pediatr Crit Care Med. 2023;10.1097/PCC.0000000000003332. doi:10.1097/PCC.0000000000003332
Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu
CITATION
Hall MW, O’Hara JE, Burns JP. Immunoparalysis and the Future of Personalized Immunotherapy for Critically Ill Children. 11/2023. OPENPediatrics. Online Podcast. https://youtu.be/hImZGqcd1Uo. Immunoparalysis and the Future of Personalized Immunotherapy for Critically Ill Children by M. Hall](https://i.ytimg.com/vi/hImZGqcd1Uo/mqdefault.jpg)








